GSK3A | ENSG00000105723 | NCBI 2931

Details for: GSK3A

Gene ID: 2931

Symbol: GSK3A

Ensembl ID: ENSG00000105723

Description: glycogen synthase kinase 3 alpha

Associated with

Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Bacterial infection pathways
(R-HSA-9824439)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ire1alpha activates chaperones
(R-HSA-381070)
Late sars-cov-2 infection events
(R-HSA-9772573)
Maturation of nucleoprotein
(R-HSA-9694631)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Response of mtb to phagocytosis
(R-HSA-9637690)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Signal transduction
(R-HSA-162582)
Suppression of apoptosis
(R-HSA-9635465)
Translation of structural proteins
(R-HSA-9694635)
Unfolded protein response (upr)
(R-HSA-381119)
Viral infection pathways
(R-HSA-9824446)
Xbp1(s) activates chaperone genes
(R-HSA-381038)
Atp binding
(GO:0005524)
Autosome genomic imprinting
(GO:0141068)
Axon
(GO:0030424)
Beta-catenin destruction complex
(GO:0030877)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to interleukin-3
(GO:0036016)
Cellular response to lithium ion
(GO:0071285)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Excitatory postsynaptic potential
(GO:0060079)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Glycogen metabolic process
(GO:0005977)
G protein-coupled dopamine receptor signaling pathway
(GO:0007212)
Histone h2as1 kinase activity
(GO:0044024)
Insulin receptor signaling pathway
(GO:0008286)
Mitochondrion
(GO:0005739)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell growth involved in cardiac muscle cell development
(GO:0061052)
Negative regulation of d-glucose import
(GO:0046325)
Negative regulation of glycogen (starch) synthase activity
(GO:2000466)
Negative regulation of glycogen biosynthetic process
(GO:0045719)
Negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
(GO:1904227)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of tor signaling
(GO:0032007)
Negative regulation of type b pancreatic cell development
(GO:2000077)
Negative regulation of udp-glucose catabolic process
(GO:0010905)
Nervous system development
(GO:0007399)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071879)
Positive regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106071)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glycogen (starch) synthase activity
(GO:2000467)
Positive regulation of heart contraction
(GO:0045823)
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901030)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of protein targeting to mitochondrion
(GO:1903955)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Regulation of mitophagy
(GO:1901524)
Regulation of neuron projection development
(GO:0010975)
Regulation of systemic arterial blood pressure
(GO:0003073)
Signaling receptor binding
(GO:0005102)
Tau-protein kinase activity
(GO:0050321)
Tau protein binding
(GO:0048156)
Viral protein processing
(GO:0019082)
Wnt signaling pathway
(GO:0016055)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 173.5187
Cell Significance Index: -26.9900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 109.7013
Cell Significance Index: -27.8300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 63.7440
Cell Significance Index: -30.1000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 54.7061
Cell Significance Index: -28.1400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.3098
Cell Significance Index: -28.7400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.2880
Cell Significance Index: -27.5600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.3441
Cell Significance Index: -28.9800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.7562
Cell Significance Index: -17.6800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.0477
Cell Significance Index: 238.6400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.5946
Cell Significance Index: 259.3500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0100
Cell Significance Index: 13.7800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.7049
Cell Significance Index: 202.8100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6398
Cell Significance Index: 44.2500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5933
Cell Significance Index: 119.0200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5926
Cell Significance Index: 30.7900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5443
Cell Significance Index: 24.6700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5133
Cell Significance Index: 92.5400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4861
Cell Significance Index: 13.9400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4822
Cell Significance Index: 59.2900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4505
Cell Significance Index: 61.8700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4439
Cell Significance Index: 28.6400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4122
Cell Significance Index: 25.9800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4065
Cell Significance Index: 221.9900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3882
Cell Significance Index: 18.1000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3879
Cell Significance Index: 11.1800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3878
Cell Significance Index: 171.4700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3534
Cell Significance Index: 9.6200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3447
Cell Significance Index: 16.2000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3146
Cell Significance Index: 16.5200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2381
Cell Significance Index: 16.8400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2219
Cell Significance Index: 5.9500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2211
Cell Significance Index: 28.3500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2165
Cell Significance Index: 77.6500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2003
Cell Significance Index: 138.5100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1708
Cell Significance Index: 2.5600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1402
Cell Significance Index: 13.8700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1233
Cell Significance Index: 23.4700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1217
Cell Significance Index: 3.2500
Cell Name: decidual cell (CL2000002)
Fold Change: 0.1156
Cell Significance Index: 1.8600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0982
Cell Significance Index: 16.7800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0960
Cell Significance Index: 12.4100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0753
Cell Significance Index: 2.6500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0418
Cell Significance Index: 8.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0417
Cell Significance Index: 3.1100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0028
Cell Significance Index: 0.0600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0049
Cell Significance Index: -3.6400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0091
Cell Significance Index: -5.7000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0103
Cell Significance Index: -19.4700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0147
Cell Significance Index: -10.8100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0168
Cell Significance Index: -30.9700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0212
Cell Significance Index: -32.5600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0227
Cell Significance Index: -17.1500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0246
Cell Significance Index: -33.4200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0304
Cell Significance Index: -17.1400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0330
Cell Significance Index: -20.9900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0403
Cell Significance Index: -4.6000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0534
Cell Significance Index: -24.2500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0619
Cell Significance Index: -0.5200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0624
Cell Significance Index: -6.3800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0694
Cell Significance Index: -8.1900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0705
Cell Significance Index: -14.8400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0756
Cell Significance Index: -8.6600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0771
Cell Significance Index: -4.7400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1266
Cell Significance Index: -8.5100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1345
Cell Significance Index: -19.5500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1671
Cell Significance Index: -4.6700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2148
Cell Significance Index: -16.4900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2460
Cell Significance Index: -7.0200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2465
Cell Significance Index: -5.1600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2498
Cell Significance Index: -8.6800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2616
Cell Significance Index: -6.8800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2685
Cell Significance Index: -2.7800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2709
Cell Significance Index: -5.8700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2744
Cell Significance Index: -28.5700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2942
Cell Significance Index: -23.3000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3035
Cell Significance Index: -17.0300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3119
Cell Significance Index: -5.2200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3503
Cell Significance Index: -7.6700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3596
Cell Significance Index: -9.6200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3605
Cell Significance Index: -3.3200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3955
Cell Significance Index: -7.3100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4122
Cell Significance Index: -25.2700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4210
Cell Significance Index: -18.6200
Cell Name: peg cell (CL4033014)
Fold Change: -0.4740
Cell Significance Index: -10.9500
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.4758
Cell Significance Index: -3.8800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4884
Cell Significance Index: -20.0100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4913
Cell Significance Index: -15.7400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5008
Cell Significance Index: -25.3100
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.5047
Cell Significance Index: -4.2900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5109
Cell Significance Index: -12.7700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5118
Cell Significance Index: -19.3800
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.5501
Cell Significance Index: -4.2400
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.5543
Cell Significance Index: -7.4800
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.5583
Cell Significance Index: -3.6400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.6012
Cell Significance Index: -6.8300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6148
Cell Significance Index: -22.5700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6156
Cell Significance Index: -10.5500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6289
Cell Significance Index: -3.8000
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.6300
Cell Significance Index: -15.1100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6506
Cell Significance Index: -20.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** GSK3A is a constitutively active enzyme that phosphorylates and regulates a wide range of substrates, including glycogen synthase, tau protein, and β-catenin. The enzyme is inhibited by lithium ions, which is a common therapeutic agent used to treat bipolar disorder. GSK3A is also regulated by various signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. The enzyme is highly conserved across species and is present in both prokaryotes and eukaryotes. **Pathways and Functions** GSK3A is involved in various cellular processes, including: 1. **Glycogen Metabolism**: GSK3A phosphorylates and regulates glycogen synthase, which is essential for glycogen synthesis and storage. 2. **Cell Signaling**: GSK3A is involved in the negative regulation of the Wnt signaling pathway, which is essential for cell growth, differentiation, and survival. 3. **Apoptosis**: GSK3A regulates the apoptotic process by phosphorylating and activating pro-apoptotic proteins. 4. **Neurodegenerative Disorders**: GSK3A is implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 5. **Cancer**: GSK3A is involved in the regulation of cancer cell growth, differentiation, and survival. **Clinical Significance** Abnormal expression of GSK3A has been implicated in various diseases, including: 1. **Cardiovascular Disease**: GSK3A is involved in the regulation of cardiac cell growth and differentiation, and its dysregulation is implicated in cardiovascular disease. 2. **Cancer**: GSK3A is involved in the regulation of cancer cell growth, differentiation, and survival, and its dysregulation is implicated in various types of cancer. 3. **Neurodegenerative Disorders**: GSK3A is implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Bipolar Disorder**: GSK3A is inhibited by lithium ions, which is a common therapeutic agent used to treat bipolar disorder. In conclusion, GSK3A is a complex enzyme that plays a crucial role in various cellular processes, including glycogen metabolism, cell signaling, and apoptosis. Its dysregulation is implicated in various diseases, including cardiovascular disease, cancer, and neurodegenerative disorders. Further research is needed to fully understand the mechanisms by which GSK3A regulates cellular processes and to identify potential therapeutic targets for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Glycogen synthase kinase-3 alpha

Genular Protein ID: 3539505301

Symbol: GSK3A_HUMAN

Name: Glycogen synthase kinase-3 alpha

UniProtKB Accession Codes:

P49840 O14959

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10868943

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

PubMed ID: 10868943

DOI: 10.2337/diabetes.49.2.263

PubMed ID: 12761548

Title: GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

PubMed ID: 12761548

DOI: 10.1038/nature01640

PubMed ID: 17229088

Title: GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.

PubMed ID: 17229088

DOI: 10.1111/j.1460-9568.2006.05243.x

PubMed ID: 11749387

Title: Glycogen synthase kinase-3: properties, functions, and regulation.

PubMed ID: 11749387

DOI: 10.1021/cr000110o

PubMed ID: 17478001

Title: The role of GSK3 in glucose homeostasis and the development of insulin resistance.

PubMed ID: 17478001

DOI: 10.1016/j.diabres.2007.01.033

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19366350

Title: Glycogen synthase kinase 3: more than a namesake.

PubMed ID: 19366350

DOI: 10.1111/j.1476-5381.2008.00085.x

PubMed ID: 19706605

Title: GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.

PubMed ID: 19706605

DOI: 10.1074/jbc.m109.002659

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22539723

Title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

PubMed ID: 22539723

DOI: 10.1126/science.1217032

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25187516

Title: Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3alpha.

PubMed ID: 25187516

DOI: 10.1074/jbc.m114.582502

PubMed ID: 25897075

Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

PubMed ID: 25897075

DOI: 10.1074/jbc.m114.633057

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 483
Mass: 50981
Checksum: F18C012C03B7D786
Sequence:

MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV 
GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT 
DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY 
SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPILY VKVYMYQLFR SLAYIHSQGV 
CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 
IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK 
AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP 
PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTPSSQA LTETPTSSDW QSTDATPTLT 
NSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GSK3A

Associated with

Cells (max top 100)

Other Information

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. PubMed ID: 10868943

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. PubMed ID: 12761548

GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt. PubMed ID: 17229088

Glycogen synthase kinase-3: properties, functions, and regulation. PubMed ID: 11749387

The role of GSK3 in glucose homeostasis and the development of insulin resistance. PubMed ID: 17478001

Identification of an antiapoptotic protein complex at death receptors. PubMed ID: 18846110

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Glycogen synthase kinase 3: more than a namesake. PubMed ID: 19366350

GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. PubMed ID: 19706605

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. PubMed ID: 22539723

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3alpha. PubMed ID: 25187516

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. PubMed ID: 25897075

Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism. PubMed ID: 30704899

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846