Details for: GPD1

Gene ID: 2819

Symbol: GPD1

Ensembl ID: ENSG00000167588

Description: glycerol-3-phosphate dehydrogenase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.74
    Marker Score: 1001
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.57
    Marker Score: 1439
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.66
    Marker Score: 3136
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.59
    Marker Score: 2451
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.52
    Marker Score: 5399
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.39
    Marker Score: 35711
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.35
    Marker Score: 524
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.33
    Marker Score: 3135
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17265
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.07
    Marker Score: 5138
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.97
    Marker Score: 256
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1944
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.95
    Marker Score: 230
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.89
    Marker Score: 388
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1448
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.82
    Marker Score: 3522
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 609.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.74
    Marker Score: 215
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.74
    Marker Score: 4727
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3079
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.69
    Marker Score: 3711
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 389
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 307
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.59
    Marker Score: 582
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.58
    Marker Score: 1313
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.56
    Marker Score: 374
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 339
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.48
    Marker Score: 369
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.46
    Marker Score: 312
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.45
    Marker Score: 180
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.45
    Marker Score: 448
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 179
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 678
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.42
    Marker Score: 127
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.42
    Marker Score: 990
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.41
    Marker Score: 172
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.41
    Marker Score: 211
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.4
    Marker Score: 151
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.39
    Marker Score: 938
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.38
    Marker Score: 185
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 168
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 195
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.36
    Marker Score: 145
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 91
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.34
    Marker Score: 306
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.33
    Marker Score: 78
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.32
    Marker Score: 122
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.32
    Marker Score: 81
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.31
    Marker Score: 332
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.3
    Marker Score: 111
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 195
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.28
    Marker Score: 70
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.25
    Marker Score: 794
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.24
    Marker Score: 89
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.24
    Marker Score: 169
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.24
    Marker Score: 302
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.23
    Marker Score: 225
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.23
    Marker Score: 84.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.21
    Marker Score: 186
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.19
    Marker Score: 94
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.19
    Marker Score: 62
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.19
    Marker Score: 64
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.18
    Marker Score: 767
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.18
    Marker Score: 60
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.17
    Marker Score: 432
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.17
    Marker Score: 553
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.16
    Marker Score: 210
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.16
    Marker Score: 83
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.16
    Marker Score: 246
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 161

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Other Information

**Key characteristics** - GPD1 is a glycoprotein that is composed of 12 transmembrane domains. - It is expressed in high levels in adipose tissue and fat cells. - GPD1 is a key enzyme in the citric acid cycle, which is responsible for the production of energy for cells. - It is also involved in the regulation of inflammation. **Pathways and functions** - GPD1 is involved in the regulation of energy production. It is a key enzyme in the citric acid cycle, which is responsible for the production of energy for cells. - It is also involved in the regulation of inflammation. - GPD1 is a key regulator of the metabolism of glycerol-3-phosphate. It is involved in the production of energy for cells and the synthesis of other molecules, such as choline and ketone bodies. - GPD1 is also involved in the regulation of cholesterol metabolism. **Clinical significance** GPD1 mutations have been linked to a number of human diseases, including obesity, diabetes, and cancer. These mutations can lead to the accumulation of G3P in cells, which can damage tissues and organs. **Conclusion** GPD1 is a key protein in the metabolism of glycerol-3-phosphate. It is involved in energy production, inflammation, and cholesterol metabolism. Mutations in GPD1 have been linked to a number of human diseases.

Genular Protein ID: 1361492613

Symbol: GPDA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P21695 F8W1L5 Q8N1B0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772607

Title: Molecular cloning, sequencing and expression of a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase.

PubMed ID: 7772607

DOI: 10.1016/0167-4781(95)00069-s

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2398890

Title: Sequence conservation and structural organization of the glycerol-3-phosphate dehydrogenase promoter in mice and humans.

PubMed ID: 2398890

DOI: 10.1128/mcb.10.10.5244-5256.1990

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22226083

Title: Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1.

PubMed ID: 22226083

DOI: 10.1016/j.ajhg.2011.11.028

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16460752

Title: Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1).

PubMed ID: 16460752

DOI: 10.1016/j.jmb.2005.12.074

PubMed ID: 24549054

Title: A compound heterozygous mutation in GPD1 causes hepatomegaly, steatohepatitis, and hypertriglyceridemia.

PubMed ID: 24549054

DOI: 10.1038/ejhg.2014.8

Sequence Information:

  • Length: 349
  • Mass: 37568
  • Checksum: CE7B7681103076EF
  • Sequence:
    • MASKKVCIVG SGNWGSAIAK IVGGNAAQLA QFDPRVTMWV FEEDIGGKKL TEIINTQHEN 
VKYLPGHKLP PNVVAVPDVV QAAEDADILI FVVPHQFIGK ICDQLKGHLK ANATGISLIK 
GVDEGPNGLK LISEVIGERL GIPMSVLMGA NIASEVADEK FCETTIGCKD PAQGQLLKEL 
MQTPNFRITV VQEVDTVEIC GALKNVVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK 
LFCSGPVSSA TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE LLNGQKLQGP 
ETARELYSIL QHKGLVDKFP LFMAVYKVCY EGQPVGEFIH CLQNHPEHM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.