Details for: GNL2

Gene ID: 29889

Symbol: GNL2

Ensembl ID: ENSG00000134697

Description: G protein nucleolar 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 121.1866
    Cell Significance Index: -18.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.4102
    Cell Significance Index: -18.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.2119
    Cell Significance Index: -26.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.8827
    Cell Significance Index: -24.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.4576
    Cell Significance Index: -20.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.3077
    Cell Significance Index: -23.8200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.5338
    Cell Significance Index: -24.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.0059
    Cell Significance Index: -21.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8490
    Cell Significance Index: -23.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3875
    Cell Significance Index: -19.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0896
    Cell Significance Index: -24.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6553
    Cell Significance Index: -17.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5972
    Cell Significance Index: 186.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0862
    Cell Significance Index: 14.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0636
    Cell Significance Index: 28.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0596
    Cell Significance Index: 956.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0543
    Cell Significance Index: 136.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.8573
    Cell Significance Index: 21.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8168
    Cell Significance Index: 132.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8026
    Cell Significance Index: 23.1300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7827
    Cell Significance Index: 5.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7607
    Cell Significance Index: 8.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7581
    Cell Significance Index: 35.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6684
    Cell Significance Index: 34.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6581
    Cell Significance Index: 49.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6377
    Cell Significance Index: 18.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6011
    Cell Significance Index: 16.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5851
    Cell Significance Index: 26.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5249
    Cell Significance Index: 36.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5125
    Cell Significance Index: 17.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4971
    Cell Significance Index: 89.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4711
    Cell Significance Index: 9.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4478
    Cell Significance Index: 88.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3882
    Cell Significance Index: 171.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3550
    Cell Significance Index: 43.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3467
    Cell Significance Index: 22.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3302
    Cell Significance Index: 23.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3237
    Cell Significance Index: 176.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3121
    Cell Significance Index: 14.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3018
    Cell Significance Index: 7.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2985
    Cell Significance Index: 5.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2857
    Cell Significance Index: 6.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2664
    Cell Significance Index: 36.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2457
    Cell Significance Index: 28.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2178
    Cell Significance Index: 43.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1813
    Cell Significance Index: 5.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1562
    Cell Significance Index: 5.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1356
    Cell Significance Index: 17.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1140
    Cell Significance Index: 21.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1023
    Cell Significance Index: 2.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0877
    Cell Significance Index: 2.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0856
    Cell Significance Index: 2.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0765
    Cell Significance Index: 27.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0686
    Cell Significance Index: 11.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0627
    Cell Significance Index: 6.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0582
    Cell Significance Index: 1.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0394
    Cell Significance Index: 2.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0295
    Cell Significance Index: 1.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0134
    Cell Significance Index: -8.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0165
    Cell Significance Index: -9.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0231
    Cell Significance Index: -2.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0305
    Cell Significance Index: -13.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0440
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0494
    Cell Significance Index: -10.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0541
    Cell Significance Index: -7.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0624
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0630
    Cell Significance Index: -7.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0670
    Cell Significance Index: -19.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0781
    Cell Significance Index: -5.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0896
    Cell Significance Index: -0.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0958
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1108
    Cell Significance Index: -12.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1256
    Cell Significance Index: -3.1400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1367
    Cell Significance Index: -1.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1383
    Cell Significance Index: -7.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1536
    Cell Significance Index: -9.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1655
    Cell Significance Index: -1.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1684
    Cell Significance Index: -3.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1693
    Cell Significance Index: -3.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1775
    Cell Significance Index: -2.6600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1875
    Cell Significance Index: -1.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2129
    Cell Significance Index: -1.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2268
    Cell Significance Index: -23.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2524
    Cell Significance Index: -19.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2606
    Cell Significance Index: -17.5200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3744
    Cell Significance Index: -5.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3775
    Cell Significance Index: -11.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3983
    Cell Significance Index: -24.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4174
    Cell Significance Index: -10.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4245
    Cell Significance Index: -7.1500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4357
    Cell Significance Index: -5.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTP-binding protein**: The GNL2 gene encodes a GTP-binding protein, NOG2_HUMAN, which is a key component of the nucleolar complex. GTP-binding proteins play a crucial role in regulating protein-protein interactions and signal transduction pathways. 2. **Ribosome biogenesis**: The GNL2 gene is involved in ribosome biogenesis, a process essential for protein synthesis. The protein product of this gene regulates the nucleolar function and ribosome biogenesis by interacting with other proteins. 3. **RNA binding**: NOG2_HUMAN has RNA binding capabilities, which suggest its involvement in RNA processing and regulation. 4. **Cellular localization**: The GNL2 gene is expressed in various cell types, including male germ cells, skeletal muscle satellite stem cells, and fibroblasts of the breast and mammary gland. This suggests its role in cell differentiation and development. **Pathways and Functions:** 1. **GTPase activity**: The GNL2 gene encodes a GTP-binding protein that exhibits GTPase activity. This activity is crucial for regulating protein-protein interactions and signal transduction pathways. 2. **Ribosome biogenesis pathway**: The GNL2 gene is involved in the ribosome biogenesis pathway, which is essential for protein synthesis. The protein product of this gene regulates the nucleolar function and ribosome biogenesis by interacting with other proteins. 3. **RNA processing pathway**: NOG2_HUMAN has RNA binding capabilities, which suggest its involvement in RNA processing and regulation. 4. **Cell differentiation pathway**: The GNL2 gene is expressed in various cell types, including male germ cells, skeletal muscle satellite stem cells, and fibroblasts of the breast and mammary gland. This suggests its role in cell differentiation and development. **Clinical Significance:** 1. **Cancer research**: The GNL2 gene is expressed in various cancer cell types, including breast and prostate cancer. This suggests its potential role in cancer development and progression. 2. **Neurological disorders**: The GNL2 gene has been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. Further research is needed to understand its role in these disorders. 3. **Regenerative medicine**: The GNL2 gene has been identified as a potential target for regenerative medicine, particularly in the context of skeletal muscle regeneration. 4. **Developmental biology**: The GNL2 gene plays a crucial role in cell differentiation and development, particularly in the context of germ cell development and skeletal muscle satellite stem cell differentiation. In conclusion, the GNL2 gene is a complex gene that plays a crucial role in various cellular processes, including ribosome biogenesis, RNA binding, and cell differentiation. Further research is needed to fully understand its role in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2296188173

Symbol: NOG2_HUMAN

Name: Nucleolar GTP-binding protein 2

UniProtKB Accession Codes:

Q13823 Q9BWN7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 21 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8822211

Title: Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor.

PubMed ID: 8822211

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21495629

Title: Signals and pathways regulating nucleolar retention of novel putative nucleolar GTPase NGP-1(GNL-2).

PubMed ID: 21495629

DOI: 10.1021/bi200425b

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26203195

Title: Nucleolar GTP-binding protein-1 (NGP-1) promotes G1 to S phase transition by activating cyclin-dependent kinase inhibitor p21 Cip1/Waf1.

PubMed ID: 26203195

DOI: 10.1074/jbc.m115.637280

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 731
  • Mass: 83655
  • Checksum: E90C638B58C0886E
  • Sequence:
    • MVKPKYKGRS TINPSKASTN PDRVQGAGGQ NMRDRATIRR LNMYRQKERR NSRGKIIKPL 
QYQSTVASGT VARVEPNIKW FGNTRVIKQS SLQKFQEEMD TVMKDPYKVV MKQSKLPMSL 
LHDRIRPHNL KVHILDTESF ETTFGPKSQR KRPNLFASDM QSLIENAEMS TESYDQGKDR 
DLVTEDTGVR NEAQEEIYKK GQSKRIWGEL YKVIDSSDVV VQVLDARDPM GTRSPHIETY 
LKKEKPWKHL IFVLNKCDLV PTWATKRWVA VLSQDYPTLA FHASLTNPFG KGAFIQLLRQ 
FGKLHTDKKQ ISVGFIGYPN VGKSSVINTL RSKKVCNVAP IAGETKVWQY ITLMRRIFLI 
DCPGVVYPSE DSETDIVLKG VVQVEKIKSP EDHIGAVLER AKPEYISKTY KIDSWENAED 
FLEKLAFRTG KLLKGGEPDL QTVGKMVLND WQRGRIPFFV KPPNAEPLVA PQLLPSSSLE 
VVPEAAQNNP GEEVTETAGE GSESIIKEET EENSHCDANT EMQQILTRVR QNFGKINVVP 
QFSGDDLVPV EVSDLEEELE SFSDEEEEEQ EQQRDDAEES SSEPEEENVG NDTKAVIKAL 
DEKIAKYQKF LDKAKAKKFS AVRISKGLSE KIFAKPEEQR KTLEEDVDDR APSKKGKKRK 
AQREEEQEHS NKAPRALTSK ERRRAVRQQR PKKVGVRYYE THNVKNRNRN KKKTNDSEGQ 
KHKRKKFRQK Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.