Details for: GLRB
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 165.0645
Cell Significance Index: -25.6800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 100.6926
Cell Significance Index: -25.5400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 53.1853
Cell Significance Index: -25.1100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 24.3364
Cell Significance Index: -23.2400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 20.8158
Cell Significance Index: -25.6700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.3659
Cell Significance Index: 474.6000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.8219
Cell Significance Index: 68.9900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.6723
Cell Significance Index: 73.9700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.4033
Cell Significance Index: 94.3600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.2941
Cell Significance Index: 36.9300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.2602
Cell Significance Index: 452.0100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.8759
Cell Significance Index: 13.2000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7113
Cell Significance Index: 491.9400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.6631
Cell Significance Index: 8.2300 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.6080
Cell Significance Index: 8.1100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3713
Cell Significance Index: 22.8200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3145
Cell Significance Index: 24.1400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2280
Cell Significance Index: 10.6300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2257
Cell Significance Index: 11.8500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1993
Cell Significance Index: 4.7800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1854
Cell Significance Index: 4.0600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1665
Cell Significance Index: 2.8500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1455
Cell Significance Index: 27.7000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1403
Cell Significance Index: 7.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1060
Cell Significance Index: 57.9000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0356
Cell Significance Index: 5.7800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.0278
Cell Significance Index: 0.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0263
Cell Significance Index: 4.4900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0123
Cell Significance Index: 1.2200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0065
Cell Significance Index: -4.0300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0098
Cell Significance Index: -5.5300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0109
Cell Significance Index: -20.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0118
Cell Significance Index: -10.7000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0133
Cell Significance Index: -9.8200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0138
Cell Significance Index: -25.4600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0168
Cell Significance Index: -25.8900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0188
Cell Significance Index: -2.0400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0191
Cell Significance Index: -26.0300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0202
Cell Significance Index: -0.7100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0217
Cell Significance Index: -15.9500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0258
Cell Significance Index: -1.5500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0341
Cell Significance Index: -25.8100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0349
Cell Significance Index: -15.8200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0394
Cell Significance Index: -25.0000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0495
Cell Significance Index: -1.0500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0595
Cell Significance Index: -26.3000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0646
Cell Significance Index: -1.8600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0658
Cell Significance Index: -13.8600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0701
Cell Significance Index: -4.3000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0738
Cell Significance Index: -2.4200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0759
Cell Significance Index: -21.8400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0835
Cell Significance Index: -2.6600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0838
Cell Significance Index: -11.5100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1034
Cell Significance Index: -2.2400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1179
Cell Significance Index: -23.4000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1195
Cell Significance Index: -15.4400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1261
Cell Significance Index: -22.7300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1414
Cell Significance Index: -1.5400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1427
Cell Significance Index: -16.3500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1442
Cell Significance Index: -4.6200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1529
Cell Significance Index: -3.0700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1661
Cell Significance Index: -24.1500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1682
Cell Significance Index: -3.4900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1712
Cell Significance Index: -21.9500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1853
Cell Significance Index: -22.7800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1881
Cell Significance Index: -3.7200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1887
Cell Significance Index: -8.5600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1906
Cell Significance Index: -22.2100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1969
Cell Significance Index: -20.1100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1988
Cell Significance Index: -14.8200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2020
Cell Significance Index: -13.9700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2054
Cell Significance Index: -23.4500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2374
Cell Significance Index: -24.7200 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.2911
Cell Significance Index: -2.7700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3205
Cell Significance Index: -25.3800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3214
Cell Significance Index: -4.6000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3334
Cell Significance Index: -8.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3468
Cell Significance Index: -16.3000 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.3496
Cell Significance Index: -4.3600 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3524
Cell Significance Index: -8.7900 - Cell Name: neural cell (CL0002319)
Fold Change: -0.3532
Cell Significance Index: -4.1200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3729
Cell Significance Index: -26.3700 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.3771
Cell Significance Index: -4.7600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4029
Cell Significance Index: -25.9900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4052
Cell Significance Index: -8.6300 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -0.4269
Cell Significance Index: -4.7100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4319
Cell Significance Index: -15.1300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4369
Cell Significance Index: -22.7600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4378
Cell Significance Index: -22.7400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4403
Cell Significance Index: -6.5000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4420
Cell Significance Index: -9.5500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4435
Cell Significance Index: -15.4100 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.5165
Cell Significance Index: -10.7800 - Cell Name: neuron (CL0000540)
Fold Change: -0.5412
Cell Significance Index: -5.1300 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.5681
Cell Significance Index: -24.7000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6034
Cell Significance Index: -22.1500 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.6469
Cell Significance Index: -10.6600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6667
Cell Significance Index: -17.5300 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.7017
Cell Significance Index: -7.3100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.7072
Cell Significance Index: -17.1300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3134143738
Symbol: GLRB_HUMAN
Name: Glycine receptor subunit beta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8717357
Title: The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.
PubMed ID: 8717357
PubMed ID: 9676428
Title: The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism.
PubMed ID: 9676428
PubMed ID: 15028279
Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.
PubMed ID: 15028279
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14551753
Title: Kinetic analysis of recombinant mammalian alpha(1) and alpha(1)beta glycine receptor channels.
PubMed ID: 14551753
PubMed ID: 12684523
Title: Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in hyperekplexia.
PubMed ID: 12684523
PubMed ID: 15302677
Title: Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants.
PubMed ID: 15302677
PubMed ID: 16144831
Title: Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
PubMed ID: 16144831
PubMed ID: 22715885
Title: Stoichiometry and subunit arrangement of alpha1beta glycine receptors as determined by atomic force microscopy.
PubMed ID: 22715885
DOI: 10.1021/bi300063m
PubMed ID: 22973015
Title: Stoichiometry of the human glycine receptor revealed by direct subunit counting.
PubMed ID: 22973015
PubMed ID: 26613940
Title: Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy.
PubMed ID: 26613940
PubMed ID: 25445488
Title: Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations.
PubMed ID: 25445488
PubMed ID: 34473954
Title: Characterization of the subunit composition and structure of adult human glycine receptors.
PubMed ID: 34473954
PubMed ID: 11929858
Title: Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB).
PubMed ID: 11929858
DOI: 10.1093/hmg/11.7.853
PubMed ID: 21391991
Title: Novel mutation in GLRB in a large family with hereditary hyperekplexia.
PubMed ID: 21391991
PubMed ID: 23238346
Title: Novel missense mutations in the glycine receptor beta subunit gene (GLRB) in startle disease.
PubMed ID: 23238346
PubMed ID: 35526563
Title: Clinical, genetic, and functional characterization of the glycine receptor beta-subunit A455P variant in a family affected by hyperekplexia syndrome.
PubMed ID: 35526563
Sequence Information:
- Length: 497
- Mass: 56122
- Checksum: C1F0B407601D3625
- Sequence:
MKFLLTTAFL ILISLWVEEA YSKEKSSKKG KGKKKQYLCP SQQSAEDLAR VPANSTSNIL NRLLVSYDPR IRPNFKGIPV DVVVNIFINS FGSIQETTMD YRVNIFLRQK WNDPRLKLPS DFRGSDALTV DPTMYKCLWK PDLFFANEKS ANFHDVTQEN ILLFIFRDGD VLVSMRLSIT LSCPLDLTLF PMDTQRCKMQ LESFGYTTDD LRFIWQSGDP VQLEKIALPQ FDIKKEDIEY GNCTKYYKGT GYYTCVEVIF TLRRQVGFYM MGVYAPTLLI VVLSWLSFWI NPDASAARVP LGIFSVLSLA SECTTLAAEL PKVSYVKALD VWLIACLLFG FASLVEYAVV QVMLNNPKRV EAEKARIAKA EQADGKGGNV AKKNTVNGTG TPVHISTLQV GETRCKKVCT SKSDLRSNDF SIVGSLPRDF ELSNYDCYGK PIEVNNGLGK SQAKNNKKPP PAKPVIPTAA KRIDLYARAL FPFCFLFFNV IYWSIYL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.