Details for: GSTM2

Gene ID: 2946

Symbol: GSTM2

Ensembl ID: ENSG00000213366

Description: glutathione S-transferase mu 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.41
    Marker Score: 5130
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.12
    Marker Score: 13770
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.49
    Marker Score: 14962
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.45
    Marker Score: 1536
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.41
    Marker Score: 2469
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.36
    Marker Score: 17884.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.29
    Marker Score: 708
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.12
    Marker Score: 1724
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1182
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.03
    Marker Score: 2903.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1
    Marker Score: 404
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5100
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.88
    Marker Score: 200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.87
    Marker Score: 630
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.84
    Marker Score: 1378
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.79
    Marker Score: 278
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.79
    Marker Score: 16861
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.79
    Marker Score: 2150
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.76
    Marker Score: 216
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.75
    Marker Score: 166
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 677
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.73
    Marker Score: 444
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.71
    Marker Score: 1295
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.7
    Marker Score: 244
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.69
    Marker Score: 805.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10585
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.67
    Marker Score: 562.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.67
    Marker Score: 214
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.66
    Marker Score: 7451
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.66
    Marker Score: 3914.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.66
    Marker Score: 4894
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.65
    Marker Score: 938
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.63
    Marker Score: 156
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.61
    Marker Score: 363
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.56
    Marker Score: 189.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.56
    Marker Score: 512
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.55
    Marker Score: 266
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.54
    Marker Score: 133
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.53
    Marker Score: 699
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.52
    Marker Score: 399
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.51
    Marker Score: 148
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.51
    Marker Score: 198
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5
    Marker Score: 262
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.49
    Marker Score: 311
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.48
    Marker Score: 597
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.48
    Marker Score: 704
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.47
    Marker Score: 1633
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.45
    Marker Score: 23861
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.45
    Marker Score: 558
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.43
    Marker Score: 119
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1012
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.42
    Marker Score: 206
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.42
    Marker Score: 341
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.41
    Marker Score: 168
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.41
    Marker Score: 306
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 228
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.4
    Marker Score: 172
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.4
    Marker Score: 89
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.39
    Marker Score: 3685
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.39
    Marker Score: 261
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.39
    Marker Score: 331
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.39
    Marker Score: 3665
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.38
    Marker Score: 1057
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.38
    Marker Score: 204
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.38
    Marker Score: 718
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.38
    Marker Score: 87
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.37
    Marker Score: 3214.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.37
    Marker Score: 13994
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.36
    Marker Score: 261
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 125
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 232.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.35
    Marker Score: 220
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.35
    Marker Score: 122
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.35
    Marker Score: 141
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.34
    Marker Score: 330
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.34
    Marker Score: 3902
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.33
    Marker Score: 82
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.32
    Marker Score: 136
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.32
    Marker Score: 327
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.32
    Marker Score: 278

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Other Information

**Key characteristics:** * GSTM2 is a single-pass membrane protein that is found in the endoplasmic reticulum. * It is a member of the GST class of enzymes, which are involved in the metabolism of glutathione, a molecule that is involved in protecting cells from damage caused by reactive oxygen species. * GSTM2 is expressed in high levels in cells that are exposed to oxidative stress, such as liver cells and immune cells. * It is also expressed in cells that are involved in calcium signaling, such as cardiac muscle cells and skeletal muscle cells. **Pathways and functions:** * GSTM2 is involved in the following pathways: * Biological oxidations * Enzyme binding * Fatty acid binding * Glutathione binding * Glutathione conjugation * Glutathione metabolic process * Glutathione peroxidase activity * Glutathione transferase activity * It also regulates the release of sequestered calcium ions into the cytosol by acting as a chaperone for calcium-binding proteins. **Clinical significance:** GSTM2 is a potential therapeutic target for a variety of diseases, including liver disease, cancer, and cardiovascular disease. Inhibition of GSTM2 has been shown to protect cells from damage caused by oxidative stress and to improve disease outcomes in animal models of these diseases. **Additional information:** * The gene encoding GSTM2 is located on chromosome 19q21.1. * It is a highly conserved gene, with a similar gene found in humans, mice, and rats. * GSTM2 is a well-studied gene, and there are a number of drugs that target it for therapeutic purposes.

Genular Protein ID: 2924460425

Symbol: GSTM2_HUMAN

Name: GST class-mu 2

UniProtKB Accession Codes:

P28161 B4DRY4 E9PEM9 Q2M318 Q5TZY5 Q8WWE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 1 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 4 SABIO-RK 1 SFLD 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2034681

Title: Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus.

PubMed ID: 2034681

DOI: 10.1073/pnas.88.10.4443

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8373352

Title: Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript.

PubMed ID: 8373352

DOI: 10.1042/bj2940373

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21046276

Title: Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.

PubMed ID: 21046276

DOI: 10.1007/s11745-010-3485-1

PubMed ID: 8182750

Title: Crystal structure of human class mu glutathione transferase GSTM2-2. Effects of lattice packing on conformational heterogeneity.

PubMed ID: 8182750

DOI: 10.1006/jmbi.1994.1336

PubMed ID: 16549767

Title: Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution.

PubMed ID: 16549767

DOI: 10.1073/pnas.0600849103

PubMed ID: 19808963

Title: Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases.

PubMed ID: 19808963

DOI: 10.1158/0008-5472.can-09-1314

Sequence Information:

  • Length: 218
  • Mass: 25745
  • Checksum: 15203709D4A63789
  • Sequence:
    • MPMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL 
PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL ENQFMDSRMQ LAKLCYDPDF 
EKLKPEYLQA LPEMLKLYSQ FLGKQPWFLG DKITFVDFIA YDVLERNQVF EPSCLDAFPN 
LKDFISRFEG LEKISAYMKS SRFLPRPVFT KMAVWGNK

Genular Protein ID: 1686413837

Symbol: Q0D2I8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0D2I8

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 Rhea 1 RuleBase 1 SFLD 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 218
  • Mass: 25685
  • Checksum: 54302608D4A62BE5
  • Sequence:
    • MPMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL 
PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL ENQFMDSRMQ LAKLCYDPDF 
EKLKPEYLQA LPEMLKLYSQ FLGKQPWSLG DKITFVDFIA YDVLERNQVF EPSCLDAFPN 
LKDFISRFEG LEKISAYMKS SRFLPRPVFT KMAVWGNK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.