Details for: UQCR10

Gene ID: 29796

Symbol: UQCR10

Ensembl ID: ENSG00000184076

Description: ubiquinol-cytochrome c reductase, complex III subunit X

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 582.2744
    Cell Significance Index: -90.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 388.9713
    Cell Significance Index: -98.6600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 304.7960
    Cell Significance Index: -125.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 254.3195
    Cell Significance Index: -120.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 231.7621
    Cell Significance Index: -119.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 179.5470
    Cell Significance Index: -120.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 91.7389
    Cell Significance Index: -113.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.9360
    Cell Significance Index: -122.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.8780
    Cell Significance Index: -77.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.9975
    Cell Significance Index: -79.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.4297
    Cell Significance Index: 50.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.8750
    Cell Significance Index: 112.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.4942
    Cell Significance Index: 810.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.2388
    Cell Significance Index: 111.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.0164
    Cell Significance Index: 493.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.9690
    Cell Significance Index: 208.3900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.9114
    Cell Significance Index: 31.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.8831
    Cell Significance Index: 2120.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.7052
    Cell Significance Index: 172.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.1507
    Cell Significance Index: 371.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9844
    Cell Significance Index: 140.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6286
    Cell Significance Index: 77.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5510
    Cell Significance Index: 47.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5318
    Cell Significance Index: 347.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.2123
    Cell Significance Index: 156.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1008
    Cell Significance Index: 207.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.0505
    Cell Significance Index: 42.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9115
    Cell Significance Index: 845.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8428
    Cell Significance Index: 50.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8263
    Cell Significance Index: 94.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7518
    Cell Significance Index: 130.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6295
    Cell Significance Index: 208.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.5888
    Cell Significance Index: 18.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5721
    Cell Significance Index: 34.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4220
    Cell Significance Index: 91.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2869
    Cell Significance Index: 81.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0474
    Cell Significance Index: 135.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0213
    Cell Significance Index: 293.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9490
    Cell Significance Index: 25.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9077
    Cell Significance Index: 147.6300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.8945
    Cell Significance Index: 5.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6755
    Cell Significance Index: 511.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6258
    Cell Significance Index: 124.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6103
    Cell Significance Index: 104.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5174
    Cell Significance Index: 103.7800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5001
    Cell Significance Index: 6.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4299
    Cell Significance Index: 315.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3448
    Cell Significance Index: 15.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0961
    Cell Significance Index: 1.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0845
    Cell Significance Index: 5.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0834
    Cell Significance Index: 29.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0133
    Cell Significance Index: 1.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0066
    Cell Significance Index: 0.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0184
    Cell Significance Index: -3.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0185
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0308
    Cell Significance Index: -22.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0332
    Cell Significance Index: -62.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0376
    Cell Significance Index: -3.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0719
    Cell Significance Index: -2.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0733
    Cell Significance Index: -135.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0807
    Cell Significance Index: -50.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0899
    Cell Significance Index: -138.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1053
    Cell Significance Index: -143.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1373
    Cell Significance Index: -87.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1458
    Cell Significance Index: -82.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2234
    Cell Significance Index: -101.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2790
    Cell Significance Index: -58.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3275
    Cell Significance Index: -3.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3343
    Cell Significance Index: -20.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3759
    Cell Significance Index: -12.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4422
    Cell Significance Index: -50.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6114
    Cell Significance Index: -15.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6367
    Cell Significance Index: -74.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6591
    Cell Significance Index: -18.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7029
    Cell Significance Index: -102.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8987
    Cell Significance Index: -102.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9091
    Cell Significance Index: -26.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0635
    Cell Significance Index: -81.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1758
    Cell Significance Index: -122.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2493
    Cell Significance Index: -21.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2834
    Cell Significance Index: -17.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3255
    Cell Significance Index: -89.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5889
    Cell Significance Index: -42.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.6497
    Cell Significance Index: -92.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7697
    Cell Significance Index: -108.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.8856
    Cell Significance Index: -19.5200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.9166
    Cell Significance Index: -11.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.9361
    Cell Significance Index: -51.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -2.0718
    Cell Significance Index: -50.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0730
    Cell Significance Index: -61.0600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -2.1835
    Cell Significance Index: -16.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.1894
    Cell Significance Index: -54.7300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -2.2611
    Cell Significance Index: -14.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.3092
    Cell Significance Index: -49.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.5390
    Cell Significance Index: -43.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.5719
    Cell Significance Index: -66.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.6347
    Cell Significance Index: -116.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.6879
    Cell Significance Index: -98.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.7266
    Cell Significance Index: -78.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.9176
    Cell Significance Index: -102.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UQCR10 is a subunit of the mitochondrial electron transport chain complex III, which is responsible for the transfer of electrons from ubiquinol to cytochrome c. This process is crucial for the generation of ATP through the process of chemiosmosis. UQCR10 is a protein that is highly conserved across species, with a high degree of sequence similarity to other subunits of the electron transport chain. The protein is characterized by a unique structure, which allows it to interact with other subunits and facilitate electron transfer. **Pathways and Functions:** The UQCR10 gene is involved in several key pathways, including: 1. **Cellular Respiration:** UQCR10 plays a critical role in the generation of ATP through the electron transport chain. The protein is essential for the transfer of electrons from ubiquinol to cytochrome c, which is a crucial step in the process of chemiosmosis. 2. **Mitochondrial Electron Transport:** UQCR10 is a key component of the mitochondrial electron transport chain, which is responsible for the generation of ATP. The protein is involved in the transfer of electrons from ubiquinol to cytochrome c, which is a critical step in the process of chemiosmosis. 3. **Proton Transmembrane Transport:** UQCR10 is involved in the transport of protons across the mitochondrial inner membrane, which is essential for the generation of ATP through the process of chemiosmosis. 4. **Heat Production by Uncoupling Proteins:** UQCR10 is also involved in the production of heat by uncoupling proteins, which is a critical process in maintaining cellular homeostasis. **Clinical Significance:** Dysregulation of UQCR10 has been implicated in various diseases, including: 1. **Mitochondrial Diseases:** UQCR10 is essential for the proper functioning of the mitochondrial electron transport chain. Dysregulation of the gene has been implicated in various mitochondrial diseases, including MELAS syndrome and Kearns-Sayre syndrome. 2. **Cancer:** UQCR10 is highly expressed in various types of cancer, including lung and thyroid cancer. The protein is involved in the regulation of cell growth and proliferation, and its dysregulation has been implicated in the development of cancer. 3. **Neurological Disorders:** UQCR10 is involved in the regulation of neuronal function and survival. Dysregulation of the gene has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, UQCR10 is a crucial component of the mitochondrial electron transport chain, and its dysregulation has been implicated in various diseases. Further research is needed to elucidate the mechanisms by which UQCR10 regulates mitochondrial function and to develop therapeutic strategies for the treatment of diseases associated with its dysregulation.

Genular Protein ID: 124225395

Symbol: QCR9_HUMAN

Name: Cytochrome b-c1 complex subunit 9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8592474

Title: Ubiquinol-cytochrome-c reductase from human and bovine mitochondria.

PubMed ID: 8592474

DOI: 10.1016/0076-6879(95)60132-5

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

Sequence Information:

  • Length: 63
  • Mass: 7308
  • Checksum: 12CCBC666F54E464
  • Sequence:
  • MAAATLTSKL YSLLFRRTST FALTIIVGVM FFERAFDQGA DAIYDHINEG KLWKHIKHKY 
    ENK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.