Details for: MYLIP

Gene ID: 29116

Symbol: MYLIP

Ensembl ID: ENSG00000007944

Description: myosin regulatory light chain interacting protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.91
    Marker Score: 591
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.9
    Marker Score: 951
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.89
    Marker Score: 1,482
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.75
    Marker Score: 6,867
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.7
    Marker Score: 4,771
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.61
    Marker Score: 691
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.6
    Marker Score: 692
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.55
    Marker Score: 2,911
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.42
    Marker Score: 4,158
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.41
    Marker Score: 13,277
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.35
    Marker Score: 4,987
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.34
    Marker Score: 13,574
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.34
    Marker Score: 308
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.33
    Marker Score: 2,773
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.31
    Marker Score: 890
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.27
    Marker Score: 14,260
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.25
    Marker Score: 1,055
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.24
    Marker Score: 453
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.24
    Marker Score: 1,796
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.18
    Marker Score: 2,365
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.17
    Marker Score: 1,729
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.17
    Marker Score: 5,029
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.15
    Marker Score: 2,876
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.15
    Marker Score: 3,641
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.15
    Marker Score: 39,120
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.14
    Marker Score: 758
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.14
    Marker Score: 1,925
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.11
    Marker Score: 744
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.11
    Marker Score: 385
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.11
    Marker Score: 338
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.11
    Marker Score: 260
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.1
    Marker Score: 1,698
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.1
    Marker Score: 58,124
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.09
    Marker Score: 635
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.09
    Marker Score: 1,182
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.08
    Marker Score: 820
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.08
    Marker Score: 1,840
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.08
    Marker Score: 546
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.07
    Marker Score: 256
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.06
    Marker Score: 2,936
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.06
    Marker Score: 208
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.06
    Marker Score: 262
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.06
    Marker Score: 261
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.04
    Marker Score: 1,116
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.03
    Marker Score: 888
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.03
    Marker Score: 566
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.03
    Marker Score: 380
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.03
    Marker Score: 687
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.03
    Marker Score: 2,327
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.02
    Marker Score: 988
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.02
    Marker Score: 4,401
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15,924
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.02
    Marker Score: 251
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.01
    Marker Score: 267
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.01
    Marker Score: 904
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.01
    Marker Score: 10,395
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.01
    Marker Score: 302
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1
    Marker Score: 213
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Marker Score: 1,050
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1
    Marker Score: 939
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,587
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,810
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.99
    Marker Score: 655
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.98
    Marker Score: 5,172
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.98
    Marker Score: 411
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,373
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.98
    Marker Score: 399
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.98
    Marker Score: 297
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.98
    Marker Score: 4,078
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.97
    Marker Score: 928
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.97
    Marker Score: 979
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.97
    Marker Score: 284
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.96
    Marker Score: 633
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.96
    Marker Score: 324
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.95
    Marker Score: 1,699
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.95
    Marker Score: 6,187
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.95
    Marker Score: 592
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.95
    Marker Score: 1,224
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.95
    Marker Score: 1,308
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.95
    Marker Score: 844
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.94
    Marker Score: 433
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.94
    Marker Score: 9,491
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.94
    Marker Score: 385
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.94
    Marker Score: 606
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.94
    Marker Score: 298
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.94
    Marker Score: 1,445
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.94
    Marker Score: 974
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,378
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.94
    Marker Score: 734
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.93
    Marker Score: 392
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.93
    Marker Score: 9,236
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.93
    Marker Score: 1,092
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.93
    Marker Score: 209
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.93
    Marker Score: 243
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.92
    Marker Score: 542
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.92
    Marker Score: 258
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.92
    Marker Score: 581
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.91
    Marker Score: 370

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYLIP is an E3 ubiquitin-protein ligase, a class of enzymes responsible for the specific targeting of proteins for degradation through the ubiquitin-proteasome pathway. This function is crucial in the regulation of protein turnover, cell signaling, and immune responses. MYLIP is specifically involved in the regulation of various cellular processes, including protein catabolism, lipid metabolism, and immune cell development. **Pathways and Functions:** MYLIP's influence is far-reaching, with significant implications in multiple cellular pathways. Notably, it plays a critical role in: 1. **Adaptive Immune System**: MYLIP is expressed in various immune cells, including T cells, NK cells, and dendritic cells, where it regulates the ubiquitination and degradation of key proteins involved in immune responses. 2. **Antigen Processing and Presentation**: MYLIP is involved in the regulation of Class I MHC-mediated antigen processing and presentation, a crucial step in the activation of cytotoxic T cells. 3. **Cholesterol Homeostasis**: MYLIP is also implicated in the regulation of cholesterol metabolism, interacting with nuclear receptors such as NR1H2 and NR1H3 to limit cholesterol uptake. 4. **Cytoskeletal Protein Binding**: MYLIP interacts with various cytoskeletal proteins, influencing the organization and dynamics of the cytoskeleton, which is essential for cell shape, movement, and signaling. **Clinical Significance:** The significance of MYLIP in human disease is becoming increasingly apparent. Alterations in MYLIP expression or function have been linked to various conditions, including: 1. **Immunodeficiency Disorders**: Dysregulation of MYLIP has been implicated in immunodeficiency disorders, such as autoimmune diseases and cancer. 2. **Lipid Metabolic Disorders**: MYLIP's role in cholesterol metabolism makes it a potential target for the treatment of lipid-related disorders, such as atherosclerosis and hyperlipidemia. 3. **Neurological Disorders**: MYLIP's involvement in neuronal development and function suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, MYLIP is a gene of great importance in the regulation of immune responses and lipid metabolism. Its widespread expression in various cell types and its involvement in multiple cellular pathways make it a prime target for further research and potential therapeutic interventions. As our understanding of MYLIP's functions and mechanisms continues to evolve, we may uncover new avenues for the treatment of human disease.

Genular Protein ID: 3256065672

Symbol: MYLIP_HUMAN

Name: E3 ubiquitin-protein ligase MYLIP

UniProtKB Accession Codes:

Q8WY64 Q5TIA4 Q9BU73 Q9NRL9 Q9UHE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10593918

Title: MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.

PubMed ID: 10593918

DOI: 10.1074/jbc.274.51.36288

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14550572

Title: Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR.

PubMed ID: 14550572

DOI: 10.1016/s0014-5793(03)01010-x

PubMed ID: 12826659

Title: MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain.

PubMed ID: 12826659

DOI: 10.1074/jbc.m306271200

PubMed ID: 19520913

Title: LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

PubMed ID: 19520913

DOI: 10.1126/science.1168974

PubMed ID: 20427281

Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

PubMed ID: 20427281

DOI: 10.1074/jbc.m110.123729

PubMed ID: 22109552

Title: FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.

PubMed ID: 22109552

DOI: 10.1073/pnas.1111589108

PubMed ID: 21685362

Title: The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

PubMed ID: 21685362

DOI: 10.1101/gad.2056211

Sequence Information:

  • Length: 445
  • Mass: 49910
  • Checksum: 342E643B0532B45C
  • Sequence:
    • MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN 
RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS 
ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS 
AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT 
VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF 
LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC 
SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV 
CRSRVEHVQH VYLPTHTSLL NLTVI

Genular Protein ID: 3094889449

Symbol: Q5TIA5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TIA5 A6NHZ0

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 264
  • Mass: 29463
  • Checksum: 50DDE3EC4DCC6A64
  • Sequence:
    • MENYGIEWHS VRDSEGQKLL IGVGPEGISI CKDDFSPINR IAYPVVQMAT QSGKNVYLTV 
TKESGNSIVL LFKMISTRAA SGLYRAITET HAFYRCDTVT SAVMMQYSRD LKGHLASLFL 
NENINLGKKY VFDIKRTSKE VYDHARRALY NAGVVDLVSR NNQSPSHSPL KSSESSMNCS 
SCEGLSCQQT RVLQEKLRKL KEAMLCMVCC EEEINSTFCP CGHTVCCESC AAQLQSCPVC 
RSRVEHVQHV YLPTHTSLLN LTVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.