AGO2 | ENSG00000123908 | NCBI 27161

Details for: AGO2

Gene ID: 27161

Symbol: AGO2

Ensembl ID: ENSG00000123908

Description: argonaute RISC catalytic component 2

Associated with

Adherens junctions interactions
(R-HSA-418990)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Competing endogenous rnas (cernas) regulate pten translation
(R-HSA-8948700)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Intracellular signaling by second messengers
(R-HSA-9006925)
M-decay: degradation of maternal mrnas by maternally stored factors
(R-HSA-9820841)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Microrna (mirna) biogenesis
(R-HSA-203927)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-transcriptional silencing by small rnas
(R-HSA-426496)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Pten regulation
(R-HSA-6807070)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 mrna translation by micrornas
(R-HSA-9759811)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of mitf-m-dependent genes involved in apoptosis
(R-HSA-9824594)
Regulation of npas4 gene expression
(R-HSA-9768759)
Regulation of npas4 mrna translation
(R-HSA-9768778)
Regulation of pten mrna translation
(R-HSA-8943723)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by tgfbr3
(R-HSA-9839373)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Small interfering rna (sirna) biogenesis
(R-HSA-426486)
Tgfbr3 expression
(R-HSA-9839394)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by npas4
(R-HSA-9634815)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation by tp53
(R-HSA-3700989)
Core promoter sequence-specific dna binding
(GO:0001046)
Double-stranded rna binding
(GO:0003725)
Endoribonuclease activity, cleaving mirna-paired mrna
(GO:0090624)
Endoribonuclease activity, cleaving sirna-paired mrna
(GO:0070551)
Metal ion binding
(GO:0046872)
Mirna-mediated gene silencing by inhibition of translation
(GO:0035278)
Mirna-mediated gene silencing by mrna destabilization
(GO:0035279)
Mirna binding
(GO:0035198)
Mirna metabolic process
(GO:0010586)
Mirna processing
(GO:0035196)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Mrna cap binding
(GO:0098808)
Negative regulation of amyloid precursor protein biosynthetic process
(GO:0042985)
P-body assembly
(GO:0033962)
Post-embryonic development
(GO:0009791)
Pre-mirna processing
(GO:0031054)
Protein binding
(GO:0005515)
Regulatory ncrna-mediated gene silencing
(GO:0031047)
Regulatory ncrna-mediated post-transcriptional gene silencing
(GO:0035194)
Rna 7-methylguanosine cap binding
(GO:0000340)
Rna binding
(GO:0003723)
Rna endonuclease activity
(GO:0004521)
Rna polymerase ii complex binding
(GO:0000993)
Rna secondary structure unwinding
(GO:0010501)
Single-stranded rna binding
(GO:0003727)
Sirna binding
(GO:0035197)
Sirna processing
(GO:0030422)
Translation
(GO:0006412)
Translational initiation
(GO:0006413)
Translation initiation factor activity
(GO:0003743)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 285.2547
Cell Significance Index: -44.3700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 203.4352
Cell Significance Index: -51.6000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 117.0247
Cell Significance Index: -55.2500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 106.5089
Cell Significance Index: -43.2700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 98.4622
Cell Significance Index: -50.6500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 82.3520
Cell Significance Index: -55.2600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 45.3839
Cell Significance Index: -43.3300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 43.0753
Cell Significance Index: -53.1100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.1051
Cell Significance Index: -51.1800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.0432
Cell Significance Index: -55.4200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.5867
Cell Significance Index: -23.1700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.7624
Cell Significance Index: 47.0600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6854
Cell Significance Index: 334.4800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6834
Cell Significance Index: 166.5300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4374
Cell Significance Index: 288.3500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.3898
Cell Significance Index: 77.9900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.0671
Cell Significance Index: 29.0500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0552
Cell Significance Index: 68.0800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0501
Cell Significance Index: 80.5800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.9833
Cell Significance Index: 27.4800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9444
Cell Significance Index: 102.7200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9000
Cell Significance Index: 146.3700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.8858
Cell Significance Index: 22.7700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.8382
Cell Significance Index: 37.0800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7322
Cell Significance Index: 21.1000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6958
Cell Significance Index: 26.3500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6252
Cell Significance Index: 76.8700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6107
Cell Significance Index: 333.5300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6096
Cell Significance Index: 421.5900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6013
Cell Significance Index: 82.5800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5989
Cell Significance Index: 214.8100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5490
Cell Significance Index: 495.7000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4699
Cell Significance Index: 10.1800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4110
Cell Significance Index: 19.3200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4043
Cell Significance Index: 11.5900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.4030
Cell Significance Index: 52.0700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3802
Cell Significance Index: 168.0800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3800
Cell Significance Index: 26.2800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3793
Cell Significance Index: 68.3800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2863
Cell Significance Index: 54.4800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2841
Cell Significance Index: 14.7600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2761
Cell Significance Index: 20.5800
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.2123
Cell Significance Index: 5.1800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1791
Cell Significance Index: 337.2300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1780
Cell Significance Index: 8.0700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1659
Cell Significance Index: 5.8300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1366
Cell Significance Index: 210.3600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1363
Cell Significance Index: 86.5900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1131
Cell Significance Index: 51.3100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0970
Cell Significance Index: 178.9800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0949
Cell Significance Index: 5.8400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0452
Cell Significance Index: 3.2000
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0354
Cell Significance Index: 0.6900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0277
Cell Significance Index: 37.6200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0104
Cell Significance Index: -1.3300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0352
Cell Significance Index: -25.7800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0604
Cell Significance Index: -1.0400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0610
Cell Significance Index: -46.1800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0624
Cell Significance Index: -46.2500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0948
Cell Significance Index: -53.4600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0990
Cell Significance Index: -4.6200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1002
Cell Significance Index: -62.5500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1049
Cell Significance Index: -12.3700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1103
Cell Significance Index: -6.9500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1334
Cell Significance Index: -22.7800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1515
Cell Significance Index: -22.0200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1623
Cell Significance Index: -46.7000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2057
Cell Significance Index: -13.8300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2576
Cell Significance Index: -30.0300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2780
Cell Significance Index: -28.4000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2871
Cell Significance Index: -60.4700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3237
Cell Significance Index: -37.0900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3672
Cell Significance Index: -38.2300
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4063
Cell Significance Index: -5.8400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4673
Cell Significance Index: -16.2400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4929
Cell Significance Index: -12.3200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5432
Cell Significance Index: -14.5600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5566
Cell Significance Index: -28.9900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5772
Cell Significance Index: -7.8800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5835
Cell Significance Index: -46.2100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.5993
Cell Significance Index: -8.6200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6783
Cell Significance Index: -35.6200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7105
Cell Significance Index: -43.5600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7878
Cell Significance Index: -22.4800
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.7897
Cell Significance Index: -18.9400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.7972
Cell Significance Index: -11.7700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8255
Cell Significance Index: -26.4400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8723
Cell Significance Index: -5.2700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.0420
Cell Significance Index: -15.3800
Cell Name: type II muscle cell (CL0002212)
Fold Change: -1.0784
Cell Significance Index: -17.4000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.0837
Cell Significance Index: -23.0800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.1021
Cell Significance Index: -35.1000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.1103
Cell Significance Index: -36.3500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.1112
Cell Significance Index: -23.2600
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.1192
Cell Significance Index: -29.4300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1431
Cell Significance Index: -33.6700
Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.1436
Cell Significance Index: -25.0400
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.1493
Cell Significance Index: -19.3600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.1588
Cell Significance Index: -42.5400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1679
Cell Significance Index: -24.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** AGO2 is a 106-kDa protein that belongs to the PIWI family of proteins, which are conserved across species and play a crucial role in RNA-mediated gene silencing. The protein contains a RING finger domain and a PAZ domain, which are essential for its interaction with target RNAs and the regulation of gene expression. AGO2 is also a component of the heterochromatic structure of the nucleus and has been implicated in the regulation of chromatin remodeling. **Pathways and Functions** AGO2 is involved in various cellular processes, including: 1. **RNA-mediated gene silencing**: AGO2 interacts with miRNAs and siRNAs to regulate the expression of target mRNAs, thereby modulating gene expression. 2. **Cell signaling**: AGO2 is involved in the regulation of cell signaling pathways, including the Wnt/β-catenin pathway, the Notch signaling pathway, and the MAPK signaling pathway. 3. **Developmental biology**: AGO2 plays a crucial role in the regulation of developmental processes, including embryonic development, post-embryonic development, and tissue homeostasis. 4. **Disease**: AGO2 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. AGO2's functions can be divided into two main categories: **post-transcriptional regulation** and **transcriptional regulation**. **Post-transcriptional regulation**: AGO2 regulates gene expression by modulating the translation of target mRNAs, either by inhibiting or enhancing translation. This is achieved through the interaction of AGO2 with miRNAs and siRNAs, which bind to the 3'-untranslated region (3' UTR) of target mRNAs, leading to their degradation or inhibition of translation. **Transcriptional regulation**: AGO2 also regulates gene expression by modulating the transcription of target genes. This is achieved through the interaction of AGO2 with miRNAs and siRNAs, which bind to the promoter region of target genes, leading to their repression or enhancement. **Clinical Significance** AGO2's involvement in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders, underscores its importance as a potential therapeutic target. Dysregulation of AGO2 has been implicated in various diseases, including: 1. **Cancer**: AGO2 is overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Neurodegenerative disorders**: AGO2 has been implicated in the regulation of neurodegenerative processes, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Metabolic disorders**: AGO2 has been implicated in the regulation of metabolic processes, including glucose and lipid metabolism. In conclusion, AGO2 is a multifunctional protein that plays a crucial role in the regulation of gene expression through the silencing of target mRNAs. Its involvement in various cellular processes, including development, cell signaling, and disease, underscores its importance as a key regulator of gene expression.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Argonaute RISC catalytic component 2

Genular Protein ID: 240794228

Symbol: AGO2_HUMAN

Name: Argonaute RISC catalytic component 2

UniProtKB Accession Codes:

Q9UKV8 Q8TCZ5 Q8WV58 Q96ID1

Database IDs:

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11914277

Title: miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.

PubMed ID: 11914277

DOI: 10.1101/gad.974702

PubMed ID: 10534406

Title: Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.

PubMed ID: 10534406

DOI: 10.1006/geno.1999.5951

PubMed ID: 14508492

Title: A micrococcal nuclease homologue in RNAi effector complexes.

PubMed ID: 14508492

DOI: 10.1038/nature01956

PubMed ID: 14749716

Title: Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.

PubMed ID: 14749716

DOI: 10.1038/sj.embor.7400070

PubMed ID: 15105377

Title: RISC is a 5' phosphomonoester-producing RNA endonuclease.

PubMed ID: 15105377

DOI: 10.1101/gad.1187904

PubMed ID: 15260970

Title: Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

PubMed ID: 15260970

DOI: 10.1016/j.molcel.2004.07.007

PubMed ID: 14703574

Title: Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway.

PubMed ID: 14703574

DOI: 10.1038/nn1174

PubMed ID: 15337849

Title: Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis.

PubMed ID: 15337849

DOI: 10.1261/rna.7131604

PubMed ID: 15284456

Title: Argonaute2 is the catalytic engine of mammalian RNAi.

PubMed ID: 15284456

DOI: 10.1126/science.1102513

PubMed ID: 15766526

Title: Involvement of microRNA in AU-rich element-mediated mRNA instability.

PubMed ID: 15766526

DOI: 10.1016/j.cell.2004.12.038

PubMed ID: 16271387

Title: Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.

PubMed ID: 16271387

DOI: 10.1016/j.cell.2005.10.022

PubMed ID: 16289642

Title: Identification of novel argonaute-associated proteins.

PubMed ID: 16289642

DOI: 10.1016/j.cub.2005.10.048

PubMed ID: 16142218

Title: TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.

PubMed ID: 16142218

DOI: 10.1038/sj.embor.7400509

PubMed ID: 16357216

Title: A human, ATP-independent, RISC assembly machine fueled by pre-miRNA.

PubMed ID: 16357216

DOI: 10.1101/gad.1384005

PubMed ID: 15800629

Title: Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.

PubMed ID: 15800629

DOI: 10.1038/nature03514

PubMed ID: 15973356

Title: TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.

PubMed ID: 15973356

DOI: 10.1038/nature03868

PubMed ID: 15908945

Title: Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies.

PubMed ID: 15908945

DOI: 10.1038/ncb1265

PubMed ID: 15800637

Title: Purified Argonaute2 and an siRNA form recombinant human RISC.

PubMed ID: 15800637

DOI: 10.1038/nsmb918

PubMed ID: 16081698

Title: Inhibition of translational initiation by Let-7 MicroRNA in human cells.

PubMed ID: 16081698

DOI: 10.1126/science.1115079

PubMed ID: 16936728

Title: Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.

PubMed ID: 16936728

DOI: 10.1038/nsmb1140

PubMed ID: 16756390

Title: Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.

PubMed ID: 16756390

DOI: 10.1371/journal.pbio.0040210

PubMed ID: 16699599

Title: Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.

PubMed ID: 16699599

DOI: 10.1371/journal.ppat.0020041

PubMed ID: 17382880

Title: AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.

PubMed ID: 17382880

DOI: 10.1016/j.cell.2007.01.038

PubMed ID: 17524464

Title: An mRNA m7G cap binding-like motif within human Ago2 represses translation.

PubMed ID: 17524464

DOI: 10.1016/j.cell.2007.05.016

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 17531811

Title: RNA helicase A interacts with RISC in human cells and functions in RISC loading.

PubMed ID: 17531811

DOI: 10.1016/j.molcel.2007.04.016

PubMed ID: 17507929

Title: MicroRNA silencing through RISC recruitment of eIF6.

PubMed ID: 17507929

DOI: 10.1038/nature05841

PubMed ID: 18048652

Title: Switching from repression to activation: microRNAs can up-regulate translation.

PubMed ID: 18048652

DOI: 10.1126/science.1149460

PubMed ID: 18771919

Title: Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.

PubMed ID: 18771919

DOI: 10.1016/j.cub.2008.07.072

PubMed ID: 18690212

Title: Prolyl 4-hydroxylation regulates Argonaute 2 stability.

PubMed ID: 18690212

DOI: 10.1038/nature07186

PubMed ID: 18178619

Title: In vitro reconstitution of the human RISC-loading complex.

PubMed ID: 18178619

DOI: 10.1073/pnas.0710869105

PubMed ID: 19167051

Title: Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.

PubMed ID: 19167051

DOI: 10.1016/j.cell.2008.12.023

PubMed ID: 19801630

Title: RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.

PubMed ID: 19801630

DOI: 10.1074/jbc.m109.032946

PubMed ID: 20616046

Title: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

PubMed ID: 20616046

DOI: 10.1073/pnas.0914987107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21981923

Title: GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

PubMed ID: 21981923

DOI: 10.1016/j.molcel.2011.09.007

PubMed ID: 22791714

Title: APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10.

PubMed ID: 22791714

DOI: 10.1074/jbc.m112.354001

PubMed ID: 22915799

Title: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

PubMed ID: 22915799

DOI: 10.1128/jvi.00595-12

PubMed ID: 23746446

Title: The making of a slicer: activation of human Argonaute-1.

PubMed ID: 23746446

DOI: 10.1016/j.celrep.2013.05.033

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23603119

Title: Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets.

PubMed ID: 23603119

DOI: 10.1016/j.molcel.2013.03.015

PubMed ID: 23125361

Title: The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.

PubMed ID: 23125361

DOI: 10.1093/nar/gks1032

PubMed ID: 24726324

Title: MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

PubMed ID: 24726324

DOI: 10.1016/j.molcel.2014.03.017

PubMed ID: 26009488

Title: Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.

PubMed ID: 26009488

DOI: 10.1016/j.bbrc.2015.05.046

PubMed ID: 25697406

Title: Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.

PubMed ID: 25697406

DOI: 10.1038/ncomms7253

PubMed ID: 28114302

Title: An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.

PubMed ID: 28114302

DOI: 10.1038/nature21025

PubMed ID: 28546213

Title: Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.

PubMed ID: 28546213

DOI: 10.1126/science.aai9372

PubMed ID: 29395067

Title: High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

PubMed ID: 29395067

DOI: 10.1016/j.molcel.2017.12.020

PubMed ID: 30258011

Title: Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production.

PubMed ID: 30258011

DOI: 10.1128/jvi.01363-18

PubMed ID: 31400113

Title: KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.

PubMed ID: 31400113

DOI: 10.1093/nar/gkz683

PubMed ID: 33184234

Title: A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.

PubMed ID: 33184234

DOI: 10.1126/science.abc9546

PubMed ID: 33184237

Title: The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.

PubMed ID: 33184237

DOI: 10.1126/science.abc9359

PubMed ID: 33199684

Title: Germline AGO2 mutations impair RNA interference and human neurological development.

PubMed ID: 33199684

DOI: 10.1038/s41467-020-19572-5

PubMed ID: 32213613

Title: Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation.

PubMed ID: 32213613

DOI: 10.1128/jvi.00258-20

PubMed ID: 34903581

Title: SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes.

PubMed ID: 34903581

DOI: 10.1073/pnas.2116668118

PubMed ID: 37328606

Title: Regulation of microRNA expression by the adaptor protein GRB2.

PubMed ID: 37328606

DOI: 10.1038/s41598-023-36996-3

PubMed ID: 20505670

Title: Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.

PubMed ID: 20505670

DOI: 10.1038/nature09039

PubMed ID: 21475248

Title: Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.

PubMed ID: 21475248

DOI: 10.1038/embor.2011.48

PubMed ID: 22682761

Title: The structure of human argonaute-2 in complex with miR-20a.

PubMed ID: 22682761

DOI: 10.1016/j.cell.2012.05.017

PubMed ID: 22539551

Title: The crystal structure of human Argonaute2.

PubMed ID: 22539551

DOI: 10.1126/science.1221551

Sequence Information:

Length: 859
Mass: 97208
Checksum: 5C8552C43FC81345
Sequence:

MYSGAGPALA PPAPPPPIQG YAFKPPPRPD FGTSGRTIKL QANFFEMDIP KIDIYHYELD 
IKPEKCPRRV NREIVEHMVQ HFKTQIFGDR KPVFDGRKNL YTAMPLPIGR DKVELEVTLP 
GEGKDRIFKV SIKWVSCVSL QALHDALSGR LPSVPFETIQ ALDVVMRHLP SMRYTPVGRS 
FFTASEGCSN PLGGGREVWF GFHQSVRPSL WKMMLNIDVS ATAFYKAQPV IEFVCEVLDF 
KSIEEQQKPL TDSQRVKFTK EIKGLKVEIT HCGQMKRKYR VCNVTRRPAS HQTFPLQQES 
GQTVECTVAQ YFKDRHKLVL RYPHLPCLQV GQEQKHTYLP LEVCNIVAGQ RCIKKLTDNQ 
TSTMIRATAR SAPDRQEEIS KLMRSASFNT DPYVREFGIM VKDEMTDVTG RVLQPPSILY 
GGRNKAIATP VQGVWDMRNK QFHTGIEIKV WAIACFAPQR QCTEVHLKSF TEQLRKISRD 
AGMPIQGQPC FCKYAQGADS VEPMFRHLKN TYAGLQLVVV ILPGKTPVYA EVKRVGDTVL 
GMATQCVQMK NVQRTTPQTL SNLCLKINVK LGGVNNILLP QGRPPVFQQP VIFLGADVTH 
PPAGDGKKPS IAAVVGSMDA HPNRYCATVR VQQHRQEIIQ DLAAMVRELL IQFYKSTRFK 
PTRIIFYRDG VSEGQFQQVL HHELLAIREA CIKLEKDYQP GITFIVVQKR HHTRLFCTDK 
NERVGKSGNI PAGTTVDTKI THPTEFDFYL CSHAGIQGTS RPSHYHVLWD DNRFSSDELQ 
ILTYQLCHTY VRCTRSVSIP APAYYAHLVA FRARYHLVDK EHDSAEGSHT SGQSNGRDHQ 
ALAKAVQVHQ DTLRTMYFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AGO2

Associated with

Cells (max top 100)

Other Information

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. PubMed ID: 11914277

Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. PubMed ID: 10534406

A micrococcal nuclease homologue in RNAi effector complexes. PubMed ID: 14508492

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. PubMed ID: 14749716

RISC is a 5' phosphomonoester-producing RNA endonuclease. PubMed ID: 15105377

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. PubMed ID: 15260970

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. PubMed ID: 14703574

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. PubMed ID: 15337849

Argonaute2 is the catalytic engine of mammalian RNAi. PubMed ID: 15284456

Involvement of microRNA in AU-rich element-mediated mRNA instability. PubMed ID: 15766526

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. PubMed ID: 16271387

Identification of novel argonaute-associated proteins. PubMed ID: 16289642

TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. PubMed ID: 16142218

A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. PubMed ID: 16357216

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. PubMed ID: 15800629

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. PubMed ID: 15973356

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. PubMed ID: 15908945

Purified Argonaute2 and an siRNA form recombinant human RISC. PubMed ID: 15800637

Inhibition of translational initiation by Let-7 MicroRNA in human cells. PubMed ID: 16081698

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. PubMed ID: 16936728

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PubMed ID: 16756390

Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PubMed ID: 16699599

AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. PubMed ID: 17382880

An mRNA m7G cap binding-like motif within human Ago2 represses translation. PubMed ID: 17524464

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. PubMed ID: 17932509

RNA helicase A interacts with RISC in human cells and functions in RISC loading. PubMed ID: 17531811

MicroRNA silencing through RISC recruitment of eIF6. PubMed ID: 17507929

Switching from repression to activation: microRNAs can up-regulate translation. PubMed ID: 18048652

Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. PubMed ID: 18771919

Prolyl 4-hydroxylation regulates Argonaute 2 stability. PubMed ID: 18690212

In vitro reconstitution of the human RISC-loading complex. PubMed ID: 18178619

Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. PubMed ID: 19167051

RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation. PubMed ID: 19801630

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. PubMed ID: 20616046

Initial characterization of the human central proteome. PubMed ID: 21269460

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. PubMed ID: 21981923

APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. PubMed ID: 22791714

HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. PubMed ID: 22915799

The making of a slicer: activation of human Argonaute-1. PubMed ID: 23746446

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets. PubMed ID: 23603119

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. PubMed ID: 23125361

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. PubMed ID: 24726324

Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929. PubMed ID: 26009488

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis. PubMed ID: 25697406

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing. PubMed ID: 28114302

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. PubMed ID: 28546213

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. PubMed ID: 29395067

Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production. PubMed ID: 30258011

KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182. PubMed ID: 31400113

A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming. PubMed ID: 33184234

The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. PubMed ID: 33184237

Germline AGO2 mutations impair RNA interference and human neurological development. PubMed ID: 33199684

Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation. PubMed ID: 32213613

SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes. PubMed ID: 34903581

Regulation of microRNA expression by the adaptor protein GRB2. PubMed ID: 37328606

Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. PubMed ID: 20505670

Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain. PubMed ID: 21475248

The structure of human argonaute-2 in complex with miR-20a. PubMed ID: 22682761

The crystal structure of human Argonaute2. PubMed ID: 22539551