Details for: TBK1

Gene ID: 29110

Symbol: TBK1

Ensembl ID: ENSG00000183735

Description: TANK binding kinase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.56
    Marker Score: 14,712
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.55
    Marker Score: 1,717
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.44
    Marker Score: 14,896
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13,628
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.43
    Marker Score: 5,809
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.42
    Marker Score: 87,502
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.42
    Marker Score: 593
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.41
    Marker Score: 12,096
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.33
    Marker Score: 48,898
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.31
    Marker Score: 1,204
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.3
    Marker Score: 2,013
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.26
    Marker Score: 25,005
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.25
    Marker Score: 2,645
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.25
    Marker Score: 4,820
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.24
    Marker Score: 725
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.23
    Marker Score: 2,693
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.19
    Marker Score: 4,948
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.17
    Marker Score: 1,703
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.17
    Marker Score: 8,957
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.16
    Marker Score: 1,337
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.16
    Marker Score: 43,950
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.14
    Marker Score: 38,618
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.11
    Marker Score: 665
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.1
    Marker Score: 643
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.1
    Marker Score: 16,497
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.1
    Marker Score: 1,325
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.08
    Marker Score: 749
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.07
    Marker Score: 19,027
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.07
    Marker Score: 945
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.04
    Marker Score: 22,142
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.04
    Marker Score: 1,253
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1
    Marker Score: 292
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,657
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,882
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,385
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.98
    Marker Score: 1,877
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.97
    Marker Score: 1,100
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.97
    Marker Score: 265
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15,141
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.96
    Marker Score: 304
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.95
    Marker Score: 464
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.95
    Marker Score: 1,283
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.95
    Marker Score: 381
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,389
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.93
    Marker Score: 461
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.92
    Marker Score: 608
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.92
    Marker Score: 3,866
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.91
    Marker Score: 337
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.91
    Marker Score: 7,951
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,694
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.89
    Marker Score: 2,197
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.88
    Marker Score: 4,089
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.87
    Marker Score: 934
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.86
    Marker Score: 294
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1,752
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.85
    Marker Score: 4,170
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.84
    Marker Score: 1,049
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,789
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,359
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.83
    Marker Score: 1,002
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.83
    Marker Score: 335
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.82
    Marker Score: 13,246
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.82
    Marker Score: 866
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.82
    Marker Score: 673
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.82
    Marker Score: 428
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.82
    Marker Score: 457
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.81
    Marker Score: 1,190
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.81
    Marker Score: 399
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 321
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.8
    Marker Score: 254
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.8
    Marker Score: 299
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.79
    Marker Score: 495
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.79
    Marker Score: 172
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.79
    Marker Score: 685
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.79
    Marker Score: 200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.78
    Marker Score: 471
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.77
    Marker Score: 298
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.77
    Marker Score: 266
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.76
    Marker Score: 220
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.76
    Marker Score: 197
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.76
    Marker Score: 2,979
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.76
    Marker Score: 327
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.76
    Marker Score: 309
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.76
    Marker Score: 218
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.76
    Marker Score: 2,689
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.75
    Marker Score: 180
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.75
    Marker Score: 672
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.75
    Marker Score: 394
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,120
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.74
    Marker Score: 794
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.74
    Marker Score: 984
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.74
    Marker Score: 1,308
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.73
    Marker Score: 948
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.73
    Marker Score: 1,748

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TBK1 is a non-canonical NF-κB kinase that is activated by the TANK-binding kinase (TBK) complex, comprising TBK1 and TANK (TRAF6-associated NF-κB kinase activator). TBK1 is a cytoplasmic kinase that is phosphorylated by TBK, which in turn activates its kinase activity. TBK1 is also known as T2K (TANK-binding kinase 1) and is encoded by the ENSG00000183735 gene. **Pathways and Functions** TBK1 is involved in various signaling pathways that regulate innate immune responses, including: 1. **Activation of innate immune response**: TBK1 is activated by the TBK complex and phosphorylates and activates downstream targets, including IRF3 and IRF7, which are essential for the production of type I interferons (IFNs). 2. **Activation of IRF3 and IRF7**: TBK1 phosphorylates and activates IRF3 and IRF7, which are transcription factors that regulate the expression of IFN-β and IFN-α, respectively. 3. **Antiviral innate immune response**: TBK1 is essential for the regulation of antiviral responses, including the production of IFNs and the activation of immune cells, such as dendritic cells and macrophages. 4. **Cytokine signaling**: TBK1 regulates the signaling of various cytokines, including IL-1β, IL-6, and IL-12, which are involved in the regulation of immune responses. 5. **Autophagy and xenophagy**: TBK1 is involved in the regulation of autophagy and xenophagy, which are essential for the degradation of pathogens and the regulation of immune responses. **Clinical Significance** TBK1 has been implicated in various diseases, including: 1. **Viral infections**: TBK1 is essential for the regulation of antiviral responses, and its dysregulation has been implicated in viral infections, such as SARS-CoV-1 and SARS-CoV-2. 2. **Cancer**: TBK1 has been implicated in the regulation of cancer cell survival and proliferation, and its dysregulation has been associated with various types of cancer. 3. **Autoimmune diseases**: TBK1 has been implicated in the regulation of autoimmune responses, and its dysregulation has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Neurological disorders**: TBK1 has been implicated in the regulation of neurological responses, and its dysregulation has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TBK1 is a critical regulator of innate immunity and has significant implications for various diseases. Its dysregulation has been implicated in viral infections, cancer, autoimmune diseases, and neurological disorders, highlighting the importance of TBK1 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 2857773395

Symbol: TBK1_HUMAN

Name: T2K

UniProtKB Accession Codes:

Q9UHD2 A8K4S4 Q8IYV3 Q9NUJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 4 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 6 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 41 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 25 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 16 RefSeq 3 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10581243

Title: NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase.

PubMed ID: 10581243

DOI: 10.1093/emboj/18.23.6694

PubMed ID: 10783893

Title: NAK is an IkappaB kinase-activating kinase.

PubMed ID: 10783893

DOI: 10.1038/35008109

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11839743

Title: IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.

PubMed ID: 11839743

DOI: 10.1074/jbc.m110474200

PubMed ID: 14530355

Title: Toll/IL-1 receptor domain-containing adapter inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.

PubMed ID: 14530355

DOI: 10.4049/jimmunol.171.8.4304

PubMed ID: 12692549

Title: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

PubMed ID: 12692549

DOI: 10.1038/ni921

PubMed ID: 12702806

Title: Triggering the interferon antiviral response through an IKK-related pathway.

PubMed ID: 12702806

DOI: 10.1126/science.1081315

PubMed ID: 14560022

Title: Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.

PubMed ID: 14560022

DOI: 10.1128/mcb.23.21.7780-7793.2003

PubMed ID: 14703513

Title: Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation.

PubMed ID: 14703513

DOI: 10.1074/jbc.m310616200

PubMed ID: 14739303

Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

PubMed ID: 14739303

DOI: 10.1074/jbc.m311629200

PubMed ID: 15485837

Title: NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.

PubMed ID: 15485837

DOI: 10.1074/jbc.m411037200

PubMed ID: 15489227

Title: Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.

PubMed ID: 15489227

DOI: 10.1074/jbc.m409825200

PubMed ID: 15367631

Title: Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.

PubMed ID: 15367631

DOI: 10.1128/jvi.78.19.10636-10649.2004

PubMed ID: 16281057

Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.

PubMed ID: 16281057

DOI: 10.1038/sj.emboj.7600863

PubMed ID: 15841462

Title: Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses.

PubMed ID: 15841462

DOI: 10.1002/hep.20666

PubMed ID: 16155125

Title: Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappa-B activator (TANK)-binding kinase-1.

PubMed ID: 16155125

DOI: 10.1073/pnas.0502883102

PubMed ID: 17018283

Title: RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.

PubMed ID: 17018283

DOI: 10.1016/j.cell.2006.08.034

PubMed ID: 17599067

Title: Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.

PubMed ID: 17599067

DOI: 10.1038/sj.emboj.7601773

PubMed ID: 18583960

Title: The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.

PubMed ID: 18583960

DOI: 10.1038/emboj.2008.126

PubMed ID: 18636086

Title: The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

PubMed ID: 18636086

DOI: 10.1038/embor.2008.136

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19419966

Title: The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.

PubMed ID: 19419966

DOI: 10.1074/jbc.m808233200

PubMed ID: 19153231

Title: Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.

PubMed ID: 19153231

DOI: 10.1128/jvi.01875-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19483718

Title: The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.

PubMed ID: 19483718

DOI: 10.1038/ni.1742

PubMed ID: 19416887

Title: ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.

PubMed ID: 19416887

DOI: 10.1073/pnas.0900818106

PubMed ID: 20628368

Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

PubMed ID: 20628368

DOI: 10.1038/cr.2010.103

PubMed ID: 21145761

Title: Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1.

PubMed ID: 21145761

DOI: 10.1016/j.immuni.2010.11.021

PubMed ID: 20375222

Title: Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.

PubMed ID: 20375222

DOI: 10.1099/vir.0.020552-0

PubMed ID: 20174559

Title: Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.

PubMed ID: 20174559

DOI: 10.1371/journal.ppat.1000778

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21447600

Title: Copy number variations on chromosome 12q14 in patients with normal tension glaucoma.

PubMed ID: 21447600

DOI: 10.1093/hmg/ddr123

PubMed ID: 21903422

Title: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

PubMed ID: 21903422

DOI: 10.1016/j.immuni.2011.06.014

PubMed ID: 21813773

Title: IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.

PubMed ID: 21813773

DOI: 10.4049/jimmunol.1100963

PubMed ID: 21270402

Title: TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.

PubMed ID: 21270402

DOI: 10.4049/jimmunol.1000262

PubMed ID: 21931631

Title: Functional dissection of the TBK1 molecular network.

PubMed ID: 21931631

DOI: 10.1371/journal.pone.0023971

PubMed ID: 21464307

Title: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

PubMed ID: 21464307

DOI: 10.1073/pnas.1016132108

PubMed ID: 21617041

Title: Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.

PubMed ID: 21617041

DOI: 10.1126/science.1205405

PubMed ID: 21042276

Title: Emerging roles for the non-canonical IKKs in cancer.

PubMed ID: 21042276

DOI: 10.1038/onc.2010.493

PubMed ID: 21138416

Title: Novel cross-talk within the IKK family controls innate immunity.

PubMed ID: 21138416

DOI: 10.1042/bj20101701

PubMed ID: 19010780

Title: Control of TANK-binding kinase 1-mediated signaling by the gamma(1)34.5 protein of herpes simplex virus 1.

PubMed ID: 19010780

DOI: 10.1074/jbc.m805905200

PubMed ID: 22750291

Title: PPM1B negatively regulates antiviral response via dephosphorylating TBK1.

PubMed ID: 22750291

DOI: 10.1016/j.cellsig.2012.06.017

PubMed ID: 22306015

Title: Confirmation of TBK1 duplication in normal tension glaucoma.

PubMed ID: 22306015

DOI: 10.1016/j.exer.2011.12.021

PubMed ID: 22851595

Title: Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.

PubMed ID: 22851595

DOI: 10.1084/jem.20111316

PubMed ID: 22945920

Title: TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.

PubMed ID: 22945920

DOI: 10.1084/jem.20120024

PubMed ID: 22388039

Title: NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.

PubMed ID: 22388039

DOI: 10.1038/ni.2239

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24478431

Title: Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses.

PubMed ID: 24478431

DOI: 10.1128/jvi.03021-13

PubMed ID: 24706939

Title: Viral suppression of innate immunity via spatial isolation of TBK1/IKKepsilon from mitochondrial antiviral platform.

PubMed ID: 24706939

DOI: 10.1093/jmcb/mju015

PubMed ID: 25943890

Title: Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease.

PubMed ID: 25943890

DOI: 10.1007/s00401-015-1436-x

PubMed ID: 25736436

Title: WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

PubMed ID: 25736436

DOI: 10.15252/embr.201439637

PubMed ID: 26513235

Title: Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.

PubMed ID: 26513235

DOI: 10.1038/gene.2015.46

PubMed ID: 25803835

Title: Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.

PubMed ID: 25803835

DOI: 10.1038/nn.4000

PubMed ID: 25636800

Title: Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

PubMed ID: 25636800

DOI: 10.1126/science.aaa2630

PubMed ID: 27692986

Title: USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.

PubMed ID: 27692986

DOI: 10.1016/j.molcel.2016.08.029

PubMed ID: 27103069

Title: Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

PubMed ID: 27103069

DOI: 10.15252/embj.201593350

PubMed ID: 26611359

Title: Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response.

PubMed ID: 26611359

DOI: 10.1093/jmcb/mjv068

PubMed ID: 27776110

Title: E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1.

PubMed ID: 27776110

DOI: 10.1038/ni.3588

PubMed ID: 28011935

Title: TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.

PubMed ID: 28011935

DOI: 10.4049/jimmunol.1601194

PubMed ID: 28848048

Title: Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction.

PubMed ID: 28848048

DOI: 10.1074/jbc.m117.805127

PubMed ID: 28680969

Title: Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins.

PubMed ID: 28680969

DOI: 10.1128/msphere.00234-17

PubMed ID: 28871090

Title: TRIM23 mediates virus-induced autophagy via activation of TBK1.

PubMed ID: 28871090

DOI: 10.1038/s41564-017-0017-2

PubMed ID: 28904192

Title: Role of Herpes Simplex Virus 1 gamma34.5 in the Regulation of IRF3 Signaling.

PubMed ID: 28904192

DOI: 10.1128/jvi.01156-17

PubMed ID: 28373913

Title: Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro.

PubMed ID: 28373913

DOI: 10.1038/celldisc.2017.6

PubMed ID: 29150432

Title: The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.

PubMed ID: 29150432

DOI: 10.15252/embj.201696164

PubMed ID: 30354798

Title: Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.

PubMed ID: 30354798

DOI: 10.1091/mbc.e18-02-0115

PubMed ID: 29251827

Title: Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.

PubMed ID: 29251827

DOI: 10.1002/pmic.201700403

PubMed ID: 30021900

Title: Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.

PubMed ID: 30021900

DOI: 10.1128/jvi.00706-18

PubMed ID: 31320558

Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.

PubMed ID: 31320558

DOI: 10.1126/science.aav0758

PubMed ID: 31530866

Title: TBK1 limits mTORC1 by promoting phosphorylation of Raptor Ser877.

PubMed ID: 31530866

DOI: 10.1038/s41598-019-49707-8

PubMed ID: 32185393

Title: CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.

PubMed ID: 32185393

DOI: 10.1093/brain/awaa039

PubMed ID: 32979938

Title: Evasion of Type I Interferon by SARS-CoV-2.

PubMed ID: 32979938

DOI: 10.1016/j.celrep.2020.108234

PubMed ID: 31709703

Title: TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease.

PubMed ID: 31709703

DOI: 10.15252/embr.201948317

PubMed ID: 32404352

Title: TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.

PubMed ID: 32404352

DOI: 10.4049/jimmunol.1901511

PubMed ID: 33226137

Title: Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

PubMed ID: 33226137

DOI: 10.15252/embj.2020104948

PubMed ID: 32366851

Title: TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination.

PubMed ID: 32366851

DOI: 10.1038/s41467-020-16014-0

PubMed ID: 34084167

Title: SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1.

PubMed ID: 34084167

DOI: 10.3389/fimmu.2021.662989

PubMed ID: 32466380

Title: The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription.

PubMed ID: 32466380

DOI: 10.3390/microorganisms8060790

PubMed ID: 37086853

Title: TRAF7 negatively regulates the RLR signaling pathway by facilitating the K48-linked ubiquitination of TBK1.

PubMed ID: 37086853

DOI: 10.1016/j.virs.2023.04.005

PubMed ID: 36802409

Title: Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1.

PubMed ID: 36802409

DOI: 10.1371/journal.ppat.1011186

PubMed ID: 23453971

Title: Crystal structure and mechanism of activation of TANK-binding kinase 1.

PubMed ID: 23453971

DOI: 10.1016/j.celrep.2013.01.034

PubMed ID: 23453972

Title: Structure and ubiquitination-dependent activation of TANK-binding kinase 1.

PubMed ID: 23453972

DOI: 10.1016/j.celrep.2013.01.033

PubMed ID: 23746807

Title: Structural insights into the functions of TBK1 in innate antimicrobial immunity.

PubMed ID: 23746807

DOI: 10.1016/j.str.2013.04.025

PubMed ID: 30842653

Title: Structural basis of STING binding with and phosphorylation by TBK1.

PubMed ID: 30842653

DOI: 10.1038/s41586-019-1000-2

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

Sequence Information:

  • Length: 729
  • Mass: 83642
  • Checksum: B58E4FE1B502276D
  • Sequence:
    • MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 
GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL 
HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG 
KPSGAISGVQ KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA 
ETSDILHRMV IHVFSLQQMT AHKIYIHSYN TATIFHELVY KQTKIISSNQ ELIYEGRRLV 
LEPGRLAQHF PKTTEENPIF VVSREPLNTI GLIYEKISLP KVHPRYDLDG DASMAKAITG 
VVCYACRIAS TLLLYQELMR KGIRWLIELI KDDYNETVHK KTEVVITLDF CIRNIEKTVK 
VYEKLMKINL EAAELGEISD IHTKLLRLSS SQGTIETSLQ DIDSRLSPGG SLADAWAHQE 
GTHPKDRNVE KLQVLLNCMT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH 
FTDECVKKYE AFLNKSEEWI RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY TNELQETLPQ 
KMFTASSGIK HTMTPIYPSS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGSLTMD 
GGLRNVDCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.