Details for: COA3

Gene ID: 28958

Symbol: COA3

Ensembl ID: ENSG00000183978

Description: cytochrome c oxidase assembly factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 283.7760
    Cell Significance Index: -44.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.5313
    Cell Significance Index: -41.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 130.6477
    Cell Significance Index: -53.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.6897
    Cell Significance Index: -48.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.8463
    Cell Significance Index: -46.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 71.5625
    Cell Significance Index: -48.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.3201
    Cell Significance Index: -48.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7013
    Cell Significance Index: -50.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.3933
    Cell Significance Index: -33.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.2432
    Cell Significance Index: -28.3900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.7375
    Cell Significance Index: 45.8100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.0024
    Cell Significance Index: 25.2200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.9825
    Cell Significance Index: 11.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.9328
    Cell Significance Index: 202.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8039
    Cell Significance Index: 985.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7973
    Cell Significance Index: 83.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7504
    Cell Significance Index: 215.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7433
    Cell Significance Index: 45.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6927
    Cell Significance Index: 35.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6342
    Cell Significance Index: 265.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5817
    Cell Significance Index: 21.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5127
    Cell Significance Index: 13.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4253
    Cell Significance Index: 32.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3875
    Cell Significance Index: 62.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3819
    Cell Significance Index: 249.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2156
    Cell Significance Index: 35.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1972
    Cell Significance Index: 164.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1139
    Cell Significance Index: 12.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0934
    Cell Significance Index: 57.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0542
    Cell Significance Index: 54.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0396
    Cell Significance Index: 77.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0180
    Cell Significance Index: 27.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9404
    Cell Significance Index: 32.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8281
    Cell Significance Index: 97.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7898
    Cell Significance Index: 349.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7597
    Cell Significance Index: 8.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6945
    Cell Significance Index: 49.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6545
    Cell Significance Index: 83.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6160
    Cell Significance Index: 9.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5977
    Cell Significance Index: 7.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5543
    Cell Significance Index: 16.2800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.5129
    Cell Significance Index: 5.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4846
    Cell Significance Index: 96.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4588
    Cell Significance Index: 414.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3761
    Cell Significance Index: 48.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3666
    Cell Significance Index: 17.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3592
    Cell Significance Index: 68.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3441
    Cell Significance Index: 11.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2663
    Cell Significance Index: 76.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2292
    Cell Significance Index: 168.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2237
    Cell Significance Index: 14.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2119
    Cell Significance Index: 20.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1471
    Cell Significance Index: 5.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1334
    Cell Significance Index: 26.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1155
    Cell Significance Index: 19.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1105
    Cell Significance Index: 83.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0883
    Cell Significance Index: 5.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0859
    Cell Significance Index: 1.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0706
    Cell Significance Index: 4.4500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0487
    Cell Significance Index: 0.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0487
    Cell Significance Index: 1.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0457
    Cell Significance Index: 0.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0385
    Cell Significance Index: 3.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0232
    Cell Significance Index: 0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0121
    Cell Significance Index: -1.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0221
    Cell Significance Index: -41.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0267
    Cell Significance Index: -9.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0303
    Cell Significance Index: -55.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0363
    Cell Significance Index: -55.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0424
    Cell Significance Index: -57.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0517
    Cell Significance Index: -38.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0525
    Cell Significance Index: -6.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0624
    Cell Significance Index: -39.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0685
    Cell Significance Index: -38.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0870
    Cell Significance Index: -54.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0934
    Cell Significance Index: -42.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1043
    Cell Significance Index: -12.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1145
    Cell Significance Index: -3.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1938
    Cell Significance Index: -4.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2096
    Cell Significance Index: -4.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2191
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2506
    Cell Significance Index: -52.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2900
    Cell Significance Index: -42.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3455
    Cell Significance Index: -21.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3608
    Cell Significance Index: -3.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4871
    Cell Significance Index: -50.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5433
    Cell Significance Index: -36.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6063
    Cell Significance Index: -46.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6441
    Cell Significance Index: -39.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6585
    Cell Significance Index: -36.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6790
    Cell Significance Index: -20.0000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.6878
    Cell Significance Index: -4.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7319
    Cell Significance Index: -18.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7933
    Cell Significance Index: -41.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8942
    Cell Significance Index: -18.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9817
    Cell Significance Index: -26.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0713
    Cell Significance Index: -39.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0842
    Cell Significance Index: -18.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0884
    Cell Significance Index: -31.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1488
    Cell Significance Index: -29.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COA3 is a mitochondrial protein that belongs to the COA3 family, which consists of three members: COA3, COA4, and COA5. COA3 is specifically involved in the assembly and maturation of cytochrome c oxidase, a complex enzyme that catalyzes the transfer of electrons from cytochrome c to oxygen, resulting in the production of water and ATP. COA3 is characterized by its ability to interact with other mitochondrial proteins, such as COA4 and cytochrome c oxidase subunit I (COX1), to facilitate the assembly of cytochrome c oxidase. **Pathways and Functions:** COA3 plays a crucial role in the following pathways: 1. **Mitochondrial cytochrome c oxidase assembly:** COA3 is essential for the assembly and maturation of cytochrome c oxidase, which is a critical step in the mitochondrial respiratory chain. 2. **Positive regulation of mitochondrial translation:** COA3 has been shown to regulate mitochondrial translation by interacting with other mitochondrial proteins, such as COX1 and COX2. 3. **Protein binding:** COA3 has the ability to bind to other mitochondrial proteins, including COA4 and cytochrome c oxidase subunit I (COX1), to facilitate the assembly of cytochrome c oxidase. **Clinical Significance:** Dysregulation of COA3 has been implicated in various diseases, including: 1. **Mitochondrial disorders:** Mutations in COA3 have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MELAS syndrome, which are characterized by progressive external ophthalmoplegia, myoclonus, and lactic acidosis. 2. **Diabetes:** Elevated COA3 expression has been observed in pancreatic islets of individuals with type 2 diabetes, suggesting a potential role in the pathogenesis of this disease. 3. **Cancer:** COA3 has been implicated in the development and progression of various cancers, including pancreatic cancer, breast cancer, and colon cancer, where it may contribute to tumor growth and metastasis. In conclusion, COA3 is a critical protein that plays a pivotal role in mitochondrial function and has implications in various diseases. Further research is needed to fully understand the mechanisms underlying COA3's functions and to explore its potential as a therapeutic target for the treatment of mitochondrial disorders and cancer.

Genular Protein ID: 787150889

Symbol: COA3_HUMAN

Name: Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

UniProtKB Accession Codes:

Q9Y2R0 A8K498

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23260140

Title: MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation.

PubMed ID: 23260140

DOI: 10.1016/j.cell.2012.11.053

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26321642

Title: MITRAC7 acts as a COX1-specific chaperone and reveals a checkpoint during cytochrome c oxidase assembly.

PubMed ID: 26321642

DOI: 10.1016/j.celrep.2015.08.009

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25604084

Title: Mutations in COA3 cause isolated complex IV deficiency associated with neuropathy, exercise intolerance, obesity, and short stature.

PubMed ID: 25604084

DOI: 10.1136/jmedgenet-2014-102914

Sequence Information:

  • Length: 106
  • Mass: 11731
  • Checksum: ED6E73527E9B6C3C
  • Sequence:
    • MASSGAGDPL DSKRGEAPFA QRIDPTREKL TPEQLHSMRQ AELAQWQKVL PRRRTRNIVT 
GLGIGALVLA IYGYTFYSIS QERFLDELED EAKAARARAL ARASGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.