Details for: RANGRF

Gene ID: 29098

Symbol: RANGRF

Ensembl ID: ENSG00000108961

Description: RAN guanine nucleotide release factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.8722
    Cell Significance Index: -18.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.4966
    Cell Significance Index: -14.3300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 47.7245
    Cell Significance Index: -19.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.7746
    Cell Significance Index: -18.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.1501
    Cell Significance Index: -19.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6778
    Cell Significance Index: -19.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0684
    Cell Significance Index: -20.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0665
    Cell Significance Index: -12.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7963
    Cell Significance Index: -6.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2976
    Cell Significance Index: -6.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4497
    Cell Significance Index: 235.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.3651
    Cell Significance Index: 34.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2527
    Cell Significance Index: 36.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1000
    Cell Significance Index: 993.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0410
    Cell Significance Index: 24.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0297
    Cell Significance Index: 64.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9578
    Cell Significance Index: 111.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7723
    Cell Significance Index: 40.5500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7083
    Cell Significance Index: 5.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6590
    Cell Significance Index: 77.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6419
    Cell Significance Index: 41.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5117
    Cell Significance Index: 6.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5077
    Cell Significance Index: 13.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5013
    Cell Significance Index: 5.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4893
    Cell Significance Index: 267.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4865
    Cell Significance Index: 33.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4805
    Cell Significance Index: 65.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4141
    Cell Significance Index: 21.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3898
    Cell Significance Index: 8.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3851
    Cell Significance Index: 10.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3672
    Cell Significance Index: 9.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3278
    Cell Significance Index: 144.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3103
    Cell Significance Index: 39.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2970
    Cell Significance Index: 7.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2910
    Cell Significance Index: 3.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2822
    Cell Significance Index: 34.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2635
    Cell Significance Index: 19.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2610
    Cell Significance Index: 47.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2204
    Cell Significance Index: 15.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2165
    Cell Significance Index: 2.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2009
    Cell Significance Index: 6.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2003
    Cell Significance Index: 39.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1554
    Cell Significance Index: 15.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1528
    Cell Significance Index: 3.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1517
    Cell Significance Index: 7.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1396
    Cell Significance Index: 18.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1241
    Cell Significance Index: 24.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0980
    Cell Significance Index: 4.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0901
    Cell Significance Index: 32.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0876
    Cell Significance Index: 2.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0740
    Cell Significance Index: 14.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0597
    Cell Significance Index: 45.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0200
    Cell Significance Index: 0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0076
    Cell Significance Index: -5.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0164
    Cell Significance Index: -22.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0174
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0197
    Cell Significance Index: -14.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0233
    Cell Significance Index: -0.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0249
    Cell Significance Index: -2.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0331
    Cell Significance Index: -15.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0353
    Cell Significance Index: -22.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0389
    Cell Significance Index: -0.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0402
    Cell Significance Index: -11.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0597
    Cell Significance Index: -10.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0626
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0912
    Cell Significance Index: -10.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0976
    Cell Significance Index: -14.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0988
    Cell Significance Index: -20.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1075
    Cell Significance Index: -2.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1138
    Cell Significance Index: -3.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1157
    Cell Significance Index: -2.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1288
    Cell Significance Index: -1.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1304
    Cell Significance Index: -4.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1689
    Cell Significance Index: -1.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1724
    Cell Significance Index: -13.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1856
    Cell Significance Index: -14.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1859
    Cell Significance Index: -19.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2052
    Cell Significance Index: -1.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2066
    Cell Significance Index: -12.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2105
    Cell Significance Index: -11.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2135
    Cell Significance Index: -1.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2310
    Cell Significance Index: -12.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2369
    Cell Significance Index: -14.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2376
    Cell Significance Index: -6.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2466
    Cell Significance Index: -16.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2657
    Cell Significance Index: -7.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2811
    Cell Significance Index: -3.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3099
    Cell Significance Index: -14.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3222
    Cell Significance Index: -14.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3441
    Cell Significance Index: -6.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3524
    Cell Significance Index: -5.2800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3675
    Cell Significance Index: -5.8300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3707
    Cell Significance Index: -6.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3747
    Cell Significance Index: -14.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The RANGRF gene is located on chromosome 11q13.4 and is expressed in a wide range of cell types, including cardiac muscle cells, pneumocytes, erythroid progenitor cells, and primordial germ cells. 2. **Function:** The RANGRF protein is a guanine nucleotide release factor that regulates the release of guanine nucleotides, which are essential for the activation of various signaling pathways. 3. **Signaling Pathways:** The RANGRF protein is involved in multiple signaling pathways, including cardiac conduction, muscle contraction, and membrane depolarization. 4. **Regulation of Cardiac Conduction:** The RANGRF protein regulates the action potential and contraction of cardiac muscle cells by modulating the activity of sodium channels and the release of guanine nucleotides. **Pathways and Functions:** 1. **Cardiac Conduction:** The RANGRF protein regulates the action potential and contraction of cardiac muscle cells by modulating the activity of sodium channels and the release of guanine nucleotides. 2. **Muscle Contraction:** The RANGRF protein regulates muscle contraction by modulating the activity of actin-myosin interactions and the release of guanine nucleotides. 3. **Membrane Depolarization:** The RANGRF protein regulates membrane depolarization by modulating the activity of sodium channels and the release of guanine nucleotides. 4. **Sodium Channel Regulation:** The RANGRF protein regulates the activity of sodium channels, which is essential for the generation of the action potential in cardiac muscle cells. 5. **Protein Localization:** The RANGRF protein regulates the localization of proteins to the cell surface and plasma membrane, which is essential for various cellular processes. **Clinical Significance:** 1. **Cardiac Disorders:** Dysregulation of the RANGRF gene has been implicated in various cardiac disorders, including arrhythmias, heart failure, and cardiac conduction disorders. 2. **Cancer:** The RANGRF protein has been implicated in the regulation of cell growth and proliferation, making it a potential target for cancer therapy. 3. **Neurological Disorders:** The RANGRF protein has been implicated in the regulation of neuronal function and synaptic transmission, making it a potential target for neurological disorders. 4. **Developmental Disorders:** The RANGRF protein plays a critical role in the development of various tissues and organs, including the heart and nervous system. In conclusion, the RANGRF gene is a critical regulator of cardiac conduction and muscle contraction, and its dysregulation has been implicated in various cardiac and non-cardiac disorders. Further research is needed to fully understand the mechanisms by which this gene regulates various cellular processes and to identify potential therapeutic targets for the treatment of these disorders.

Genular Protein ID: 150384464

Symbol: MOG1_HUMAN

Name: Ran guanine nucleotide release factor

UniProtKB Accession Codes:

Q9HD47 D3DTR6 Q68DI3 Q9BR68 Q9HD48 Q9NRU9 Q9P001 Q9P0P2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 4 GO 28 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11290418

Title: Identification and characterization of the human MOG1 gene.

PubMed ID: 11290418

DOI: 10.1016/s0378-1119(01)00364-x

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18184654

Title: Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5.

PubMed ID: 18184654

DOI: 10.1074/jbc.m709721200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23420830

Title: MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome.

PubMed ID: 23420830

DOI: 10.1161/circep.111.000206

PubMed ID: 21621375

Title: A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.

PubMed ID: 21621375

DOI: 10.1016/j.cjca.2011.01.003

PubMed ID: 21447824

Title: MOG1: a new susceptibility gene for Brugada syndrome.

PubMed ID: 21447824

DOI: 10.1161/circgenetics.110.959130

PubMed ID: 24142675

Title: Brugada syndrome and p.E61X_RANGRF.

PubMed ID: 24142675

DOI: 10.5603/cj.a2013.0125

PubMed ID: 29040603

Title: Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.

PubMed ID: 29040603

DOI: 10.1093/jmcb/mjx045

Sequence Information:

  • Length: 186
  • Mass: 20448
  • Checksum: BE2C459C90459042
  • Sequence:
    • MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE LLELQAHVRG 
EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ EAWVLSGKQQ IAKENQQVAK 
DVTLHQALLR LPQYQTDLLL TFNQPPPDNR SSLGPENLSP APWSLGDFEQ LVTSLTLHDP 
NIFGPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.