Details for: GPR12

Gene ID: 2835

Symbol: GPR12

Ensembl ID: ENSG00000132975

Description: G protein-coupled receptor 12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.34
    Marker Score: 6718
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.76
    Marker Score: 1215
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.17
    Marker Score: 1105
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.16
    Marker Score: 2191
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.06
    Marker Score: 9075
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.03
    Marker Score: 6825
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1935
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.92
    Marker Score: 293
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.92
    Marker Score: 700.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.91
    Marker Score: 1105
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.9
    Marker Score: 3711
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.85
    Marker Score: 8061
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8
    Marker Score: 3109
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12224
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 441
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.72
    Marker Score: 10748
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.71
    Marker Score: 299
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.7
    Marker Score: 6567
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.7
    Marker Score: 299
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 451
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.65
    Marker Score: 4997
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.59
    Marker Score: 326
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.59
    Marker Score: 1203
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.58
    Marker Score: 2356
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.56
    Marker Score: 19066
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.56
    Marker Score: 531
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.54
    Marker Score: 20581
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.54
    Marker Score: 147
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.48
    Marker Score: 29317
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.47
    Marker Score: 17473
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.44
    Marker Score: 8761
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 205
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.38
    Marker Score: 3934
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.35
    Marker Score: 1615
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.31
    Marker Score: 1312
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.28
    Marker Score: 131
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 117
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.24
    Marker Score: 544
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 138
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.23
    Marker Score: 247
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.2
    Marker Score: 194
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 68
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.2
    Marker Score: 1067
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.2
    Marker Score: 318
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.19
    Marker Score: 212
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.19
    Marker Score: 628
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.15
    Marker Score: 351
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 143.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.13
    Marker Score: 136
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 160
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.12
    Marker Score: 338
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.12
    Marker Score: 1189
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 235
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.11
    Marker Score: 825
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.1
    Marker Score: 108
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.09
    Marker Score: 276
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 98

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Other Information

**Key characteristics:** * GPR12 is a transmembrane protein that is expressed in the plasma membrane. * It is a member of the GPCR family of cell surface receptors. * It is a high-density lipoprotein receptor (HDL) that is expressed in endothelial cells. * It is a ligand for apolipoprotein E receptor. * It is a key regulator of cell migration and proliferation in the retina. **Pathways and functions:** * GPR12 is a key regulator of cell migration and proliferation in the retina. * It is expressed in retinal cone cells, which are responsible for detecting light. * When GPR12 binds to its ligand, apolipoprotein E, it activates the G protein G protein. * The G protein then activates the adenylate cyclase, which leads to the production of cyclic GMP. * Cyclic GMP acts on the retinal pigment epithelial cells, which are responsible for the color of the eye. * This signaling pathway is essential for the development and maintenance of the retina. **Clinical significance:** * Mutations in GPR12 have been linked to a number of eye diseases, including retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy. * These mutations can lead to the loss of vision and other eye problems. * Therefore, GPR12 is an important target for the treatment of eye diseases. **Additional information:** * The human GPR12 gene is located on chromosome 19. * It is a single-exon gene that encodes a protein of 177 amino acids. * The protein is expressed in a variety of cell types, including endothelial cells, retinal cells, and immune cells. * It is a highly conserved protein, with a similar protein found in mammals, birds, and fish.

Genular Protein ID: 2446642685

Symbol: GPR12_HUMAN

Name: G-protein coupled receptor 12

UniProtKB Accession Codes:

P47775 Q5T8P3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8530049

Title: Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.

PubMed ID: 8530049

DOI: 10.1006/geno.1995.1154

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12220620

Title: Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.

PubMed ID: 12220620

DOI: 10.1016/s0898-6568(02)00041-4

PubMed ID: 19286662

Title: Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.

PubMed ID: 19286662

DOI: 10.1074/jbc.m806516200

Sequence Information:

  • Length: 334
  • Mass: 36730
  • Checksum: 618334A6582D744B
  • Sequence:
    • MNEDLKVNLS GLPRDYLDAA AAENISAAVS SRVPAVEPEP ELVVNPWDIV LCTSGTLISC 
ENAIVVLIIF HNPSLRAPMF LLIGSLALAD LLAGIGLITN FVFAYLLQSE ATKLVTIGLI 
VASFSASVCS LLAITVDRYL SLYYALTYHS ERTVTFTYVM LVMLWGTSIC LGLLPVMGWN 
CLRDESTCSV VRPLTKNNAA ILSVSFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT 
SHYVTTRKGV STLAIILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI 
YAFRNQEIQK ALCLICCGCI PSSLAQRARS PSDV

Genular Protein ID: 491258119

Symbol: B4DG25_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DG25

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 RefSeq 1 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 175
  • Mass: 19593
  • Checksum: 10CF94EDB45A2447
  • Sequence:
    • MLVMLWGTSI CLGLLPVMGW NCLRDESTCS VVRPLTKNNA AILSVSFLFM FALMLQLYIQ 
ICKIVMRHAH QIALQHHFLA TSHYVTTRKG VSTLAIILGT FAACWMPFTL YSLIADYTYP 
SIYTYATLLP ATYNSIINPV IYAFRNQEIQ KALCLICCGC IPSSLAQRAR SPSDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.