Details for: DBNL

Gene ID: 28988

Symbol: DBNL

Ensembl ID: ENSG00000136279

Description: drebrin like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 221.5111
    Cell Significance Index: -34.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 129.5914
    Cell Significance Index: -32.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.5614
    Cell Significance Index: -38.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 88.9811
    Cell Significance Index: -42.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.0980
    Cell Significance Index: -42.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.3250
    Cell Significance Index: -38.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.6272
    Cell Significance Index: -39.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3217
    Cell Significance Index: -40.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1874
    Cell Significance Index: -31.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7724
    Cell Significance Index: -23.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6899
    Cell Significance Index: -16.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1931
    Cell Significance Index: 64.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0939
    Cell Significance Index: 246.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9943
    Cell Significance Index: 36.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8888
    Cell Significance Index: 220.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6441
    Cell Significance Index: 106.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5285
    Cell Significance Index: 1380.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3135
    Cell Significance Index: 213.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6974
    Cell Significance Index: 68.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6589
    Cell Significance Index: 118.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6425
    Cell Significance Index: 88.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6107
    Cell Significance Index: 28.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5869
    Cell Significance Index: 72.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5146
    Cell Significance Index: 281.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4770
    Cell Significance Index: 22.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4646
    Cell Significance Index: 93.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4635
    Cell Significance Index: 24.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4492
    Cell Significance Index: 57.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4055
    Cell Significance Index: 21.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3843
    Cell Significance Index: 10.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3324
    Cell Significance Index: 146.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3136
    Cell Significance Index: 112.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2967
    Cell Significance Index: 58.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2752
    Cell Significance Index: 52.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2679
    Cell Significance Index: 9.3100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2462
    Cell Significance Index: 1.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2427
    Cell Significance Index: 167.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1918
    Cell Significance Index: 24.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1676
    Cell Significance Index: 3.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1452
    Cell Significance Index: 3.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1096
    Cell Significance Index: 4.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0813
    Cell Significance Index: 5.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0690
    Cell Significance Index: 0.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0605
    Cell Significance Index: 4.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0445
    Cell Significance Index: 7.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0161
    Cell Significance Index: 0.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0135
    Cell Significance Index: 25.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0122
    Cell Significance Index: 22.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0091
    Cell Significance Index: 13.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0036
    Cell Significance Index: 2.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0094
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0259
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0285
    Cell Significance Index: -17.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0290
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0318
    Cell Significance Index: -23.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0338
    Cell Significance Index: -21.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0430
    Cell Significance Index: -0.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0484
    Cell Significance Index: -27.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0596
    Cell Significance Index: -27.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0680
    Cell Significance Index: -4.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0713
    Cell Significance Index: -5.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0755
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1138
    Cell Significance Index: -23.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1225
    Cell Significance Index: -35.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1633
    Cell Significance Index: -18.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1963
    Cell Significance Index: -28.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2769
    Cell Significance Index: -17.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3050
    Cell Significance Index: -9.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3451
    Cell Significance Index: -7.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3464
    Cell Significance Index: -23.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3569
    Cell Significance Index: -37.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3593
    Cell Significance Index: -9.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3626
    Cell Significance Index: -20.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3629
    Cell Significance Index: -41.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3884
    Cell Significance Index: -5.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4055
    Cell Significance Index: -10.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4231
    Cell Significance Index: -22.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4493
    Cell Significance Index: -11.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4677
    Cell Significance Index: -37.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5105
    Cell Significance Index: -5.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5366
    Cell Significance Index: -23.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5864
    Cell Significance Index: -8.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6014
    Cell Significance Index: -36.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6165
    Cell Significance Index: -10.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6425
    Cell Significance Index: -24.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6488
    Cell Significance Index: -19.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6992
    Cell Significance Index: -20.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7475
    Cell Significance Index: -13.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7657
    Cell Significance Index: -19.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7735
    Cell Significance Index: -17.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8320
    Cell Significance Index: -23.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8901
    Cell Significance Index: -25.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9209
    Cell Significance Index: -32.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.9345
    Cell Significance Index: -7.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9586
    Cell Significance Index: -22.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9632
    Cell Significance Index: -35.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9676
    Cell Significance Index: -31.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DBNL is a member of the drebrin-like protein family, characterized by its ability to bind to actin filaments and other cytoskeletal proteins. The protein exhibits structural similarity to drebrin, a protein involved in maintaining actin cytoskeleton organization in neurons. DBNL has been shown to interact with various proteins, including actin-binding proteins, signaling molecules, and immune-related proteins, further emphasizing its role in multiple cellular processes. **Pathways and Functions** DBNL is involved in several cellular pathways, including: 1. **Actin binding and cytoskeletal organization**: DBNL interacts with actin-binding proteins to regulate cytoskeletal organization and dynamics, which is essential for cell migration, division, and signaling. 2. **Immune response**: DBNL is highly expressed in immune cells, including myeloid leukocytes, epithelial cells of the esophagus, and B cells, suggesting its role in immune system function and regulation. 3. **Cell signaling**: DBNL interacts with signaling molecules, such as Rac proteins, to regulate cell signaling pathways involved in immune response, cell migration, and cytoskeletal organization. 4. **Apoptosis**: DBNL has been implicated in programmed cell death, suggesting its role in regulating cell survival and death in immune cells. **Clinical Significance** DBNL's involvement in immune response and cellular structure makes it a potential candidate for therapeutic targeting in various diseases, including: 1. **Immunological disorders**: DBNL's role in immune system function and regulation makes it a potential target for therapeutic interventions in immunological disorders, such as autoimmune diseases or cancer. 2. **Neurological disorders**: DBNL's involvement in neuronal structure and function suggests its potential role in neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer**: DBNL's interaction with signaling molecules and cytoskeletal proteins makes it a potential target for therapeutic interventions in cancer. In conclusion, DBNL is a multifunctional protein involved in various cellular processes, including immune response, cell structure, and cytoskeletal organization. Its clinical significance lies in its potential as a therapeutic target for various diseases, including immunological disorders, neurological disorders, and cancer. Further research is needed to fully elucidate DBNL's role in immune system function and cellular structure.

Genular Protein ID: 269519627

Symbol: DBNL_HUMAN

Name: Drebrin-like protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10567356

Title: A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.

PubMed ID: 10567356

DOI: 10.1074/jbc.274.48.33945

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9891087

Title: SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors.

PubMed ID: 9891087

DOI: 10.1128/mcb.19.2.1539

PubMed ID: 11689006

Title: Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.

PubMed ID: 11689006

DOI: 10.1006/bbrc.2001.5862

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 14729663

Title: Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.

PubMed ID: 14729663

DOI: 10.1074/jbc.m312659200

PubMed ID: 15637062

Title: PRAM-1 potentiates arsenic trioxide-induced JNK activation.

PubMed ID: 15637062

DOI: 10.1074/jbc.m413564200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19768801

Title: NMR solution structures of actin depolymerizing factor homology domains.

PubMed ID: 19768801

DOI: 10.1002/pro.248

Sequence Information:

  • Length: 430
  • Mass: 48207
  • Checksum: 7E8C42ED047257AE
  • Sequence:
  • MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL EEMVEELNSG 
    KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACASH VSTMASFLKG AHVTINARAE 
    EDVEPECIME KVAKASGANY SFHKESGRFQ DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW 
    AKAEKEEENR RLEEKRRAEE AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ 
    QEVVSRNRNE QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE 
    PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV QQQGAGSEHI 
    DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG IEVIDEGWWR GYGPDGHFGM 
    FPANYVELIE

Genular Protein ID: 3144171516

Symbol: B4DUF9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 336
  • Mass: 37917
  • Checksum: BB2C2E5286DAEF4B
  • Sequence:
  • MKATAMTSAW LAQGGAHVTI NARAEEDVEP ECIMEKVAKA SGANYSFHKE SGRFQDVGPQ 
    APVGSVYQKT NAVSEIKRVG KDSFWAKAEK EEENRRLEEK RRAEEAQRQL EQERRERELR 
    EAARREQRYQ EQGGEASPQS RMWEQQQGVV SRNRNEQESA VHPREIFKQK ERAMSTTSIS 
    SPQPGKLRSP FLQKQLTQPE THFGREPAAA ISRPRADLPA EEPAPSTPPC LVQAEEEAVY 
    EEPPEQETFY EQPPLVQQQG AGSEHIDHHI QGQGLSGQGL CARALYDYQA ADDTEISFDP 
    ENLITGIEVI DEGWWRGYGP DGHFGMFPAN YVELIE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.