Details for: MRPS18B

Gene ID: 28973

Symbol: MRPS18B

Ensembl ID: ENSG00000204568

Description: mitochondrial ribosomal protein S18B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 210.5497
    Cell Significance Index: -32.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.4737
    Cell Significance Index: -27.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.8765
    Cell Significance Index: -40.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 90.2732
    Cell Significance Index: -42.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.1246
    Cell Significance Index: -35.4000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.8125
    Cell Significance Index: -40.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.9025
    Cell Significance Index: -42.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.1618
    Cell Significance Index: -35.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.8470
    Cell Significance Index: -36.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5684
    Cell Significance Index: -30.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6654
    Cell Significance Index: -38.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9762
    Cell Significance Index: -27.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.2408
    Cell Significance Index: 293.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4245
    Cell Significance Index: 89.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2590
    Cell Significance Index: 34.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0517
    Cell Significance Index: 189.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0478
    Cell Significance Index: 143.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0467
    Cell Significance Index: 128.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9391
    Cell Significance Index: 66.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9335
    Cell Significance Index: 10.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9169
    Cell Significance Index: 12.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8457
    Cell Significance Index: 43.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8122
    Cell Significance Index: 37.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7963
    Cell Significance Index: 352.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7901
    Cell Significance Index: 93.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7785
    Cell Significance Index: 9.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7211
    Cell Significance Index: 93.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6904
    Cell Significance Index: 32.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6884
    Cell Significance Index: 375.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6563
    Cell Significance Index: 5.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6287
    Cell Significance Index: 33.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6037
    Cell Significance Index: 13.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6003
    Cell Significance Index: 15.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5999
    Cell Significance Index: 76.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5363
    Cell Significance Index: 5.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5183
    Cell Significance Index: 102.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4926
    Cell Significance Index: 11.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4801
    Cell Significance Index: 433.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4633
    Cell Significance Index: 29.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4328
    Cell Significance Index: 73.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4228
    Cell Significance Index: 8.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3918
    Cell Significance Index: 17.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3899
    Cell Significance Index: 29.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3236
    Cell Significance Index: 2.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3102
    Cell Significance Index: 7.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3004
    Cell Significance Index: 10.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2600
    Cell Significance Index: 15.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2567
    Cell Significance Index: 7.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2465
    Cell Significance Index: 7.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2317
    Cell Significance Index: 46.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2093
    Cell Significance Index: 39.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1771
    Cell Significance Index: 17.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0885
    Cell Significance Index: 31.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0882
    Cell Significance Index: 2.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0724
    Cell Significance Index: 50.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0672
    Cell Significance Index: 49.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0415
    Cell Significance Index: 1.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0303
    Cell Significance Index: 22.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0161
    Cell Significance Index: 0.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0081
    Cell Significance Index: 0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0139
    Cell Significance Index: -8.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0193
    Cell Significance Index: -1.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0201
    Cell Significance Index: -37.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0260
    Cell Significance Index: -39.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0330
    Cell Significance Index: -44.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0411
    Cell Significance Index: -26.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0477
    Cell Significance Index: -0.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0484
    Cell Significance Index: -27.2800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0536
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0611
    Cell Significance Index: -7.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0706
    Cell Significance Index: -32.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0860
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0963
    Cell Significance Index: -20.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1056
    Cell Significance Index: -17.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1239
    Cell Significance Index: -14.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1405
    Cell Significance Index: -40.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1582
    Cell Significance Index: -2.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1714
    Cell Significance Index: -2.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1801
    Cell Significance Index: -4.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1871
    Cell Significance Index: -14.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1906
    Cell Significance Index: -27.7100
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.2350
    Cell Significance Index: -1.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2486
    Cell Significance Index: -10.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2604
    Cell Significance Index: -29.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2822
    Cell Significance Index: -6.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3072
    Cell Significance Index: -3.1800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3100
    Cell Significance Index: -3.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3316
    Cell Significance Index: -5.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3678
    Cell Significance Index: -38.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4065
    Cell Significance Index: -22.8100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4727
    Cell Significance Index: -7.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4862
    Cell Significance Index: -25.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5082
    Cell Significance Index: -14.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5187
    Cell Significance Index: -31.8000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5848
    Cell Significance Index: -8.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6900
    Cell Significance Index: -19.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7189
    Cell Significance Index: -31.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7660
    Cell Significance Index: -18.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization:** MRPS18B is a mitochondrial ribosomal protein, specifically associated with the mitochondrial small ribosomal subunit. 2. **Translation initiation and elongation:** MRPS18B participates in the initiation and elongation phases of mitochondrial translation, ensuring the accurate synthesis of mitochondrial proteins. 3. **Protein binding:** MRPS18B interacts with various proteins, including ribosomal RNA and other ribosomal proteins, to facilitate translation. 4. **Cellular expression:** MRPS18B is highly expressed in cells involved in tissue development, immune response, and energy metabolism. **Pathways and Functions:** 1. **Mitochondrial translation:** MRPS18B is integral to the mitochondrial translation process, ensuring the accurate synthesis of mitochondrial proteins. 2. **Cellular energy metabolism:** As a mitochondrial ribosomal protein, MRPS18B contributes to the regulation of energy metabolism, particularly in cells involved in energy-intensive processes. 3. **Protein synthesis regulation:** MRPS18B regulates protein synthesis by participating in the initiation and elongation phases of translation. 4. **Cellular stress response:** MRPS18B may play a role in the cellular response to stress, particularly in the context of mitochondrial dysfunction. **Clinical Significance:** 1. **Mitochondrial disorders:** Alterations in MRPS18B expression have been linked to mitochondrial disorders, such as mitochondrial myopathies and encephalopathies. 2. **Cancer:** Overexpression of MRPS18B has been observed in certain types of cancer, suggesting its potential role in tumorigenesis. 3. **Neurodegenerative diseases:** MRPS18B may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's, by modulating mitochondrial function and protein synthesis. 4. **Immunological disorders:** MRPS18B expression is altered in immunological disorders, such as multiple sclerosis and rheumatoid arthritis, highlighting its potential role in immune regulation. In conclusion, MRPS18B is a crucial mitochondrial ribosomal protein that plays a vital role in maintaining cellular homeostasis and function. Its dysregulation has been linked to various diseases, emphasizing the need for further research into the molecular mechanisms underlying its function and the development of therapeutic strategies targeting MRPS18B.

Genular Protein ID: 4045610879

Symbol: RT18B_HUMAN

Name: 28S ribosomal protein S18-2, mitochondrial

UniProtKB Accession Codes:

Q9Y676 A6NDQ0 Q659G4 Q9BS27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EMDB 41 Ensembl 7 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27023846

Title: Structure and function of the mitochondrial ribosome.

PubMed ID: 27023846

DOI: 10.1146/annurev-biochem-060815-014343

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 258
  • Mass: 29396
  • Checksum: B4C83E5593796C5D
  • Sequence:
    • MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP YKDEPWKYLE 
SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV VGNPCPICRD HKLHVDFRNV 
KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL TQAIQKARDH GLLIYHIPQV EPRDLDFSTS 
HGAVSATPPA PTLVSGDPWY PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP 
RTPAEASSTG QTGPQSAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.