Details for: IGKV2 18

Gene ID: 28926

Symbol: IGKV2 18

Ensembl ID: ENSG00000254157

Description: immunoglobulin kappa variable 2-18 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2865
    Cell Significance Index: 3.5200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0244
    Cell Significance Index: 0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0110
    Cell Significance Index: -0.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0127
    Cell Significance Index: -0.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0152
    Cell Significance Index: -0.1700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0173
    Cell Significance Index: -0.2100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0189
    Cell Significance Index: -0.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0333
    Cell Significance Index: -0.3400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0360
    Cell Significance Index: -0.3200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0378
    Cell Significance Index: -0.3400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0379
    Cell Significance Index: -0.3500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0390
    Cell Significance Index: -0.2600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0402
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0423
    Cell Significance Index: -0.2700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0441
    Cell Significance Index: -0.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0468
    Cell Significance Index: -0.5100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0473
    Cell Significance Index: -0.4900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0474
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0475
    Cell Significance Index: -1.2100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0527
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0541
    Cell Significance Index: -0.5100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0549
    Cell Significance Index: -0.5900
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0553
    Cell Significance Index: -0.4900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0585
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0599
    Cell Significance Index: -0.6100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0643
    Cell Significance Index: -0.5800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0646
    Cell Significance Index: -0.7400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0677
    Cell Significance Index: -0.7200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0694
    Cell Significance Index: -0.8200
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0711
    Cell Significance Index: -0.6200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0750
    Cell Significance Index: -0.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0757
    Cell Significance Index: -1.4800
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0772
    Cell Significance Index: -0.6200
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0782
    Cell Significance Index: -0.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0813
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0866
    Cell Significance Index: -0.5400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0877
    Cell Significance Index: -0.8300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0892
    Cell Significance Index: -0.7600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0897
    Cell Significance Index: -0.8200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0903
    Cell Significance Index: -1.0000
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0933
    Cell Significance Index: -0.8100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0937
    Cell Significance Index: -0.9500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0968
    Cell Significance Index: -1.1000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0991
    Cell Significance Index: -1.0200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0995
    Cell Significance Index: -0.8700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1002
    Cell Significance Index: -1.0100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1005
    Cell Significance Index: -0.9400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1022
    Cell Significance Index: -1.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1042
    Cell Significance Index: -1.9300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1043
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1076
    Cell Significance Index: -1.0200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1094
    Cell Significance Index: -1.0200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1139
    Cell Significance Index: -1.1100
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1160
    Cell Significance Index: -0.8200
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1197
    Cell Significance Index: -0.6000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1236
    Cell Significance Index: -1.4600
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.1248
    Cell Significance Index: -0.8700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1278
    Cell Significance Index: -1.4700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1300
    Cell Significance Index: -1.2100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1322
    Cell Significance Index: -1.4900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1323
    Cell Significance Index: -2.6600
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1327
    Cell Significance Index: -0.8600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1345
    Cell Significance Index: -1.4900
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.1440
    Cell Significance Index: -0.7700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1527
    Cell Significance Index: -1.2200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1560
    Cell Significance Index: -1.3300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1637
    Cell Significance Index: -1.4600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1662
    Cell Significance Index: -1.4800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1668
    Cell Significance Index: -1.4900
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1675
    Cell Significance Index: -0.8400
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.1718
    Cell Significance Index: -0.8100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1810
    Cell Significance Index: -1.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1813
    Cell Significance Index: -4.5300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2733
    Cell Significance Index: -1.4900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2920
    Cell Significance Index: -0.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2-18 is a pseudogene, meaning it lacks a functional gene or has a non-functional gene product. However, its expression in numerous B cell subsets, including naive B cells, plasmablasts, precursor B cells, IgM plasma cells, lymphocytes, IgA plasma cells, and IgG plasma cells, indicates that it may play a regulatory or supportive role in B cell development and function. The Ensembl ID (ENSG00000254157) and significantly expressed cell types further highlight the gene's significance in the immune system. **Pathways and Functions:** The IGKV2-18 gene is part of the immunoglobulin kappa variable family, which plays a crucial role in the development and function of B cells. The pathways and functions of IGKV2-18 are not yet fully understood, but several theories have emerged: 1. **Regulation of B cell development**: IGKV2-18 may influence B cell development and maturation by regulating gene expression or modulating signaling pathways. 2. **Inhibition of B cell activation**: The pseudogene might suppress B cell activation, thereby modulating the immune response. 3. **Supporting IgM class switching**: IGKV2-18 may contribute to the class switching from IgM to other immunoglobulin classes (IgA and IgG) by regulating the expression of key switch recombination factors. **Clinical Significance:** IGKV2-18's widespread expression in B cells and its potential regulatory functions make it an interesting candidate for further investigation. The clinical significance of IGKV2-18 lies in its possible implications for: 1. **Immunodeficiency disorders**: Abnormalities in IGKV2-18 expression or function might contribute to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). 2. **Autoimmune diseases**: Dysregulation of IGKV2-18 could contribute to autoimmune diseases, such as rheumatoid arthritis, lupus, or multiple sclerosis. 3. **Cancer**: IGKV2-18's expression in plasma cells might be associated with cancer, particularly in the context of MALT lymphoma. In conclusion, IGKV2-18 is a pseudogene with significant implications for our understanding of B cell biology and the immune system. Further research is necessary to elucidate its pathways and functions, as well as its clinical significance in various diseases. As an immunologist, it is essential to continue exploring the mysteries of IGKV2-18 to unravel its potential as a therapeutic target or biomarker.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.