Details for: ERLEC1

Gene ID: 27248

Symbol: ERLEC1

Ensembl ID: ENSG00000068912

Description: endoplasmic reticulum lectin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 315.0209
    Cell Significance Index: -49.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 184.4322
    Cell Significance Index: -46.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 117.8454
    Cell Significance Index: -55.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 111.2596
    Cell Significance Index: -45.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 101.6164
    Cell Significance Index: -52.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.1120
    Cell Significance Index: -55.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.6673
    Cell Significance Index: -45.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.7533
    Cell Significance Index: -51.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.5821
    Cell Significance Index: -47.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1587
    Cell Significance Index: -51.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1978
    Cell Significance Index: -37.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.1435
    Cell Significance Index: -22.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7743
    Cell Significance Index: 129.3500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.2964
    Cell Significance Index: 17.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2838
    Cell Significance Index: 29.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1472
    Cell Significance Index: 157.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1436
    Cell Significance Index: 113.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1275
    Cell Significance Index: 30.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1232
    Cell Significance Index: 202.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0699
    Cell Significance Index: 214.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9860
    Cell Significance Index: 538.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9657
    Cell Significance Index: 118.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8683
    Cell Significance Index: 45.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7244
    Cell Significance Index: 92.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7234
    Cell Significance Index: 123.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6659
    Cell Significance Index: 17.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6607
    Cell Significance Index: 41.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6409
    Cell Significance Index: 127.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6326
    Cell Significance Index: 437.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4908
    Cell Significance Index: 36.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4902
    Cell Significance Index: 33.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4897
    Cell Significance Index: 175.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4692
    Cell Significance Index: 24.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4141
    Cell Significance Index: 183.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4127
    Cell Significance Index: 11.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3700
    Cell Significance Index: 19.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2786
    Cell Significance Index: 53.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2716
    Cell Significance Index: 12.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2559
    Cell Significance Index: 41.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2405
    Cell Significance Index: 11.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1994
    Cell Significance Index: 180.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1809
    Cell Significance Index: 12.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1778
    Cell Significance Index: 2.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1330
    Cell Significance Index: 1.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0974
    Cell Significance Index: 12.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0964
    Cell Significance Index: 73.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0834
    Cell Significance Index: 9.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0815
    Cell Significance Index: 5.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0372
    Cell Significance Index: 4.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0172
    Cell Significance Index: 32.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0016
    Cell Significance Index: 1.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -11.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0290
    Cell Significance Index: -18.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0295
    Cell Significance Index: -18.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0340
    Cell Significance Index: -46.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0385
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0534
    Cell Significance Index: -30.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0542
    Cell Significance Index: -5.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0619
    Cell Significance Index: -1.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0722
    Cell Significance Index: -32.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0741
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0900
    Cell Significance Index: -18.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0941
    Cell Significance Index: -1.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1014
    Cell Significance Index: -7.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1419
    Cell Significance Index: -20.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1469
    Cell Significance Index: -9.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1566
    Cell Significance Index: -45.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1591
    Cell Significance Index: -18.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1709
    Cell Significance Index: -9.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2193
    Cell Significance Index: -4.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2683
    Cell Significance Index: -7.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2738
    Cell Significance Index: -8.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2915
    Cell Significance Index: -33.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3490
    Cell Significance Index: -12.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4315
    Cell Significance Index: -49.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4518
    Cell Significance Index: -30.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4803
    Cell Significance Index: -50.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4808
    Cell Significance Index: -15.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5282
    Cell Significance Index: -15.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5819
    Cell Significance Index: -25.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5846
    Cell Significance Index: -46.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6663
    Cell Significance Index: -18.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6980
    Cell Significance Index: -26.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7475
    Cell Significance Index: -12.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7624
    Cell Significance Index: -46.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8162
    Cell Significance Index: -12.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8283
    Cell Significance Index: -9.4100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8768
    Cell Significance Index: -7.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8854
    Cell Significance Index: -12.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9034
    Cell Significance Index: -24.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9993
    Cell Significance Index: -24.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.0187
    Cell Significance Index: -12.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0612
    Cell Significance Index: -25.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0882
    Cell Significance Index: -6.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0975
    Cell Significance Index: -14.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1109
    Cell Significance Index: -56.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1289
    Cell Significance Index: -28.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1759
    Cell Significance Index: -38.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERLEC1 is a lectin, a type of carbohydrate-binding protein, that is specifically localized to the ER lumen. It is involved in the regulation of protein transport, quality control, and signaling within the ER. ERLEC1 exhibits a unique ability to bind to specific carbohydrates on proteins, which enables it to interact with and regulate the activity of various proteins involved in protein transport and signaling. Its expression is significantly observed in cells involved in immune responses, such as IgA plasma cells and IgG plasmablasts, suggesting a potential role in immune regulation. **Pathways and Functions:** ERLEC1 is involved in several key pathways, including: 1. **Abc-family proteins mediated transport:** ERLEC1 interacts with ABC transporters, which are responsible for transporting proteins across the ER membrane. This interaction regulates the transport of proteins between the ER and the Golgi apparatus. 2. **Defective CFTR causes cystic fibrosis:** ERLEC1 has been implicated in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) function. Mutations in the CFTR gene can lead to cystic fibrosis, a disease characterized by defective protein transport and signaling. 3. **Disease, Diseases of signal transduction by growth factor receptors and second messengers:** ERLEC1 regulates signaling pathways involved in disease, including those related to growth factor receptors and second messengers. 4. **Disorders of transmembrane transporters:** ERLEC1 interacts with transmembrane transporters, which are responsible for transporting proteins across the ER membrane. This interaction regulates the transport of proteins and can lead to disorders of transmembrane transport. 5. **Endoplasmic reticulum unfolded protein response:** ERLEC1 is involved in the unfolded protein response (UPR), a signaling pathway that is activated in response to ER stress. 6. **Erad pathway:** ERLEC1 interacts with the ER-associated degradation (ERAD) pathway, which is responsible for degrading misfolded proteins in the ER. 7. **Hedgehog ligand biogenesis:** ERLEC1 regulates the biogenesis of Hedgehog ligands, which are involved in signaling pathways that control cell growth and differentiation. 8. **Negative regulation of retrograde protein transport:** ERLEC1 regulates the transport of proteins from the ER to the Golgi apparatus, which is essential for protein quality control and signaling. **Clinical Significance:** The ERLEC1 gene has significant clinical implications, particularly in diseases related to protein transport and signaling. Mutations in the ERLEC1 gene may contribute to diseases such as cystic fibrosis, diseases of signal transduction by growth factor receptors and second messengers, and disorders of transmembrane transporters. Additionally, ERLEC1 may play a role in various diseases, including those related to the unfolded protein response and ER-associated degradation. Further research is needed to fully understand the clinical significance of ERLEC1 and its potential as a therapeutic target for diseases related to protein transport and signaling.

Genular Protein ID: 1591033115

Symbol: ERLEC_HUMAN

Name: Endoplasmic reticulum lectin 1

UniProtKB Accession Codes:

Q96DZ1 B2RDB4 B5MC72 O95901 Q6UWN7 Q9NUY7 Q9UQL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16531414

Title: The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.

PubMed ID: 16531414

DOI: 10.1074/jbc.m511872200

PubMed ID: 18502753

Title: Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

PubMed ID: 18502753

DOI: 10.1074/jbc.m709336200

PubMed ID: 18264092

Title: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

PubMed ID: 18264092

DOI: 10.1038/ncb1689

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 483
  • Mass: 54858
  • Checksum: 35F78A1468457468
  • Sequence:
    • MEEGGGGVRS LVPGGPVLLV LCGLLEASGG GRALPQLSDD IPFRVNWPGT EFSLPTTGVL 
YKEDNYVIMT TAHKEKYKCI LPLVTSGDEE EEKDYKGPNP RELLEPLFKQ SSCSYRIESY 
WTYEVCHGKH IRQYHEEKET GQKINIHEYY LGNMLAKNLL FEKEREAEEK EKSNEIPTKN 
IEGQMTPYYP VGMGNGTPCS LKQNRPRSST VMYICHPESK HEILSVAEVT TCEYEVVILT 
PLLCSHPKYR FRASPVNDIF CQSLPGSPFK PLTLRQLEQQ EEILRVPFRR NKEEDLQSTK 
EERFPAIHKS IAIGSQPVLT VGTTHISKLT DDQLIKEFLS GSYCFRGGVG WWKYEFCYGK 
HVHQYHEDKD SGKTSVVVGT WNQEEHIEWA KKNTARAYHL QDDGTQTVRM VSHFYGNGDI 
CDITDKPRQV TVKLKCKESD SPHAVTVYML EPHSCQYILG VESPVICKIL DTADENGLLS 
LPN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.