Details for: FSCN3

Gene ID: 29999

Symbol: FSCN3

Ensembl ID: ENSG00000106328

Description: fascin actin-bundling protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.6727
    Cell Significance Index: -3.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.1036
    Cell Significance Index: -3.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 5.7930
    Cell Significance Index: -2.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.3934
    Cell Significance Index: 5.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1921
    Cell Significance Index: 31.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1846
    Cell Significance Index: 18.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1732
    Cell Significance Index: 10.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1713
    Cell Significance Index: 3.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1568
    Cell Significance Index: 29.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1246
    Cell Significance Index: 1.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0917
    Cell Significance Index: 4.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0831
    Cell Significance Index: 2.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0812
    Cell Significance Index: 4.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0628
    Cell Significance Index: 6.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0543
    Cell Significance Index: 3.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0471
    Cell Significance Index: 1.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0365
    Cell Significance Index: 0.7900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0301
    Cell Significance Index: 0.2600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0295
    Cell Significance Index: 0.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0261
    Cell Significance Index: 1.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0241
    Cell Significance Index: 4.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0171
    Cell Significance Index: 3.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0163
    Cell Significance Index: 0.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0156
    Cell Significance Index: 0.4400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0151
    Cell Significance Index: 0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0135
    Cell Significance Index: 4.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0125
    Cell Significance Index: 0.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0122
    Cell Significance Index: 0.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0113
    Cell Significance Index: 10.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0075
    Cell Significance Index: 0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0062
    Cell Significance Index: 1.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0056
    Cell Significance Index: 0.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0047
    Cell Significance Index: 0.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0046
    Cell Significance Index: 2.0200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0044
    Cell Significance Index: 0.0300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0030
    Cell Significance Index: 0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0028
    Cell Significance Index: -1.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.9500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0030
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0034
    Cell Significance Index: -0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0036
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0058
    Cell Significance Index: -3.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0065
    Cell Significance Index: -2.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0074
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0119
    Cell Significance Index: -2.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0120
    Cell Significance Index: -0.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0125
    Cell Significance Index: -0.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0150
    Cell Significance Index: -1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0151
    Cell Significance Index: -2.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0165
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0183
    Cell Significance Index: -3.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0186
    Cell Significance Index: -1.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0187
    Cell Significance Index: -2.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0241
    Cell Significance Index: -1.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0279
    Cell Significance Index: -1.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0288
    Cell Significance Index: -3.0000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0289
    Cell Significance Index: -0.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0304
    Cell Significance Index: -1.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0327
    Cell Significance Index: -2.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0336
    Cell Significance Index: -3.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0337
    Cell Significance Index: -2.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0377
    Cell Significance Index: -1.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0380
    Cell Significance Index: -1.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0390
    Cell Significance Index: -1.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0400
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0430
    Cell Significance Index: -0.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0440
    Cell Significance Index: -2.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0444
    Cell Significance Index: -1.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0481
    Cell Significance Index: -0.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0497
    Cell Significance Index: -2.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0502
    Cell Significance Index: -0.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0524
    Cell Significance Index: -3.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0541
    Cell Significance Index: -1.0600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0542
    Cell Significance Index: -0.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0570
    Cell Significance Index: -0.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0577
    Cell Significance Index: -0.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0599
    Cell Significance Index: -2.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0618
    Cell Significance Index: -1.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0642
    Cell Significance Index: -0.9200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0648
    Cell Significance Index: -1.0400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0665
    Cell Significance Index: -0.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0708
    Cell Significance Index: -2.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0708
    Cell Significance Index: -2.0200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0713
    Cell Significance Index: -0.9700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0735
    Cell Significance Index: -1.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0737
    Cell Significance Index: -1.2700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0749
    Cell Significance Index: -1.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0763
    Cell Significance Index: -2.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0764
    Cell Significance Index: -2.2500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0797
    Cell Significance Index: -1.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-bundling protein:** FSCN3 is a member of the fascin family, which is characterized by its ability to bundle actin filaments into thin filaments. 2. **Highly expressed in various cell types:** FSCN3 is expressed in retinal bipolar neurons, retina horizontal cells, colon goblet cells, retinal cone cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells. 3. **Involved in cell polarity and migration:** FSCN3 is essential for the establishment and maintenance of cell polarity, which is critical for cell migration, axon guidance, and tissue development. 4. **Regulates filopodium and lamellipodium formation:** FSCN3 is involved in the formation of filopodia and lamellipodia, structures that are essential for cellular movement and exploration of the extracellular environment. **Pathways and Functions:** 1. **Actin cytoskeleton organization:** FSCN3 regulates the organization of the actin cytoskeleton, which is essential for cell shape, movement, and intracellular transport. 2. **Cell migration:** FSCN3 is involved in the regulation of cell migration, which is critical for development, tissue repair, and immune responses. 3. **Establishment or maintenance of cell polarity:** FSCN3 is essential for the establishment and maintenance of cell polarity, which is critical for cell migration, axon guidance, and tissue development. 4. **Protein-macromolecule adaptor activity:** FSCN3 has been shown to interact with various proteins and molecules, including actin-binding proteins, cytoskeletal regulators, and signaling molecules. **Clinical Significance:** 1. **Cancer:** Dysregulation of FSCN3 has been implicated in various cancers, including colorectal, breast, and lung cancers. 2. **Neurological disorders:** FSCN3 mutations have been associated with neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 3. **Gastrointestinal diseases:** FSCN3 is involved in the regulation of gut motility and secretion, and dysregulation of FSCN3 has been implicated in gastrointestinal diseases, including inflammatory bowel disease and irritable bowel syndrome. 4. **Regenerative medicine:** FSCN3 has been shown to be involved in the regulation of stem cell migration and differentiation, and its dysregulation has been implicated in various regenerative medicine applications, including tissue engineering and wound healing. In conclusion, FSCN3 is a critical component of the actin cytoskeleton, involved in the regulation of cell polarity, migration, and the formation of filopodia and lamellipodia. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and gastrointestinal diseases, highlighting the importance of FSCN3 in human health and disease.

Genular Protein ID: 3361834873

Symbol: FSCN3_HUMAN

Name: Fascin-3

UniProtKB Accession Codes:

Q9NQT6 A4D0Z2 A6NLL7 B2RA62 B4DU68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11925108

Title: Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head.

PubMed ID: 11925108

DOI: 10.1006/excr.2002.5486

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 498
  • Mass: 56624
  • Checksum: FF9A1BE44F7D4354
  • Sequence:
    • MDETEWIHRH PKAEDLRVGL ISWAGTYLTF EACKNTVTAT AKSLGRRQTW EILVSNEHET 
QAVVRLKSVQ GLYLLCECDG TVCYGRPRTS HHGCFLLRFH RNSKWTLQCL ISGRYLESNG 
KDVFCTSHVL SAYHMWTPRP ALHVHVILYS PIHRCYARAD PTMGRIWVDA AVPCLEECGF 
LLHFRDGCYH LETSTHHFLS HVDRLFSQPS SQTAFHMQVR PGGLVALCDG EGGMLYPQGT 
HLLLGMGCNP MRGEEWFILQ HCPTWVSLRS KTGRFISVIY DGEVRAASER LNRMSLFQFE 
CDSESPTVQL RSANGYYLSQ RRHRAVMADG HPLESDTFFR MHWNCGRIIL QSCRGRFLGI 
APNSLLMANV ILPGPNEEFG ILFANRSFLV LRGRYGYVGS SSGHDLIQCN QDQPDRIHLL 
PCRPGIYHFQ AQGGSFWSIT SFGTFRPWGK FALNFCIELQ GSNLLTVLAP NGFYMRADQS 
GTLLADSEDI TRECIWEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.