Details for: TRBV12 2

Gene ID: 28578

Symbol: TRBV12 2

Ensembl ID: ENSG00000211739

Description: T cell receptor beta variable 12-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9995
    Cell Significance Index: 24.2100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3170
    Cell Significance Index: 4.1600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2076
    Cell Significance Index: 2.7100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0257
    Cell Significance Index: 0.3300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0213
    Cell Significance Index: 0.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0074
    Cell Significance Index: 0.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0020
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0049
    Cell Significance Index: -0.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0115
    Cell Significance Index: -0.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0152
    Cell Significance Index: -0.2100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0155
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0178
    Cell Significance Index: -0.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0196
    Cell Significance Index: -0.5000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0200
    Cell Significance Index: -0.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0204
    Cell Significance Index: -0.5200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0211
    Cell Significance Index: -0.2500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0222
    Cell Significance Index: -0.2500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0229
    Cell Significance Index: -0.1900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0256
    Cell Significance Index: -0.2600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0257
    Cell Significance Index: -0.1400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0264
    Cell Significance Index: -0.2500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0267
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0282
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0331
    Cell Significance Index: -0.3100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0339
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0347
    Cell Significance Index: -0.3600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0356
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0358
    Cell Significance Index: -0.2900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0367
    Cell Significance Index: -0.3100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0375
    Cell Significance Index: -0.3800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0377
    Cell Significance Index: -0.4000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0389
    Cell Significance Index: -0.3600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0392
    Cell Significance Index: -0.4000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0394
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0395
    Cell Significance Index: -0.3800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0395
    Cell Significance Index: -0.3400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0398
    Cell Significance Index: -0.3600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0402
    Cell Significance Index: -0.4100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0421
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0421
    Cell Significance Index: -0.4000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0441
    Cell Significance Index: -0.4300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0442
    Cell Significance Index: -0.4700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0443
    Cell Significance Index: -0.5100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0444
    Cell Significance Index: -0.3300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0446
    Cell Significance Index: -0.3900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0450
    Cell Significance Index: -0.3500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0460
    Cell Significance Index: -0.5100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0461
    Cell Significance Index: -0.5100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0465
    Cell Significance Index: -0.3200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0480
    Cell Significance Index: -0.5100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0484
    Cell Significance Index: -0.5100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0487
    Cell Significance Index: -0.5100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0490
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0530
    Cell Significance Index: -0.4900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0538
    Cell Significance Index: -0.4500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0542
    Cell Significance Index: -0.5100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0550
    Cell Significance Index: -0.5100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0562
    Cell Significance Index: -0.5000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0587
    Cell Significance Index: -0.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0607
    Cell Significance Index: -0.6600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0613
    Cell Significance Index: -0.4900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0663
    Cell Significance Index: -0.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0697
    Cell Significance Index: -0.8800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0799
    Cell Significance Index: -0.5000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0875
    Cell Significance Index: -0.7400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1181
    Cell Significance Index: -0.3600
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: -0.1242
    Cell Significance Index: -0.5100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.1572
    Cell Significance Index: -0.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** TRBV12-2 is classified as a pseudogene, meaning that it has undergone mutations that render it non-functional. However, its expression in immune cells suggests that it may have retained some residual function or has been co-opted for alternative purposes. 2. **T cell receptor beta family:** TRBV12-2 is a member of the TCR beta family, which is responsible for recognizing and binding to antigens presented by MHC molecules. 3. **Significant expression in immune cells:** TRBV12-2 has been found to be significantly expressed in various immune cells, including CD4-positive helper T cells, alpha-beta T cells, and T follicular helper cells. 4. **Alpha-beta T cell specificity:** TRBV12-2 is specific to alpha-beta T cells, which are a subset of T cells that recognize antigens presented by MHC class I and II molecules. **Pathways and Functions:** 1. **Antigen recognition:** TRBV12-2 is expected to play a role in recognizing and binding to antigens presented by MHC molecules. However, the precise mechanism of antigen recognition by TRBV12-2 is unclear. 2. **T cell activation:** TRBV12-2 may contribute to T cell activation, which is the process by which T cells become responsive to antigens. 3. **T cell differentiation:** TRBV12-2 may also play a role in T cell differentiation, which is the process by which naive T cells become effector T cells. 4. **Immune regulation:** TRBV12-2 may have a role in regulating immune responses, particularly in the context of T cell-mediated immunity. **Clinical Significance:** 1. **Cancer immunotherapy:** TRBV12-2 may have a role in cancer immunotherapy, particularly in the context of alpha-beta T cell-mediated immunity. 2. **Autoimmune diseases:** TRBV12-2 may also contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where T cell-mediated immunity plays a key role. 3. **Vaccine development:** TRBV12-2 may be a useful target for vaccine development, particularly in the context of alpha-beta T cell-mediated immunity. 4. **Immunological surveillance:** TRBV12-2 may also have a role in immunological surveillance, which is the process by which the immune system detects and responds to pathogens and tumor cells. In conclusion, the TRBV12-2 gene is a complex and enigmatic pseudogene that has significant implications for our understanding of T cell-mediated immunity. Further research is needed to elucidate the precise mechanism of action of TRBV12-2 and its role in various immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.