Details for: MYLIP
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 198.0774
Cell Significance Index: -30.8100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 119.4591
Cell Significance Index: -30.3000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 67.4397
Cell Significance Index: -34.6900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 51.2576
Cell Significance Index: -34.4000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.9434
Cell Significance Index: -33.2200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.6281
Cell Significance Index: -31.1500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.9041
Cell Significance Index: -30.4200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.6770
Cell Significance Index: -34.2400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.3322
Cell Significance Index: -11.6700 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.8782
Cell Significance Index: 368.9700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.9416
Cell Significance Index: 67.4700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.4142
Cell Significance Index: 37.7600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3140
Cell Significance Index: 84.7700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.2905
Cell Significance Index: 22.8100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.1815
Cell Significance Index: 16.1200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8766
Cell Significance Index: 791.5500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8146
Cell Significance Index: 146.8400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.6808
Cell Significance Index: 14.2500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6750
Cell Significance Index: 19.3500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6430
Cell Significance Index: 38.6000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6346
Cell Significance Index: 78.0400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6118
Cell Significance Index: 66.5400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5782
Cell Significance Index: 26.2100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5373
Cell Significance Index: 87.3800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5335
Cell Significance Index: 14.9100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5095
Cell Significance Index: 278.2300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3817
Cell Significance Index: 10.3900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3733
Cell Significance Index: 74.8900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3723
Cell Significance Index: 9.7900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3629
Cell Significance Index: 49.8400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3586
Cell Significance Index: 18.6300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.3404
Cell Significance Index: 38.8600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.3231
Cell Significance Index: 2.9800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3027
Cell Significance Index: 57.6100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2812
Cell Significance Index: 13.1100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2774
Cell Significance Index: 55.0500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2713
Cell Significance Index: 18.7600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2403
Cell Significance Index: 23.7700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2317
Cell Significance Index: 5.0200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1950
Cell Significance Index: 86.2300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1888
Cell Significance Index: 13.3500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1813
Cell Significance Index: 21.3800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1662
Cell Significance Index: 12.3900 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1579
Cell Significance Index: 3.6500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1374
Cell Significance Index: 0.8300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1107
Cell Significance Index: 3.8900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0326
Cell Significance Index: 5.5600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0299
Cell Significance Index: 1.5700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0228
Cell Significance Index: 0.6100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0018
Cell Significance Index: -0.8200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0038
Cell Significance Index: -7.2000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0089
Cell Significance Index: -6.7700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0096
Cell Significance Index: -7.1200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0100
Cell Significance Index: -6.3300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0109
Cell Significance Index: -6.8100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0177
Cell Significance Index: -32.6600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0214
Cell Significance Index: -33.0200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0233
Cell Significance Index: -2.3900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0250
Cell Significance Index: -8.9800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0252
Cell Significance Index: -34.2400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0287
Cell Significance Index: -21.0100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0402
Cell Significance Index: -22.6700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0648
Cell Significance Index: -1.0900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0660
Cell Significance Index: -8.5300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0689
Cell Significance Index: -3.8700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0732
Cell Significance Index: -3.4400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0740
Cell Significance Index: -0.8100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0836
Cell Significance Index: -17.6000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0892
Cell Significance Index: -25.6700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1049
Cell Significance Index: -15.2500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1316
Cell Significance Index: -15.3400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1379
Cell Significance Index: -10.5900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1631
Cell Significance Index: -18.6900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1928
Cell Significance Index: -5.5600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2154
Cell Significance Index: -6.9000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2704
Cell Significance Index: -6.7600 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.2806
Cell Significance Index: -2.2400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2898
Cell Significance Index: -7.4500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3029
Cell Significance Index: -7.3900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3108
Cell Significance Index: -32.3600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3187
Cell Significance Index: -6.2200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3409
Cell Significance Index: -6.3000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3878
Cell Significance Index: -30.7100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4075
Cell Significance Index: -10.9200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4109
Cell Significance Index: -25.9000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4115
Cell Significance Index: -27.6700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4619
Cell Significance Index: -28.3200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4885
Cell Significance Index: -5.5500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5186
Cell Significance Index: -31.8800 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.5187
Cell Significance Index: -8.0300 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.5814
Cell Significance Index: -5.8300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5950
Cell Significance Index: -26.3200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.6390
Cell Significance Index: -9.6300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6392
Cell Significance Index: -24.2100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6494
Cell Significance Index: -23.8400 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.6707
Cell Significance Index: -10.6400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7096
Cell Significance Index: -20.2500 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.7170
Cell Significance Index: -6.8100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7253
Cell Significance Index: -25.4100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.7310
Cell Significance Index: -21.5300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3256065672
Symbol: MYLIP_HUMAN
Name: E3 ubiquitin-protein ligase MYLIP
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10593918
Title: MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.
PubMed ID: 10593918
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 15498874
Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.
PubMed ID: 15498874
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14550572
Title: Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR.
PubMed ID: 14550572
PubMed ID: 12826659
Title: MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain.
PubMed ID: 12826659
PubMed ID: 19520913
Title: LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.
PubMed ID: 19520913
PubMed ID: 20427281
Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.
PubMed ID: 20427281
PubMed ID: 22109552
Title: FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.
PubMed ID: 22109552
PubMed ID: 21685362
Title: The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.
PubMed ID: 21685362
DOI: 10.1101/gad.2056211
Sequence Information:
- Length: 445
- Mass: 49910
- Checksum: 342E643B0532B45C
- Sequence:
MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV CRSRVEHVQH VYLPTHTSLL NLTVI
Genular Protein ID: 3094889449
Symbol: Q5TIA5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 264
- Mass: 29463
- Checksum: 50DDE3EC4DCC6A64
- Sequence:
MENYGIEWHS VRDSEGQKLL IGVGPEGISI CKDDFSPINR IAYPVVQMAT QSGKNVYLTV TKESGNSIVL LFKMISTRAA SGLYRAITET HAFYRCDTVT SAVMMQYSRD LKGHLASLFL NENINLGKKY VFDIKRTSKE VYDHARRALY NAGVVDLVSR NNQSPSHSPL KSSESSMNCS SCEGLSCQQT RVLQEKLRKL KEAMLCMVCC EEEINSTFCP CGHTVCCESC AAQLQSCPVC RSRVEHVQHV YLPTHTSLLN LTVI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.