Details for: TBK1

Gene ID: 29110

Symbol: TBK1

Ensembl ID: ENSG00000183735

Description: TANK binding kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 215.5643
    Cell Significance Index: -33.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.4711
    Cell Significance Index: -34.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.5833
    Cell Significance Index: -34.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.1365
    Cell Significance Index: -36.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.4787
    Cell Significance Index: -31.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.3340
    Cell Significance Index: -35.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 55.1472
    Cell Significance Index: -37.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.5428
    Cell Significance Index: -31.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.8980
    Cell Significance Index: -35.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6355
    Cell Significance Index: -31.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.6599
    Cell Significance Index: -29.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1813
    Cell Significance Index: -36.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6814
    Cell Significance Index: -19.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6578
    Cell Significance Index: 60.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7017
    Cell Significance Index: 72.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7617
    Cell Significance Index: 286.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5401
    Cell Significance Index: 308.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1557
    Cell Significance Index: 229.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0639
    Cell Significance Index: 14.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0164
    Cell Significance Index: 110.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9399
    Cell Significance Index: 25.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9351
    Cell Significance Index: 18.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8778
    Cell Significance Index: 52.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7829
    Cell Significance Index: 21.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7218
    Cell Significance Index: 258.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7115
    Cell Significance Index: 492.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6738
    Cell Significance Index: 10.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6704
    Cell Significance Index: 34.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5094
    Cell Significance Index: 35.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4240
    Cell Significance Index: 12.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4001
    Cell Significance Index: 49.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3972
    Cell Significance Index: 22.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3912
    Cell Significance Index: 70.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3625
    Cell Significance Index: 27.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3300
    Cell Significance Index: 9.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3286
    Cell Significance Index: 7.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2439
    Cell Significance Index: 11.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2258
    Cell Significance Index: 42.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2241
    Cell Significance Index: 202.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2102
    Cell Significance Index: 10.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1914
    Cell Significance Index: 26.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1750
    Cell Significance Index: 95.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1466
    Cell Significance Index: 64.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1406
    Cell Significance Index: 16.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1287
    Cell Significance Index: 12.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1277
    Cell Significance Index: 3.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1002
    Cell Significance Index: 6.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0994
    Cell Significance Index: 1.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0849
    Cell Significance Index: 3.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0782
    Cell Significance Index: 2.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0708
    Cell Significance Index: 44.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0656
    Cell Significance Index: 123.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0638
    Cell Significance Index: 98.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0550
    Cell Significance Index: 101.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0525
    Cell Significance Index: 23.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0477
    Cell Significance Index: 2.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0434
    Cell Significance Index: 59.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0358
    Cell Significance Index: 2.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0213
    Cell Significance Index: 0.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0041
    Cell Significance Index: -0.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0066
    Cell Significance Index: -0.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0127
    Cell Significance Index: -1.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0136
    Cell Significance Index: -1.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0229
    Cell Significance Index: -3.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0294
    Cell Significance Index: -21.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0334
    Cell Significance Index: -24.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0387
    Cell Significance Index: -29.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0453
    Cell Significance Index: -2.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0462
    Cell Significance Index: -0.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0590
    Cell Significance Index: -33.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0642
    Cell Significance Index: -40.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0687
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0714
    Cell Significance Index: -12.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0773
    Cell Significance Index: -5.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0966
    Cell Significance Index: -2.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0969
    Cell Significance Index: -9.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0969
    Cell Significance Index: -2.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1082
    Cell Significance Index: -31.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1193
    Cell Significance Index: -2.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1307
    Cell Significance Index: -15.2300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1310
    Cell Significance Index: -1.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1342
    Cell Significance Index: -8.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1459
    Cell Significance Index: -1.1900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1574
    Cell Significance Index: -2.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1739
    Cell Significance Index: -11.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1814
    Cell Significance Index: -38.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1927
    Cell Significance Index: -22.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2965
    Cell Significance Index: -30.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2972
    Cell Significance Index: -9.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3004
    Cell Significance Index: -15.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3183
    Cell Significance Index: -7.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3262
    Cell Significance Index: -9.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3732
    Cell Significance Index: -10.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3964
    Cell Significance Index: -8.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3997
    Cell Significance Index: -31.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4445
    Cell Significance Index: -10.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4488
    Cell Significance Index: -7.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4955
    Cell Significance Index: -12.0900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.4968
    Cell Significance Index: -4.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5447
    Cell Significance Index: -11.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TBK1 is a non-canonical NF-κB kinase that is activated by the TANK-binding kinase (TBK) complex, comprising TBK1 and TANK (TRAF6-associated NF-κB kinase activator). TBK1 is a cytoplasmic kinase that is phosphorylated by TBK, which in turn activates its kinase activity. TBK1 is also known as T2K (TANK-binding kinase 1) and is encoded by the ENSG00000183735 gene. **Pathways and Functions** TBK1 is involved in various signaling pathways that regulate innate immune responses, including: 1. **Activation of innate immune response**: TBK1 is activated by the TBK complex and phosphorylates and activates downstream targets, including IRF3 and IRF7, which are essential for the production of type I interferons (IFNs). 2. **Activation of IRF3 and IRF7**: TBK1 phosphorylates and activates IRF3 and IRF7, which are transcription factors that regulate the expression of IFN-β and IFN-α, respectively. 3. **Antiviral innate immune response**: TBK1 is essential for the regulation of antiviral responses, including the production of IFNs and the activation of immune cells, such as dendritic cells and macrophages. 4. **Cytokine signaling**: TBK1 regulates the signaling of various cytokines, including IL-1β, IL-6, and IL-12, which are involved in the regulation of immune responses. 5. **Autophagy and xenophagy**: TBK1 is involved in the regulation of autophagy and xenophagy, which are essential for the degradation of pathogens and the regulation of immune responses. **Clinical Significance** TBK1 has been implicated in various diseases, including: 1. **Viral infections**: TBK1 is essential for the regulation of antiviral responses, and its dysregulation has been implicated in viral infections, such as SARS-CoV-1 and SARS-CoV-2. 2. **Cancer**: TBK1 has been implicated in the regulation of cancer cell survival and proliferation, and its dysregulation has been associated with various types of cancer. 3. **Autoimmune diseases**: TBK1 has been implicated in the regulation of autoimmune responses, and its dysregulation has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Neurological disorders**: TBK1 has been implicated in the regulation of neurological responses, and its dysregulation has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TBK1 is a critical regulator of innate immunity and has significant implications for various diseases. Its dysregulation has been implicated in viral infections, cancer, autoimmune diseases, and neurological disorders, highlighting the importance of TBK1 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 2857773395

Symbol: TBK1_HUMAN

Name: T2K

UniProtKB Accession Codes:

Q9UHD2 A8K4S4 Q8IYV3 Q9NUJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 4 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 6 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 19 RefSeq 3 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10581243

Title: NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase.

PubMed ID: 10581243

DOI: 10.1093/emboj/18.23.6694

PubMed ID: 10783893

Title: NAK is an IkappaB kinase-activating kinase.

PubMed ID: 10783893

DOI: 10.1038/35008109

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11839743

Title: IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.

PubMed ID: 11839743

DOI: 10.1074/jbc.m110474200

PubMed ID: 14530355

Title: Toll/IL-1 receptor domain-containing adapter inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.

PubMed ID: 14530355

DOI: 10.4049/jimmunol.171.8.4304

PubMed ID: 12692549

Title: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

PubMed ID: 12692549

DOI: 10.1038/ni921

PubMed ID: 12702806

Title: Triggering the interferon antiviral response through an IKK-related pathway.

PubMed ID: 12702806

DOI: 10.1126/science.1081315

PubMed ID: 14560022

Title: Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.

PubMed ID: 14560022

DOI: 10.1128/mcb.23.21.7780-7793.2003

PubMed ID: 14703513

Title: Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation.

PubMed ID: 14703513

DOI: 10.1074/jbc.m310616200

PubMed ID: 14739303

Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

PubMed ID: 14739303

DOI: 10.1074/jbc.m311629200

PubMed ID: 15485837

Title: NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.

PubMed ID: 15485837

DOI: 10.1074/jbc.m411037200

PubMed ID: 15489227

Title: Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.

PubMed ID: 15489227

DOI: 10.1074/jbc.m409825200

PubMed ID: 15367631

Title: Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.

PubMed ID: 15367631

DOI: 10.1128/jvi.78.19.10636-10649.2004

PubMed ID: 16281057

Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.

PubMed ID: 16281057

DOI: 10.1038/sj.emboj.7600863

PubMed ID: 15841462

Title: Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses.

PubMed ID: 15841462

DOI: 10.1002/hep.20666

PubMed ID: 16155125

Title: Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappa-B activator (TANK)-binding kinase-1.

PubMed ID: 16155125

DOI: 10.1073/pnas.0502883102

PubMed ID: 17018283

Title: RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.

PubMed ID: 17018283

DOI: 10.1016/j.cell.2006.08.034

PubMed ID: 17599067

Title: Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.

PubMed ID: 17599067

DOI: 10.1038/sj.emboj.7601773

PubMed ID: 18583960

Title: The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.

PubMed ID: 18583960

DOI: 10.1038/emboj.2008.126

PubMed ID: 18636086

Title: The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

PubMed ID: 18636086

DOI: 10.1038/embor.2008.136

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19419966

Title: The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.

PubMed ID: 19419966

DOI: 10.1074/jbc.m808233200

PubMed ID: 19153231

Title: Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.

PubMed ID: 19153231

DOI: 10.1128/jvi.01875-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19483718

Title: The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.

PubMed ID: 19483718

DOI: 10.1038/ni.1742

PubMed ID: 19416887

Title: ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.

PubMed ID: 19416887

DOI: 10.1073/pnas.0900818106

PubMed ID: 20628368

Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

PubMed ID: 20628368

DOI: 10.1038/cr.2010.103

PubMed ID: 21145761

Title: Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1.

PubMed ID: 21145761

DOI: 10.1016/j.immuni.2010.11.021

PubMed ID: 20375222

Title: Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.

PubMed ID: 20375222

DOI: 10.1099/vir.0.020552-0

PubMed ID: 20174559

Title: Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.

PubMed ID: 20174559

DOI: 10.1371/journal.ppat.1000778

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21447600

Title: Copy number variations on chromosome 12q14 in patients with normal tension glaucoma.

PubMed ID: 21447600

DOI: 10.1093/hmg/ddr123

PubMed ID: 21903422

Title: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

PubMed ID: 21903422

DOI: 10.1016/j.immuni.2011.06.014

PubMed ID: 21813773

Title: IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.

PubMed ID: 21813773

DOI: 10.4049/jimmunol.1100963

PubMed ID: 21270402

Title: TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.

PubMed ID: 21270402

DOI: 10.4049/jimmunol.1000262

PubMed ID: 21931631

Title: Functional dissection of the TBK1 molecular network.

PubMed ID: 21931631

DOI: 10.1371/journal.pone.0023971

PubMed ID: 21464307

Title: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

PubMed ID: 21464307

DOI: 10.1073/pnas.1016132108

PubMed ID: 21617041

Title: Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.

PubMed ID: 21617041

DOI: 10.1126/science.1205405

PubMed ID: 21042276

Title: Emerging roles for the non-canonical IKKs in cancer.

PubMed ID: 21042276

DOI: 10.1038/onc.2010.493

PubMed ID: 21138416

Title: Novel cross-talk within the IKK family controls innate immunity.

PubMed ID: 21138416

DOI: 10.1042/bj20101701

PubMed ID: 19010780

Title: Control of TANK-binding kinase 1-mediated signaling by the gamma(1)34.5 protein of herpes simplex virus 1.

PubMed ID: 19010780

DOI: 10.1074/jbc.m805905200

PubMed ID: 22750291

Title: PPM1B negatively regulates antiviral response via dephosphorylating TBK1.

PubMed ID: 22750291

DOI: 10.1016/j.cellsig.2012.06.017

PubMed ID: 22306015

Title: Confirmation of TBK1 duplication in normal tension glaucoma.

PubMed ID: 22306015

DOI: 10.1016/j.exer.2011.12.021

PubMed ID: 22851595

Title: Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.

PubMed ID: 22851595

DOI: 10.1084/jem.20111316

PubMed ID: 22945920

Title: TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.

PubMed ID: 22945920

DOI: 10.1084/jem.20120024

PubMed ID: 22388039

Title: NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.

PubMed ID: 22388039

DOI: 10.1038/ni.2239

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24478431

Title: Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses.

PubMed ID: 24478431

DOI: 10.1128/jvi.03021-13

PubMed ID: 24706939

Title: Viral suppression of innate immunity via spatial isolation of TBK1/IKKepsilon from mitochondrial antiviral platform.

PubMed ID: 24706939

DOI: 10.1093/jmcb/mju015

PubMed ID: 25943890

Title: Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease.

PubMed ID: 25943890

DOI: 10.1007/s00401-015-1436-x

PubMed ID: 25736436

Title: WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

PubMed ID: 25736436

DOI: 10.15252/embr.201439637

PubMed ID: 26513235

Title: Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.

PubMed ID: 26513235

DOI: 10.1038/gene.2015.46

PubMed ID: 25803835

Title: Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.

PubMed ID: 25803835

DOI: 10.1038/nn.4000

PubMed ID: 25636800

Title: Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

PubMed ID: 25636800

DOI: 10.1126/science.aaa2630

PubMed ID: 27692986

Title: USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.

PubMed ID: 27692986

DOI: 10.1016/j.molcel.2016.08.029

PubMed ID: 27103069

Title: Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

PubMed ID: 27103069

DOI: 10.15252/embj.201593350

PubMed ID: 26611359

Title: Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response.

PubMed ID: 26611359

DOI: 10.1093/jmcb/mjv068

PubMed ID: 27776110

Title: E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1.

PubMed ID: 27776110

DOI: 10.1038/ni.3588

PubMed ID: 28011935

Title: TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.

PubMed ID: 28011935

DOI: 10.4049/jimmunol.1601194

PubMed ID: 28848048

Title: Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction.

PubMed ID: 28848048

DOI: 10.1074/jbc.m117.805127

PubMed ID: 28680969

Title: Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins.

PubMed ID: 28680969

DOI: 10.1128/msphere.00234-17

PubMed ID: 28871090

Title: TRIM23 mediates virus-induced autophagy via activation of TBK1.

PubMed ID: 28871090

DOI: 10.1038/s41564-017-0017-2

PubMed ID: 28904192

Title: Role of Herpes Simplex Virus 1 gamma34.5 in the Regulation of IRF3 Signaling.

PubMed ID: 28904192

DOI: 10.1128/jvi.01156-17

PubMed ID: 28373913

Title: Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro.

PubMed ID: 28373913

DOI: 10.1038/celldisc.2017.6

PubMed ID: 29150432

Title: The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.

PubMed ID: 29150432

DOI: 10.15252/embj.201696164

PubMed ID: 30354798

Title: Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.

PubMed ID: 30354798

DOI: 10.1091/mbc.e18-02-0115

PubMed ID: 29251827

Title: Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.

PubMed ID: 29251827

DOI: 10.1002/pmic.201700403

PubMed ID: 30021900

Title: Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.

PubMed ID: 30021900

DOI: 10.1128/jvi.00706-18

PubMed ID: 31320558

Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.

PubMed ID: 31320558

DOI: 10.1126/science.aav0758

PubMed ID: 31530866

Title: TBK1 limits mTORC1 by promoting phosphorylation of Raptor Ser877.

PubMed ID: 31530866

DOI: 10.1038/s41598-019-49707-8

PubMed ID: 32185393

Title: CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis.

PubMed ID: 32185393

DOI: 10.1093/brain/awaa039

PubMed ID: 32979938

Title: Evasion of Type I Interferon by SARS-CoV-2.

PubMed ID: 32979938

DOI: 10.1016/j.celrep.2020.108234

PubMed ID: 31709703

Title: TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease.

PubMed ID: 31709703

DOI: 10.15252/embr.201948317

PubMed ID: 32404352

Title: TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.

PubMed ID: 32404352

DOI: 10.4049/jimmunol.1901511

PubMed ID: 33226137

Title: Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

PubMed ID: 33226137

DOI: 10.15252/embj.2020104948

PubMed ID: 32366851

Title: TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination.

PubMed ID: 32366851

DOI: 10.1038/s41467-020-16014-0

PubMed ID: 32209697

Title: Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production.

PubMed ID: 32209697

DOI: 10.1126/scisignal.aay0574

PubMed ID: 34084167

Title: SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1.

PubMed ID: 34084167

DOI: 10.3389/fimmu.2021.662989

PubMed ID: 32466380

Title: The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription.

PubMed ID: 32466380

DOI: 10.3390/microorganisms8060790

PubMed ID: 37086853

Title: TRAF7 negatively regulates the RLR signaling pathway by facilitating the K48-linked ubiquitination of TBK1.

PubMed ID: 37086853

DOI: 10.1016/j.virs.2023.04.005

PubMed ID: 36802409

Title: Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1.

PubMed ID: 36802409

DOI: 10.1371/journal.ppat.1011186

PubMed ID: 23453971

Title: Crystal structure and mechanism of activation of TANK-binding kinase 1.

PubMed ID: 23453971

DOI: 10.1016/j.celrep.2013.01.034

PubMed ID: 23453972

Title: Structure and ubiquitination-dependent activation of TANK-binding kinase 1.

PubMed ID: 23453972

DOI: 10.1016/j.celrep.2013.01.033

PubMed ID: 23746807

Title: Structural insights into the functions of TBK1 in innate antimicrobial immunity.

PubMed ID: 23746807

DOI: 10.1016/j.str.2013.04.025

PubMed ID: 30842653

Title: Structural basis of STING binding with and phosphorylation by TBK1.

PubMed ID: 30842653

DOI: 10.1038/s41586-019-1000-2

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

Sequence Information:

  • Length: 729
  • Mass: 83642
  • Checksum: B58E4FE1B502276D
  • Sequence:
    • MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 
GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL 
HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG 
KPSGAISGVQ KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA 
ETSDILHRMV IHVFSLQQMT AHKIYIHSYN TATIFHELVY KQTKIISSNQ ELIYEGRRLV 
LEPGRLAQHF PKTTEENPIF VVSREPLNTI GLIYEKISLP KVHPRYDLDG DASMAKAITG 
VVCYACRIAS TLLLYQELMR KGIRWLIELI KDDYNETVHK KTEVVITLDF CIRNIEKTVK 
VYEKLMKINL EAAELGEISD IHTKLLRLSS SQGTIETSLQ DIDSRLSPGG SLADAWAHQE 
GTHPKDRNVE KLQVLLNCMT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH 
FTDECVKKYE AFLNKSEEWI RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY TNELQETLPQ 
KMFTASSGIK HTMTPIYPSS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGSLTMD 
GGLRNVDCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.