Details for: HHEX

Gene ID: 3087

Symbol: HHEX

Ensembl ID: ENSG00000152804

Description: hematopoietically expressed homeobox

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Pou5f1 (oct4), sox2, nanog repress genes related to differentiation
    (R-HSA-2892245)
  • Transcriptional regulation of pluripotent stem cells
    (R-HSA-452723)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • B cell differentiation
    (GO:0030183)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding, bending
    (GO:0008301)
  • Dna conformation change
    (GO:0071103)
  • Eukaryotic initiation factor 4e binding
    (GO:0008190)
  • Mrna export from nucleus
    (GO:0006406)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of cyclin-dependent protein serine/threonine kinase activity
    (GO:0045736)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by competitive promoter binding
    (GO:0010944)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transcription by transcription factor localization
    (GO:0010621)
  • Negative regulation of vascular endothelial growth factor receptor signaling pathway
    (GO:0030948)
  • Nuclear body
    (GO:0016604)
  • Nucleus
    (GO:0005634)
  • Poly(a)+ mrna export from nucleus
    (GO:0016973)
  • Positive regulation of canonical wnt signaling pathway
    (GO:0090263)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of wnt signaling pathway
    (GO:0030177)
  • Protein-dna complex
    (GO:0032993)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein localization to nucleus
    (GO:0034504)
  • Regulation of leukocyte proliferation
    (GO:0070663)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Tbp-class protein binding
    (GO:0017025)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Wnt signaling pathway
    (GO:0016055)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.71
    Marker Score: 2973
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.73
    Marker Score: 844
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.64
    Marker Score: 1708
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.59
    Marker Score: 1248
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.57
    Marker Score: 2258
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.53
    Marker Score: 3063
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.51
    Marker Score: 6179
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.48
    Marker Score: 372
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.46
    Marker Score: 1377
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.43
    Marker Score: 1407
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.41
    Marker Score: 343
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.41
    Marker Score: 2957
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.39
    Marker Score: 767
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.38
    Marker Score: 2816.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.25
    Marker Score: 2367.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.24
    Marker Score: 610
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.19
    Marker Score: 10455
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.16
    Marker Score: 697
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4792
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.14
    Marker Score: 777
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.14
    Marker Score: 827
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.11
    Marker Score: 479
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.1
    Marker Score: 2734
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.1
    Marker Score: 794
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.07
    Marker Score: 374
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.07
    Marker Score: 951
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.98
    Marker Score: 2913
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.98
    Marker Score: 54875
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.98
    Marker Score: 9936
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.98
    Marker Score: 346
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.97
    Marker Score: 224
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.94
    Marker Score: 636.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.94
    Marker Score: 563
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5270
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.92
    Marker Score: 1088
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.91
    Marker Score: 1097
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.91
    Marker Score: 445
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.9
    Marker Score: 568
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.89
    Marker Score: 834
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.85
    Marker Score: 861
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.85
    Marker Score: 2298
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.82
    Marker Score: 264
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.82
    Marker Score: 703
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.8
    Marker Score: 485
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1246
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.76
    Marker Score: 161
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.73
    Marker Score: 1268
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.72
    Marker Score: 294
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.72
    Marker Score: 172
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.7
    Marker Score: 636
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.69
    Marker Score: 302
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.69
    Marker Score: 404
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.68
    Marker Score: 689
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.68
    Marker Score: 212
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10586
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.67
    Marker Score: 157
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 212
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.66
    Marker Score: 345
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.65
    Marker Score: 336
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.65
    Marker Score: 702
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.64
    Marker Score: 157
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.63
    Marker Score: 139
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.63
    Marker Score: 480
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.63
    Marker Score: 312
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.62
    Marker Score: 560
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.61
    Marker Score: 765.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.61
    Marker Score: 403
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.61
    Marker Score: 144
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.6
    Marker Score: 878
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.59
    Marker Score: 1661
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.57
    Marker Score: 160
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.57
    Marker Score: 236
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.56
    Marker Score: 131
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.56
    Marker Score: 644
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.56
    Marker Score: 1094
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.56
    Marker Score: 1352
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.56
    Marker Score: 217
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.56
    Marker Score: 799
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.55
    Marker Score: 796
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.55
    Marker Score: 1389
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.55
    Marker Score: 875
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.54
    Marker Score: 187
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.54
    Marker Score: 3279
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.54
    Marker Score: 580

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Other Information

**Key characteristics:** - HHEX is a transcription factor with a crucial role in hematopoiesis - It is expressed in early promyelocytes, hematopoietic multipotent progenitor cells, pancreatic ductal cells, thyroid follicular cells, respiratory basal cells, endothelial cells of the uterus, pro-T cells, late promyelocytes, type EC enteroendocrine cells, and IgG-negative class switched memory B cells. - It is a key regulator of pluripotent stem cells and plays an essential role in the regulation of their differentiation into various cell types. **Pathways and functions:** - HHEX is a key regulator of hematopoietic stem cell differentiation. - It is involved in the specification of hematopoietic stem cells and the development of various hematopoietic cell types. - HHEX is a key regulator of pluripotent stem cells and plays an essential role in the regulation of their differentiation into various cell types. - It is also involved in the regulation of immune responses and inflammation. **Clinical significance:** - Mutations in HHEX have been linked to several human diseases, including leukemia, lymphoma, and autoimmune disorders. - Understanding the role of HHEX in hematopoiesis could lead to the development of new therapeutic strategies for these diseases.

Genular Protein ID: 3133268984

Symbol: HHEX_HUMAN

Name: Hematopoietically-expressed homeobox protein HHEX

UniProtKB Accession Codes:

Q03014 B1AQ17 Q96CE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1360645

Title: Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells.

PubMed ID: 1360645

DOI: 10.1093/nar/20.21.5661

PubMed ID: 8103988

Title: PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells.

PubMed ID: 8103988

DOI: 10.1006/bbrc.1993.2140

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8096636

Title: HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human.

PubMed ID: 8096636

DOI: 10.1093/nar/21.5.1245

PubMed ID: 12554669

Title: The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.

PubMed ID: 12554669

DOI: 10.1093/emboj/cdg069

PubMed ID: 20028982

Title: Interaction between Hhex and SOX13 modulates Wnt/TCF activity.

PubMed ID: 20028982

DOI: 10.1074/jbc.m109.046649

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 7911091

Title: A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells.

PubMed ID: 7911091

DOI: 10.1016/0014-5793(94)00446-3

Sequence Information:

  • Length: 270
  • Mass: 30022
  • Checksum: 9C16BB6D494475FC
  • Sequence:
    • MQYPHPGPAA GAVGVPLYAP TPLLQPAHPT PFYIEDILGR GPAAPTPAPT LPSPNSSFTS 
LVSPYRTPVY EPTPIHPAFS HHSAAALAAA YGPGGFGGPL YPFPRTVNDY THALLRHDPL 
GKPLLWSPFL QRPLHKRKGG QVRFSNDQTI ELEKKFETQK YLSPPERKRL AKMLQLSERQ 
VKTWFQNRRA KWRRLKQENP QSNKKEELES LDSSCDQRQD LPSEQNKGAS LDSSQCSPSP 
ASQEDLESEI SEDSDQEVDI EGDKSYFNAG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.