Details for: NENF

Gene ID: 29937

Symbol: NENF

Ensembl ID: ENSG00000117691

Description: neudesin neurotrophic factor

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.91
    Marker Score: 99,104
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.62
    Marker Score: 10,117
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.62
    Marker Score: 1,044
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.58
    Marker Score: 6,498
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.56
    Marker Score: 16,652
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.53
    Marker Score: 4,745
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.51
    Marker Score: 10,824
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.35
    Marker Score: 5,749
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.34
    Marker Score: 6,127
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.32
    Marker Score: 3,842
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.3
    Marker Score: 12,106
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.3
    Marker Score: 518
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.28
    Marker Score: 25,649
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.24
    Marker Score: 2,707
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.24
    Marker Score: 2,392
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.24
    Marker Score: 16,665
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.23
    Marker Score: 29,466
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.17
    Marker Score: 1,262
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.11
    Marker Score: 669
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.11
    Marker Score: 1,991
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.1
    Marker Score: 846
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.06
    Marker Score: 7,305
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.05
    Marker Score: 5,490
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.03
    Marker Score: 2,640
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.03
    Marker Score: 755
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.99
    Marker Score: 7,835
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.97
    Marker Score: 2,784
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.96
    Marker Score: 1,116
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.94
    Marker Score: 3,444
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.94
    Marker Score: 49,632
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.94
    Marker Score: 3,080
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.93
    Marker Score: 1,519
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.93
    Marker Score: 2,648
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.9
    Marker Score: 1,927
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.9
    Marker Score: 548
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9
    Marker Score: 4,323
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.89
    Marker Score: 436
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.89
    Marker Score: 691
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.88
    Marker Score: 1,340
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.86
    Marker Score: 2,740
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.86
    Marker Score: 1,584
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.85
    Marker Score: 524
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.85
    Marker Score: 2,074
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.84
    Marker Score: 15,890
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.84
    Marker Score: 1,953
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.84
    Marker Score: 654
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.81
    Marker Score: 2,514
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.81
    Marker Score: 752
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.8
    Marker Score: 1,139
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.79
    Marker Score: 835
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.79
    Marker Score: 402
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.76
    Marker Score: 906
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.76
    Marker Score: 641
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.71
    Marker Score: 425
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.71
    Marker Score: 2,139
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.71
    Marker Score: 3,466
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.7
    Marker Score: 547
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.7
    Marker Score: 713
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.69
    Marker Score: 425
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.69
    Marker Score: 804
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.67
    Marker Score: 1,047
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.66
    Marker Score: 1,563
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.66
    Marker Score: 1,187
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.65
    Marker Score: 620
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.64
    Marker Score: 2,019
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.63
    Marker Score: 1,698
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.63
    Marker Score: 999
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.62
    Marker Score: 3,817
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.62
    Marker Score: 55,944
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.61
    Marker Score: 2,590
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.61
    Marker Score: 12,565
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.6
    Marker Score: 1,709
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.59
    Marker Score: 458
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.58
    Marker Score: 3,791
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.58
    Marker Score: 381
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.57
    Marker Score: 677
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.57
    Marker Score: 865
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.56
    Marker Score: 1,644
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.55
    Marker Score: 5,753
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.55
    Marker Score: 3,683
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.55
    Marker Score: 3,097
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.55
    Marker Score: 764
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.54
    Marker Score: 393
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.53
    Marker Score: 528
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.52
    Marker Score: 375
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.52
    Marker Score: 1,447
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.51
    Marker Score: 530
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.51
    Marker Score: 993
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.5
    Marker Score: 3,160
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.5
    Marker Score: 1,712
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.49
    Marker Score: 4,066
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.48
    Marker Score: 514
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.48
    Marker Score: 767
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.47
    Marker Score: 499
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.47
    Marker Score: 1,417
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.46
    Marker Score: 993
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.43
    Marker Score: 1,678
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.43
    Marker Score: 9,315
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.43
    Marker Score: 3,242
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.42
    Marker Score: 945

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Neudesin is a secreted protein that belongs to the neurotrophic factor family, which is characterized by its ability to promote cell growth, differentiation, and survival. NENF is primarily expressed in fibroblasts of mammary glands, progenitor cells of mammary luminal epithelium, and other specialized cell types in various organs, such as the kidney, ovary, lung, and prostate. The expression of NENF is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer and metabolic disorders. **Pathways and Functions:** NENF exerts its effects through various signaling pathways, including the MAPK (mitogen-activated protein kinase) cascade, which is a key regulator of cell growth, differentiation, and survival. NENF also interacts with other growth factors, such as insulin-like growth factor-1 (IGF-1), to modulate its effects on cell proliferation and differentiation. In addition, NENF has been shown to regulate the expression of genes involved in cell adhesion, migration, and apoptosis. The functions of NENF are diverse and tissue-specific, with roles in regulating: 1. Cell growth and differentiation in mammary glands and other tissues 2. Regulation of appetite and energy homeostasis 3. Maintenance of epithelial barrier function in the kidney and lung 4. Regulation of ovarian follicular development and ovulation 5. Modulation of immune responses and inflammation **Clinical Significance:** Dysregulation of NENF has been implicated in various human diseases, including: 1. **Breast cancer**: Elevated expression of NENF has been observed in breast cancer tissues, suggesting a potential role in tumorigenesis and metastasis. 2. **Metabolic disorders**: NENF has been shown to regulate glucose and lipid metabolism, and its dysregulation may contribute to the development of metabolic disorders, such as obesity and type 2 diabetes. 3. **Kidney disease**: NENF has been implicated in the regulation of kidney function and fibrosis, and its dysregulation may contribute to the progression of kidney disease. 4. **Ovarian cancer**: NENF has been shown to regulate ovarian follicular development and ovulation, and its dysregulation may contribute to the development of ovarian cancer. In conclusion, neudesin (NENF) is a multifunctional growth factor that plays a crucial role in regulating various physiological processes, including growth, development, and maintenance of different cell types. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the molecular mechanisms underlying NENF's functions and its role in human disease.

Genular Protein ID: 551847390

Symbol: NENF_HUMAN

Name: Neudesin

UniProtKB Accession Codes:

Q9UMX5 A1KYQ8 Q53FZ6 Q5TM90

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15605373

Title: Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity.

PubMed ID: 15605373

DOI: 10.1002/jnr.20356

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9771976

Title: Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines.

PubMed ID: 9771976

DOI: 10.1038/sj.onc.1202058

PubMed ID: 16645950

Title: Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection.

PubMed ID: 16645950

DOI: 10.1002/elps.200500739

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22748190

Title: The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis.

PubMed ID: 22748190

DOI: 10.1186/1471-2407-12-274

PubMed ID: 23763432

Title: Nonclassical progesterone signalling molecules in the nervous system.

PubMed ID: 23763432

DOI: 10.1111/jne.12060

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28396637

Title: Membrane associated progesterone receptors: promiscuous proteins with pleiotropic functions - focus on interactions with cytochromes P450.

PubMed ID: 28396637

DOI: 10.3389/fphar.2017.00159

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

Sequence Information:

  • Length: 172
  • Mass: 18856
  • Checksum: 24527D540B000F2E
  • Sequence:
    • MVGPAPRRRL RPLAALALVL ALAPGLPTAR AGQTPRPAER GPPVRLFTEE ELARYGGEEE 
DQPIYLAVKG VVFDVTSGKE FYGRGAPYNA LTGKDSTRGV AKMSLDPADL THDTTGLTAK 
ELEALDEVFT KVYKAKYPIV GYTARRILNE DGSPNLDFKP EDQPHFDIKD EF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.