Details for: IGKV2 18

Gene ID: 28926

Symbol: IGKV2 18

Ensembl ID: ENSG00000254157

Description: immunoglobulin kappa variable 2-18 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 141
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.03
    Marker Score: 46
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.01
    Marker Score: 66
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 4

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2-18 is a pseudogene, meaning it lacks a functional gene or has a non-functional gene product. However, its expression in numerous B cell subsets, including naive B cells, plasmablasts, precursor B cells, IgM plasma cells, lymphocytes, IgA plasma cells, and IgG plasma cells, indicates that it may play a regulatory or supportive role in B cell development and function. The Ensembl ID (ENSG00000254157) and significantly expressed cell types further highlight the gene's significance in the immune system. **Pathways and Functions:** The IGKV2-18 gene is part of the immunoglobulin kappa variable family, which plays a crucial role in the development and function of B cells. The pathways and functions of IGKV2-18 are not yet fully understood, but several theories have emerged: 1. **Regulation of B cell development**: IGKV2-18 may influence B cell development and maturation by regulating gene expression or modulating signaling pathways. 2. **Inhibition of B cell activation**: The pseudogene might suppress B cell activation, thereby modulating the immune response. 3. **Supporting IgM class switching**: IGKV2-18 may contribute to the class switching from IgM to other immunoglobulin classes (IgA and IgG) by regulating the expression of key switch recombination factors. **Clinical Significance:** IGKV2-18's widespread expression in B cells and its potential regulatory functions make it an interesting candidate for further investigation. The clinical significance of IGKV2-18 lies in its possible implications for: 1. **Immunodeficiency disorders**: Abnormalities in IGKV2-18 expression or function might contribute to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). 2. **Autoimmune diseases**: Dysregulation of IGKV2-18 could contribute to autoimmune diseases, such as rheumatoid arthritis, lupus, or multiple sclerosis. 3. **Cancer**: IGKV2-18's expression in plasma cells might be associated with cancer, particularly in the context of MALT lymphoma. In conclusion, IGKV2-18 is a pseudogene with significant implications for our understanding of B cell biology and the immune system. Further research is necessary to elucidate its pathways and functions, as well as its clinical significance in various diseases. As an immunologist, it is essential to continue exploring the mysteries of IGKV2-18 to unravel its potential as a therapeutic target or biomarker.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.