Gene GSK3A - ENSG00000105723 | NCBI Gene ID: 2931

Details for: GSK3A

Gene ID: 2931

Symbol: GSK3A

Ensembl ID: ENSG00000105723

Description: glycogen synthase kinase 3 alpha

Associated with

Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Bacterial infection pathways
(R-HSA-9824439)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ire1alpha activates chaperones
(R-HSA-381070)
Late sars-cov-2 infection events
(R-HSA-9772573)
Maturation of nucleoprotein
(R-HSA-9694631)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Response of mtb to phagocytosis
(R-HSA-9637690)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Signal transduction
(R-HSA-162582)
Suppression of apoptosis
(R-HSA-9635465)
Translation of structural proteins
(R-HSA-9694635)
Unfolded protein response (upr)
(R-HSA-381119)
Viral infection pathways
(R-HSA-9824446)
Xbp1(s) activates chaperone genes
(R-HSA-381038)
Atp binding
(GO:0005524)
Autosome genomic imprinting
(GO:0141068)
Axon
(GO:0030424)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to interleukin-3
(GO:0036016)
Cellular response to lithium ion
(GO:0071285)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dopamine receptor signaling pathway
(GO:0007212)
Excitatory postsynaptic potential
(GO:0060079)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Glycogen metabolic process
(GO:0005977)
Insulin receptor signaling pathway
(GO:0008286)
Mitochondrion
(GO:0005739)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell growth involved in cardiac muscle cell development
(GO:0061052)
Negative regulation of glucose import
(GO:0046325)
Negative regulation of glycogen (starch) synthase activity
(GO:2000466)
Negative regulation of glycogen biosynthetic process
(GO:0045719)
Negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
(GO:1904227)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of tor signaling
(GO:0032007)
Negative regulation of type b pancreatic cell development
(GO:2000077)
Negative regulation of udp-glucose catabolic process
(GO:0010905)
Nervous system development
(GO:0007399)
Nucleus
(GO:0005634)
Peptidyl-threonine phosphorylation
(GO:0018107)
Positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071879)
Positive regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106071)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glycogen (starch) synthase activity
(GO:2000467)
Positive regulation of heart contraction
(GO:0045823)
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901030)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of protein targeting to mitochondrion
(GO:1903955)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Regulation of mitophagy
(GO:1901524)
Regulation of systemic arterial blood pressure
(GO:0003073)
Signaling receptor binding
(GO:0005102)
Tau-protein kinase activity
(GO:0050321)
Tau protein binding
(GO:0048156)
Viral protein processing
(GO:0019082)
Wnt signaling pathway
(GO:0016055)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.34
Marker Score: 2730
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2
Marker Score: 18786
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.14
Marker Score: 686
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.14
Marker Score: 38804
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.11
Marker Score: 2619
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.06
Marker Score: 333
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.06
Marker Score: 1563
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.03
Marker Score: 333
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71709
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47932
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30395
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.97
Marker Score: 1964
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.95
Marker Score: 644
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2396
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 477
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 434
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2703
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.9
Marker Score: 1007.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.89
Marker Score: 3294
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5237
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4833
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.84
Marker Score: 1294
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.84
Marker Score: 1908
Cell Name: neural cell (CL0002319)
Fold Change: 0.84
Marker Score: 403
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.83
Marker Score: 7136
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.82
Marker Score: 390
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.81
Marker Score: 872
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.81
Marker Score: 8315
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8
Marker Score: 49141
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.79
Marker Score: 7986
Cell Name: enterocyte (CL0000584)
Fold Change: 0.79
Marker Score: 3771
Cell Name: Unknown (CL0002371)
Fold Change: 0.78
Marker Score: 834
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.77
Marker Score: 815
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.77
Marker Score: 1365
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.77
Marker Score: 795
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 583
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.75
Marker Score: 189
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.75
Marker Score: 1852
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 302
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.75
Marker Score: 25900
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.73
Marker Score: 781
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 373
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.72
Marker Score: 3533
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.72
Marker Score: 6812
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 458
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.71
Marker Score: 254
Cell Name: neuron (CL0000540)
Fold Change: 0.7
Marker Score: 2848
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.69
Marker Score: 261
Cell Name: PP cell (CL0000696)
Fold Change: 0.68
Marker Score: 154
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2858.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.66
Marker Score: 2613
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.66
Marker Score: 399
Cell Name: acinar cell (CL0000622)
Fold Change: 0.66
Marker Score: 467
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.66
Marker Score: 164
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.66
Marker Score: 197
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.66
Marker Score: 1498
Cell Name: brush cell (CL0002204)
Fold Change: 0.66
Marker Score: 601
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.66
Marker Score: 6174
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.65
Marker Score: 198
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.65
Marker Score: 442
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.65
Marker Score: 286
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.64
Marker Score: 774
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.64
Marker Score: 604
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.64
Marker Score: 363
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.63
Marker Score: 7148
Cell Name: leukocyte (CL0000738)
Fold Change: 0.63
Marker Score: 362.5
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.63
Marker Score: 218
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.62
Marker Score: 411
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.61
Marker Score: 158
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.61
Marker Score: 252
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.61
Marker Score: 3874
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.61
Marker Score: 33941
Cell Name: keratocyte (CL0002363)
Fold Change: 0.6
Marker Score: 139
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.6
Marker Score: 260
Cell Name: precursor cell (CL0011115)
Fold Change: 0.6
Marker Score: 145.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6
Marker Score: 597
Cell Name: stromal cell (CL0000499)
Fold Change: 0.59
Marker Score: 696
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.59
Marker Score: 134
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.59
Marker Score: 305
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.59
Marker Score: 208
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.58
Marker Score: 3554
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.58
Marker Score: 387
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.58
Marker Score: 1162
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.58
Marker Score: 180
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.57
Marker Score: 138
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.57
Marker Score: 128
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.57
Marker Score: 2648
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.57
Marker Score: 165
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.57
Marker Score: 556
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.57
Marker Score: 1543
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.57
Marker Score: 1411
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.57
Marker Score: 211
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.56
Marker Score: 3674
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.56
Marker Score: 5663.5
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.56
Marker Score: 1762
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.56
Marker Score: 566
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.56
Marker Score: 1404

Hover over a box to see details here...

**Key characteristics:** * GSK3A is a multi-functional kinase that can be activated by a variety of stimuli, including growth factors, cytokines, and stress signals. * It is a key regulator of cell growth, differentiation, and survival. * It is also involved in apoptosis and inflammation. **Pathways and functions:** * GSK3A is involved in a variety of cellular pathways, including the Akt signaling pathway, the MAPK signaling pathway, and the PI3K/AKT pathway. * It is also involved in the regulation of inflammation, cell cycle regulation, and apoptosis. **Clinical significance:** * Mutations in GSK3A have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * Targeting GSK3A has been investigated as a therapeutic strategy for these diseases. **Additional notes:** * GSK3A is a highly conserved protein that is found in all eukaryotic cells. * It is a key regulator of cell growth, differentiation, and survival. * It is also involved in a variety of cellular processes, including cell cycle regulation, proliferation, differentiation, and apoptosis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Glycogen synthase kinase-3 alpha

Genular Protein ID: 3539505301

Symbol: GSK3A_HUMAN

Name: Glycogen synthase kinase-3 alpha

UniProtKB Accession Codes:

P49840 O14959

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10868943

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

PubMed ID: 10868943

DOI: 10.2337/diabetes.49.2.263

PubMed ID: 12761548

Title: GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

PubMed ID: 12761548

DOI: 10.1038/nature01640

PubMed ID: 17229088

Title: GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.

PubMed ID: 17229088

DOI: 10.1111/j.1460-9568.2006.05243.x

PubMed ID: 11749387

Title: Glycogen synthase kinase-3: properties, functions, and regulation.

PubMed ID: 11749387

DOI: 10.1021/cr000110o

PubMed ID: 17478001

Title: The role of GSK3 in glucose homeostasis and the development of insulin resistance.

PubMed ID: 17478001

DOI: 10.1016/j.diabres.2007.01.033

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19366350

Title: Glycogen synthase kinase 3: more than a namesake.

PubMed ID: 19366350

DOI: 10.1111/j.1476-5381.2008.00085.x

PubMed ID: 19706605

Title: GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.

PubMed ID: 19706605

DOI: 10.1074/jbc.m109.002659

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22539723

Title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

PubMed ID: 22539723

DOI: 10.1126/science.1217032

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25187516

Title: Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3alpha.

PubMed ID: 25187516

DOI: 10.1074/jbc.m114.582502

PubMed ID: 25897075

Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.

PubMed ID: 25897075

DOI: 10.1074/jbc.m114.633057

PubMed ID: 30704899

Title: Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.

PubMed ID: 30704899

DOI: 10.1016/j.molcel.2018.12.017

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 483
Mass: 50981
Checksum: F18C012C03B7D786
Sequence:

MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV 
GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT 
DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY 
SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPILY VKVYMYQLFR SLAYIHSQGV 
CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 
IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK 
AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP 
PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTPSSQA LTETPTSSDW QSTDATPTLT 
NSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GSK3A

Associated with

Cells (max top 100)

Other Information

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. PubMed ID: 10868943

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. PubMed ID: 12761548

GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt. PubMed ID: 17229088

Glycogen synthase kinase-3: properties, functions, and regulation. PubMed ID: 11749387

The role of GSK3 in glucose homeostasis and the development of insulin resistance. PubMed ID: 17478001

Identification of an antiapoptotic protein complex at death receptors. PubMed ID: 18846110

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Glycogen synthase kinase 3: more than a namesake. PubMed ID: 19366350

GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. PubMed ID: 19706605

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. PubMed ID: 22539723

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3alpha. PubMed ID: 25187516

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. PubMed ID: 25897075

Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism. PubMed ID: 30704899

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846