Details for: FSCN3

Gene ID: 29999

Symbol: FSCN3

Ensembl ID: ENSG00000106328

Description: fascin actin-bundling protein 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.6
    Marker Score: 30,402
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.87
    Marker Score: 2,751
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,173
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.2
    Marker Score: 3,457
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 643
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 390
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,312
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1,653
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12,571
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.78
    Marker Score: 1,482
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.71
    Marker Score: 1,471
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,873
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 370
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 459
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 224
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 273
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 152
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 307
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.27
    Marker Score: 394
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.18
    Marker Score: 1,068
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.16
    Marker Score: 371
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 79
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.13
    Marker Score: 72
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 51
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.11
    Marker Score: 105
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.1
    Marker Score: 162
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.09
    Marker Score: 97
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.09
    Marker Score: 812
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 350
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.08
    Marker Score: 95
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.08
    Marker Score: 67
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.08
    Marker Score: 123
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.07
    Marker Score: 710
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 91
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.07
    Marker Score: 4,520
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.07
    Marker Score: 618
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.06
    Marker Score: 119
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.06
    Marker Score: 2,173
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 106
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.06
    Marker Score: 239
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 167
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.05
    Marker Score: 82
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 55

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-bundling protein:** FSCN3 is a member of the fascin family, which is characterized by its ability to bundle actin filaments into thin filaments. 2. **Highly expressed in various cell types:** FSCN3 is expressed in retinal bipolar neurons, retina horizontal cells, colon goblet cells, retinal cone cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells. 3. **Involved in cell polarity and migration:** FSCN3 is essential for the establishment and maintenance of cell polarity, which is critical for cell migration, axon guidance, and tissue development. 4. **Regulates filopodium and lamellipodium formation:** FSCN3 is involved in the formation of filopodia and lamellipodia, structures that are essential for cellular movement and exploration of the extracellular environment. **Pathways and Functions:** 1. **Actin cytoskeleton organization:** FSCN3 regulates the organization of the actin cytoskeleton, which is essential for cell shape, movement, and intracellular transport. 2. **Cell migration:** FSCN3 is involved in the regulation of cell migration, which is critical for development, tissue repair, and immune responses. 3. **Establishment or maintenance of cell polarity:** FSCN3 is essential for the establishment and maintenance of cell polarity, which is critical for cell migration, axon guidance, and tissue development. 4. **Protein-macromolecule adaptor activity:** FSCN3 has been shown to interact with various proteins and molecules, including actin-binding proteins, cytoskeletal regulators, and signaling molecules. **Clinical Significance:** 1. **Cancer:** Dysregulation of FSCN3 has been implicated in various cancers, including colorectal, breast, and lung cancers. 2. **Neurological disorders:** FSCN3 mutations have been associated with neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 3. **Gastrointestinal diseases:** FSCN3 is involved in the regulation of gut motility and secretion, and dysregulation of FSCN3 has been implicated in gastrointestinal diseases, including inflammatory bowel disease and irritable bowel syndrome. 4. **Regenerative medicine:** FSCN3 has been shown to be involved in the regulation of stem cell migration and differentiation, and its dysregulation has been implicated in various regenerative medicine applications, including tissue engineering and wound healing. In conclusion, FSCN3 is a critical component of the actin cytoskeleton, involved in the regulation of cell polarity, migration, and the formation of filopodia and lamellipodia. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and gastrointestinal diseases, highlighting the importance of FSCN3 in human health and disease.

Genular Protein ID: 3361834873

Symbol: FSCN3_HUMAN

Name: Fascin-3

UniProtKB Accession Codes:

Q9NQT6 A4D0Z2 A6NLL7 B2RA62 B4DU68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11925108

Title: Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head.

PubMed ID: 11925108

DOI: 10.1006/excr.2002.5486

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 498
  • Mass: 56624
  • Checksum: FF9A1BE44F7D4354
  • Sequence:
    • MDETEWIHRH PKAEDLRVGL ISWAGTYLTF EACKNTVTAT AKSLGRRQTW EILVSNEHET 
QAVVRLKSVQ GLYLLCECDG TVCYGRPRTS HHGCFLLRFH RNSKWTLQCL ISGRYLESNG 
KDVFCTSHVL SAYHMWTPRP ALHVHVILYS PIHRCYARAD PTMGRIWVDA AVPCLEECGF 
LLHFRDGCYH LETSTHHFLS HVDRLFSQPS SQTAFHMQVR PGGLVALCDG EGGMLYPQGT 
HLLLGMGCNP MRGEEWFILQ HCPTWVSLRS KTGRFISVIY DGEVRAASER LNRMSLFQFE 
CDSESPTVQL RSANGYYLSQ RRHRAVMADG HPLESDTFFR MHWNCGRIIL QSCRGRFLGI 
APNSLLMANV ILPGPNEEFG ILFANRSFLV LRGRYGYVGS SSGHDLIQCN QDQPDRIHLL 
PCRPGIYHFQ AQGGSFWSIT SFGTFRPWGK FALNFCIELQ GSNLLTVLAP NGFYMRADQS 
GTLLADSEDI TRECIWEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.