Details for: ERLEC1
Gene ID: 27248
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ERLEC1
Ensembl ID: ENSG00000068912
Description: endoplasmic reticulum lectin 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 78.9rCSI 62.07%PRS 39.43
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CSI 44.04rCSI 57.72%PRS 75.18
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CSI 36.12rCSI 35.52%PRS 35.83
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CSI 34.06rCSI 49.83%PRS 35.92
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CSI 28.15rCSI 29.49%PRS 35.66
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CSI 26.63rCSI 31.89%PRS 52.18
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CSI 24.49rCSI 54.23%PRS 31.25
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CSI 19.71rCSI 43.39%PRS 37.48
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CSI 17.92rCSI 21.39%PRS 52.64
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CSI 17.28rCSI 17.25%PRS 29
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CSI 16.79rCSI 36.66%PRS 54.52
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CSI 16.03rCSI 71.28%PRS 79.9
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CSI 13.54rCSI 32.19%PRS 46.03
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CSI 12.46rCSI 10.95%PRS 25.06
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CSI 12.08rCSI 39.17%PRS 37.6
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CSI 11.43rCSI 20.16%PRS 41.86
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CSI 11.26rCSI 18.1%PRS 23.23
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CSI 10.3rCSI 11.04%PRS 31.6
-
CSI 10.13rCSI 10.37%PRS 52.48
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CSI 9.98rCSI 11.54%PRS 25.62
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CSI 9.38rCSI 6.53%PRS 45.22
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CSI 8.85rCSI 13.35%PRS 34.86
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CSI 8.81rCSI 35.08%PRS 49.71
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CSI 8.74rCSI 6.28%PRS 44.86
-
CSI 8.43rCSI 23.62%PRS 48.38
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CSI 8.37rCSI 33.44%PRS 56.52
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CSI 8.07rCSI 36.3%PRS 80.21
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CSI 7.78rCSI 17.18%PRS 24.66
-
CSI 7.74rCSI 13.91%PRS 28.47
-
CSI 7.74rCSI 11.09%PRS 41.57
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CSI 7.58rCSI 9.52%PRS 42.3
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CSI 7.52rCSI 5.72%PRS 43.32
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CSI 7.43rCSI 43.25%PRS 45.12
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CSI 7.24rCSI 20.98%PRS 27.17
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CSI 7.23rCSI 19.05%PRS 56.79
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CSI 7.12rCSI 5.79%PRS 34.61
-
CSI 7.11rCSI 6.31%PRS 33.28
-
CSI 7.06rCSI 11.27%PRS 36.62
-
CSI 6.5rCSI 8.85%PRS 62.35
-
CSI 6.4rCSI 6.67%PRS 34.34
-
CSI 6.25rCSI 5.17%PRS 34.28
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CSI 6.2rCSI 27.53%PRS 32.43
-
CSI 6.06rCSI 16%PRS 39.8
-
CSI 5.94rCSI 8.69%PRS 35.27
-
CSI 5.87rCSI 18.35%PRS 24.24
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CSI 5.82rCSI 10.21%PRS 27.3
-
CSI 5.76rCSI 16.69%PRS 36.57
-
CSI 5.72rCSI 8.73%PRS 33.99
-
CSI 5.67rCSI 5.46%PRS 34.57
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CSI 5.54rCSI 6.86%PRS 30.12
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CSI 5.43rCSI 4.04%PRS 46.03
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CSI 5.34rCSI 8.25%PRS 31.97
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CSI 5.24rCSI 8.33%PRS 28.53
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CSI 5.16rCSI 8.93%PRS 26.28
-
CSI 5.03rCSI 3.51%PRS 35.37
-
CSI 5.03rCSI 5.83%PRS 44.44
-
CSI 4.95rCSI 17.82%PRS 20.42
-
CSI 4.87rCSI 17.09%PRS 50.09
-
CSI 4.82rCSI 11%PRS 33.28
-
CSI 4.8rCSI 9.52%PRS 33.99
-
CSI 4.71rCSI 13.58%PRS 52.34
-
CSI 4.65rCSI 6.7%PRS 47.49
-
CSI 4.63rCSI 45.59%PRS 63.31
-
CSI 4.49rCSI 3.12%PRS 40.49
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CSI 4.46rCSI 10.83%PRS 20.81
-
CSI 4.39rCSI 6%PRS 45.07
-
CSI 4.33rCSI 4.09%PRS 34.82
-
CSI 4.14rCSI 4.22%PRS 45.49
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CSI 4.13rCSI 3.21%PRS 33.33
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CSI 4.09rCSI 3.53%PRS 43.85
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CSI 4.08rCSI 6.26%PRS 39.57
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CSI 4.05rCSI 9.23%PRS 29.1
-
CSI 4.02rCSI 7.75%PRS 63.75
-
CSI 4.01rCSI 8.95%PRS 39.14
-
CSI 3.99rCSI 2.66%PRS 61.45
-
CSI 3.94rCSI 5.24%PRS 37.21
-
CSI 3.91rCSI 3.29%PRS 49.73
-
CSI 3.89rCSI 9.63%PRS 31.99
-
CSI 3.8rCSI 5.2%PRS 37.65
-
CSI 3.78rCSI 5.24%PRS 40.46
-
CSI 3.76rCSI 40.95%PRS 55.04
-
CSI 3.67rCSI 21.63%PRS 22.53
-
CSI 3.64rCSI 3.18%PRS 42.85
-
CSI 3.62rCSI 5.56%PRS 39.08
-
CSI 3.61rCSI 2.89%PRS 54.21
-
CSI 3.54rCSI 3.11%PRS 38.27
-
CSI 3.44rCSI 4.78%PRS 33.89
-
CSI 3.44rCSI 5.55%PRS 44.31
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CSI 3.37rCSI 6.42%PRS 49.83
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CSI 3.23rCSI 9.54%PRS 38.28
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CSI 3.22rCSI 5.22%PRS 33.04
-
CSI 3.18rCSI 6.53%PRS 31.09
-
CSI 3.18rCSI 12.28%PRS 54.18
-
CSI 3.11rCSI 4.16%PRS 35.52
-
CSI 3.1rCSI 3.9%PRS 46.76
-
CSI 3.05rCSI 2.94%PRS 25.97
-
CSI 3rCSI 3.85%PRS 38.17
-
CSI 2.98rCSI 2.92%PRS 47.93
-
CSI 2.96rCSI 4.73%PRS 28.91
-
CSI 2.92rCSI 31.94%PRS 51
-
CSI 0.1rCSI 0.6%PRS 45.9%
-
CSI 0.2rCSI 4.1%PRS 20.8%
-
CSI 0.3rCSI 6.0%PRS 21.7%
-
CSI 0.3rCSI 7.2%PRS 85.4%
-
CSI 0.3rCSI 2.5%PRS 22.9%
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CSI 0.3rCSI 2.3%PRS 53.0%
-
CSI 0.3rCSI 1.2%PRS 47.9%
-
CSI 0.4rCSI 2.7%PRS 62.6%
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CSI 0.4rCSI 1.4%PRS 28.5%
-
CSI 0.4rCSI 2.8%PRS 66.1%
-
CSI 0.4rCSI 2.2%PRS 43.9%
-
CSI 0.5rCSI 0.4%PRS 37.2%
-
CSI 0.5rCSI 2.6%PRS 57.2%
-
CSI 0.5rCSI 2.7%PRS 50.2%
-
CSI 0.5rCSI 5.0%PRS 62.6%
-
CSI 0.5rCSI 0.8%PRS 49.9%
-
CSI 0.6rCSI 4.1%PRS 54.2%
-
CSI 0.6rCSI 1.0%PRS 20.7%
-
CSI 0.6rCSI 2.5%PRS 51.3%
-
CSI 0.6rCSI 1.0%PRS 42.7%
-
CSI 0.6rCSI 1.7%PRS 42.3%
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CSI 0.7rCSI 2.9%PRS 23.9%
-
CSI 0.7rCSI 1.2%PRS 32.0%
-
CSI 0.8rCSI 5.6%PRS 23.9%
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CSI 0.8rCSI 1.3%PRS 21.4%
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CSI 0.8rCSI 1.7%PRS 55.9%
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CSI 0.8rCSI 2.0%PRS 61.0%
-
CSI 0.8rCSI 2.1%PRS 34.1%
-
CSI 0.8rCSI 1.1%PRS 46.2%
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CSI 0.8rCSI 1.9%PRS 44.8%
-
CSI 0.8rCSI 1.3%PRS 51.3%
-
CSI 0.8rCSI 2.0%PRS 51.4%
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CSI 0.8rCSI 1.1%PRS 54.4%
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CSI 0.9rCSI 5.3%PRS 68.8%
-
CSI 0.9rCSI 0.8%PRS 39.7%
-
CSI 0.9rCSI 1.8%PRS 42.3%
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CSI 0.9rCSI 1.8%PRS 54.7%
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CSI 0.9rCSI 2.1%PRS 47.7%
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CSI 1.0rCSI 1.7%PRS 29.3%
-
CSI 1.0rCSI 4.2%PRS 60.5%
-
CSI 1.0rCSI 3.2%PRS 42.4%
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CSI 1.0rCSI 3.3%PRS 68.0%
-
CSI 1.0rCSI 4.5%PRS 29.3%
-
CSI 1.0rCSI 1.7%PRS 26.4%
-
CSI 1.1rCSI 3.0%PRS 36.9%
-
CSI 1.1rCSI 5.6%PRS 72.4%
-
CSI 1.1rCSI 1.6%PRS 49.6%
-
CSI 1.1rCSI 1.0%PRS 31.0%
-
CSI 1.1rCSI 1.0%PRS 41.7%
-
CSI 1.1rCSI 1.3%PRS 32.4%
-
CSI 1.2rCSI 12.9%PRS 71.9%
-
CSI 1.2rCSI 1.2%PRS 39.1%
-
CSI 1.2rCSI 2.0%PRS 26.5%
-
CSI 1.2rCSI 7.0%PRS 22.7%
-
CSI 1.2rCSI 1.0%PRS 54.4%
-
CSI 1.2rCSI 3.4%PRS 49.6%
-
CSI 1.3rCSI 2.8%PRS 43.1%
-
CSI 1.3rCSI 3.2%PRS 67.0%
-
CSI 1.3rCSI 2.7%PRS 56.7%
-
CSI 1.3rCSI 1.5%PRS 37.3%
-
CSI 1.3rCSI 6.2%PRS 58.7%
-
CSI 1.4rCSI 3.3%PRS 50.1%
-
CSI 1.4rCSI 2.5%PRS 49.7%
-
CSI 1.4rCSI 3.6%PRS 40.9%
-
CSI 1.5rCSI 7.3%PRS 43.2%
-
CSI 1.5rCSI 2.9%PRS 35.0%
-
CSI 1.5rCSI 1.2%PRS 34.0%
-
CSI 1.5rCSI 3.6%PRS 45.4%
-
CSI 1.5rCSI 7.6%PRS 74.6%
-
CSI 1.5rCSI 3.8%PRS 26.4%
-
CSI 1.5rCSI 1.9%PRS 40.7%
-
CSI 1.5rCSI 1.2%PRS 36.3%
-
CSI 1.6rCSI 5.2%PRS 30.8%
-
CSI 1.6rCSI 1.9%PRS 21.3%
-
CSI 1.6rCSI 10.1%PRS 71.3%
-
CSI 1.7rCSI 2.6%PRS 42.0%
-
CSI 1.7rCSI 1.8%PRS 37.3%
-
CSI 1.7rCSI 1.3%PRS 32.1%
-
CSI 1.7rCSI 3.1%PRS 48.9%
-
CSI 1.7rCSI 3.5%PRS 20.1%
-
CSI 1.7rCSI 4.5%PRS 31.0%
-
CSI 1.7rCSI 2.5%PRS 36.3%
-
CSI 1.7rCSI 3.7%PRS 48.5%
-
CSI 1.7rCSI 2.9%PRS 38.6%
-
CSI 1.7rCSI 2.3%PRS 41.2%
-
CSI 1.8rCSI 6.5%PRS 28.7%
-
CSI 1.8rCSI 2.5%PRS 31.5%
-
CSI 1.8rCSI 2.7%PRS 37.9%
-
CSI 1.8rCSI 1.9%PRS 34.0%
-
CSI 1.8rCSI 1.2%PRS 41.9%
-
CSI 1.8rCSI 2.4%PRS 22.1%
-
CSI 1.9rCSI 4.8%PRS 31.6%
-
CSI 1.9rCSI 2.2%PRS 49.0%
-
CSI 1.9rCSI 45.0%PRS 56.5%
-
CSI 1.9rCSI 7.6%PRS 52.7%
-
CSI 2.0rCSI 2.3%PRS 29.5%
-
CSI 2.0rCSI 2.8%PRS 43.4%
-
CSI 2.0rCSI 8.1%PRS 33.3%
-
CSI 2.0rCSI 1.9%PRS 34.9%
-
CSI 2.0rCSI 4.5%PRS 22.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1591033115
Symbol: ERLEC_HUMAN
Name: Endoplasmic reticulum lectin 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16531414
Title: The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.
PubMed ID: 16531414
PubMed ID: 18502753
Title: Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.
PubMed ID: 18502753
PubMed ID: 18264092
Title: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.
PubMed ID: 18264092
DOI: 10.1038/ncb1689
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 483
- Mass: 54858
- Checksum: 35F78A1468457468
- Sequence:
MEEGGGGVRS LVPGGPVLLV LCGLLEASGG GRALPQLSDD IPFRVNWPGT EFSLPTTGVL YKEDNYVIMT TAHKEKYKCI LPLVTSGDEE EEKDYKGPNP RELLEPLFKQ SSCSYRIESY WTYEVCHGKH IRQYHEEKET GQKINIHEYY LGNMLAKNLL FEKEREAEEK EKSNEIPTKN IEGQMTPYYP VGMGNGTPCS LKQNRPRSST VMYICHPESK HEILSVAEVT TCEYEVVILT PLLCSHPKYR FRASPVNDIF CQSLPGSPFK PLTLRQLEQQ EEILRVPFRR NKEEDLQSTK EERFPAIHKS IAIGSQPVLT VGTTHISKLT DDQLIKEFLS GSYCFRGGVG WWKYEFCYGK HVHQYHEDKD SGKTSVVVGT WNQEEHIEWA KKNTARAYHL QDDGTQTVRM VSHFYGNGDI CDITDKPRQV TVKLKCKESD SPHAVTVYML EPHSCQYILG VESPVICKIL DTADENGLLS LPN