Details for: MYLIP

Gene ID: 29116

Symbol: MYLIP

Ensembl ID: ENSG00000007944

Description: myosin regulatory light chain interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 198.0774
    Cell Significance Index: -30.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.4591
    Cell Significance Index: -30.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.4397
    Cell Significance Index: -34.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.2576
    Cell Significance Index: -34.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.9434
    Cell Significance Index: -33.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6281
    Cell Significance Index: -31.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9041
    Cell Significance Index: -30.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6770
    Cell Significance Index: -34.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3322
    Cell Significance Index: -11.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.8782
    Cell Significance Index: 368.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9416
    Cell Significance Index: 67.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4142
    Cell Significance Index: 37.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3140
    Cell Significance Index: 84.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2905
    Cell Significance Index: 22.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1815
    Cell Significance Index: 16.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8766
    Cell Significance Index: 791.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8146
    Cell Significance Index: 146.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6808
    Cell Significance Index: 14.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6750
    Cell Significance Index: 19.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6430
    Cell Significance Index: 38.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6346
    Cell Significance Index: 78.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6118
    Cell Significance Index: 66.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5782
    Cell Significance Index: 26.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5373
    Cell Significance Index: 87.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5335
    Cell Significance Index: 14.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5095
    Cell Significance Index: 278.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3817
    Cell Significance Index: 10.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3733
    Cell Significance Index: 74.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3723
    Cell Significance Index: 9.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3629
    Cell Significance Index: 49.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3586
    Cell Significance Index: 18.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3404
    Cell Significance Index: 38.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3231
    Cell Significance Index: 2.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3027
    Cell Significance Index: 57.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2812
    Cell Significance Index: 13.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2774
    Cell Significance Index: 55.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2713
    Cell Significance Index: 18.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2403
    Cell Significance Index: 23.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2317
    Cell Significance Index: 5.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1950
    Cell Significance Index: 86.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1888
    Cell Significance Index: 13.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1813
    Cell Significance Index: 21.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1662
    Cell Significance Index: 12.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1579
    Cell Significance Index: 3.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1374
    Cell Significance Index: 0.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1107
    Cell Significance Index: 3.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0326
    Cell Significance Index: 5.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0299
    Cell Significance Index: 1.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0228
    Cell Significance Index: 0.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0096
    Cell Significance Index: -7.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0109
    Cell Significance Index: -6.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0177
    Cell Significance Index: -32.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0214
    Cell Significance Index: -33.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0233
    Cell Significance Index: -2.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0250
    Cell Significance Index: -8.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0252
    Cell Significance Index: -34.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0287
    Cell Significance Index: -21.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0402
    Cell Significance Index: -22.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0648
    Cell Significance Index: -1.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0660
    Cell Significance Index: -8.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0689
    Cell Significance Index: -3.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0732
    Cell Significance Index: -3.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0740
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0836
    Cell Significance Index: -17.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0892
    Cell Significance Index: -25.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1049
    Cell Significance Index: -15.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1316
    Cell Significance Index: -15.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1379
    Cell Significance Index: -10.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1631
    Cell Significance Index: -18.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1928
    Cell Significance Index: -5.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2154
    Cell Significance Index: -6.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2704
    Cell Significance Index: -6.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2806
    Cell Significance Index: -2.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2898
    Cell Significance Index: -7.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3029
    Cell Significance Index: -7.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3108
    Cell Significance Index: -32.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3187
    Cell Significance Index: -6.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3409
    Cell Significance Index: -6.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3878
    Cell Significance Index: -30.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4075
    Cell Significance Index: -10.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4109
    Cell Significance Index: -25.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4115
    Cell Significance Index: -27.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4619
    Cell Significance Index: -28.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4885
    Cell Significance Index: -5.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5186
    Cell Significance Index: -31.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5187
    Cell Significance Index: -8.0300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.5814
    Cell Significance Index: -5.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5950
    Cell Significance Index: -26.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6390
    Cell Significance Index: -9.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6392
    Cell Significance Index: -24.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6494
    Cell Significance Index: -23.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6707
    Cell Significance Index: -10.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7096
    Cell Significance Index: -20.2500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.7170
    Cell Significance Index: -6.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7253
    Cell Significance Index: -25.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7310
    Cell Significance Index: -21.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYLIP is an E3 ubiquitin-protein ligase, a class of enzymes responsible for the specific targeting of proteins for degradation through the ubiquitin-proteasome pathway. This function is crucial in the regulation of protein turnover, cell signaling, and immune responses. MYLIP is specifically involved in the regulation of various cellular processes, including protein catabolism, lipid metabolism, and immune cell development. **Pathways and Functions:** MYLIP's influence is far-reaching, with significant implications in multiple cellular pathways. Notably, it plays a critical role in: 1. **Adaptive Immune System**: MYLIP is expressed in various immune cells, including T cells, NK cells, and dendritic cells, where it regulates the ubiquitination and degradation of key proteins involved in immune responses. 2. **Antigen Processing and Presentation**: MYLIP is involved in the regulation of Class I MHC-mediated antigen processing and presentation, a crucial step in the activation of cytotoxic T cells. 3. **Cholesterol Homeostasis**: MYLIP is also implicated in the regulation of cholesterol metabolism, interacting with nuclear receptors such as NR1H2 and NR1H3 to limit cholesterol uptake. 4. **Cytoskeletal Protein Binding**: MYLIP interacts with various cytoskeletal proteins, influencing the organization and dynamics of the cytoskeleton, which is essential for cell shape, movement, and signaling. **Clinical Significance:** The significance of MYLIP in human disease is becoming increasingly apparent. Alterations in MYLIP expression or function have been linked to various conditions, including: 1. **Immunodeficiency Disorders**: Dysregulation of MYLIP has been implicated in immunodeficiency disorders, such as autoimmune diseases and cancer. 2. **Lipid Metabolic Disorders**: MYLIP's role in cholesterol metabolism makes it a potential target for the treatment of lipid-related disorders, such as atherosclerosis and hyperlipidemia. 3. **Neurological Disorders**: MYLIP's involvement in neuronal development and function suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, MYLIP is a gene of great importance in the regulation of immune responses and lipid metabolism. Its widespread expression in various cell types and its involvement in multiple cellular pathways make it a prime target for further research and potential therapeutic interventions. As our understanding of MYLIP's functions and mechanisms continues to evolve, we may uncover new avenues for the treatment of human disease.

Genular Protein ID: 3256065672

Symbol: MYLIP_HUMAN

Name: E3 ubiquitin-protein ligase MYLIP

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10593918

Title: MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.

PubMed ID: 10593918

DOI: 10.1074/jbc.274.51.36288

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14550572

Title: Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR.

PubMed ID: 14550572

DOI: 10.1016/s0014-5793(03)01010-x

PubMed ID: 12826659

Title: MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain.

PubMed ID: 12826659

DOI: 10.1074/jbc.m306271200

PubMed ID: 19520913

Title: LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

PubMed ID: 19520913

DOI: 10.1126/science.1168974

PubMed ID: 20427281

Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

PubMed ID: 20427281

DOI: 10.1074/jbc.m110.123729

PubMed ID: 22109552

Title: FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.

PubMed ID: 22109552

DOI: 10.1073/pnas.1111589108

PubMed ID: 21685362

Title: The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

PubMed ID: 21685362

DOI: 10.1101/gad.2056211

Sequence Information:

  • Length: 445
  • Mass: 49910
  • Checksum: 342E643B0532B45C
  • Sequence:
  • MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN 
    RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS 
    ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS 
    AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT 
    VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF 
    LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC 
    SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV 
    CRSRVEHVQH VYLPTHTSLL NLTVI

Genular Protein ID: 3094889449

Symbol: Q5TIA5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 264
  • Mass: 29463
  • Checksum: 50DDE3EC4DCC6A64
  • Sequence:
  • MENYGIEWHS VRDSEGQKLL IGVGPEGISI CKDDFSPINR IAYPVVQMAT QSGKNVYLTV 
    TKESGNSIVL LFKMISTRAA SGLYRAITET HAFYRCDTVT SAVMMQYSRD LKGHLASLFL 
    NENINLGKKY VFDIKRTSKE VYDHARRALY NAGVVDLVSR NNQSPSHSPL KSSESSMNCS 
    SCEGLSCQQT RVLQEKLRKL KEAMLCMVCC EEEINSTFCP CGHTVCCESC AAQLQSCPVC 
    RSRVEHVQHV YLPTHTSLLN LTVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.