HES1 | ENSG00000114315 | NCBI 3280

Details for: HES1

Gene ID: 3280

Symbol: HES1

Ensembl ID: ENSG00000114315

Description: hes family bHLH transcription factor 1

Associated with

Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Notch2 intracellular domain regulates transcription
(R-HSA-2197563)
Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Notch4 intracellular domain regulates transcription
(R-HSA-9013695)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
(R-HSA-210744)
Rna polymerase ii transcription
(R-HSA-73857)
Runx2 regulates bone development
(R-HSA-8941326)
Runx2 regulates osteoblast differentiation
(R-HSA-8940973)
Runx3 regulates notch signaling
(R-HSA-8941856)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Adenohypophysis development
(GO:0021984)
Amacrine cell differentiation
(GO:0035881)
Anterior/posterior pattern specification
(GO:0009952)
Ascending aorta morphogenesis
(GO:0035910)
Bmp signaling pathway
(GO:0030509)
Cajal-retzius cell differentiation
(GO:0021870)
Cell adhesion
(GO:0007155)
Cell fate determination
(GO:0001709)
Cell migration
(GO:0016477)
Chromatin binding
(GO:0003682)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Embryonic heart tube morphogenesis
(GO:0003143)
Forebrain radial glial cell differentiation
(GO:0021861)
Hindbrain morphogenesis
(GO:0021575)
Histone deacetylase binding
(GO:0042826)
Hlh domain binding
(GO:0043398)
Inner ear auditory receptor cell differentiation
(GO:0042491)
Jun kinase binding
(GO:0008432)
Lateral inhibition
(GO:0046331)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Midbrain-hindbrain boundary morphogenesis
(GO:0021555)
Midbrain development
(GO:0030901)
N-box binding
(GO:0071820)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of inner ear auditory receptor cell differentiation
(GO:0045608)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Notch signaling pathway
(GO:0007219)
Oculomotor nerve development
(GO:0021557)
Outflow tract morphogenesis
(GO:0003151)
Pancreatic a cell differentiation
(GO:0003310)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mitotic cell cycle, embryonic
(GO:0045977)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of protein-containing complex assembly
(GO:0043254)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Regulation of secondary heart field cardioblast proliferation
(GO:0003266)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to alkaloid
(GO:0043279)
Response to organic cyclic compound
(GO:0014070)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Smoothened signaling pathway
(GO:0007224)
Somatic stem cell population maintenance
(GO:0035019)
T cell proliferation
(GO:0042098)
Telencephalon development
(GO:0021537)
Transcription corepressor binding
(GO:0001222)
Trochlear nerve development
(GO:0021558)
Ventricular septum development
(GO:0003281)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 448.2941
Cell Significance Index: -69.7300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 275.5443
Cell Significance Index: -69.8900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 176.2360
Cell Significance Index: -72.6000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 146.2967
Cell Significance Index: -69.0700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 127.3170
Cell Significance Index: -65.4900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 102.7537
Cell Significance Index: -68.9500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 56.5714
Cell Significance Index: -69.7500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 26.2649
Cell Significance Index: -70.3600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.6430
Cell Significance Index: -69.6200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.1450
Cell Significance Index: -52.6600
Cell Name: theca cell (CL0000503)
Fold Change: 10.8766
Cell Significance Index: 63.9000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 9.7865
Cell Significance Index: 172.9400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 8.4946
Cell Significance Index: 295.1900
Cell Name: kidney cell (CL1000497)
Fold Change: 8.0496
Cell Significance Index: 64.2700
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 6.6090
Cell Significance Index: 60.8600
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 5.2670
Cell Significance Index: 19.6300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.9746
Cell Significance Index: 896.7600
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 4.9192
Cell Significance Index: 30.3500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.7650
Cell Significance Index: 129.7000
Cell Name: odontoblast (CL0000060)
Fold Change: 4.5989
Cell Significance Index: 589.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 4.4466
Cell Significance Index: 331.4000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.4171
Cell Significance Index: 543.1200
Cell Name: epidermal cell (CL0000362)
Fold Change: 3.9699
Cell Significance Index: 8.9500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.9368
Cell Significance Index: 112.8500
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 3.8380
Cell Significance Index: 23.6200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 3.7731
Cell Significance Index: 196.0000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 3.5851
Cell Significance Index: 53.7200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.3284
Cell Significance Index: 150.8700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.3355
Cell Significance Index: 25.3900
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.1093
Cell Significance Index: 1151.9500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.0798
Cell Significance Index: 147.0900
Cell Name: lactocyte (CL0002325)
Fold Change: 1.8481
Cell Significance Index: 238.7700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.5050
Cell Significance Index: 84.4500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.4796
Cell Significance Index: 30.9700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.4790
Cell Significance Index: 653.9200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.4067
Cell Significance Index: 1270.1500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.3338
Cell Significance Index: 131.9500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.2568
Cell Significance Index: 59.0700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1675
Cell Significance Index: 70.0900
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.0287
Cell Significance Index: 27.0500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.9625
Cell Significance Index: 109.8700
Cell Name: glioblast (CL0000030)
Fold Change: 0.9443
Cell Significance Index: 5.9300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.7037
Cell Significance Index: 17.5900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6713
Cell Significance Index: 18.7600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6634
Cell Significance Index: 30.9300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.5879
Cell Significance Index: 905.1100
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.5588
Cell Significance Index: 4.9600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.5292
Cell Significance Index: 16.9500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.4965
Cell Significance Index: 5.6400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4777
Cell Significance Index: 90.9100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4306
Cell Significance Index: 70.0400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3725
Cell Significance Index: 236.5800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3449
Cell Significance Index: 68.4500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3125
Cell Significance Index: 10.9800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2988
Cell Significance Index: 551.0300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1519
Cell Significance Index: 16.5300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1102
Cell Significance Index: 149.7900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0824
Cell Significance Index: 5.6900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0660
Cell Significance Index: 1.1100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0615
Cell Significance Index: 115.7500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0526
Cell Significance Index: 7.2300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0201
Cell Significance Index: 3.4400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0149
Cell Significance Index: 10.9200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0146
Cell Significance Index: 0.3900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0051
Cell Significance Index: 3.7900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0047
Cell Significance Index: -3.5700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0323
Cell Significance Index: -20.2000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0770
Cell Significance Index: -43.4300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1265
Cell Significance Index: -57.4200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1407
Cell Significance Index: -0.8500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1492
Cell Significance Index: -31.4200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1571
Cell Significance Index: -22.8300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1642
Cell Significance Index: -2.2400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1678
Cell Significance Index: -17.1400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1967
Cell Significance Index: -70.5400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2102
Cell Significance Index: -60.4800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2112
Cell Significance Index: -24.2000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2555
Cell Significance Index: -51.2600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3292
Cell Significance Index: -38.3700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3374
Cell Significance Index: -7.3100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.5483
Cell Significance Index: -64.6600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5833
Cell Significance Index: -46.2000
Cell Name: Mueller cell (CL0000636)
Fold Change: -0.6525
Cell Significance Index: -5.0200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6640
Cell Significance Index: -69.1400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6692
Cell Significance Index: -51.3600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.7070
Cell Significance Index: -20.3700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7615
Cell Significance Index: -46.6900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8700
Cell Significance Index: -45.6800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.9034
Cell Significance Index: -55.5300
Cell Name: peg cell (CL4033014)
Fold Change: -0.9739
Cell Significance Index: -22.5000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.0170
Cell Significance Index: -65.6100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0306
Cell Significance Index: -64.9600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.0651
Cell Significance Index: -71.6200
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.0679
Cell Significance Index: -8.9700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -1.1141
Cell Significance Index: -15.8600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.2899
Cell Significance Index: -47.3500
Cell Name: keratinocyte (CL0000312)
Fold Change: -1.2984
Cell Significance Index: -32.4300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.3122
Cell Significance Index: -38.6500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.3271
Cell Significance Index: -27.5300
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.3504
Cell Significance Index: -32.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Notch signaling pathway**: HES1 is a key downstream effector of Notch signaling, which is a highly conserved signaling system that regulates cell fate decisions during development and tissue homeostasis. 2. **Transcription factor**: HES1 is a transcription factor that regulates gene expression by binding to specific DNA sequences, known as E-boxes. 3. **Cell differentiation**: HES1 is involved in the regulation of cell differentiation, particularly in the development of the nervous system, heart, and other tissues. 4. **Proliferation and migration**: HES1 also regulates cell proliferation and migration, which are critical processes during development and tissue repair. 5. **Tissue-specific expression**: HES1 is expressed in various tissues, including the nervous system, heart, and mammary gland, suggesting its importance in different developmental processes. **Pathways and Functions** 1. **Notch signaling pathway**: HES1 is a key downstream effector of Notch signaling, which is involved in cell fate decisions during development and tissue homeostasis. 2. **Cell differentiation**: HES1 regulates cell differentiation in various tissues, including the nervous system, heart, and mammary gland. 3. **Proliferation and migration**: HES1 regulates cell proliferation and migration, which are critical processes during development and tissue repair. 4. **Transcriptional regulation**: HES1 regulates gene expression by binding to specific DNA sequences, known as E-boxes. 5. **Signaling by Notch**: HES1 is involved in signaling by Notch, which is a highly conserved signaling system that regulates cell fate decisions during development and tissue homeostasis. **Clinical Significance** 1. **Cancer**: HES1 is overexpressed in various types of cancer, including breast cancer, leukemia, and lymphoma, suggesting its role in tumorigenesis. 2. **Neurological disorders**: HES1 is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 3. **Heart development**: HES1 is involved in the regulation of heart development, and its dysregulation has been implicated in congenital heart defects. 4. **Mammary gland development**: HES1 is involved in the regulation of mammary gland development, and its dysregulation has been implicated in breast cancer. 5. **Regulation of beta-cell development**: HES1 regulates beta-cell development in the pancreas, and its dysregulation has been implicated in diabetes. In conclusion, HES1 is a transcription factor that plays a crucial role in various developmental processes, including cell differentiation, proliferation, and migration. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and congenital heart defects. Further research is needed to fully understand the mechanisms of HES1 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor HES-1

Genular Protein ID: 1144877213

Symbol: HES1_HUMAN

Name: Transcription factor HES-1

UniProtKB Accession Codes:

Q14469 Q6FHB2

Database IDs:

Citations:

PubMed ID: 8020957

Title: Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy.

PubMed ID: 8020957

DOI: 10.1006/geno.1994.1126

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12535671

Title: Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression.

PubMed ID: 12535671

DOI: 10.1016/s0006-291x(02)03020-6

PubMed ID: 18550849

Title: HES1 is a novel interactor of the Fanconi anemia core complex.

PubMed ID: 18550849

DOI: 10.1182/blood-2008-04-152710

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28750047

Title: Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase.

PubMed ID: 28750047

DOI: 10.1371/journal.ppat.1006542

Sequence Information:

Length: 280
Mass: 29541
Checksum: F9342A88FC749E3C
Sequence:

MPADIMEKNS SSPVAATPAS VNTTPDKPKT ASEHRKSSKP IMEKRRRARI NESLSQLKTL 
ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRAQMTAAL STDPSVLGKY RAGFSECMNE 
VTRFLSTCEG VNTEVRTRLL GHLANCMTQI NAMTYPGQPH PALQAPPPPP PGPGGPQHAP 
FAPPPPLVPI PGGAAPPPGG APCKLGSQAG EAAKVFGGFQ VVPAPDGQFA FLIPNGAFAH 
SGPVIPVYTS NSGTSVGPNA VSPSSGPSLT ADSMWRPWRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HES1

Associated with

Cells (max top 100)

Other Information

Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy. PubMed ID: 8020957

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. PubMed ID: 12535671

HES1 is a novel interactor of the Fanconi anemia core complex. PubMed ID: 18550849

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase. PubMed ID: 28750047