Details for: MRPL15

Gene ID: 29088

Symbol: MRPL15

Ensembl ID: ENSG00000137547

Description: mitochondrial ribosomal protein L15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 167.9254
    Cell Significance Index: -26.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.2361
    Cell Significance Index: -20.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 74.4269
    Cell Significance Index: -30.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.3554
    Cell Significance Index: -31.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.4327
    Cell Significance Index: -25.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.2637
    Cell Significance Index: -29.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 47.3904
    Cell Significance Index: -31.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.3896
    Cell Significance Index: -26.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.5832
    Cell Significance Index: -30.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3510
    Cell Significance Index: -25.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0359
    Cell Significance Index: -31.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1204
    Cell Significance Index: -21.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1137
    Cell Significance Index: 56.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.6343
    Cell Significance Index: 103.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5805
    Cell Significance Index: 82.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3498
    Cell Significance Index: 12.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3354
    Cell Significance Index: 155.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2703
    Cell Significance Index: 13.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2143
    Cell Significance Index: 83.9800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1422
    Cell Significance Index: 9.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9004
    Cell Significance Index: 162.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8522
    Cell Significance Index: 60.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8368
    Cell Significance Index: 102.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8292
    Cell Significance Index: 22.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8039
    Cell Significance Index: 94.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7566
    Cell Significance Index: 413.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7071
    Cell Significance Index: 14.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6924
    Cell Significance Index: 306.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6645
    Cell Significance Index: 51.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6609
    Cell Significance Index: 85.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6538
    Cell Significance Index: 22.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6313
    Cell Significance Index: 102.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6076
    Cell Significance Index: 27.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5831
    Cell Significance Index: 80.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5419
    Cell Significance Index: 11.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5381
    Cell Significance Index: 34.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5285
    Cell Significance Index: 6.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4399
    Cell Significance Index: 87.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4393
    Cell Significance Index: 20.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4359
    Cell Significance Index: 10.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4045
    Cell Significance Index: 19.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3921
    Cell Significance Index: 10.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3831
    Cell Significance Index: 11.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3759
    Cell Significance Index: 4.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3616
    Cell Significance Index: 9.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3400
    Cell Significance Index: 5.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3141
    Cell Significance Index: 23.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3047
    Cell Significance Index: 30.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3038
    Cell Significance Index: 60.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2969
    Cell Significance Index: 9.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2057
    Cell Significance Index: 26.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1467
    Cell Significance Index: 7.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1345
    Cell Significance Index: 48.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1032
    Cell Significance Index: 2.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0986
    Cell Significance Index: 16.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0782
    Cell Significance Index: 57.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0552
    Cell Significance Index: 10.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0039
    Cell Significance Index: 2.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0068
    Cell Significance Index: -4.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0121
    Cell Significance Index: -0.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0187
    Cell Significance Index: -1.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0198
    Cell Significance Index: -36.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0242
    Cell Significance Index: -37.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0249
    Cell Significance Index: -14.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0267
    Cell Significance Index: -16.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0277
    Cell Significance Index: -37.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0376
    Cell Significance Index: -17.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0498
    Cell Significance Index: -3.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0624
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0626
    Cell Significance Index: -13.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0727
    Cell Significance Index: -20.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0870
    Cell Significance Index: -12.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0911
    Cell Significance Index: -4.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1111
    Cell Significance Index: -12.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1355
    Cell Significance Index: -2.0300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1867
    Cell Significance Index: -1.1600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2003
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2121
    Cell Significance Index: -24.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2170
    Cell Significance Index: -13.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2235
    Cell Significance Index: -3.7400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2607
    Cell Significance Index: -2.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2669
    Cell Significance Index: -7.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2960
    Cell Significance Index: -30.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3097
    Cell Significance Index: -17.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3119
    Cell Significance Index: -7.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3318
    Cell Significance Index: -8.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3369
    Cell Significance Index: -4.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3615
    Cell Significance Index: -24.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4178
    Cell Significance Index: -5.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4299
    Cell Significance Index: -4.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4405
    Cell Significance Index: -11.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4736
    Cell Significance Index: -13.5800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4867
    Cell Significance Index: -3.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5086
    Cell Significance Index: -31.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5436
    Cell Significance Index: -24.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5902
    Cell Significance Index: -10.4300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6222
    Cell Significance Index: -3.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6472
    Cell Significance Index: -24.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL15 is a mitochondrial ribosomal protein that belongs to the L15 family of ribosomal proteins. It is composed of 139 amino acids and is encoded by the ENSG00000137547 gene. MRPL15 is specifically localized to the mitochondrial large ribosomal subunit, where it interacts with other ribosomal proteins to form the 60S subunit. This protein is highly conserved across species, suggesting its essential role in mitochondrial function. **Pathways and Functions:** MRPL15 is involved in various cellular processes, including: 1. **Mitochondrial Translation:** MRPL15 plays a crucial role in the translation of mitochondrial mRNAs, which are essential for the production of mitochondrial proteins. This process is critical for maintaining mitochondrial function and energy production. 2. **Mitochondrial Inner Membrane:** MRPL15 is also involved in the assembly and maintenance of the mitochondrial inner membrane, where it interacts with other mitochondrial proteins to regulate membrane structure and function. 3. **Protein Metabolism:** MRPL15 is involved in the metabolism of proteins, including the degradation of misfolded or damaged proteins, which is essential for maintaining protein homeostasis. 4. **Cell Differentiation:** MRPL15 is expressed in various cell types, including erythroid progenitor cells, placental villous trophoblasts, and kidney collecting duct intercalated cells. Its expression is often regulated during cell differentiation, suggesting its role in cellular development and maturation. **Clinical Significance:** Dysregulation of MRPL15 has been implicated in various human diseases, including: 1. **Mitochondrial Diseases:** Mutations in the MRPL15 gene have been associated with mitochondrial diseases, such as mitochondrial myopathies and encephalopathies. 2. **Cancer:** MRPL15 has been identified as a tumor suppressor gene, with its expression often reduced in cancer cells. 3. **Neurodegenerative Disorders:** MRPL15 has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders:** MRPL15 has been linked to metabolic disorders, such as type 2 diabetes and obesity, where its expression is often dysregulated. In conclusion, MRPL15 is a critical component of the mitochondrial ribosome, playing a pivotal role in mitochondrial function and disease. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the mechanisms of MRPL15 and its potential as a therapeutic target.

Genular Protein ID: 664877678

Symbol: RM15_HUMAN

Name: 39S ribosomal protein L15, mitochondrial

UniProtKB Accession Codes:

Q9P015 Q96Q54 Q9H0Y1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 23 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 296
  • Mass: 33420
  • Checksum: D7396086F808A72C
  • Sequence:
    • MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG RGHKGERQRG 
TRPRLGFEGG QTPFYIRIPK YGFNEGHSFR RQYKPLSLNR LQYLIDLGRV DPSQPIDLTQ 
LVNGRGVTIQ PLKRDYGVQL VEEGADTFTA KVNIEVQLAS ELAIAAIEKN GGVVTTAFYD 
PRSLDIVCKP VPFFLRGQPI PKRMLPPEEL VPYYTDAKNR GYLADPAKFP EARLELARKY 
GYILPDITKD ELFKMLCTRK DPRQIFFGLA PGWVVNMADK KILKPTDENL LKYYTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.