Gene HES1 - ENSG00000114315 | NCBI Gene ID: 3280

Details for: HES1

Gene ID: 3280

Symbol: HES1

Ensembl ID: ENSG00000114315

Description: hes family bHLH transcription factor 1

Associated with

Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Notch2 intracellular domain regulates transcription
(R-HSA-2197563)
Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Notch4 intracellular domain regulates transcription
(R-HSA-9013695)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
(R-HSA-210744)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates bone development
(R-HSA-8941326)
Runx2 regulates osteoblast differentiation
(R-HSA-8940973)
Runx3 regulates notch signaling
(R-HSA-8941856)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Adenohypophysis development
(GO:0021984)
Amacrine cell differentiation
(GO:0035881)
Anterior/posterior pattern specification
(GO:0009952)
Ascending aorta morphogenesis
(GO:0035910)
Bmp signaling pathway
(GO:0030509)
Cajal-retzius cell differentiation
(GO:0021870)
Cell adhesion
(GO:0007155)
Cell fate determination
(GO:0001709)
Cell maturation
(GO:0048469)
Cell migration
(GO:0016477)
Chromatin binding
(GO:0003682)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Embryonic heart tube morphogenesis
(GO:0003143)
Forebrain radial glial cell differentiation
(GO:0021861)
Hindbrain morphogenesis
(GO:0021575)
Histone deacetylase binding
(GO:0042826)
Hlh domain binding
(GO:0043398)
Inner ear auditory receptor cell differentiation
(GO:0042491)
Jun kinase binding
(GO:0008432)
Lateral inhibition
(GO:0046331)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Midbrain-hindbrain boundary morphogenesis
(GO:0021555)
Midbrain development
(GO:0030901)
N-box binding
(GO:0071820)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of inner ear auditory receptor cell differentiation
(GO:0045608)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Notch signaling pathway
(GO:0007219)
Oculomotor nerve development
(GO:0021557)
Outflow tract morphogenesis
(GO:0003151)
Pancreatic a cell differentiation
(GO:0003310)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mitotic cell cycle, embryonic
(GO:0045977)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of protein-containing complex assembly
(GO:0043254)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Regulation of secondary heart field cardioblast proliferation
(GO:0003266)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to alkaloid
(GO:0043279)
Response to organic cyclic compound
(GO:0014070)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Smoothened signaling pathway
(GO:0007224)
Somatic stem cell population maintenance
(GO:0035019)
T cell proliferation
(GO:0042098)
Telencephalon development
(GO:0021537)
Transcription corepressor binding
(GO:0001222)
Trochlear nerve development
(GO:0021558)
Ventricular septum development
(GO:0003281)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 4.04
Marker Score: 7909
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.23
Marker Score: 3906
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 3.21
Marker Score: 2227
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.14
Marker Score: 6280
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.71
Marker Score: 92343
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.65
Marker Score: 3672
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.64
Marker Score: 10179
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.61
Marker Score: 3508
Cell Name: theca cell (CL0000503)
Fold Change: 2.54
Marker Score: 1817
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.51
Marker Score: 4252.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.5
Marker Score: 3857
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.5
Marker Score: 19504
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.45
Marker Score: 777
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.39
Marker Score: 556
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.26
Marker Score: 2946
Cell Name: supporting cell (CL0000630)
Fold Change: 2.24
Marker Score: 4215
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.23
Marker Score: 19187
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.21
Marker Score: 14088
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.2
Marker Score: 28989
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.17
Marker Score: 9038
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.16
Marker Score: 1915
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.09
Marker Score: 72457
Cell Name: secretory cell (CL0000151)
Fold Change: 2.08
Marker Score: 3804
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.08
Marker Score: 3067
Cell Name: stem cell (CL0000034)
Fold Change: 2.07
Marker Score: 4914
Cell Name: enterocyte (CL0000584)
Fold Change: 2.04
Marker Score: 9811
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.04
Marker Score: 2177
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 2.01
Marker Score: 7793
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.98
Marker Score: 1978
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.97
Marker Score: 2074.5
Cell Name: club cell (CL0000158)
Fold Change: 1.93
Marker Score: 2259
Cell Name: kidney cell (CL1000497)
Fold Change: 1.93
Marker Score: 1287
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.92
Marker Score: 2053
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.89
Marker Score: 1627.5
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.88
Marker Score: 1770
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.87
Marker Score: 1032
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.86
Marker Score: 684
Cell Name: basal cell (CL0000646)
Fold Change: 1.85
Marker Score: 2392
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.84
Marker Score: 4177
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.82
Marker Score: 4599
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.82
Marker Score: 399
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.81
Marker Score: 686
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.81
Marker Score: 2627
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.81
Marker Score: 1702
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.79
Marker Score: 431
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.78
Marker Score: 513
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.78
Marker Score: 1399
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.76
Marker Score: 866
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.73
Marker Score: 4225.5
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.72
Marker Score: 338
Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.72
Marker Score: 738
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.71
Marker Score: 5375
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.71
Marker Score: 1773
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.7
Marker Score: 996
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.69
Marker Score: 985
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.67
Marker Score: 391
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.66
Marker Score: 485
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.64
Marker Score: 4177
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.64
Marker Score: 1418
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.62
Marker Score: 2341
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.59
Marker Score: 1422
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.59
Marker Score: 3327
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.59
Marker Score: 1712
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.57
Marker Score: 8248
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.53
Marker Score: 2106
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.53
Marker Score: 379
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.49
Marker Score: 1338
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.48
Marker Score: 1488
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 1.48
Marker Score: 375
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.46
Marker Score: 2768.5
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166784
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.45
Marker Score: 1601
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.45
Marker Score: 2462.5
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.45
Marker Score: 967
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.44
Marker Score: 674
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.42
Marker Score: 969
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.41
Marker Score: 530.5
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.41
Marker Score: 584
Cell Name: pericyte (CL0000669)
Fold Change: 1.39
Marker Score: 811
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.38
Marker Score: 1324
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.38
Marker Score: 2127
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.38
Marker Score: 868
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.37
Marker Score: 394
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.37
Marker Score: 1071
Cell Name: muscle cell (CL0000187)
Fold Change: 1.37
Marker Score: 387
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 1.37
Marker Score: 361
Cell Name: keratocyte (CL0002363)
Fold Change: 1.36
Marker Score: 313
Cell Name: reticular cell (CL0000432)
Fold Change: 1.34
Marker Score: 489
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.32
Marker Score: 791
Cell Name: peptic cell (CL0000155)
Fold Change: 1.31
Marker Score: 549
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.3
Marker Score: 2304
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.3
Marker Score: 3482
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.29
Marker Score: 11243
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.29
Marker Score: 3381
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.29
Marker Score: 1825
Cell Name: fibroblast (CL0000057)
Fold Change: 1.25
Marker Score: 1208
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.25
Marker Score: 19500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.24
Marker Score: 641
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.24
Marker Score: 2834
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.22
Marker Score: 1106

Hover over a box to see details here...

**Key characteristics:** * The protein is a bHLH transcription factor. * It is a key regulator of beta-cell development. * It is also involved in the regulation of gene expression in late-stage (branching morphogenesis) pancreatic bud precursor cells. * It is a key regulator of Notch signaling. **Pathways and functions:** * Hes1 is a key regulator of Notch1 and Notch2 signaling pathways. * It is also involved in the regulation of beta-cell development. * It is involved in the regulation of gene expression in late-stage (branching morphogenesis) pancreatic bud precursor cells. * It is a key regulator of Notch1 signaling in cancer. **Clinical significance:** * Mutations in the HES1 gene have been linked to a number of human cancers. * Targeting the HES1 gene has been shown to be a promising strategy for the treatment of cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor HES-1

Genular Protein ID: 1144877213

Symbol: HES1_HUMAN

Name: Transcription factor HES-1

UniProtKB Accession Codes:

Q14469 Q6FHB2

Database IDs:

Citations:

PubMed ID: 8020957

Title: Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy.

PubMed ID: 8020957

DOI: 10.1006/geno.1994.1126

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12535671

Title: Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression.

PubMed ID: 12535671

DOI: 10.1016/s0006-291x(02)03020-6

PubMed ID: 18550849

Title: HES1 is a novel interactor of the Fanconi anemia core complex.

PubMed ID: 18550849

DOI: 10.1182/blood-2008-04-152710

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28750047

Title: Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase.

PubMed ID: 28750047

DOI: 10.1371/journal.ppat.1006542

Sequence Information:

Length: 280
Mass: 29541
Checksum: F9342A88FC749E3C
Sequence:

MPADIMEKNS SSPVAATPAS VNTTPDKPKT ASEHRKSSKP IMEKRRRARI NESLSQLKTL 
ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRAQMTAAL STDPSVLGKY RAGFSECMNE 
VTRFLSTCEG VNTEVRTRLL GHLANCMTQI NAMTYPGQPH PALQAPPPPP PGPGGPQHAP 
FAPPPPLVPI PGGAAPPPGG APCKLGSQAG EAAKVFGGFQ VVPAPDGQFA FLIPNGAFAH 
SGPVIPVYTS NSGTSVGPNA VSPSSGPSLT ADSMWRPWRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HES1

Associated with

Cells (max top 100)

Other Information

Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. PubMed ID: 8020957

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. PubMed ID: 12535671

HES1 is a novel interactor of the Fanconi anemia core complex. PubMed ID: 18550849

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase. PubMed ID: 28750047