Details for: HADHB

Gene ID: 3032

Symbol: HADHB

Ensembl ID: ENSG00000138029

Description: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 314.1851
    Cell Significance Index: -48.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 177.9073
    Cell Significance Index: -45.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 149.4122
    Cell Significance Index: -61.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.5336
    Cell Significance Index: -62.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 129.7208
    Cell Significance Index: -52.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.8276
    Cell Significance Index: -59.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.8211
    Cell Significance Index: -62.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.7742
    Cell Significance Index: -53.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.3463
    Cell Significance Index: -55.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.1947
    Cell Significance Index: -51.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1772
    Cell Significance Index: -59.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1096
    Cell Significance Index: -30.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.7036
    Cell Significance Index: -42.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.2914
    Cell Significance Index: 88.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.2484
    Cell Significance Index: 79.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.1592
    Cell Significance Index: 242.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4070
    Cell Significance Index: 22.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9324
    Cell Significance Index: 100.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.8668
    Cell Significance Index: 27.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7819
    Cell Significance Index: 47.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7477
    Cell Significance Index: 29.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7344
    Cell Significance Index: 213.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6785
    Cell Significance Index: 302.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5634
    Cell Significance Index: 310.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.5148
    Cell Significance Index: 25.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4653
    Cell Significance Index: 39.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3468
    Cell Significance Index: 35.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3281
    Cell Significance Index: 93.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3124
    Cell Significance Index: 180.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1104
    Cell Significance Index: 490.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0337
    Cell Significance Index: 207.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0118
    Cell Significance Index: 21.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9770
    Cell Significance Index: 45.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9069
    Cell Significance Index: 495.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8788
    Cell Significance Index: 45.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8509
    Cell Significance Index: 63.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8458
    Cell Significance Index: 108.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8264
    Cell Significance Index: 106.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7066
    Cell Significance Index: 45.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6830
    Cell Significance Index: 32.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5805
    Cell Significance Index: 12.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5318
    Cell Significance Index: 18.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4740
    Cell Significance Index: 5.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4701
    Cell Significance Index: 168.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3514
    Cell Significance Index: 10.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3507
    Cell Significance Index: 66.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3430
    Cell Significance Index: 645.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3381
    Cell Significance Index: 9.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3373
    Cell Significance Index: 21.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3243
    Cell Significance Index: 292.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3062
    Cell Significance Index: 36.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2837
    Cell Significance Index: 48.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2571
    Cell Significance Index: 5.9400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.2353
    Cell Significance Index: 2.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2346
    Cell Significance Index: 162.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2188
    Cell Significance Index: 21.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1818
    Cell Significance Index: 8.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1588
    Cell Significance Index: 116.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1155
    Cell Significance Index: 4.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1155
    Cell Significance Index: 1.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0323
    Cell Significance Index: 2.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0143
    Cell Significance Index: 26.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0097
    Cell Significance Index: 14.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0051
    Cell Significance Index: 3.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0044
    Cell Significance Index: 6.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0013
    Cell Significance Index: 0.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0045
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0243
    Cell Significance Index: -18.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0255
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0301
    Cell Significance Index: -22.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0387
    Cell Significance Index: -3.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0729
    Cell Significance Index: -41.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0930
    Cell Significance Index: -2.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1080
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1388
    Cell Significance Index: -29.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1647
    Cell Significance Index: -1.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1684
    Cell Significance Index: -48.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1762
    Cell Significance Index: -25.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1772
    Cell Significance Index: -20.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1870
    Cell Significance Index: -21.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2008
    Cell Significance Index: -5.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2198
    Cell Significance Index: -2.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2277
    Cell Significance Index: -12.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2785
    Cell Significance Index: -8.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2841
    Cell Significance Index: -46.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2961
    Cell Significance Index: -19.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2969
    Cell Significance Index: -8.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3072
    Cell Significance Index: -9.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3181
    Cell Significance Index: -5.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3645
    Cell Significance Index: -5.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3778
    Cell Significance Index: -16.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3964
    Cell Significance Index: -7.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4108
    Cell Significance Index: -42.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4184
    Cell Significance Index: -47.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4845
    Cell Significance Index: -6.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5286
    Cell Significance Index: -20.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6548
    Cell Significance Index: -12.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6629
    Cell Significance Index: -16.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7023
    Cell Significance Index: -43.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HADHB is a mitochondrial protein that belongs to the trifunctional enzyme complex, which is composed of three subunits: alpha, beta, and gamma. The beta subunit is the most studied and is responsible for the hydroxyacyl-CoA dehydrogenase activity. HADHB is a multifunctional enzyme, with the ability to catalyze multiple reactions involved in fatty acid metabolism, including beta-oxidation, acetyl-CoA carboxylase activity, and acyl chain remodeling. **Pathways and Functions:** The primary function of HADHB is to participate in beta-oxidation, a process that involves the sequential removal of two-carbon units from fatty acids, resulting in the production of acetyl-CoA, which can then enter the citric acid cycle for energy production. HADHB is also involved in the regulation of fatty acid metabolism through its interactions with other enzymes, such as carnitine palmitoyltransferase 1 (CPT1) and acetyl-CoA carboxylase (ACC). In addition to beta-oxidation, HADHB has been implicated in other pathways, including: 1. **Acetyl-CoA carboxylase activity**: HADHB can catalyze the carboxylation of acetyl-CoA to malonyl-CoA, a key step in fatty acid synthesis. 2. **Acyl chain remodeling**: HADHB can participate in the remodeling of fatty acid acyl chains, which is essential for the regulation of fatty acid metabolism. 3. **Endoplasmic reticulum**: HADHB has been shown to interact with proteins in the endoplasmic reticulum, suggesting a role in lipid metabolism and cellular signaling. **Clinical Significance:** Alterations in HADHB expression have been implicated in various diseases, including: 1. **Metabolic disorders**: HADHB mutations have been associated with metabolic disorders, such as insulin resistance, type 2 diabetes, and obesity. 2. **Cardiovascular diseases**: HADHB has been implicated in the development of cardiovascular diseases, including atherosclerosis and cardiac arrhythmias. 3. **Cancer**: HADHB has been shown to be overexpressed in certain types of cancer, including breast cancer and colon cancer. In conclusion, HADHB is a critical component of the mitochondrial trifunctional enzyme complex, playing a pivotal role in fatty acid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of HADHB in maintaining energy homeostasis and cellular function. Further research is needed to fully elucidate the mechanisms by which HADHB regulates fatty acid metabolism and to explore its therapeutic potential in treating metabolic and cardiovascular diseases.

Genular Protein ID: 3073439848

Symbol: ECHB_HUMAN

Name: Trifunctional enzyme subunit beta, mitochondrial

UniProtKB Accession Codes:

P55084 B2RB16 B4E2W0 O14969 Q53TA6 Q96C77 Q9H3F5 Q9T2V8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 4 Rhea 14 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8135828

Title: Structural analysis of cDNAs for subunits of human mitochondrial fatty acid beta-oxidation trifunctional protein.

PubMed ID: 8135828

DOI: 10.1006/bbrc.1994.1302

PubMed ID: 9259266

Title: Genomic and mutational analysis of the mitochondrial trifunctional protein beta-subunit (HADHB) gene in patients with trifunctional protein deficiency.

PubMed ID: 9259266

DOI: 10.1093/hmg/6.8.1215

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7958339

Title: The mitochondrial long-chain trifunctional enzyme: 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase and 3-oxoacyl-CoA thiolase.

PubMed ID: 7958339

DOI: 10.1042/bst0220427

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 1550553

Title: Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria.

PubMed ID: 1550553

DOI: 10.1016/0006-291x(92)90501-b

PubMed ID: 8163672

Title: Mitochondrial trifunctional protein deficiency. Catalytic heterogeneity of the mutant enzyme in two patients.

PubMed ID: 8163672

DOI: 10.1172/jci117158

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21527675

Title: Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.

PubMed ID: 21527675

DOI: 10.1126/science.1202007

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29915090

Title: Cryo-EM structure of human mitochondrial trifunctional protein.

PubMed ID: 29915090

DOI: 10.1073/pnas.1801252115

PubMed ID: 32243843

Title: Mitoregulin Controls beta-Oxidation in Human and Mouse Adipocytes.

PubMed ID: 32243843

DOI: 10.1016/j.stemcr.2020.03.002

PubMed ID: 30850536

Title: Crystal structure of human mitochondrial trifunctional protein, a fatty acid beta-oxidation metabolon.

PubMed ID: 30850536

DOI: 10.1073/pnas.1816317116

PubMed ID: 8651282

Title: Molecular characterization of mitochondrial trifunctional protein deficiency: formation of the enzyme complex is important for stabilization of both alpha- and beta-subunits.

PubMed ID: 8651282

PubMed ID: 12754706

Title: Molecular and phenotypic heterogeneity in mitochondrial trifunctional protein deficiency due to beta-subunit mutations.

PubMed ID: 12754706

DOI: 10.1002/humu.10211

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 474
  • Mass: 51294
  • Checksum: A7B41C37BEC1E6AD
  • Sequence:
    • MTILTYPFKN LPTASKWALR FSIRPLSCSS QLRAAPAVQT KTKKTLAKPN IRNVVVVDGV 
RTPFLLSGTS YKDLMPHDLA RAALTGLLHR TSVPKEVVDY IIFGTVIQEV KTSNVAREAA 
LGAGFSDKTP AHTVTMACIS ANQAMTTGVG LIASGQCDVI VAGGVELMSD VPIRHSRKMR 
KLMLDLNKAK SMGQRLSLIS KFRFNFLAPE LPAVSEFSTS ETMGHSADRL AAAFAVSRLE 
QDEYALRSHS LAKKAQDEGL LSDVVPFKVP GKDTVTKDNG IRPSSLEQMA KLKPAFIKPY 
GTVTAANSSF LTDGASAMLI MAEEKALAMG YKPKAYLRDF MYVSQDPKDQ LLLGPTYATP 
KVLEKAGLTM NDIDAFEFHE AFSGQILANF KAMDSDWFAE NYMGRKTKVG LPPLEKFNNW 
GGSLSLGHPF GATGCRLVMA AANRLRKEGG QYGLVAACAA GGQGHAMIVE AYPK

Genular Protein ID: 478404071

Symbol: F5GZQ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GZQ3

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 28 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 14 RuleBase 1 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 459
  • Mass: 49597
  • Checksum: CED0D1A038DD1512
  • Sequence:
    • MTILTYPFKN LPTASKWALR FSIRPLSCSS QLRAAPAVQT KTKKTLAKPN IRNVVVVDGV 
RTPFLLSGTS GLLHRTSVPK EVVDYIIFGT VIQEVKTSNV AREAALGAGF SDKTPAHTVT 
MACISANQAM TTGVGLIASG QCDVIVAGGV ELMSDVPIRH SRKMRKLMLD LNKAKSMGQR 
LSLISKFRFN FLAPELPAVS EFSTSETMGH SADRLAAAFA VSRLEQDEYA LRSHSLAKKA 
QDEGLLSDVV PFKVPGKDTV TKDNGIRPSS LEQMAKLKPA FIKPYGTVTA ANSSFLTDGA 
SAMLIMAEEK ALAMGYKPKA YLRDFMYVSQ DPKDQLLLGP TYATPKVLEK AGLTMNDIDA 
FEFHEAFSGQ ILANFKAMDS DWFAENYMGR KTKVGLPPLE KFNNWGGSLS LGHPFGATGC 
RLVMAAANRL RKEGGQYGLV AACAAGGQGH AMIVEAYPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.