Details for: MED4

Gene ID: 29079

Symbol: MED4

Ensembl ID: ENSG00000136146

Description: mediator complex subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 255.9063
    Cell Significance Index: -39.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.7445
    Cell Significance Index: -42.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 126.1568
    Cell Significance Index: -51.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 111.7083
    Cell Significance Index: -52.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 111.7027
    Cell Significance Index: -45.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.7186
    Cell Significance Index: -50.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 78.6561
    Cell Significance Index: -52.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.8453
    Cell Significance Index: -45.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.0842
    Cell Significance Index: -50.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.7292
    Cell Significance Index: -45.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5414
    Cell Significance Index: -53.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0648
    Cell Significance Index: -32.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0295
    Cell Significance Index: 121.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5029
    Cell Significance Index: 40.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4015
    Cell Significance Index: 48.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3891
    Cell Significance Index: 37.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3731
    Cell Significance Index: 168.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2114
    Cell Significance Index: 218.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1203
    Cell Significance Index: 224.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0974
    Cell Significance Index: 150.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0057
    Cell Significance Index: 444.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0010
    Cell Significance Index: 198.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9738
    Cell Significance Index: 124.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8734
    Cell Significance Index: 788.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8526
    Cell Significance Index: 22.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7987
    Cell Significance Index: 436.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6869
    Cell Significance Index: 246.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6858
    Cell Significance Index: 35.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6442
    Cell Significance Index: 45.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6312
    Cell Significance Index: 5.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5802
    Cell Significance Index: 27.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5559
    Cell Significance Index: 41.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5213
    Cell Significance Index: 24.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4761
    Cell Significance Index: 21.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4733
    Cell Significance Index: 46.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4690
    Cell Significance Index: 29.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4556
    Cell Significance Index: 31.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4524
    Cell Significance Index: 29.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3992
    Cell Significance Index: 51.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3952
    Cell Significance Index: 20.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3265
    Cell Significance Index: 38.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3226
    Cell Significance Index: 52.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2634
    Cell Significance Index: 7.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2479
    Cell Significance Index: 19.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2154
    Cell Significance Index: 11.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1960
    Cell Significance Index: 11.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1880
    Cell Significance Index: 12.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1318
    Cell Significance Index: 25.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0715
    Cell Significance Index: 2.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0571
    Cell Significance Index: 3.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0426
    Cell Significance Index: 1.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0292
    Cell Significance Index: 53.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0277
    Cell Significance Index: 0.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0266
    Cell Significance Index: 0.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0255
    Cell Significance Index: 48.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0151
    Cell Significance Index: 0.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0121
    Cell Significance Index: 8.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0261
    Cell Significance Index: -35.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0363
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0574
    Cell Significance Index: -42.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0625
    Cell Significance Index: -10.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0798
    Cell Significance Index: -8.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0867
    Cell Significance Index: -48.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0953
    Cell Significance Index: -59.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1161
    Cell Significance Index: -2.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1225
    Cell Significance Index: -5.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1501
    Cell Significance Index: -43.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1570
    Cell Significance Index: -4.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1637
    Cell Significance Index: -19.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1656
    Cell Significance Index: -6.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1675
    Cell Significance Index: -2.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1800
    Cell Significance Index: -26.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1868
    Cell Significance Index: -1.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2232
    Cell Significance Index: -4.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2315
    Cell Significance Index: -2.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2466
    Cell Significance Index: -1.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2552
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2731
    Cell Significance Index: -57.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3285
    Cell Significance Index: -37.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3511
    Cell Significance Index: -8.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3686
    Cell Significance Index: -7.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3753
    Cell Significance Index: -5.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4061
    Cell Significance Index: -7.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4077
    Cell Significance Index: -9.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4496
    Cell Significance Index: -35.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4624
    Cell Significance Index: -48.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4995
    Cell Significance Index: -13.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5448
    Cell Significance Index: -5.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5548
    Cell Significance Index: -17.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5684
    Cell Significance Index: -16.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6596
    Cell Significance Index: -17.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6826
    Cell Significance Index: -41.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7291
    Cell Significance Index: -18.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7391
    Cell Significance Index: -21.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8681
    Cell Significance Index: -21.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mediator Complex Subunit**: MED4 is a subunit of the mediator complex, a multi-protein complex that regulates RNA polymerase II transcription. 2. **RNA Polymerase II Transcription**: MED4 co-activates RNA polymerase II, facilitating the transcription of genes. 3. **Cell Type Specificity**: MED4 is expressed in various cell types, including erythroid progenitor cells, epithelial cells, and mesenchymal cells. 4. **Regulation of Gene Expression**: MED4 plays a critical role in regulating gene expression, influencing development, disease, and metabolic homeostasis. **Pathways and Functions:** MED4 is involved in several key pathways and functions, including: 1. **Transcriptional Regulation**: MED4 regulates gene expression by co-activating RNA polymerase II, influencing the transcription of genes involved in development, disease, and metabolic homeostasis. 2. **Metabolic Processes**: MED4 is involved in regulating lipid metabolism, as suggested by its association with PPARα and PPARγ. 3. **Nuclear Receptor Coactivation**: MED4 co-activates nuclear receptors, such as thyroid hormone receptor and vitamin D receptor, influencing gene expression. 4. **Infectious Disease**: MED4 is involved in the regulation of transcription during viral infections, including Respiratory Syncytial Virus (RSV) infection. **Clinical Significance:** The MED4 gene has significant clinical implications, particularly in the context of: 1. **Developmental Disorders**: MED4 mutations have been associated with developmental disorders, such as intellectual disability and autism spectrum disorder. 2. **Cancer**: MED4 is overexpressed in various cancers, including breast, lung, and colon cancer, suggesting its potential as a therapeutic target. 3. **Metabolic Disorders**: MED4 plays a critical role in regulating lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as obesity and type 2 diabetes. 4. **Infectious Diseases**: MED4 is involved in the regulation of transcription during viral infections, highlighting its potential as a therapeutic target for the treatment of RSV and other viral infections. In conclusion, the MED4 gene is a critical regulator of gene expression and metabolic processes, influencing various biological pathways and functions. Its clinical significance is underscored by its involvement in developmental disorders, cancer, metabolic disorders, and infectious diseases. Further research is necessary to fully elucidate the mechanisms by which MED4 regulates gene expression and metabolic processes, as well as its potential as a therapeutic target for various diseases.

Genular Protein ID: 3357365318

Symbol: MED4_HUMAN

Name: Mediator of RNA polymerase II transcription subunit 4

UniProtKB Accession Codes:

Q9NPJ6 B4DX67 Q53GB4 Q53H68 Q5T912 Q6FHC4 Q6IA79 Q9BS95 Q9NYR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10235266

Title: Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.

PubMed ID: 10235266

DOI: 10.1038/19783

PubMed ID: 10882111

Title: The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.

PubMed ID: 10882111

DOI: 10.1016/s1097-2765(00)80254-3

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10235267

Title: Composite co-activator ARC mediates chromatin-directed transcriptional activation.

PubMed ID: 10235267

DOI: 10.1038/19789

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 270
  • Mass: 29745
  • Checksum: 05641357EBFA85F4
  • Sequence:
    • MAASSSGEKE KERLGGGLGV AGGNSTRERL LSALEDLEVL SRELIEMLAI SRNQKLLQAG 
EENQVLELLI HRDGEFQELM KLALNQGKIH HEMQVLEKEV EKRDSDIQQL QKQLKEAEQI 
LATAVYQAKE KLKSIEKARK GAISSEEIIK YAHRISASNA VCAPLTWVPG DPRRPYPTDL 
EMRSGLLGQM NNPSTNGVNG HLPGDALAAG RLPDVLAPQY PWQSNDMSMN MLPPNHSSDF 
LLEPPGHNKE NEDDVEIMST DSSSSSSESD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.