Details for: SERTAD1

Gene ID: 29950

Symbol: SERTAD1

Ensembl ID: ENSG00000197019

Description: SERTA domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 318.7497
    Cell Significance Index: -49.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 193.5394
    Cell Significance Index: -49.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.4998
    Cell Significance Index: -39.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.6386
    Cell Significance Index: -45.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 70.5416
    Cell Significance Index: -47.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.9904
    Cell Significance Index: -40.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.2529
    Cell Significance Index: -49.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.8762
    Cell Significance Index: -42.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.6760
    Cell Significance Index: -50.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2805
    Cell Significance Index: -27.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.2354
    Cell Significance Index: 145.5300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.6344
    Cell Significance Index: 70.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.7764
    Cell Significance Index: 102.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.7997
    Cell Significance Index: 17.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6038
    Cell Significance Index: 74.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.1143
    Cell Significance Index: 110.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7801
    Cell Significance Index: 228.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6677
    Cell Significance Index: 78.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6631
    Cell Significance Index: 123.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5847
    Cell Significance Index: 33.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3758
    Cell Significance Index: 71.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3128
    Cell Significance Index: 580.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2432
    Cell Significance Index: 1122.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1329
    Cell Significance Index: 146.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1125
    Cell Significance Index: 136.8000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.0893
    Cell Significance Index: 17.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0744
    Cell Significance Index: 48.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9051
    Cell Significance Index: 172.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8467
    Cell Significance Index: 24.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8332
    Cell Significance Index: 455.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7627
    Cell Significance Index: 137.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6531
    Cell Significance Index: 7.1000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6262
    Cell Significance Index: 8.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6195
    Cell Significance Index: 16.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6079
    Cell Significance Index: 66.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5794
    Cell Significance Index: 40.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5055
    Cell Significance Index: 69.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4932
    Cell Significance Index: 7.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4480
    Cell Significance Index: 5.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4355
    Cell Significance Index: 28.1000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.3343
    Cell Significance Index: 1.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2878
    Cell Significance Index: 10.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2795
    Cell Significance Index: 13.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2757
    Cell Significance Index: 19.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2687
    Cell Significance Index: 26.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0404
    Cell Significance Index: 0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0108
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.8900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0230
    Cell Significance Index: -0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0245
    Cell Significance Index: -46.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0289
    Cell Significance Index: -21.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0307
    Cell Significance Index: -23.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0322
    Cell Significance Index: -59.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0375
    Cell Significance Index: -23.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0384
    Cell Significance Index: -59.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0428
    Cell Significance Index: -58.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0577
    Cell Significance Index: -39.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0603
    Cell Significance Index: -33.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0620
    Cell Significance Index: -39.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0649
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0702
    Cell Significance Index: -11.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0751
    Cell Significance Index: -2.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0776
    Cell Significance Index: -3.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0985
    Cell Significance Index: -1.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1026
    Cell Significance Index: -46.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1184
    Cell Significance Index: -1.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1317
    Cell Significance Index: -47.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1365
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1503
    Cell Significance Index: -31.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1558
    Cell Significance Index: -18.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1561
    Cell Significance Index: -44.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1647
    Cell Significance Index: -19.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1818
    Cell Significance Index: -36.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1825
    Cell Significance Index: -36.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1854
    Cell Significance Index: -21.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2349
    Cell Significance Index: -26.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2821
    Cell Significance Index: -41.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2892
    Cell Significance Index: -6.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3060
    Cell Significance Index: -6.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3267
    Cell Significance Index: -9.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3327
    Cell Significance Index: -2.0100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3826
    Cell Significance Index: -3.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4192
    Cell Significance Index: -5.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4499
    Cell Significance Index: -14.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4890
    Cell Significance Index: -50.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5109
    Cell Significance Index: -40.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5381
    Cell Significance Index: -11.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5624
    Cell Significance Index: -29.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6304
    Cell Significance Index: -38.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6518
    Cell Significance Index: -50.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7231
    Cell Significance Index: -48.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7500
    Cell Significance Index: -22.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7791
    Cell Significance Index: -20.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7889
    Cell Significance Index: -49.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8109
    Cell Significance Index: -49.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8683
    Cell Significance Index: -20.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8742
    Cell Significance Index: -6.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9097
    Cell Significance Index: -51.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9698
    Cell Significance Index: -35.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **SERTA Domain:** The SERTAD1 gene encodes a protein containing a SERTA domain, which is a conserved domain found in several proteins involved in cell signaling and regulation. 2. **Cell Type-Specific Expression:** SERTAD1 is significantly expressed in various cell types, including B-2 B cells, skeletal muscle satellite stem cells, vascular lymphangioblasts, and endothelial cells, suggesting its involvement in tissue-specific functions. 3. **Pathway Involvement:** SERTAD1 is implicated in multiple signaling pathways, including positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, protein binding, regulation of cyclin-dependent protein serine/threonine kinase activity, and transcription regulator activity. 4. **Protein Interaction:** The protein encoded by SERTAD1 interacts with other proteins, such as cyclin-dependent kinases, which are involved in cell cycle regulation and proliferation. **Pathways and Functions:** 1. **Cell Proliferation:** SERTAD1 is involved in the regulation of cell population proliferation, which is essential for tissue growth and development. 2. **Transcription Regulation:** SERTAD1 interacts with RNA polymerase II, a key enzyme involved in transcriptional regulation, to modulate gene expression. 3. **Protein Binding:** The SERTA domain of SERTAD1 interacts with other proteins, such as cyclin-dependent kinases, to regulate protein activity and cell signaling. 4. **Regulation of Cyclin-Dependent Kinase Activity:** SERTAD1 regulates the activity of cyclin-dependent kinases, which are essential for cell cycle progression and proliferation. **Clinical Significance:** 1. **Cancer Research:** SERTAD1's role in cell proliferation and transcription regulation makes it a potential target for cancer therapy. 2. **Immunological Disorders:** The expression of SERTAD1 in B-2 B cells and other immune cells suggests its involvement in immune function and disorders, such as autoimmune diseases. 3. **Cardiovascular Disease:** SERTAD1's expression in endothelial cells and vascular lymphangioblasts implies its potential role in cardiovascular disease, including atherosclerosis and hypertension. 4. **Regenerative Medicine:** SERTAD1's involvement in skeletal muscle satellite stem cells and other stem cells suggests its potential use in regenerative medicine, particularly for tissue repair and regeneration. In conclusion, SERTAD1 is a multifaceted gene that plays a crucial role in various cellular processes, including cell proliferation, transcription regulation, and tissue homeostasis. Further research is necessary to fully understand the functions and significance of SERTAD1, particularly in the context of disease and therapeutic applications.

Genular Protein ID: 3479425199

Symbol: SRTD1_HUMAN

Name: SERTA domain-containing protein 1

UniProtKB Accession Codes:

Q9UHV2 Q9BUE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10580009

Title: Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).

PubMed ID: 10580009

DOI: 10.1101/gad.13.22.3027

PubMed ID: 11331592

Title: TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.

PubMed ID: 11331592

DOI: 10.1093/emboj/20.9.2273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18316374

Title: CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.

PubMed ID: 18316374

DOI: 10.1074/jbc.m708365200

Sequence Information:

  • Length: 236
  • Mass: 24704
  • Checksum: 8659505783FBF50B
  • Sequence:
    • MLSKGLKRKR EEEEEKEPLA VDSWWLDPGH TAVAQAPPAV ASSSLFDLSV LKLHHSLQQS 
EPDLRHLVLV VNTLRRIQAS MAPAAALPPV PSPPAAPSVA DNLLASSDAA LSASMASLLE 
DLSHIEGLSQ APQPLADEGP PGRSIGGAAP SLGALDLLGP ATGCLLDDGL EGLFEDIDTS 
MYDNELWAPA SEGLKPGPED GPGKEEAPEL DEAELDYLMD VLVGTQALER PPGPGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.