Details for: UBQLN1

Gene ID: 29979

Symbol: UBQLN1

Ensembl ID: ENSG00000135018

Description: ubiquilin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 325.5645
    Cell Significance Index: -50.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 203.8689
    Cell Significance Index: -51.7100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.0556
    Cell Significance Index: -54.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 123.1732
    Cell Significance Index: -50.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.9765
    Cell Significance Index: -58.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 108.6345
    Cell Significance Index: -55.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.9252
    Cell Significance Index: -50.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.3244
    Cell Significance Index: -54.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.3702
    Cell Significance Index: -51.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.5057
    Cell Significance Index: -57.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.4752
    Cell Significance Index: -44.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4947
    Cell Significance Index: -20.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3074
    Cell Significance Index: 61.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9309
    Cell Significance Index: 26.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.8483
    Cell Significance Index: 47.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8331
    Cell Significance Index: 367.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2951
    Cell Significance Index: 140.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2881
    Cell Significance Index: 255.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2539
    Cell Significance Index: 75.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0411
    Cell Significance Index: 373.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8671
    Cell Significance Index: 102.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7330
    Cell Significance Index: 38.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7320
    Cell Significance Index: 19.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7154
    Cell Significance Index: 128.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7107
    Cell Significance Index: 39.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6427
    Cell Significance Index: 79.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6346
    Cell Significance Index: 48.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6280
    Cell Significance Index: 434.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5771
    Cell Significance Index: 14.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5534
    Cell Significance Index: 302.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5353
    Cell Significance Index: 236.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5154
    Cell Significance Index: 14.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4494
    Cell Significance Index: 21.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4313
    Cell Significance Index: 29.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4239
    Cell Significance Index: 27.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4211
    Cell Significance Index: 12.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4023
    Cell Significance Index: 24.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3973
    Cell Significance Index: 54.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3519
    Cell Significance Index: 26.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3081
    Cell Significance Index: 8.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2941
    Cell Significance Index: 13.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2827
    Cell Significance Index: 36.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2606
    Cell Significance Index: 11.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2256
    Cell Significance Index: 38.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2242
    Cell Significance Index: 11.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1819
    Cell Significance Index: 342.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1583
    Cell Significance Index: 10.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1161
    Cell Significance Index: 4.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1144
    Cell Significance Index: 155.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1044
    Cell Significance Index: 10.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0963
    Cell Significance Index: 18.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0940
    Cell Significance Index: 6.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0710
    Cell Significance Index: 45.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0708
    Cell Significance Index: 9.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0311
    Cell Significance Index: 47.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0256
    Cell Significance Index: 47.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0228
    Cell Significance Index: 10.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0094
    Cell Significance Index: -8.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0246
    Cell Significance Index: -18.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0323
    Cell Significance Index: -1.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0369
    Cell Significance Index: -27.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0382
    Cell Significance Index: -23.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0631
    Cell Significance Index: -35.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0768
    Cell Significance Index: -2.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0807
    Cell Significance Index: -8.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1127
    Cell Significance Index: -18.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1127
    Cell Significance Index: -7.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1402
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1448
    Cell Significance Index: -30.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1741
    Cell Significance Index: -50.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1784
    Cell Significance Index: -3.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1814
    Cell Significance Index: -26.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1878
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2228
    Cell Significance Index: -25.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2320
    Cell Significance Index: -3.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2350
    Cell Significance Index: -6.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2452
    Cell Significance Index: -4.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2886
    Cell Significance Index: -6.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3222
    Cell Significance Index: -11.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3380
    Cell Significance Index: -39.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3930
    Cell Significance Index: -44.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4254
    Cell Significance Index: -44.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4407
    Cell Significance Index: -7.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5175
    Cell Significance Index: -4.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5724
    Cell Significance Index: -12.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5904
    Cell Significance Index: -17.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5905
    Cell Significance Index: -46.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6804
    Cell Significance Index: -12.5800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7233
    Cell Significance Index: -4.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7560
    Cell Significance Index: -24.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8010
    Cell Significance Index: -49.1100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.8038
    Cell Significance Index: -12.9700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.8145
    Cell Significance Index: -10.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8485
    Cell Significance Index: -17.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8531
    Cell Significance Index: -18.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8717
    Cell Significance Index: -22.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9026
    Cell Significance Index: -13.3300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9549
    Cell Significance Index: -7.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBQL1 is a ubiquitin-like protein that is involved in the regulation of protein degradation and autophagy. It is a member of the ubiquilin family, which consists of proteins that are characterized by their ability to bind to ubiquitin-like proteins. UBQL1 is expressed in multiple cell types, including neurons, epithelial cells, and fibroblasts, and is involved in various cellular processes, including: * Protein degradation: UBQL1 regulates the ubiquitination and degradation of proteins involved in cellular homeostasis. * Autophagy: UBQL1 is involved in the regulation of autophagy, a process by which cells degrade and recycle damaged or dysfunctional proteins and organelles. * Endoplasmic reticulum stress response: UBQL1 regulates the response to endoplasmic reticulum stress, a condition in which the endoplasmic reticulum is subjected to stress due to the accumulation of misfolded proteins. **Pathways and Functions:** UBQL1 is involved in various cellular pathways, including: * Aggrephagy: UBQL1 regulates the degradation of protein aggregates through the autophagy pathway. * Autophagosome assembly: UBQL1 is involved in the regulation of autophagosome assembly, a process by which autophagosomes are formed. * Macroautophagy: UBQL1 regulates the regulation of macroautophagy, a process by which cells degrade and recycle damaged or dysfunctional proteins and organelles. * Clathrin-mediated endocytosis: UBQL1 regulates the regulation of clathrin-mediated endocytosis, a process by which cells internalize proteins and lipids from the extracellular environment. **Clinical Significance:** UBQL1 has been implicated in the pathogenesis of several diseases, including: * Neurodegenerative disorders: UBQL1 has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. * Cancer: UBQL1 has been implicated in the regulation of cancer cell growth and survival. * Metabolic disorders: UBQL1 has been implicated in the regulation of metabolic disorders, including obesity and type 2 diabetes. In conclusion, UBQL1 is a key regulator of cellular homeostasis and disease pathogenesis. Further research is needed to fully understand the mechanisms by which UBQL1 regulates various cellular processes and to identify potential therapeutic targets for the treatment of diseases associated with UBQL1 dysfunction.

Genular Protein ID: 1944070419

Symbol: UBQL1_HUMAN

Name: Ubiquilin-1

UniProtKB Accession Codes:

Q9UMX0 A0A024R284 Q5T6J5 Q5T6J9 Q8IXS9 Q8N2Q3 Q9H0T8 Q9H3R4 Q9HAZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11076969

Title: Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.

PubMed ID: 11076969

DOI: 10.1083/jcb.151.4.847

PubMed ID: 10983987

Title: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.

PubMed ID: 10983987

DOI: 10.1016/s1097-2765(00)00040-x

PubMed ID: 10807547

Title: Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3.

PubMed ID: 10807547

DOI: 10.1007/s100380050209

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11853878

Title: Characterization of ubiquilin 1, an mTOR-interacting protein.

PubMed ID: 11853878

DOI: 10.1016/s0167-4889(01)00164-1

PubMed ID: 12095988

Title: Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death.

PubMed ID: 12095988

DOI: 10.1074/jbc.m203412200

PubMed ID: 15147878

Title: Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.

PubMed ID: 15147878

DOI: 10.1016/j.febslet.2004.04.031

PubMed ID: 16159959

Title: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.

PubMed ID: 16159959

DOI: 10.1242/jcs.02571

PubMed ID: 16813565

Title: Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.

PubMed ID: 16813565

DOI: 10.1042/bj20060441

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18307982

Title: Herp enhances ER-associated protein degradation by recruiting ubiquilins.

PubMed ID: 18307982

DOI: 10.1016/j.bbrc.2008.02.086

PubMed ID: 18199683

Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.

PubMed ID: 18199683

DOI: 10.1091/mbc.e07-08-0775

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19148225

Title: PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.

PubMed ID: 19148225

DOI: 10.1038/embor.2008.238

PubMed ID: 19822669

Title: Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.

PubMed ID: 19822669

DOI: 10.1083/jcb.200903024

PubMed ID: 18953672

Title: Effects of ubiquilin 1 on the unfolded protein response.

PubMed ID: 18953672

DOI: 10.1007/s12031-008-9155-6

PubMed ID: 20729634

Title: Ubiquilin at a crossroads in protein degradation pathways.

PubMed ID: 20729634

DOI: 10.4161/auto.6.7.13118

PubMed ID: 20529957

Title: Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.

PubMed ID: 20529957

DOI: 10.1093/hmg/ddq231

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21966562

Title: Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation.

PubMed ID: 21966562

DOI: 10.4161/cib.4.4.15283

PubMed ID: 21695056

Title: The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling.

PubMed ID: 21695056

DOI: 10.1371/journal.pone.0021153

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21143716

Title: Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.

PubMed ID: 21143716

DOI: 10.1111/j.1600-0854.2010.01149.x

PubMed ID: 22628307

Title: Ubiquilins in the crosstalk among proteolytic pathways.

PubMed ID: 22628307

DOI: 10.1515/hsz-2012-0120

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22233804

Title: Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.

PubMed ID: 22233804

DOI: 10.1073/pnas.1119167109

PubMed ID: 23459205

Title: Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.

PubMed ID: 23459205

DOI: 10.1038/embor.2013.22

PubMed ID: 23600477

Title: Targeting ubiquilin-1 in Alzheimer's disease.

PubMed ID: 23600477

DOI: 10.1517/14728222.2013.791284

PubMed ID: 23979357

Title: The TREX1 C-terminal region controls cellular localization through ubiquitination.

PubMed ID: 23979357

DOI: 10.1074/jbc.m113.503391

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23307288

Title: Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization.

PubMed ID: 23307288

DOI: 10.1007/s10059-013-2268-7

PubMed ID: 24674348

Title: The ubiquilin gene family: evolutionary patterns and functional insights.

PubMed ID: 24674348

DOI: 10.1186/1471-2148-14-63

PubMed ID: 18241885

Title: Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains.

PubMed ID: 18241885

DOI: 10.1016/j.jmb.2007.12.029

Sequence Information:

  • Length: 589
  • Mass: 62519
  • Checksum: 8B4756B6113B7025
  • Sequence:
    • MAESGESGGP PGSQDSAAGA EGAGAPAAAA SAEPKIMKVT VKTPKEKEEF AVPENSSVQQ 
FKEEISKRFK SHTDQLVLIF AGKILKDQDT LSQHGIHDGL TVHLVIKTQN RPQDHSAQQT 
NTAGSNVTTS STPNSNSTSG SATSNPFGLG GLGGLAGLSS LGLNTTNFSE LQSQMQRQLL 
SNPEMMVQIM ENPFVQSMLS NPDLMRQLIM ANPQMQQLIQ RNPEISHMLN NPDIMRQTLE 
LARNPAMMQE MMRNQDRALS NLESIPGGYN ALRRMYTDIQ EPMLSAAQEQ FGGNPFASLV 
SNTSSGEGSQ PSRTENRDPL PNPWAPQTSQ SSSASSGTAS TVGGTTGSTA SGTSGQSTTA 
PNLVPGVGAS MFNTPGMQSL LQQITENPQL MQNMLSAPYM RSMMQSLSQN PDLAAQMMLN 
NPLFAGNPQL QEQMRQQLPT FLQQMQNPDT LSAMSNPRAM QALLQIQQGL QTLATEAPGL 
IPGFTPGLGA LGSTGGSSGT NGSNATPSEN TSPTAGTTEP GHQQFIQQML QALAGVNPQL 
QNPEVRFQQQ LEQLSAMGFL NREANLQALI ATGGDINAAI ERLLGSQPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.