Details for: HHEX

Gene ID: 3087

Symbol: HHEX

Ensembl ID: ENSG00000152804

Description: hematopoietically expressed homeobox

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Pou5f1 (oct4), sox2, nanog repress genes related to differentiation
    (R-HSA-2892245)
  • Transcriptional regulation of pluripotent stem cells
    (R-HSA-452723)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • B cell differentiation
    (GO:0030183)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding, bending
    (GO:0008301)
  • Dna conformation change
    (GO:0071103)
  • Eukaryotic initiation factor 4e binding
    (GO:0008190)
  • Mrna export from nucleus
    (GO:0006406)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of cyclin-dependent protein serine/threonine kinase activity
    (GO:0045736)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by competitive promoter binding
    (GO:0010944)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transcription by transcription factor localization
    (GO:0010621)
  • Negative regulation of vascular endothelial growth factor receptor signaling pathway
    (GO:0030948)
  • Nuclear body
    (GO:0016604)
  • Nucleus
    (GO:0005634)
  • Poly(a)+ mrna export from nucleus
    (GO:0016973)
  • Positive regulation of canonical wnt signaling pathway
    (GO:0090263)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of wnt signaling pathway
    (GO:0030177)
  • Protein-dna complex
    (GO:0032993)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein localization to nucleus
    (GO:0034504)
  • Regulation of leukocyte proliferation
    (GO:0070663)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Tbp-class protein binding
    (GO:0017025)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Wnt signaling pathway
    (GO:0016055)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 45.3887
    Cell Significance Index: -7.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 21.9931
    Cell Significance Index: -9.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.9627
    Cell Significance Index: -8.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 17.7299
    Cell Significance Index: -9.1200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 8.7691
    Cell Significance Index: 93.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.6515
    Cell Significance Index: -8.2600
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 7.2325
    Cell Significance Index: 5.5200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 6.1743
    Cell Significance Index: 14.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.7342
    Cell Significance Index: -7.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 3.3445
    Cell Significance Index: 85.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.1282
    Cell Significance Index: -8.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0983
    Cell Significance Index: 45.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8880
    Cell Significance Index: -7.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5500
    Cell Significance Index: 80.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4587
    Cell Significance Index: 39.0900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.4318
    Cell Significance Index: 9.1400
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.3417
    Cell Significance Index: 6.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3168
    Cell Significance Index: 14.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0246
    Cell Significance Index: 66.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8779
    Cell Significance Index: 103.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.8313
    Cell Significance Index: 5.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8253
    Cell Significance Index: 157.0600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.8019
    Cell Significance Index: 5.3200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.7004
    Cell Significance Index: 4.1400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.6466
    Cell Significance Index: 2.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6437
    Cell Significance Index: 11.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5979
    Cell Significance Index: 11.0500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.5748
    Cell Significance Index: 2.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5058
    Cell Significance Index: 50.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4753
    Cell Significance Index: 12.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4448
    Cell Significance Index: 401.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3930
    Cell Significance Index: 78.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3469
    Cell Significance Index: 7.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2826
    Cell Significance Index: 4.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2780
    Cell Significance Index: 45.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2760
    Cell Significance Index: 30.0300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1901
    Cell Significance Index: 1.5400
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.1869
    Cell Significance Index: 1.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1846
    Cell Significance Index: 11.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1390
    Cell Significance Index: 9.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1357
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1131
    Cell Significance Index: 19.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0651
    Cell Significance Index: 35.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0455
    Cell Significance Index: 5.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0443
    Cell Significance Index: 2.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0384
    Cell Significance Index: 0.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0342
    Cell Significance Index: 4.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0118
    Cell Significance Index: 2.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0059
    Cell Significance Index: 0.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0019
    Cell Significance Index: -0.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0029
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0103
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0107
    Cell Significance Index: -1.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0173
    Cell Significance Index: -7.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0214
    Cell Significance Index: -7.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0275
    Cell Significance Index: -7.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0290
    Cell Significance Index: -2.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0348
    Cell Significance Index: -4.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0359
    Cell Significance Index: -7.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0365
    Cell Significance Index: -1.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0425
    Cell Significance Index: -5.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0470
    Cell Significance Index: -2.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0515
    Cell Significance Index: -0.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0587
    Cell Significance Index: -8.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0590
    Cell Significance Index: -2.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0593
    Cell Significance Index: -7.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0669
    Cell Significance Index: -6.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0757
    Cell Significance Index: -1.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0800
    Cell Significance Index: -5.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0821
    Cell Significance Index: -3.5700
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.0845
    Cell Significance Index: -0.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0849
    Cell Significance Index: -4.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0860
    Cell Significance Index: -3.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0904
    Cell Significance Index: -6.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1024
    Cell Significance Index: -3.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1138
    Cell Significance Index: -7.1700
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.1194
    Cell Significance Index: -1.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1194
    Cell Significance Index: -8.0300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.1236
    Cell Significance Index: -0.4300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1273
    Cell Significance Index: -1.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1276
    Cell Significance Index: -7.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1327
    Cell Significance Index: -2.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1390
    Cell Significance Index: -6.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1401
    Cell Significance Index: -7.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1447
    Cell Significance Index: -1.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1641
    Cell Significance Index: -2.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1754
    Cell Significance Index: -7.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1970
    Cell Significance Index: -7.2300
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.1970
    Cell Significance Index: -1.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2047
    Cell Significance Index: -7.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2057
    Cell Significance Index: -5.6000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2060
    Cell Significance Index: -2.6100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2095
    Cell Significance Index: -2.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** HHEX acts as a transcription factor, regulating gene expression by binding to specific DNA sequences and modulating the activity of RNA polymerase II. 2. **Cell Differentiation:** HHEX is involved in the regulation of cell differentiation, particularly in hematopoietic cells, where it represses genes related to differentiation and promotes the expression of pluripotent transcription factors. 3. **Hematopoiesis:** HHEX is highly expressed in hematopoietic multipotent progenitor cells and early promyelocytes, suggesting its critical role in the development and maintenance of hematopoietic cells. 4. **Pluripotent Stem Cells:** HHEX is also expressed in pancreatic ductal cells and endothelial cells, highlighting its involvement in the regulation of pluripotent stem cells and tissue development. **Pathways and Functions:** 1. **Wnt Signaling Pathway:** HHEX positively regulates the Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Canonical Wnt Signaling Pathway:** HHEX also positively regulates the canonical Wnt signaling pathway, which is critical for the development and maintenance of various tissues. 3. **Negative Regulation of Angiogenesis:** HHEX negatively regulates angiogenesis, a process essential for tumor growth and metastasis. 4. **Negative Regulation of Cyclin-Dependent Kinase Activity:** HHEX also negatively regulates cyclin-dependent kinase activity, which is involved in cell cycle progression and proliferation. **Clinical Significance:** 1. **Cancer Research:** HHEX's involvement in the regulation of cell proliferation and differentiation makes it a potential target for cancer therapy. 2. **Hematopoietic Disorders:** HHEX's role in hematopoiesis and cell differentiation highlights its potential as a therapeutic target for hematopoietic disorders, such as leukemia and lymphoma. 3. **Developmental Biology:** HHEX's involvement in the regulation of pluripotent stem cells and tissue development underscores its importance in understanding human development and disease. 4. **Immunology:** HHEX's expression in immune cells, such as B cells and T cells, suggests its potential role in regulating immune responses and immune-related diseases. In conclusion, HHEX is a multifaceted transcription factor that plays a critical role in hematopoiesis, developmental biology, and cancer research. Further studies on HHEX's functions and mechanisms will provide valuable insights into its potential as a therapeutic target and its role in human disease.

Genular Protein ID: 3133268984

Symbol: HHEX_HUMAN

Name: Hematopoietically-expressed homeobox protein HHEX

UniProtKB Accession Codes:

Q03014 B1AQ17 Q96CE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1360645

Title: Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells.

PubMed ID: 1360645

DOI: 10.1093/nar/20.21.5661

PubMed ID: 8103988

Title: PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells.

PubMed ID: 8103988

DOI: 10.1006/bbrc.1993.2140

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8096636

Title: HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human.

PubMed ID: 8096636

DOI: 10.1093/nar/21.5.1245

PubMed ID: 12554669

Title: The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.

PubMed ID: 12554669

DOI: 10.1093/emboj/cdg069

PubMed ID: 20028982

Title: Interaction between Hhex and SOX13 modulates Wnt/TCF activity.

PubMed ID: 20028982

DOI: 10.1074/jbc.m109.046649

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 7911091

Title: A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells.

PubMed ID: 7911091

DOI: 10.1016/0014-5793(94)00446-3

Sequence Information:

  • Length: 270
  • Mass: 30022
  • Checksum: 9C16BB6D494475FC
  • Sequence:
    • MQYPHPGPAA GAVGVPLYAP TPLLQPAHPT PFYIEDILGR GPAAPTPAPT LPSPNSSFTS 
LVSPYRTPVY EPTPIHPAFS HHSAAALAAA YGPGGFGGPL YPFPRTVNDY THALLRHDPL 
GKPLLWSPFL QRPLHKRKGG QVRFSNDQTI ELEKKFETQK YLSPPERKRL AKMLQLSERQ 
VKTWFQNRRA KWRRLKQENP QSNKKEELES LDSSCDQRQD LPSEQNKGAS LDSSQCSPSP 
ASQEDLESEI SEDSDQEVDI EGDKSYFNAG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.