Details for: EIF2AK1

Gene ID: 27102

Symbol: EIF2AK1

Ensembl ID: ENSG00000086232

Description: eukaryotic translation initiation factor 2 alpha kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 149.8955
    Cell Significance Index: -38.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 107.3073
    Cell Significance Index: -44.2100
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.2854
    Cell Significance Index: -15.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.4323
    Cell Significance Index: -46.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.4538
    Cell Significance Index: -37.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.5172
    Cell Significance Index: -42.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.4556
    Cell Significance Index: -37.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.8451
    Cell Significance Index: -29.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.7115
    Cell Significance Index: -39.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1998
    Cell Significance Index: -44.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3664
    Cell Significance Index: -31.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4379
    Cell Significance Index: -14.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.5713
    Cell Significance Index: 95.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1722
    Cell Significance Index: 236.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1731
    Cell Significance Index: 144.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0573
    Cell Significance Index: 209.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0427
    Cell Significance Index: 187.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9789
    Cell Significance Index: 45.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9185
    Cell Significance Index: 501.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8719
    Cell Significance Index: 174.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6474
    Cell Significance Index: 88.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6311
    Cell Significance Index: 21.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5968
    Cell Significance Index: 27.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5647
    Cell Significance Index: 5.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4908
    Cell Significance Index: 48.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4738
    Cell Significance Index: 35.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4707
    Cell Significance Index: 168.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4664
    Cell Significance Index: 206.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4308
    Cell Significance Index: 50.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4299
    Cell Significance Index: 12.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4141
    Cell Significance Index: 26.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3971
    Cell Significance Index: 20.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3717
    Cell Significance Index: 60.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3615
    Cell Significance Index: 25.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3045
    Cell Significance Index: 210.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2890
    Cell Significance Index: 37.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2626
    Cell Significance Index: 7.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2480
    Cell Significance Index: 42.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2380
    Cell Significance Index: 14.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1620
    Cell Significance Index: 4.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1611
    Cell Significance Index: 3.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1486
    Cell Significance Index: 8.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1399
    Cell Significance Index: 6.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1354
    Cell Significance Index: 7.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1075
    Cell Significance Index: 13.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1059
    Cell Significance Index: 3.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0791
    Cell Significance Index: 2.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0771
    Cell Significance Index: 14.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0629
    Cell Significance Index: 1.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0343
    Cell Significance Index: 64.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0341
    Cell Significance Index: 62.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0273
    Cell Significance Index: 19.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0253
    Cell Significance Index: 39.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0211
    Cell Significance Index: 19.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0043
    Cell Significance Index: 0.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0019
    Cell Significance Index: 0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0006
    Cell Significance Index: 0.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0126
    Cell Significance Index: -9.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0255
    Cell Significance Index: -0.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0270
    Cell Significance Index: -0.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0382
    Cell Significance Index: -3.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0387
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0447
    Cell Significance Index: -25.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0581
    Cell Significance Index: -1.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0595
    Cell Significance Index: -3.7500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0596
    Cell Significance Index: -6.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0930
    Cell Significance Index: -19.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1215
    Cell Significance Index: -14.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1286
    Cell Significance Index: -36.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1566
    Cell Significance Index: -4.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1772
    Cell Significance Index: -25.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2071
    Cell Significance Index: -23.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2486
    Cell Significance Index: -4.2600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2881
    Cell Significance Index: -2.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3306
    Cell Significance Index: -26.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3363
    Cell Significance Index: -22.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3895
    Cell Significance Index: -40.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4046
    Cell Significance Index: -5.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4186
    Cell Significance Index: -8.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4205
    Cell Significance Index: -18.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5105
    Cell Significance Index: -26.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5181
    Cell Significance Index: -19.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5984
    Cell Significance Index: -14.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6497
    Cell Significance Index: -39.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7004
    Cell Significance Index: -13.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7092
    Cell Significance Index: -20.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7304
    Cell Significance Index: -13.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7474
    Cell Significance Index: -8.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7489
    Cell Significance Index: -18.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7617
    Cell Significance Index: -19.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7819
    Cell Significance Index: -8.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9013
    Cell Significance Index: -9.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9061
    Cell Significance Index: -45.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9088
    Cell Significance Index: -26.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9157
    Cell Significance Index: -15.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine Kinase Activity:** EIF2AK1 possesses serine kinase activity, which enables it to phosphorylate and regulate target proteins. 2. **Heme Binding:** The gene's product, HRI, exhibits high affinity for heme, allowing it to respond to changes in iron levels and regulate cellular processes accordingly. 3. **Regulation of eIF2α Phosphorylation:** EIF2AK1 phosphorylates and regulates eIF2α, a key regulator of translation initiation, thereby modulating protein synthesis and cellular homeostasis. 4. **Negative Regulation of Cell Proliferation:** EIF2AK1 has been shown to negatively regulate cell proliferation, suggesting its role in maintaining cellular balance and preventing uncontrolled growth. **Pathways and Functions:** 1. **Acute Inflammatory Response:** EIF2AK1 plays a crucial role in regulating the acute inflammatory response by modulating the activity of immune cells, such as T cells and macrophages. 2. **Integrated Stress Response (ISR):** EIF2AK1 is involved in the ISR, a cellular response to stress, by regulating eIF2α phosphorylation and modulating protein synthesis. 3. **Regulation of Translation Initiation:** EIF2AK1 regulates translation initiation by phosphorylating eIF2α, thereby modulating protein synthesis and cellular homeostasis. 4. **Mitochondrial Stress Response:** EIF2AK1 has been shown to respond to mitochondrial stress by regulating the activity of mitochondrial proteins and modulating cellular homeostasis. **Clinical Significance:** 1. **Iron Deficiency Anemia:** EIF2AK1 has been implicated in the regulation of iron homeostasis, and its dysregulation has been linked to iron deficiency anemia. 2. **Immune System Disorders:** EIF2AK1 plays a crucial role in regulating the immune response, and its dysregulation has been implicated in various immune system disorders, including autoimmune diseases and cancer. 3. **Cancer:** EIF2AK1 has been shown to regulate cell proliferation and apoptosis, and its dysregulation has been linked to cancer development and progression. 4. **Neurodegenerative Diseases:** EIF2AK1 has been implicated in the regulation of protein synthesis and cellular homeostasis, and its dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, EIF2AK1 is a complex gene that plays a pivotal role in regulating various cellular processes, including immune response, stress response, and translation initiation. Its dysregulation has been implicated in various diseases, including iron deficiency anemia, immune system disorders, cancer, and neurodegenerative diseases. Further research is needed to fully elucidate the mechanisms of EIF2AK1 and its role in maintaining cellular balance and responding to environmental cues.

Genular Protein ID: 2089374960

Symbol: E2AK1_HUMAN

Name: Heme-controlled repressor

UniProtKB Accession Codes:

Q9BQI3 A8K2R2 Q549K6 Q8NBW3 Q9HC02 Q9NYE0 Q9P0V6 Q9P1J5 Q9P2H8 Q9UHG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 14 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11101152

Title: Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2alpha kinase: down-regulated in epithelial ovarian cancers.

PubMed ID: 11101152

DOI: 10.1007/s10059-000-0584-5

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12391722

Title: Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture.

PubMed ID: 12391722

DOI: 10.1080/10425170290023428

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11036079

Title: Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase.

PubMed ID: 11036079

DOI: 10.1074/jbc.m007583200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20071449

Title: Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.

PubMed ID: 20071449

DOI: 10.1124/mol.109.061259

PubMed ID: 34404736

Title: Notice of Retraction: Acharya P, Chen J-J, Correia MA (2010) Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. Mol Pharmacol 77(4):575-592; doi:10.1124/mol.109.061259.

PubMed ID: 34404736

DOI: 10.1124/mol.109.061259retraction

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32197074

Title: De novo EIF2AK1 and EIF2AK2 variants are associated with developmental delay, leukoencephalopathy, and neurologic decompensation.

PubMed ID: 32197074

DOI: 10.1016/j.ajhg.2020.02.016

PubMed ID: 32132706

Title: A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

PubMed ID: 32132706

DOI: 10.1038/s41586-020-2076-4

PubMed ID: 32132707

Title: Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.

PubMed ID: 32132707

DOI: 10.1038/s41586-020-2078-2

PubMed ID: 37327776

Title: A mitochondrial iron-responsive pathway regulated by DELE1.

PubMed ID: 37327776

DOI: 10.1016/j.molcel.2023.05.031

PubMed ID: 37550454

Title: DELE1 oligomerization promotes integrated stress response activation.

PubMed ID: 37550454

DOI: 10.1038/s41594-023-01061-0

PubMed ID: 38340717

Title: The HRI branch of the integrated stress response selectively triggers mitophagy.

PubMed ID: 38340717

DOI: 10.1016/j.molcel.2024.01.016

PubMed ID: 38297121

Title: Stress response silencing by an E3 ligase mutated in neurodegeneration.

PubMed ID: 38297121

DOI: 10.1038/s41586-023-06985-7

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 28501589

Title: Genetic modifiers of multiple sclerosis progression, severity and onset.

PubMed ID: 28501589

DOI: 10.1016/j.clim.2017.05.009

Sequence Information:

  • Length: 630
  • Mass: 71106
  • Checksum: D63021651806620B
  • Sequence:
    • MQGGNSGVRK REEEGDGAGA VAAPPAIDFP AEGPDPEYDE SDVPAEIQVL KEPLQQPTFP 
FAVANQLLLV SLLEHLSHVH EPNPLRSRQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 
NRAITHLMRS AKERVRQDPC EDISRIQKIR SREVALEAQT SRYLNEFEEL AILGKGGYGR 
VYKVRNKLDG QYYAIKKILI KGATKTVCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVI 
QPRADRAAIE LPSLEVLSDQ EEDREQCGVK NDESSSSSII FAEPTPEKEK RFGESDTENQ 
NNKSVKYTTN LVIRESGELE STLELQENGL AGLSASSIVE QQLPLRRNSH LEESFTSTEE 
SSEENVNFLG QTEAQYHLML HIQMQLCELS LWDWIVERNK RGREYVDESA CPYVMANVAT 
KIFQELVEGV FYIHNMGIVH RDLKPRNIFL HGPDQQVKIG DFGLACTDIL QKNTDWTNRN 
GKRTPTHTSR VGTCLYASPE QLEGSEYDAK SDMYSLGVVL LELFQPFGTE MERAEVLTGL 
RTGQLPESLR KRCPVQAKYI QHLTRRNSSQ RPSAIQLLQS ELFQNSGNVN LTLQMKIIEQ 
EKEIAELKKQ LNLLSQDKGV RDDGKDGGVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.