Details for: TRBJ2 4

Gene ID: 28625

Symbol: TRBJ2 4

Ensembl ID: ENSG00000211768

Description: T cell receptor beta joining 2-4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.1296
    Cell Significance Index: 51.5900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.5609
    Cell Significance Index: 7.3600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3551
    Cell Significance Index: 5.1800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1586
    Cell Significance Index: 0.8700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0446
    Cell Significance Index: 0.4800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0245
    Cell Significance Index: 0.3100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0158
    Cell Significance Index: 0.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0018
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0069
    Cell Significance Index: -0.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0077
    Cell Significance Index: -0.1500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0111
    Cell Significance Index: -0.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0119
    Cell Significance Index: -0.2400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0134
    Cell Significance Index: -0.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0146
    Cell Significance Index: -0.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0149
    Cell Significance Index: -0.2800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0158
    Cell Significance Index: -0.1900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0166
    Cell Significance Index: -0.2300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0221
    Cell Significance Index: -0.2100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0229
    Cell Significance Index: -0.2700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0240
    Cell Significance Index: -0.2700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0243
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0256
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0256
    Cell Significance Index: -0.2700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0259
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0267
    Cell Significance Index: -0.2500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0281
    Cell Significance Index: -0.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0284
    Cell Significance Index: -0.3800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0298
    Cell Significance Index: -0.2500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0301
    Cell Significance Index: -0.2800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0304
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0310
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0312
    Cell Significance Index: -0.3000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0343
    Cell Significance Index: -0.4200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0362
    Cell Significance Index: -0.3100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0364
    Cell Significance Index: -0.3100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0365
    Cell Significance Index: -0.4200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0369
    Cell Significance Index: -0.3300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0385
    Cell Significance Index: -0.4100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0396
    Cell Significance Index: -0.4200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0406
    Cell Significance Index: -0.3500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0415
    Cell Significance Index: -0.4200
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0419
    Cell Significance Index: -0.3400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0421
    Cell Significance Index: -0.4200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0422
    Cell Significance Index: -0.3900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0425
    Cell Significance Index: -0.3600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0457
    Cell Significance Index: -0.4600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0477
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0485
    Cell Significance Index: -0.4900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0513
    Cell Significance Index: -0.5900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0522
    Cell Significance Index: -0.5500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0616
    Cell Significance Index: -0.5200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0622
    Cell Significance Index: -0.3300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0632
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0655
    Cell Significance Index: -0.5300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0656
    Cell Significance Index: -0.5100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0663
    Cell Significance Index: -0.5800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1359
    Cell Significance Index: -0.9400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1721
    Cell Significance Index: -1.5900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1989
    Cell Significance Index: -1.5900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.3084
    Cell Significance Index: -0.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBJ2 4 gene is a member of the T cell receptor beta (TRBJ) family, which is essential for the recognition and binding of antigens by T cells. The unique structure of TRBJ2 4, with its distinct joining region, allows it to form heterodimers with other TRBJ family members, enabling the generation of a diverse repertoire of T cell receptors. This gene is significantly expressed in several cell types, including those involved in innate immunity, such as natural killer cells, and those involved in adaptive immunity, such as mature alpha-beta T cells. **Pathways and Functions:** TRBJ2 4 is involved in the adaptive immune response through several key pathways: 1. **T cell receptor complex formation:** TRBJ2 4 joins with other TRBJ family members to form heterodimers, which recognize and bind to antigens through the T cell receptor complex. 2. **Immune cell development:** TRBJ2 4 is expressed in various cell types during development, including alpha-beta thymocytes and double-positive thymocytes, highlighting its role in the maturation of T cells. 3. **Innate immune response:** TRBJ2 4 is also expressed in natural killer cells, which are crucial for the innate immune response, particularly in the recognition and elimination of infected cells or tumor cells. **Clinical Significance:** The TRBJ2 4 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer: 1. **Autoimmune diseases:** Alterations in TRBJ2 4 expression or function may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 2. **Cancer immunotherapy:** TRBJ2 4 may play a role in the recognition and elimination of cancer cells by T cells, making it a potential target for cancer immunotherapy. 3. **Infectious diseases:** TRBJ2 4 may also be involved in the recognition and elimination of pathogens by T cells, highlighting its potential role in the prevention and treatment of infectious diseases. In conclusion, the TRBJ2 4 gene is a complex and multifunctional gene that plays a crucial role in the adaptive immune response. Further research on this gene is necessary to fully understand its mechanisms of action and its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.