Details for: HLA DRA

Gene ID: 3122

Symbol: HLA DRA

Ensembl ID: ENSG00000204287

Description: major histocompatibility complex, class II, DR alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 439.6792
    Cell Significance Index: -68.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 221.2392
    Cell Significance Index: -89.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 189.6600
    Cell Significance Index: -78.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 178.5129
    Cell Significance Index: -84.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 175.5688
    Cell Significance Index: -90.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 125.5696
    Cell Significance Index: -84.2600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 97.0624
    Cell Significance Index: 403.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 94.5071
    Cell Significance Index: -90.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.6250
    Cell Significance Index: -20.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.8033
    Cell Significance Index: -67.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.1920
    Cell Significance Index: -80.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.8640
    Cell Significance Index: -79.4400
  • Cell Name: centroblast (CL0009112)
    Fold Change: 19.4508
    Cell Significance Index: 45.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.1356
    Cell Significance Index: -75.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.4581
    Cell Significance Index: -36.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 14.8664
    Cell Significance Index: 274.7700
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 9.8189
    Cell Significance Index: 43.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.7868
    Cell Significance Index: 172.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.6043
    Cell Significance Index: 1014.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.5895
    Cell Significance Index: 86.2200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 7.4740
    Cell Significance Index: 128.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.7422
    Cell Significance Index: 434.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.6132
    Cell Significance Index: 106.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 4.4459
    Cell Significance Index: 31.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.3719
    Cell Significance Index: 67.6400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 4.1616
    Cell Significance Index: 15.5100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 4.0081
    Cell Significance Index: 26.5900
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 3.0740
    Cell Significance Index: 23.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.0342
    Cell Significance Index: 89.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4885
    Cell Significance Index: 404.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.3889
    Cell Significance Index: 36.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6090
    Cell Significance Index: 24.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.4802
    Cell Significance Index: 39.6000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.2219
    Cell Significance Index: 7.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1592
    Cell Significance Index: 69.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9688
    Cell Significance Index: 105.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9244
    Cell Significance Index: 48.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.8458
    Cell Significance Index: 640.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8435
    Cell Significance Index: 39.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8233
    Cell Significance Index: 20.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5450
    Cell Significance Index: 103.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4617
    Cell Significance Index: 31.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4570
    Cell Significance Index: 56.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3674
    Cell Significance Index: 66.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3116
    Cell Significance Index: 30.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2580
    Cell Significance Index: 114.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2484
    Cell Significance Index: 135.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2297
    Cell Significance Index: 23.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1874
    Cell Significance Index: 37.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1809
    Cell Significance Index: 23.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1335
    Cell Significance Index: 120.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0959
    Cell Significance Index: 12.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0309
    Cell Significance Index: 0.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0043
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0353
    Cell Significance Index: -22.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0373
    Cell Significance Index: -70.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0566
    Cell Significance Index: -104.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0662
    Cell Significance Index: -101.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0747
    Cell Significance Index: -55.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0769
    Cell Significance Index: -104.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0784
    Cell Significance Index: -44.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0964
    Cell Significance Index: -70.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1282
    Cell Significance Index: -81.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1772
    Cell Significance Index: -8.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1805
    Cell Significance Index: -8.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1860
    Cell Significance Index: -84.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2084
    Cell Significance Index: -74.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2482
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2490
    Cell Significance Index: -42.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2916
    Cell Significance Index: -83.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3020
    Cell Significance Index: -12.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3059
    Cell Significance Index: -64.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3918
    Cell Significance Index: -44.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3944
    Cell Significance Index: -79.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4308
    Cell Significance Index: -59.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5076
    Cell Significance Index: -59.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5612
    Cell Significance Index: -81.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6215
    Cell Significance Index: -19.9100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.6254
    Cell Significance Index: -6.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6494
    Cell Significance Index: -74.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7212
    Cell Significance Index: -75.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8009
    Cell Significance Index: -59.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8057
    Cell Significance Index: -49.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8955
    Cell Significance Index: -46.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.9234
    Cell Significance Index: -65.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0518
    Cell Significance Index: -80.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1033
    Cell Significance Index: -87.3800
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -1.1296
    Cell Significance Index: -6.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3946
    Cell Significance Index: -87.9000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -1.4390
    Cell Significance Index: -17.8000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.4395
    Cell Significance Index: -20.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4889
    Cell Significance Index: -83.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.5559
    Cell Significance Index: -81.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6410
    Cell Significance Index: -60.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.6839
    Cell Significance Index: -47.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.7948
    Cell Significance Index: -83.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8059
    Cell Significance Index: -79.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.0545
    Cell Significance Index: -77.8000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -2.0791
    Cell Significance Index: -40.6500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -2.1147
    Cell Significance Index: -17.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Molecular structure:** The HLA DRA gene encodes for the alpha subunit of the HLA-DR protein complex, which is composed of two chains: the alpha chain (DRα) and the beta chain (DRβ). The DRα chain is responsible for the binding of antigens to the MHC class II molecule. 2. **Antigen presentation:** HLA DRA is involved in the presentation of antigens to CD4+ T-cells, a type of immune cell that plays a crucial role in the adaptive immune response. The HLA-DR protein complex is formed by the association of the DRα and DRβ chains, and it is responsible for the presentation of antigens to CD4+ T-cells. 3. **Cellular expression:** HLA DRA is significantly expressed in various cell types, including professional APCs such as dendritic cells, B cells, and monocytes. It is also expressed in other cell types, such as thymocytes, germinal center B cells, and alveolar capillary type 1 endothelial cells. 4. **Function:** HLA DRA plays a critical role in the activation of CD4+ T-cells, which is essential for the proper functioning of the adaptive immune response. **Pathways and Functions:** The HLA DRA gene is involved in various signaling pathways, including: 1. **Adaptive immune response:** HLA DRA is involved in the activation of CD4+ T-cells, which is essential for the proper functioning of the adaptive immune response. 2. **Antigen processing and presentation:** HLA DRA is involved in the presentation of antigens to CD4+ T-cells, which is essential for the activation of immune responses. 3. **Cytokine signaling:** HLA DRA is involved in the signaling pathways that regulate the production of cytokines, such as IL-2 and IFN-γ, which are essential for the activation of immune responses. 4. **T-cell activation:** HLA DRA is involved in the activation of CD4+ T-cells, which is essential for the proper functioning of the adaptive immune response. **Clinical Significance:** Alterations in the expression of HLA DRA have been implicated in various autoimmune and inflammatory diseases, including: 1. **Rheumatoid arthritis:** HLA DRA has been associated with an increased risk of developing rheumatoid arthritis. 2. **Multiple sclerosis:** HLA DRA has been associated with an increased risk of developing multiple sclerosis. 3. **Type 1 diabetes:** HLA DRA has been associated with an increased risk of developing type 1 diabetes. 4. **Autoimmune diseases:** HLA DRA has been implicated in the pathogenesis of various autoimmune diseases, including lupus, scleroderma, and psoriasis. In conclusion, the HLA DRA gene plays a critical role in the presentation of antigens to CD4+ T-cells, which is essential for the proper functioning of the adaptive immune response. Alterations in its expression have been implicated in various autoimmune and inflammatory diseases, highlighting the importance of HLA DRA in the regulation of immune responses.

Genular Protein ID: 3240599561

Symbol: DRA_HUMAN

Name: HLA class II histocompatibility antigen, DR alpha chain

UniProtKB Accession Codes:

P01903 A2BET4 Q30160 Q6IAZ1 Q861I2 Q9TP70

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 18 EMDB 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6811954

Title: Sequence of an HLA-DR alpha-chain cDNA clone and intron-exon organization of the corresponding gene.

PubMed ID: 6811954

DOI: 10.1038/299750a0

PubMed ID: 6416803

Title: Cloning the heavy chain of human HLA-DR antigen using synthetic oligodeoxyribonucleotides as hybridization probes.

PubMed ID: 6416803

DOI: 10.1089/dna.1983.2.175

PubMed ID: 2212658

Title: Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain.

PubMed ID: 2212658

PubMed ID: 6324094

Title: Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain.

PubMed ID: 6324094

DOI: 10.1093/nar/11.24.8663

PubMed ID: 6304715

Title: Structure and nucleotide sequence of the heavy chain gene of HLA-DR.

PubMed ID: 6304715

DOI: 10.1073/pnas.80.12.3543

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 6812963

Title: Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.

PubMed ID: 6812963

DOI: 10.1016/0092-8674(82)90021-6

PubMed ID: 6821129

Title: The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins.

PubMed ID: 6821129

DOI: 10.1073/pnas.79.19.6013

PubMed ID: 12445311

Title: The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes.

PubMed ID: 12445311

DOI: 10.1034/j.1399-0039.2002.600310.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6955253

Title: Primary structure of class II human histocompatibility antigens. 2nd Communication. Amino acid sequence of the N-terminal 179 residues of the alpha-chain of an HLA-Dw2/DR2 alloantigen.

PubMed ID: 6955253

PubMed ID: 6600932

Title: N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens.

PubMed ID: 6600932

DOI: 10.1021/bi00270a027

PubMed ID: 2658055

Title: Class II MHC molecules are specific receptors for staphylococcus enterotoxin A.

PubMed ID: 2658055

DOI: 10.1126/science.2658055

PubMed ID: 2210803

Title: Targeting of human cytotoxic T lymphocytes to MHC class II-expressing cells by staphylococcal enterotoxins.

PubMed ID: 2210803

PubMed ID: 7479981

Title: Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1.

PubMed ID: 7479981

DOI: 10.1073/pnas.92.24.11289

PubMed ID: 9075930

Title: HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

PubMed ID: 9075930

DOI: 10.1016/s1074-7613(00)80332-5

PubMed ID: 11070170

Title: Determination of the HLA-DM interaction site on HLA-DR molecules.

PubMed ID: 11070170

DOI: 10.1016/s1074-7613(00)00051-0

PubMed ID: 15265931

Title: Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.

PubMed ID: 15265931

DOI: 10.4049/jimmunol.173.3.1966

PubMed ID: 15322540

Title: Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.

PubMed ID: 15322540

DOI: 10.1038/ni1108

PubMed ID: 17182262

Title: Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

PubMed ID: 17182262

DOI: 10.1016/j.immuni.2006.10.018

PubMed ID: 18305173

Title: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

PubMed ID: 18305173

DOI: 10.1073/pnas.0708874105

PubMed ID: 19117940

Title: The HLA-DRalpha chain is modified by polyubiquitination.

PubMed ID: 19117940

DOI: 10.1074/jbc.m805736200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22327072

Title: Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire.

PubMed ID: 22327072

DOI: 10.4049/jimmunol.1102190

PubMed ID: 23783831

Title: Exploring the MHC-peptide matrix of central tolerance in the human thymus.

PubMed ID: 23783831

DOI: 10.1038/ncomms3039

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25413013

Title: Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

PubMed ID: 25413013

DOI: 10.1038/ncomms6369

PubMed ID: 27591323

Title: Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans.

PubMed ID: 27591323

DOI: 10.4049/jimmunol.1600663

PubMed ID: 27114505

Title: Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

PubMed ID: 27114505

DOI: 10.1073/pnas.1513918113

PubMed ID: 31495665

Title: Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction.

PubMed ID: 31495665

DOI: 10.1016/j.immuni.2019.08.012

PubMed ID: 8316295

Title: Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

PubMed ID: 8316295

DOI: 10.1038/364033a0

PubMed ID: 8145819

Title: Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.

PubMed ID: 8145819

DOI: 10.1038/368215a0

PubMed ID: 8152483

Title: Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.

PubMed ID: 8152483

DOI: 10.1038/368711a0

PubMed ID: 7477400

Title: The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.

PubMed ID: 7477400

DOI: 10.1038/378457a0

PubMed ID: 9354468

Title: X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II.

PubMed ID: 9354468

DOI: 10.1016/s1074-7613(00)80369-6

PubMed ID: 9782128

Title: Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.

PubMed ID: 9782128

DOI: 10.1084/jem.188.8.1511

PubMed ID: 11080454

Title: Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.

PubMed ID: 11080454

DOI: 10.1006/jmbi.2000.4198

PubMed ID: 11432818

Title: Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence.

PubMed ID: 11432818

DOI: 10.1093/emboj/20.13.3306

PubMed ID: 11163233

Title: Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.

PubMed ID: 11163233

DOI: 10.1016/s1074-7613(01)00092-9

PubMed ID: 11864610

Title: Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.

PubMed ID: 11864610

DOI: 10.1016/s1097-2765(02)00465-3

PubMed ID: 12244309

Title: A functional and structural basis for TCR cross-reactivity in multiple sclerosis.

PubMed ID: 12244309

DOI: 10.1038/ni835

PubMed ID: 16079912

Title: Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.

PubMed ID: 16079912

DOI: 10.1038/sj.emboj.7600771

PubMed ID: 17583734

Title: Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity.

PubMed ID: 17583734

DOI: 10.1016/j.jmb.2007.05.025

PubMed ID: 17334368

Title: Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor.

PubMed ID: 17334368

DOI: 10.1038/ni1447

PubMed ID: 18697946

Title: The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles.

PubMed ID: 18697946

DOI: 10.1073/pnas.0805810105

PubMed ID: 21081917

Title: The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.

PubMed ID: 21081917

DOI: 10.1038/ncomms1117

PubMed ID: 21115828

Title: Bidirectional binding of invariant chain peptides to an MHC class II molecule.

PubMed ID: 21115828

DOI: 10.1073/pnas.1014708107

PubMed ID: 23260142

Title: Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.

PubMed ID: 23260142

DOI: 10.1016/j.cell.2012.11.025

PubMed ID: 24190431

Title: A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.

PubMed ID: 24190431

DOI: 10.1084/jem.20131241

PubMed ID: 29317506

Title: The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.

PubMed ID: 29317506

DOI: 10.1074/jbc.ra117.001013

PubMed ID: 29884618

Title: CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers.

PubMed ID: 29884618

DOI: 10.1126/sciimmunol.aat0687

PubMed ID: 31619516

Title: Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.

PubMed ID: 31619516

DOI: 10.1074/jbc.ra119.009437

PubMed ID: 32668259

Title: CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features.

PubMed ID: 32668259

DOI: 10.1016/j.celrep.2020.107885

Sequence Information:

  • Length: 254
  • Mass: 28621
  • Checksum: 3CD1CDBA89D92350
  • Sequence:
    • MAISGVPVLG FFIIAVLMSA QESWAIKEEH VIIQAEFYLN PDQSGEFMFD FDGDEIFHVD 
MAKKETVWRL EEFGRFASFE AQGALANIAV DKANLEIMTK RSNYTPITNV PPEVTVLTNS 
PVELREPNVL ICFIDKFTPP VVNVTWLRNG KPVTTGVSET VFLPREDHLF RKFHYLPFLP 
STEDVYDCRV EHWGLDEPLL KHWEFDAPSP LPETTENVVC ALGLTVGLVG IIIGTIFIIK 
GLRKSNAAER RGPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.