Details for: IGHJ5

Gene ID: 28476

Symbol: IGHJ5

Ensembl ID: ENSG00000242472

Description: immunoglobulin heavy joining 5

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.4022
    Cell Significance Index: 3.3200
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.0261
    Cell Significance Index: 0.2100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0079
    Cell Significance Index: -0.1100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0082
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0192
    Cell Significance Index: -0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0208
    Cell Significance Index: -0.9700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0224
    Cell Significance Index: -0.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0227
    Cell Significance Index: -0.5500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0256
    Cell Significance Index: -0.2600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0309
    Cell Significance Index: -0.5000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0310
    Cell Significance Index: -0.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0314
    Cell Significance Index: -0.5800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0337
    Cell Significance Index: -0.3800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0357
    Cell Significance Index: -0.4800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0372
    Cell Significance Index: -0.4700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0398
    Cell Significance Index: -0.5200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0469
    Cell Significance Index: -0.8000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0473
    Cell Significance Index: -0.5700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0517
    Cell Significance Index: -0.4800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0521
    Cell Significance Index: -0.6000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0522
    Cell Significance Index: -0.5500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0526
    Cell Significance Index: -0.5600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0536
    Cell Significance Index: -0.4900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0549
    Cell Significance Index: -0.4900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0552
    Cell Significance Index: -0.5600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0578
    Cell Significance Index: -0.6700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0594
    Cell Significance Index: -0.5400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0613
    Cell Significance Index: -0.7500
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.0626
    Cell Significance Index: -0.5500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0629
    Cell Significance Index: -0.5600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0634
    Cell Significance Index: -0.6000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0644
    Cell Significance Index: -0.6000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0649
    Cell Significance Index: -0.5600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0649
    Cell Significance Index: -0.7500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0655
    Cell Significance Index: -0.8600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0659
    Cell Significance Index: -0.7300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0670
    Cell Significance Index: -0.7300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0683
    Cell Significance Index: -0.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0691
    Cell Significance Index: -0.7100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0693
    Cell Significance Index: -0.5900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0696
    Cell Significance Index: -0.9000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0708
    Cell Significance Index: -0.9700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0713
    Cell Significance Index: -0.7200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0728
    Cell Significance Index: -0.6900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0731
    Cell Significance Index: -0.6000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0751
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0754
    Cell Significance Index: -0.7300
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0755
    Cell Significance Index: -0.5800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0810
    Cell Significance Index: -0.6900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0849
    Cell Significance Index: -0.9000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0861
    Cell Significance Index: -0.7100
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0871
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0884
    Cell Significance Index: -0.8300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0914
    Cell Significance Index: -0.7400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0923
    Cell Significance Index: -0.6400
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -0.0931
    Cell Significance Index: -0.7800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0933
    Cell Significance Index: -0.9200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0941
    Cell Significance Index: -1.0000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0968
    Cell Significance Index: -2.4200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1015
    Cell Significance Index: -0.6300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1059
    Cell Significance Index: -1.1600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1158
    Cell Significance Index: -0.6200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1229
    Cell Significance Index: -0.8000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1262
    Cell Significance Index: -1.4800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1302
    Cell Significance Index: -0.7100
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.1643
    Cell Significance Index: -1.7500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1671
    Cell Significance Index: -1.4900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1773
    Cell Significance Index: -2.0900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1807
    Cell Significance Index: -1.1200
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.1828
    Cell Significance Index: -1.0200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2794
    Cell Significance Index: -2.3600
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: -0.3109
    Cell Significance Index: -0.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHJ5 is a non-coding gene, meaning it does not encode a protein product. Instead, it serves as a regulatory element that influences the expression of nearby immunoglobulin genes. The IGHJ5 gene is part of the immunoglobulin gene locus, a complex region on chromosome 14q32 that contains multiple genes responsible for producing the heavy and light chains of antibodies. IGHJ5 is expressed in a wide range of cell types, including IgG plasma cells, IgG plasmablasts, naive B cells, dendritic cells, and erythrocytes. **Pathways and Functions:** IGHJ5 is involved in the regulation of immunoglobulin gene expression through its interaction with other regulatory elements and transcription factors. Specifically, IGHJ5 has been shown to: 1. **Regulate gene expression**: IGHJ5 acts as a enhancer element, promoting the expression of nearby immunoglobulin genes. 2. **Influence B cell development**: IGHJ5 is expressed during B cell development, particularly during the transition from a naive B cell to a mature B cell. 3. **Modulate immune responses**: IGHJ5 has been implicated in the regulation of immune responses, including the production of antibodies and the activation of immune cells. **Clinical Significance:** The IGHJ5 gene has significant clinical implications, particularly in the context of autoimmune and inflammatory diseases. Abnormal expression or mutations in IGHJ5 have been associated with: 1. **Autoimmune disorders**: IGHJ5 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Immunodeficiency disorders**: Mutations in IGHJ5 have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia. 3. **Cancer**: IGHJ5 has been found to be overexpressed in certain types of cancer, including lymphomas and leukemias. In conclusion, the IGHJ5 gene is a critical component of the human immune system, playing a key role in the regulation of immunoglobulin gene expression and B cell development. Further research is needed to fully understand the mechanisms by which IGHJ5 influences immune responses and to explore its clinical significance in autoimmune and inflammatory diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.