Details for: TRAJ26

Gene ID: 28729

Symbol: TRAJ26

Ensembl ID: ENSG00000211863

Description: T cell receptor alpha joining 26

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 9.7106
    Cell Significance Index: 189.8600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 6.1459
    Cell Significance Index: 77.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.0671
    Cell Significance Index: 50.0700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.5860
    Cell Significance Index: 7.6900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.3845
    Cell Significance Index: 5.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3686
    Cell Significance Index: 5.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0432
    Cell Significance Index: 0.9500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0293
    Cell Significance Index: 0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0039
    Cell Significance Index: 0.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0008
    Cell Significance Index: 0.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0017
    Cell Significance Index: -0.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0063
    Cell Significance Index: -0.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0084
    Cell Significance Index: -0.3400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0087
    Cell Significance Index: -0.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0096
    Cell Significance Index: -0.3700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0140
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0192
    Cell Significance Index: -0.4000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0217
    Cell Significance Index: -0.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0218
    Cell Significance Index: -0.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0222
    Cell Significance Index: -0.2700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0232
    Cell Significance Index: -0.2600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0263
    Cell Significance Index: -0.3200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0267
    Cell Significance Index: -0.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0268
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0285
    Cell Significance Index: -0.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0292
    Cell Significance Index: -0.5800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0328
    Cell Significance Index: -0.4200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0338
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0339
    Cell Significance Index: -0.4500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0344
    Cell Significance Index: -0.4300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0344
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0353
    Cell Significance Index: -0.3300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0359
    Cell Significance Index: -0.3400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0359
    Cell Significance Index: -0.4500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0363
    Cell Significance Index: -0.4400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0364
    Cell Significance Index: -0.2800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0366
    Cell Significance Index: -0.4500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0376
    Cell Significance Index: -0.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0390
    Cell Significance Index: -0.7200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0390
    Cell Significance Index: -0.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0404
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0404
    Cell Significance Index: -0.4900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0409
    Cell Significance Index: -0.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0414
    Cell Significance Index: -0.4800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0427
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0432
    Cell Significance Index: -0.4100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0434
    Cell Significance Index: -0.4400
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0434
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0443
    Cell Significance Index: -0.4700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0451
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0465
    Cell Significance Index: -0.4900
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0471
    Cell Significance Index: -0.5400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0495
    Cell Significance Index: -0.5200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0497
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0497
    Cell Significance Index: -0.5400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0510
    Cell Significance Index: -0.5500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0520
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0527
    Cell Significance Index: -0.5000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0533
    Cell Significance Index: -0.4400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0554
    Cell Significance Index: -0.6400
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0567
    Cell Significance Index: -0.5400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0575
    Cell Significance Index: -0.5200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0599
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0641
    Cell Significance Index: -0.6500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0663
    Cell Significance Index: -0.6700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0665
    Cell Significance Index: -0.6700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0697
    Cell Significance Index: -0.3800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0706
    Cell Significance Index: -0.5400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0707
    Cell Significance Index: -0.6100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0800
    Cell Significance Index: -0.7000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0848
    Cell Significance Index: -0.6600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0990
    Cell Significance Index: -0.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ26 is a gene that encodes a protein with a single transmembrane domain and a cytoplasmic tail. It belongs to the TRAJ family of genes, which are involved in the assembly and maturation of TCRs. TRAJ26 is specifically expressed in various immune cells, including CD8+ and CD4+ T cells, alpha-beta thymocytes, natural killer T (NK T) cells, and retinal rod cells. The expression of TRAJ26 is tightly regulated and is essential for the proper development and function of these cells. **Pathways and Functions:** TRAJ26 is involved in the assembly and maturation of functional TCRs, which are critical for recognizing and responding to antigens. The TCR complex consists of the TRAJ26 protein, along with other components such as the TCR alpha chain, beta chain, and gamma chains. The assembly of the TCR complex is a complex process that involves the interaction of various proteins, including TRAJ26, to facilitate the formation of functional TCRs. TRAJ26 has been shown to interact with other components of the TCR complex, such as the TCR alpha chain, to facilitate the maturation and stabilization of functional TCRs. The TCR complex plays a critical role in the immune response, allowing T cells to recognize and respond to antigens. The activation of T cells by the TCR complex triggers a signaling cascade that leads to the activation of various transcription factors, including NF-κB and AP-1, which regulate the expression of genes involved in the immune response. TRAJ26 has been shown to modulate the activity of these transcription factors, influencing the function and phenotype of T cells. **Clinical Significance:** Dysregulation of TRAJ26 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, alterations in TRAJ26 expression have been observed in patients with multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Additionally, TRAJ26 has been shown to play a role in the development and progression of cancer, including leukemia and lymphoma. Furthermore, TRAJ26 has been identified as a potential target for immunotherapy in cancer. The manipulation of TRAJ26 expression has been shown to enhance the function and activity of T cells, leading to improved anti-tumor responses. Additionally, TRAJ26 has been identified as a potential biomarker for the diagnosis and monitoring of immune-related disorders. In conclusion, TRAJ26 is a critical component of the T cell receptor complex, playing a pivotal role in the development, function, and maintenance of various immune cells. The dysregulation of TRAJ26 has been implicated in various immune-related disorders, and it has potential as a target for immunotherapy in cancer. Further research is needed to fully understand the function and clinical significance of TRAJ26, but the current evidence highlights its importance in the regulation of the immune response.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.