Details for: HLA DRA

Gene ID: 3122

Symbol: HLA DRA

Ensembl ID: ENSG00000204287

Description: major histocompatibility complex, class II, DR alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 20.8
    Marker Score: 21777
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.89
    Marker Score: 12347
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.54
    Marker Score: 3909
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.78
    Marker Score: 2901
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.66
    Marker Score: 3727
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.49
    Marker Score: 11408
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.49
    Marker Score: 2315
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.32
    Marker Score: 2628
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.19
    Marker Score: 4124
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.03
    Marker Score: 5839
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.02
    Marker Score: 225079
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.99
    Marker Score: 4565
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.94
    Marker Score: 20693
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.93
    Marker Score: 4744
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.93
    Marker Score: 3507
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.81
    Marker Score: 24865
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.59
    Marker Score: 14923
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.57
    Marker Score: 6947
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.51
    Marker Score: 4138
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.34
    Marker Score: 2871
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 3.3
    Marker Score: 8553
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.29
    Marker Score: 1622
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.28
    Marker Score: 9738
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.23
    Marker Score: 750
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.2
    Marker Score: 1928
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.18
    Marker Score: 31484.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.08
    Marker Score: 2893
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 3.08
    Marker Score: 5362
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.05
    Marker Score: 1319
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.05
    Marker Score: 1079
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 3.05
    Marker Score: 78047
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.05
    Marker Score: 35409
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.03
    Marker Score: 4863
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.01
    Marker Score: 7269
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.98
    Marker Score: 30157
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.85
    Marker Score: 1668
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.83
    Marker Score: 2145
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.81
    Marker Score: 2038
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.78
    Marker Score: 16911
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.77
    Marker Score: 5540
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.74
    Marker Score: 804
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.68
    Marker Score: 4134
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.68
    Marker Score: 10977
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.65
    Marker Score: 1754.5
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.59
    Marker Score: 1079
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.5
    Marker Score: 1222
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.48
    Marker Score: 33323
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.43
    Marker Score: 4113
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.41
    Marker Score: 20914
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.38
    Marker Score: 6464.5
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.35
    Marker Score: 560
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.35
    Marker Score: 2545
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.32
    Marker Score: 902
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.31
    Marker Score: 668
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.31
    Marker Score: 6368
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.3
    Marker Score: 631
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.28
    Marker Score: 5182
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.26
    Marker Score: 521
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.24
    Marker Score: 2239
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.24
    Marker Score: 809
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.23
    Marker Score: 5565
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.23
    Marker Score: 1540
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.23
    Marker Score: 776
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.22
    Marker Score: 1104
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.21
    Marker Score: 1270
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.15
    Marker Score: 4091.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.15
    Marker Score: 620
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.11
    Marker Score: 536
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.06
    Marker Score: 13160
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.05
    Marker Score: 1853
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.05
    Marker Score: 694
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.05
    Marker Score: 5162
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 2.04
    Marker Score: 619
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.02
    Marker Score: 429
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.01
    Marker Score: 1061
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.99
    Marker Score: 508
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.97
    Marker Score: 3229
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.96
    Marker Score: 1306
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.94
    Marker Score: 678
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.93
    Marker Score: 1637
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.93
    Marker Score: 9241
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.91
    Marker Score: 942
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.91
    Marker Score: 890
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.88
    Marker Score: 602
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.87
    Marker Score: 702
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.84
    Marker Score: 1253
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.83
    Marker Score: 1865
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.82
    Marker Score: 1215
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.82
    Marker Score: 1621
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.8
    Marker Score: 4722
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.8
    Marker Score: 451
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.79
    Marker Score: 617
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.75
    Marker Score: 1199
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.74
    Marker Score: 721
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.71
    Marker Score: 1630
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.7
    Marker Score: 475
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.69
    Marker Score: 1881
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.68
    Marker Score: 403
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.67
    Marker Score: 6201
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.66
    Marker Score: 5882

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Other Information

**Key characteristics:** * The DR alpha chain is a glycoprotein that is expressed in the cytoplasm of antigen-presenting cells. * It is a key component of the MHC class II complex and is responsible for the recognition of MHC class II molecules by T cells. * It is expressed in a variety of cell types, including thymocytes, CD38-negative naive B cells, CD14-low monocytes, myeloid dendritic cells, early promyelocytes, alveolar capillary type 1 endothelial cells, professional antigen presenting cells, germinal center B cells, and IgG-negative class switched memory B cells. **Pathways and functions:** * The DR alpha chain is expressed on the surface of antigen-presenting cells. * It is a key component of the MHC class II complex and is responsible for the recognition of MHC class II molecules by T cells. * When an antigen is presented on an MHC class II molecule by an antigen-presenting cell, the DR alpha chain binds to the MHC class II molecule and triggers the subsequent activation of T cells. * This activation leads to the proliferation and differentiation of T cells and the production of cytotoxic molecules that can kill infected cells or tumor cells. **Clinical significance:** * Mutations in the DR alpha gene have been linked to several autoimmune disorders, including systemic sclerosis, rheumatoid arthritis, and asthma. * In these disorders, the DR alpha chain is expressed on the surface of immune cells, and it is not able to bind to MHC class II molecules. This leads to the inability of T cells to be activated and to develop autoimmune diseases. * Therefore, DR alpha is a promising target for the treatment of autoimmune disorders.

Genular Protein ID: 3240599561

Symbol: DRA_HUMAN

Name: HLA class II histocompatibility antigen, DR alpha chain

UniProtKB Accession Codes:

P01903 A2BET4 Q30160 Q6IAZ1 Q861I2 Q9TP70

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 18 EPD 1 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6811954

Title: Sequence of an HLA-DR alpha-chain cDNA clone and intron-exon organization of the corresponding gene.

PubMed ID: 6811954

DOI: 10.1038/299750a0

PubMed ID: 6416803

Title: Cloning the heavy chain of human HLA-DR antigen using synthetic oligodeoxyribonucleotides as hybridization probes.

PubMed ID: 6416803

DOI: 10.1089/dna.1983.2.175

PubMed ID: 2212658

Title: Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain.

PubMed ID: 2212658

PubMed ID: 6324094

Title: Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain.

PubMed ID: 6324094

DOI: 10.1093/nar/11.24.8663

PubMed ID: 6304715

Title: Structure and nucleotide sequence of the heavy chain gene of HLA-DR.

PubMed ID: 6304715

DOI: 10.1073/pnas.80.12.3543

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 6812963

Title: Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.

PubMed ID: 6812963

DOI: 10.1016/0092-8674(82)90021-6

PubMed ID: 6821129

Title: The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins.

PubMed ID: 6821129

DOI: 10.1073/pnas.79.19.6013

PubMed ID: 12445311

Title: The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes.

PubMed ID: 12445311

DOI: 10.1034/j.1399-0039.2002.600310.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6955253

Title: Primary structure of class II human histocompatibility antigens. 2nd Communication. Amino acid sequence of the N-terminal 179 residues of the alpha-chain of an HLA-Dw2/DR2 alloantigen.

PubMed ID: 6955253

PubMed ID: 6600932

Title: N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens.

PubMed ID: 6600932

DOI: 10.1021/bi00270a027

PubMed ID: 2658055

Title: Class II MHC molecules are specific receptors for staphylococcus enterotoxin A.

PubMed ID: 2658055

DOI: 10.1126/science.2658055

PubMed ID: 2210803

Title: Targeting of human cytotoxic T lymphocytes to MHC class II-expressing cells by staphylococcal enterotoxins.

PubMed ID: 2210803

PubMed ID: 7479981

Title: Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1.

PubMed ID: 7479981

DOI: 10.1073/pnas.92.24.11289

PubMed ID: 9075930

Title: HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

PubMed ID: 9075930

DOI: 10.1016/s1074-7613(00)80332-5

PubMed ID: 11070170

Title: Determination of the HLA-DM interaction site on HLA-DR molecules.

PubMed ID: 11070170

DOI: 10.1016/s1074-7613(00)00051-0

PubMed ID: 15265931

Title: Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.

PubMed ID: 15265931

DOI: 10.4049/jimmunol.173.3.1966

PubMed ID: 15322540

Title: Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.

PubMed ID: 15322540

DOI: 10.1038/ni1108

PubMed ID: 17182262

Title: Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

PubMed ID: 17182262

DOI: 10.1016/j.immuni.2006.10.018

PubMed ID: 18305173

Title: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

PubMed ID: 18305173

DOI: 10.1073/pnas.0708874105

PubMed ID: 19117940

Title: The HLA-DRalpha chain is modified by polyubiquitination.

PubMed ID: 19117940

DOI: 10.1074/jbc.m805736200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22327072

Title: Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire.

PubMed ID: 22327072

DOI: 10.4049/jimmunol.1102190

PubMed ID: 23783831

Title: Exploring the MHC-peptide matrix of central tolerance in the human thymus.

PubMed ID: 23783831

DOI: 10.1038/ncomms3039

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25413013

Title: Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

PubMed ID: 25413013

DOI: 10.1038/ncomms6369

PubMed ID: 27591323

Title: Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans.

PubMed ID: 27591323

DOI: 10.4049/jimmunol.1600663

PubMed ID: 27114505

Title: Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

PubMed ID: 27114505

DOI: 10.1073/pnas.1513918113

PubMed ID: 31495665

Title: Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction.

PubMed ID: 31495665

DOI: 10.1016/j.immuni.2019.08.012

PubMed ID: 8316295

Title: Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

PubMed ID: 8316295

DOI: 10.1038/364033a0

PubMed ID: 8145819

Title: Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.

PubMed ID: 8145819

DOI: 10.1038/368215a0

PubMed ID: 8152483

Title: Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.

PubMed ID: 8152483

DOI: 10.1038/368711a0

PubMed ID: 7477400

Title: The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.

PubMed ID: 7477400

DOI: 10.1038/378457a0

PubMed ID: 9354468

Title: X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II.

PubMed ID: 9354468

DOI: 10.1016/s1074-7613(00)80369-6

PubMed ID: 9782128

Title: Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.

PubMed ID: 9782128

DOI: 10.1084/jem.188.8.1511

PubMed ID: 11080454

Title: Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.

PubMed ID: 11080454

DOI: 10.1006/jmbi.2000.4198

PubMed ID: 11432818

Title: Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence.

PubMed ID: 11432818

DOI: 10.1093/emboj/20.13.3306

PubMed ID: 11163233

Title: Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.

PubMed ID: 11163233

DOI: 10.1016/s1074-7613(01)00092-9

PubMed ID: 11864610

Title: Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.

PubMed ID: 11864610

DOI: 10.1016/s1097-2765(02)00465-3

PubMed ID: 12244309

Title: A functional and structural basis for TCR cross-reactivity in multiple sclerosis.

PubMed ID: 12244309

DOI: 10.1038/ni835

PubMed ID: 16079912

Title: Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.

PubMed ID: 16079912

DOI: 10.1038/sj.emboj.7600771

PubMed ID: 17583734

Title: Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity.

PubMed ID: 17583734

DOI: 10.1016/j.jmb.2007.05.025

PubMed ID: 17334368

Title: Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor.

PubMed ID: 17334368

DOI: 10.1038/ni1447

PubMed ID: 18697946

Title: The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles.

PubMed ID: 18697946

DOI: 10.1073/pnas.0805810105

PubMed ID: 21081917

Title: The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.

PubMed ID: 21081917

DOI: 10.1038/ncomms1117

PubMed ID: 21115828

Title: Bidirectional binding of invariant chain peptides to an MHC class II molecule.

PubMed ID: 21115828

DOI: 10.1073/pnas.1014708107

PubMed ID: 23260142

Title: Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.

PubMed ID: 23260142

DOI: 10.1016/j.cell.2012.11.025

PubMed ID: 24190431

Title: A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.

PubMed ID: 24190431

DOI: 10.1084/jem.20131241

PubMed ID: 29317506

Title: The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.

PubMed ID: 29317506

DOI: 10.1074/jbc.ra117.001013

PubMed ID: 29884618

Title: CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers.

PubMed ID: 29884618

DOI: 10.1126/sciimmunol.aat0687

PubMed ID: 31619516

Title: Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.

PubMed ID: 31619516

DOI: 10.1074/jbc.ra119.009437

PubMed ID: 32668259

Title: CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features.

PubMed ID: 32668259

DOI: 10.1016/j.celrep.2020.107885

Sequence Information:

  • Length: 254
  • Mass: 28621
  • Checksum: 3CD1CDBA89D92350
  • Sequence:
    • MAISGVPVLG FFIIAVLMSA QESWAIKEEH VIIQAEFYLN PDQSGEFMFD FDGDEIFHVD 
MAKKETVWRL EEFGRFASFE AQGALANIAV DKANLEIMTK RSNYTPITNV PPEVTVLTNS 
PVELREPNVL ICFIDKFTPP VVNVTWLRNG KPVTTGVSET VFLPREDHLF RKFHYLPFLP 
STEDVYDCRV EHWGLDEPLL KHWEFDAPSP LPETTENVVC ALGLTVGLVG IIIGTIFIIK 
GLRKSNAAER RGPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.