Details for: HDGF

Gene ID: 3068

Symbol: HDGF

Ensembl ID: ENSG00000143321

Description: heparin binding growth factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.9699
    Cell Significance Index: -29.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 163.3593
    Cell Significance Index: -41.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 107.6350
    Cell Significance Index: -44.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.6171
    Cell Significance Index: -48.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.3675
    Cell Significance Index: -39.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.0687
    Cell Significance Index: -46.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.8292
    Cell Significance Index: -48.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.5295
    Cell Significance Index: -39.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.5812
    Cell Significance Index: -43.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.2830
    Cell Significance Index: -43.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.0323
    Cell Significance Index: -47.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3567
    Cell Significance Index: -31.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.4340
    Cell Significance Index: -16.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.3350
    Cell Significance Index: 621.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.8553
    Cell Significance Index: 52.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1059
    Cell Significance Index: 84.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.0472
    Cell Significance Index: 81.5100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.6680
    Cell Significance Index: 17.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.5673
    Cell Significance Index: 279.2400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.4892
    Cell Significance Index: 15.8900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7122
    Cell Significance Index: 27.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7120
    Cell Significance Index: 221.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.5810
    Cell Significance Index: 9.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5611
    Cell Significance Index: 44.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5073
    Cell Significance Index: 185.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5004
    Cell Significance Index: 111.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4940
    Cell Significance Index: 70.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4650
    Cell Significance Index: 800.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3612
    Cell Significance Index: 601.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3249
    Cell Significance Index: 68.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3068
    Cell Significance Index: 37.6500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.2778
    Cell Significance Index: 10.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2766
    Cell Significance Index: 90.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2390
    Cell Significance Index: 11.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1901
    Cell Significance Index: 193.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1597
    Cell Significance Index: 209.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1532
    Cell Significance Index: 158.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1503
    Cell Significance Index: 74.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0323
    Cell Significance Index: 204.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9697
    Cell Significance Index: 33.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8308
    Cell Significance Index: 18.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7982
    Cell Significance Index: 18.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7875
    Cell Significance Index: 35.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7792
    Cell Significance Index: 40.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7428
    Cell Significance Index: 20.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7372
    Cell Significance Index: 34.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6636
    Cell Significance Index: 17.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6561
    Cell Significance Index: 39.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5651
    Cell Significance Index: 6.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4813
    Cell Significance Index: 47.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4408
    Cell Significance Index: 88.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2865
    Cell Significance Index: 33.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2771
    Cell Significance Index: 52.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2645
    Cell Significance Index: 45.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2588
    Cell Significance Index: 92.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2395
    Cell Significance Index: 5.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2349
    Cell Significance Index: 3.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1687
    Cell Significance Index: 8.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1555
    Cell Significance Index: 1.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1272
    Cell Significance Index: 16.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1140
    Cell Significance Index: 2.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1107
    Cell Significance Index: 3.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0842
    Cell Significance Index: 5.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0279
    Cell Significance Index: 21.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0187
    Cell Significance Index: 35.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0182
    Cell Significance Index: 0.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0141
    Cell Significance Index: 10.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0114
    Cell Significance Index: 1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0086
    Cell Significance Index: 15.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0104
    Cell Significance Index: -6.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0194
    Cell Significance Index: -14.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0216
    Cell Significance Index: -29.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0560
    Cell Significance Index: -31.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0656
    Cell Significance Index: -6.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0696
    Cell Significance Index: -1.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0780
    Cell Significance Index: -35.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0804
    Cell Significance Index: -1.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0977
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1001
    Cell Significance Index: -21.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1291
    Cell Significance Index: -37.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1702
    Cell Significance Index: -19.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1910
    Cell Significance Index: -27.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2013
    Cell Significance Index: -3.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2317
    Cell Significance Index: -13.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2473
    Cell Significance Index: -15.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2650
    Cell Significance Index: -7.1000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3199
    Cell Significance Index: -2.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3632
    Cell Significance Index: -27.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3765
    Cell Significance Index: -29.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4164
    Cell Significance Index: -21.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4280
    Cell Significance Index: -28.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4361
    Cell Significance Index: -45.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4426
    Cell Significance Index: -14.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4756
    Cell Significance Index: -8.7900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4982
    Cell Significance Index: -3.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5461
    Cell Significance Index: -13.9500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.5988
    Cell Significance Index: -1.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7072
    Cell Significance Index: -20.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HDGF is a 23-kDa protein with a distinctive heparin-binding domain. This domain is essential for its interaction with heparan sulfate proteoglycans on the cell surface, which enables HDGF to enter the cell and initiate signaling. HDGF has been shown to bind to various extracellular matrix components, including collagen, and to interact with growth factor receptors, such as the insulin-like growth factor-1 receptor. The protein's expression is tightly regulated, with significant fluctuations in response to cellular stress, growth factors, and other signaling molecules. **Pathways and Functions** HDGF is involved in several signaling pathways, including: 1. **Cellular responses to stimuli**: HDGF is activated by various stimuli, such as growth factors, cytokines, and stress signals, which triggers its entry into the cell and subsequent signaling. 2. **Cellular responses to stress**: HDGF plays a crucial role in the unfolded protein response (UPR), a cellular response to endoplasmic reticulum stress. HDGF interacts with chaperone proteins, such as XBP1, to regulate the expression of genes involved in stress response. 3. **Growth factor activity**: HDGF is a growth factor that regulates cell growth, differentiation, and survival. It interacts with growth factor receptors, such as the insulin-like growth factor-1 receptor, to initiate signaling cascades. 4. **Transcriptional regulation**: HDGF regulates gene expression by interacting with transcription factors, such as RNA polymerase II, and by modulating the activity of transcriptional co-repressors. **Clinical Significance** HDGF has been implicated in various diseases, including: 1. **Cancer**: HDGF is overexpressed in several types of cancer, including hepatocellular carcinoma, prostate cancer, and breast cancer. Its overexpression is associated with tumor growth, metastasis, and poor prognosis. 2. **Neurological disorders**: HDGF has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of genes involved in neuronal survival and differentiation. 3. **Regenerative medicine**: HDGF has been shown to promote the proliferation and differentiation of stem cells, making it a potential therapeutic agent for tissue engineering and regenerative medicine. In conclusion, HDGF is a multifunctional protein that plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. Its unique ability to bind heparin and interact with growth factor receptors makes it an important regulator of signaling pathways involved in cellular responses to stimuli, stress, and growth factor activity. Its clinical significance is evident in its involvement in various diseases, including cancer, neurological disorders, and regenerative medicine.

Genular Protein ID: 1511215789

Symbol: HDGF_HUMAN

Name: Hepatoma-derived growth factor

UniProtKB Accession Codes:

P51858 B3KU21 D3DVC9 Q5SZ07 Q5SZ08 Q5SZ09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7929202

Title: Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein.

PubMed ID: 7929202

DOI: 10.1016/s0021-9258(17)31509-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11751870

Title: Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals.

PubMed ID: 11751870

DOI: 10.1074/jbc.m111122200

PubMed ID: 15302935

Title: Large-scale characterization of HeLa cell nuclear phosphoproteins.

PubMed ID: 15302935

DOI: 10.1073/pnas.0404720101

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 17974029

Title: Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain.

PubMed ID: 17974029

DOI: 10.1186/1471-2199-8-101

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 18331345

Title: SUMOylation of the hepatoma-derived growth factor negatively influences its binding to chromatin.

PubMed ID: 18331345

DOI: 10.1111/j.1742-4658.2008.06303.x

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 26845719

Title: Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton.

PubMed ID: 26845719

DOI: 10.1515/hsz-2015-0273

PubMed ID: 27926477

Title: Intra- or extra-exosomal secretion of HDGF isoforms: the extraordinary function of the HDGF-A N-terminal peptide.

PubMed ID: 27926477

DOI: 10.1515/hsz-2016-0315

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17270212

Title: PWWP module of human hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparin.

PubMed ID: 17270212

DOI: 10.1016/j.jmb.2007.01.010

PubMed ID: 15491618

Title: Solution structure and heparin interaction of human hepatoma-derived growth factor.

PubMed ID: 15491618

DOI: 10.1016/j.jmb.2004.09.014

Sequence Information:

  • Length: 240
  • Mass: 26788
  • Checksum: DD60D9203BDD4B34
  • Sequence:
    • MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP 
KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY QSSQKKSCVE EPEPEPEAAE 
GDGDKKGNAE GSSDEEGKLV IDEPAKEKNE KGALKRRAGD LLEDSPKRPK EAENPEGEEK 
EAATLEVERP LPMEVEKNST PSEPGSGRGP PQEEEEEEDE EEEATKEDAE APGIRDHESL

Genular Protein ID: 1728905763

Symbol: B7Z958_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z958

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 215
  • Mass: 23715
  • Checksum: 0BE808C4A36C9503
  • Sequence:
    • MPEAAVKSTA NKYQVFFFGT HETAFLGPKD LFPYEESKEK FGKPNKRKGF SEGLWEIENN 
PTVKASGYQP VLSLLQSSQK KSCVEEPEPE PEAAEGDGDK KGNAEGSSDE EGKLVIDEPA 
KEKNEKGALK RRAGDLLEDS PKRPKEAENP EGEEKEAATL EVERPLPMEV EKNSTPSEPG 
SGRGPPQEEE EEEDEEEEAT KEDAEAPGIR DHESL

Genular Protein ID: 2692646514

Symbol: A8K8G0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8G0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 5 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 208
  • Mass: 22964
  • Checksum: 0C374AC4E016B727
  • Sequence:
    • MPEAAVKSTA NKYQVFFFGT HETAFLGPKD LFPYEESKEK FGKPNKRKGF SEGLWEIENN 
PTVKASGYQS SQKKSCVEEP EPEPEAAEGD GDKKGNAEGS SDEEGKLVID EPAKEKNEKG 
ALKRRAGDLL EDSPKRPKEA ENPEGEEKEA ATLEVERPLP MEVEKNSTPS EPGSGRGPPQ 
EEEEEEDEEE EATKEDAEAP GIRDHESL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.