Details for: SERTAD3

Gene ID: 29946

Symbol: SERTAD3

Ensembl ID: ENSG00000167565

Description: SERTA domain containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.4730
    Cell Significance Index: -20.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.4369
    Cell Significance Index: -19.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.6539
    Cell Significance Index: -20.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.5993
    Cell Significance Index: -16.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.9591
    Cell Significance Index: -20.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.2981
    Cell Significance Index: -17.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6997
    Cell Significance Index: -20.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4241
    Cell Significance Index: -16.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2508
    Cell Significance Index: -20.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6475
    Cell Significance Index: -12.4500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.3707
    Cell Significance Index: 14.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9826
    Cell Significance Index: 27.0500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.6940
    Cell Significance Index: 14.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5934
    Cell Significance Index: 43.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5731
    Cell Significance Index: 12.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5684
    Cell Significance Index: 81.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5262
    Cell Significance Index: 12.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4735
    Cell Significance Index: 171.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3173
    Cell Significance Index: 59.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3107
    Cell Significance Index: 68.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3074
    Cell Significance Index: 1180.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9877
    Cell Significance Index: 97.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9787
    Cell Significance Index: 10.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9764
    Cell Significance Index: 58.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9749
    Cell Significance Index: 106.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9417
    Cell Significance Index: 12.0600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8791
    Cell Significance Index: 15.5400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.8659
    Cell Significance Index: 9.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7649
    Cell Significance Index: 16.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7455
    Cell Significance Index: 11.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7382
    Cell Significance Index: 120.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7381
    Cell Significance Index: 15.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6329
    Cell Significance Index: 77.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6305
    Cell Significance Index: 46.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6055
    Cell Significance Index: 17.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6011
    Cell Significance Index: 28.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5498
    Cell Significance Index: 70.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4950
    Cell Significance Index: 17.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4501
    Cell Significance Index: 81.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4458
    Cell Significance Index: 243.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3892
    Cell Significance Index: 172.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3476
    Cell Significance Index: 47.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2767
    Cell Significance Index: 19.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2746
    Cell Significance Index: 7.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2623
    Cell Significance Index: 12.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2470
    Cell Significance Index: 7.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2404
    Cell Significance Index: 45.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2206
    Cell Significance Index: 5.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1660
    Cell Significance Index: 21.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1608
    Cell Significance Index: 5.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0890
    Cell Significance Index: 1.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0850
    Cell Significance Index: 1.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0713
    Cell Significance Index: 0.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0497
    Cell Significance Index: 3.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0099
    Cell Significance Index: 0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0120
    Cell Significance Index: -1.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0125
    Cell Significance Index: -22.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0134
    Cell Significance Index: -20.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0181
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0236
    Cell Significance Index: -2.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0250
    Cell Significance Index: -15.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0266
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0338
    Cell Significance Index: -19.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0398
    Cell Significance Index: -0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0402
    Cell Significance Index: -18.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0411
    Cell Significance Index: -25.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0462
    Cell Significance Index: -5.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0492
    Cell Significance Index: -17.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0561
    Cell Significance Index: -0.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0610
    Cell Significance Index: -17.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0839
    Cell Significance Index: -16.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0969
    Cell Significance Index: -16.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1028
    Cell Significance Index: -14.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1048
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1084
    Cell Significance Index: -22.8400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1128
    Cell Significance Index: -0.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1454
    Cell Significance Index: -7.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1592
    Cell Significance Index: -6.5200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1606
    Cell Significance Index: -0.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1933
    Cell Significance Index: -14.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1967
    Cell Significance Index: -20.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2020
    Cell Significance Index: -1.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2025
    Cell Significance Index: -2.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2136
    Cell Significance Index: -16.9200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2300
    Cell Significance Index: -1.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2509
    Cell Significance Index: -7.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3073
    Cell Significance Index: -20.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3086
    Cell Significance Index: -18.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3097
    Cell Significance Index: -16.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3283
    Cell Significance Index: -20.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3345
    Cell Significance Index: -20.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3578
    Cell Significance Index: -20.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3637
    Cell Significance Index: -3.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3803
    Cell Significance Index: -11.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** SERTAD3 is widely expressed in various cell types, including pulmonary interstitial fibroblasts, cortical thymic epithelial cells, placental villous trophoblasts, myeloid leukocytes, bladder urothelial cells, smooth muscle cells of the large intestine, kidney collecting duct cells, neural progenitor cells, and lung endothelial cells. 2. **Domain structure:** The SERTAD3 protein contains a SERTA domain, which is a characteristic feature of this protein family. 3. **Regulatory functions:** SERTAD3 is involved in negative regulation of cell growth, positive regulation of DNA-templated transcription, and protein binding. **Pathways and Functions:** 1. **Negative regulation of cell growth:** SERTAD3 may play a role in regulating cell growth by modulating signaling pathways that control cell proliferation and differentiation. 2. **Positive regulation of DNA-templated transcription:** SERTAD3 may be involved in regulating gene expression by interacting with transcription factors and co-regulators that control DNA-templated transcription. 3. **Protein binding:** SERTAD3 may interact with other proteins to regulate various cellular processes, including signal transduction and protein degradation. **Clinical Significance:** 1. **Cancer:** Alterations in SERTAD3 expression have been observed in various cancers, including lung, breast, and colon cancer. Further studies are needed to understand the role of SERTAD3 in cancer development and progression. 2. **Immune response:** SERTAD3 may play a role in regulating immune response by modulating the activity of myeloid leukocytes, which are critical for innate immunity. 3. **Regenerative medicine:** SERTAD3 may be involved in regulating cellular differentiation and proliferation in regenerative medicine, including tissue engineering and organ regeneration. In conclusion, SERTAD3 is a gene that plays a crucial role in regulating various cellular processes, including cell growth, DNA-templated transcription, and immune response. Further studies are needed to understand the mechanisms by which SERTAD3 regulates these processes and to explore its potential applications in cancer, immune response, and regenerative medicine.

Genular Protein ID: 2146668028

Symbol: SRTD3_HUMAN

Name: SERTA domain-containing protein 3

UniProtKB Accession Codes:

Q9UJW9 B3KQB3 Q96CQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 4 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10982866

Title: RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A.

PubMed ID: 10982866

DOI: 10.1093/nar/28.18.3478

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33147462

Title: Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex.

PubMed ID: 33147462

DOI: 10.1016/j.celrep.2020.108342

PubMed ID: 36594413

Title: SERTAD3 induces proteasomal degradation of ZIKV capsid protein and represents a therapeutic target.

PubMed ID: 36594413

DOI: 10.1002/jmv.28451

Sequence Information:

  • Length: 196
  • Mass: 21769
  • Checksum: 9C54AFA126F17AF1
  • Sequence:
    • MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP SLRRHVLIHN 
TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR ELDTSMDGTE PPQNPVTPLG 
LQNEVPPQPD PVFLEALSSR YLGDSGLDDF FLDIDTSAVE KEPARAPPEP PHNLFCAPGS 
WEWNELDHIM EIILGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.