Details for: MAGEH1

Gene ID: 28986

Symbol: MAGEH1

Ensembl ID: ENSG00000187601

Description: MAGE family member H1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.5531
    Cell Significance Index: -24.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.2415
    Cell Significance Index: -20.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.5801
    Cell Significance Index: -23.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.2637
    Cell Significance Index: -20.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.3880
    Cell Significance Index: -20.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.0778
    Cell Significance Index: -24.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5144
    Cell Significance Index: -20.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3355
    Cell Significance Index: -25.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6716
    Cell Significance Index: -17.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0616
    Cell Significance Index: 16.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5429
    Cell Significance Index: 12.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4080
    Cell Significance Index: 229.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2047
    Cell Significance Index: 25.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1067
    Cell Significance Index: 29.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0022
    Cell Significance Index: 99.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9719
    Cell Significance Index: 113.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9569
    Cell Significance Index: 20.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8557
    Cell Significance Index: 44.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8321
    Cell Significance Index: 751.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7140
    Cell Significance Index: 77.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6615
    Cell Significance Index: 90.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6244
    Cell Significance Index: 80.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5927
    Cell Significance Index: 7.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4690
    Cell Significance Index: 89.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4386
    Cell Significance Index: 15.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3725
    Cell Significance Index: 74.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3512
    Cell Significance Index: 24.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3293
    Cell Significance Index: 20.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3064
    Cell Significance Index: 7.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3059
    Cell Significance Index: 19.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2394
    Cell Significance Index: 85.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1703
    Cell Significance Index: 75.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1223
    Cell Significance Index: 1.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0751
    Cell Significance Index: 41.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0440
    Cell Significance Index: 8.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0298
    Cell Significance Index: 5.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0255
    Cell Significance Index: 1.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0123
    Cell Significance Index: 1.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0111
    Cell Significance Index: 8.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0098
    Cell Significance Index: 7.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0037
    Cell Significance Index: -2.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0055
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0144
    Cell Significance Index: -1.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0150
    Cell Significance Index: -27.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0151
    Cell Significance Index: -0.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0168
    Cell Significance Index: -11.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0174
    Cell Significance Index: -26.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0182
    Cell Significance Index: -24.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0211
    Cell Significance Index: -0.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0236
    Cell Significance Index: -14.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0246
    Cell Significance Index: -0.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0265
    Cell Significance Index: -14.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0317
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0375
    Cell Significance Index: -7.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0412
    Cell Significance Index: -18.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0418
    Cell Significance Index: -4.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0435
    Cell Significance Index: -1.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0460
    Cell Significance Index: -1.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0516
    Cell Significance Index: -3.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0554
    Cell Significance Index: -0.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0604
    Cell Significance Index: -17.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0632
    Cell Significance Index: -7.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0735
    Cell Significance Index: -1.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0880
    Cell Significance Index: -6.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0908
    Cell Significance Index: -0.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1131
    Cell Significance Index: -3.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1220
    Cell Significance Index: -8.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1232
    Cell Significance Index: -3.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1379
    Cell Significance Index: -20.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1415
    Cell Significance Index: -18.2900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1845
    Cell Significance Index: -1.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1936
    Cell Significance Index: -22.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2043
    Cell Significance Index: -5.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2080
    Cell Significance Index: -3.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2086
    Cell Significance Index: -2.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2208
    Cell Significance Index: -5.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2236
    Cell Significance Index: -7.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2353
    Cell Significance Index: -2.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2383
    Cell Significance Index: -24.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2469
    Cell Significance Index: -12.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2557
    Cell Significance Index: -20.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2628
    Cell Significance Index: -12.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2806
    Cell Significance Index: -6.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2873
    Cell Significance Index: -8.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2924
    Cell Significance Index: -7.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2946
    Cell Significance Index: -3.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3019
    Cell Significance Index: -18.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3160
    Cell Significance Index: -6.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3171
    Cell Significance Index: -24.3400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3177
    Cell Significance Index: -2.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3191
    Cell Significance Index: -16.6200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3717
    Cell Significance Index: -2.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3936
    Cell Significance Index: -11.5600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3946
    Cell Significance Index: -2.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4062
    Cell Significance Index: -13.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4161
    Cell Significance Index: -11.1300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4194
    Cell Significance Index: -3.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4248
    Cell Significance Index: -10.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** MAGEH1 is highly expressed in various cell types, including those that are not typically associated with cancer. 2. **Molecular Function:** The gene is involved in the regulation of transcription and is associated with the apoptotic process. 3. **Pathways:** MAGEH1 is involved in negative regulation of transcription by RNA polymerase II and protein binding. 4. **Cell Types:** The gene is significantly expressed in GABAergic amacrine cells, primary sensory neurons, kidney cells, decidual cells, and epithelial cells of the nephron. **Pathways and Functions:** 1. **Apoptotic Process:** MAGEH1 is involved in the regulation of apoptosis, which is a critical process for eliminating damaged or unwanted cells. 2. **Negative Regulation of Transcription:** The gene is involved in the negative regulation of transcription by RNA polymerase II, which is essential for maintaining gene expression homeostasis. 3. **Protein Binding:** MAGEH1 is associated with protein binding, which is a critical process for regulating protein-protein interactions and cellular signaling. **Clinical Significance:** 1. **Cancer Immunotherapy:** MAGEH1 has been identified as a potential tumor antigen for cancer immunotherapy, which involves using the immune system to target and eliminate cancer cells. 2. **Immunological Monitoring:** The gene's expression profile can be used as a biomarker for monitoring the effectiveness of cancer immunotherapy. 3. **Understanding Immune Evasion:** MAGEH1's expression in normal cells, but not in cancer cells, highlights the complex mechanisms of immune evasion employed by cancer cells. 4. **Potential Therapeutic Applications:** Further research on MAGEH1's molecular mechanisms and its role in cancer immunotherapy may lead to the development of novel therapeutic strategies for cancer treatment. In conclusion, the MAGEH1 gene is a complex and multifunctional gene that plays a critical role in regulating transcription, apoptosis, and protein binding. Its expression profile and clinical significance make it an attractive target for cancer immunotherapy and immunological monitoring. Further research is necessary to fully understand the molecular mechanisms underlying MAGEH1's role in cancer and to explore its potential therapeutic applications.

Genular Protein ID: 1266621144

Symbol: MAGH1_HUMAN

Name: Melanoma-associated antigen H1

UniProtKB Accession Codes:

Q9H213 B2R8V9 Q5JRJ3 Q9Y5M2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11454705

Title: An overview of the MAGE gene family with the identification of all human members of the family.

PubMed ID: 11454705

PubMed ID: 10948432

Title: Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes.

PubMed ID: 10948432

DOI: 10.2144/00292st06

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 219
  • Mass: 24441
  • Checksum: 408C59F0CCAA6781
  • Sequence:
    • MPRGRKSRRR RNARAAEENR NNRKIQASEA SETPMAASVV ASTPEDDLSG PEEDPSTPEE 
ASTTPEEASS TAQAQKPSVP RSNFQGTKKS LLMSILALIF IMGNSAKEAL VWKVLGKLGM 
QPGRQHSIFG DPKKIVTEEF VRRGYLIYKP VPRSSPVEYE FFWGPRAHVE SSKLKVMHFV 
ARVRNRCSKD WPCNYDWDSD DDAEVEAILN SGARGYSAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.