Details for: NENF

Gene ID: 29937

Symbol: NENF

Ensembl ID: ENSG00000117691

Description: neudesin neurotrophic factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 313.0922
    Cell Significance Index: -48.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 203.5141
    Cell Significance Index: -51.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 153.4661
    Cell Significance Index: -63.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.7255
    Cell Significance Index: -59.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.4164
    Cell Significance Index: -48.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 109.6066
    Cell Significance Index: -56.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 89.6915
    Cell Significance Index: -60.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.4694
    Cell Significance Index: -49.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.9174
    Cell Significance Index: -59.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.0468
    Cell Significance Index: -55.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4081
    Cell Significance Index: -43.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.4408
    Cell Significance Index: -60.9300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.9889
    Cell Significance Index: 30.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.9476
    Cell Significance Index: 107.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2847
    Cell Significance Index: 153.1500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.1854
    Cell Significance Index: 40.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.9698
    Cell Significance Index: 79.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9465
    Cell Significance Index: 404.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.9014
    Cell Significance Index: 83.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.8929
    Cell Significance Index: 215.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.2800
    Cell Significance Index: 47.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.0655
    Cell Significance Index: 97.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.0004
    Cell Significance Index: 105.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9644
    Cell Significance Index: 253.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9283
    Cell Significance Index: 44.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7728
    Cell Significance Index: 16.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6150
    Cell Significance Index: 714.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6112
    Cell Significance Index: 290.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5345
    Cell Significance Index: 196.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4056
    Cell Significance Index: 1269.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3524
    Cell Significance Index: 166.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2956
    Cell Significance Index: 91.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0588
    Cell Significance Index: 578.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0224
    Cell Significance Index: 46.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9551
    Cell Significance Index: 49.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8548
    Cell Significance Index: 162.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7318
    Cell Significance Index: 38.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7011
    Cell Significance Index: 119.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5352
    Cell Significance Index: 6.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5277
    Cell Significance Index: 9.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4494
    Cell Significance Index: 12.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3876
    Cell Significance Index: 77.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3288
    Cell Significance Index: 21.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3280
    Cell Significance Index: 65.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2852
    Cell Significance Index: 3.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1816
    Cell Significance Index: 65.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0598
    Cell Significance Index: 1.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0531
    Cell Significance Index: 38.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0440
    Cell Significance Index: 33.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0077
    Cell Significance Index: -14.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0281
    Cell Significance Index: -51.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0299
    Cell Significance Index: -18.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0356
    Cell Significance Index: -54.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0431
    Cell Significance Index: -58.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0532
    Cell Significance Index: -29.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0546
    Cell Significance Index: -34.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0568
    Cell Significance Index: -1.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0652
    Cell Significance Index: -29.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0740
    Cell Significance Index: -15.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0746
    Cell Significance Index: -7.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0834
    Cell Significance Index: -9.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1189
    Cell Significance Index: -4.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1461
    Cell Significance Index: -42.0300
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1685
    Cell Significance Index: -0.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1960
    Cell Significance Index: -19.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2023
    Cell Significance Index: -7.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2168
    Cell Significance Index: -6.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2240
    Cell Significance Index: -25.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2473
    Cell Significance Index: -6.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2597
    Cell Significance Index: -30.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3038
    Cell Significance Index: -19.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3158
    Cell Significance Index: -45.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4437
    Cell Significance Index: -27.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4767
    Cell Significance Index: -54.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4837
    Cell Significance Index: -6.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5149
    Cell Significance Index: -40.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5343
    Cell Significance Index: -11.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5488
    Cell Significance Index: -57.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5939
    Cell Significance Index: -45.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6159
    Cell Significance Index: -34.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6276
    Cell Significance Index: -42.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6437
    Cell Significance Index: -16.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7679
    Cell Significance Index: -6.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8023
    Cell Significance Index: -49.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9770
    Cell Significance Index: -6.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9924
    Cell Significance Index: -14.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1152
    Cell Significance Index: -49.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3067
    Cell Significance Index: -28.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.3586
    Cell Significance Index: -25.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3804
    Cell Significance Index: -40.6600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.3823
    Cell Significance Index: -14.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.3942
    Cell Significance Index: -57.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.4062
    Cell Significance Index: -53.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4086
    Cell Significance Index: -51.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.4515
    Cell Significance Index: -41.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.4597
    Cell Significance Index: -28.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5085
    Cell Significance Index: -40.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5169
    Cell Significance Index: -53.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5596
    Cell Significance Index: -49.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Neudesin is a secreted protein that belongs to the neurotrophic factor family, which is characterized by its ability to promote cell growth, differentiation, and survival. NENF is primarily expressed in fibroblasts of mammary glands, progenitor cells of mammary luminal epithelium, and other specialized cell types in various organs, such as the kidney, ovary, lung, and prostate. The expression of NENF is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer and metabolic disorders. **Pathways and Functions:** NENF exerts its effects through various signaling pathways, including the MAPK (mitogen-activated protein kinase) cascade, which is a key regulator of cell growth, differentiation, and survival. NENF also interacts with other growth factors, such as insulin-like growth factor-1 (IGF-1), to modulate its effects on cell proliferation and differentiation. In addition, NENF has been shown to regulate the expression of genes involved in cell adhesion, migration, and apoptosis. The functions of NENF are diverse and tissue-specific, with roles in regulating: 1. Cell growth and differentiation in mammary glands and other tissues 2. Regulation of appetite and energy homeostasis 3. Maintenance of epithelial barrier function in the kidney and lung 4. Regulation of ovarian follicular development and ovulation 5. Modulation of immune responses and inflammation **Clinical Significance:** Dysregulation of NENF has been implicated in various human diseases, including: 1. **Breast cancer**: Elevated expression of NENF has been observed in breast cancer tissues, suggesting a potential role in tumorigenesis and metastasis. 2. **Metabolic disorders**: NENF has been shown to regulate glucose and lipid metabolism, and its dysregulation may contribute to the development of metabolic disorders, such as obesity and type 2 diabetes. 3. **Kidney disease**: NENF has been implicated in the regulation of kidney function and fibrosis, and its dysregulation may contribute to the progression of kidney disease. 4. **Ovarian cancer**: NENF has been shown to regulate ovarian follicular development and ovulation, and its dysregulation may contribute to the development of ovarian cancer. In conclusion, neudesin (NENF) is a multifunctional growth factor that plays a crucial role in regulating various physiological processes, including growth, development, and maintenance of different cell types. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the molecular mechanisms underlying NENF's functions and its role in human disease.

Genular Protein ID: 551847390

Symbol: NENF_HUMAN

Name: Neudesin

UniProtKB Accession Codes:

Q9UMX5 A1KYQ8 Q53FZ6 Q5TM90

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15605373

Title: Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity.

PubMed ID: 15605373

DOI: 10.1002/jnr.20356

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9771976

Title: Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines.

PubMed ID: 9771976

DOI: 10.1038/sj.onc.1202058

PubMed ID: 16645950

Title: Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection.

PubMed ID: 16645950

DOI: 10.1002/elps.200500739

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22748190

Title: The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis.

PubMed ID: 22748190

DOI: 10.1186/1471-2407-12-274

PubMed ID: 23763432

Title: Nonclassical progesterone signalling molecules in the nervous system.

PubMed ID: 23763432

DOI: 10.1111/jne.12060

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28396637

Title: Membrane associated progesterone receptors: promiscuous proteins with pleiotropic functions - focus on interactions with cytochromes P450.

PubMed ID: 28396637

DOI: 10.3389/fphar.2017.00159

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

Sequence Information:

  • Length: 172
  • Mass: 18856
  • Checksum: 24527D540B000F2E
  • Sequence:
    • MVGPAPRRRL RPLAALALVL ALAPGLPTAR AGQTPRPAER GPPVRLFTEE ELARYGGEEE 
DQPIYLAVKG VVFDVTSGKE FYGRGAPYNA LTGKDSTRGV AKMSLDPADL THDTTGLTAK 
ELEALDEVFT KVYKAKYPIV GYTARRILNE DGSPNLDFKP EDQPHFDIKD EF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.