HSPA8 | ENSG00000109971 | NCBI 3312

Details for: HSPA8

Gene ID: 3312

Symbol: HSPA8

Ensembl ID: ENSG00000109971

Description: heat shock protein family A (Hsp70) member 8

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Attenuation phase
(R-HSA-3371568)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Chaperone mediated autophagy
(R-HSA-9613829)
Chl1 interactions
(R-HSA-447041)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Gaba synthesis, release, reuptake and degradation
(R-HSA-888590)
Golgi associated vesicle biogenesis
(R-HSA-432722)
Hsf1-dependent transactivation
(R-HSA-3371571)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon signaling
(R-HSA-913531)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
L1cam interactions
(R-HSA-373760)
Late endosomal microautophagy
(R-HSA-9615710)
Lipophagy
(R-HSA-9613354)
Lysosome vesicle biogenesis
(R-HSA-432720)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter release cycle
(R-HSA-112310)
Neutrophil degranulation
(R-HSA-6798695)
Pkr-mediated signaling
(R-HSA-9833482)
Post-translational protein modification
(R-HSA-597592)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Protein methylation
(R-HSA-8876725)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Respiratory syncytial virus (rsv) genome replication, transcription and translation
(R-HSA-9820965)
Respiratory syncytial virus genome transcription
(R-HSA-9828642)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Selective autophagy
(R-HSA-9663891)
Signaling by interleukins
(R-HSA-449147)
Trans-golgi network vesicle budding
(R-HSA-199992)
Transmission across chemical synapses
(R-HSA-112315)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
A1 adenosine receptor binding
(GO:0031686)
Adp binding
(GO:0043531)
Atp-dependent protein disaggregase activity
(GO:0140545)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
C3hc4-type ring finger domain binding
(GO:0055131)
Cadherin binding
(GO:0045296)
Cellular response to starvation
(GO:0009267)
Cerebellum development
(GO:0021549)
Clathrin-uncoating atpase activity
(GO:1990833)
Enzyme binding
(GO:0019899)
Forebrain development
(GO:0030900)
G1/s transition of mitotic cell cycle
(GO:0000082)
G protein-coupled receptor binding
(GO:0001664)
Heat shock protein binding
(GO:0031072)
Kidney development
(GO:0001822)
Mhc class ii protein complex binding
(GO:0023026)
Mrna splicing, via spliceosome
(GO:0000398)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Peptide binding
(GO:0042277)
Phosphatidylserine binding
(GO:0001786)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Prostaglandin binding
(GO:1904593)
Protein-folding chaperone binding
(GO:0051087)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein carrier chaperone
(GO:0140597)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein import into nucleus
(GO:0006606)
Receptor ligand activity
(GO:0048018)
Regulation of protein stability
(GO:0031647)
Response to activity
(GO:0014823)
Response to estradiol
(GO:0032355)
Response to nickel cation
(GO:0010045)
Response to progesterone
(GO:0032570)
Response to unfolded protein
(GO:0006986)
Response to xenobiotic stimulus
(GO:0009410)
Rna binding
(GO:0003723)
Signal transduction
(GO:0007165)
Skeletal muscle tissue development
(GO:0007519)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: odontoblast (CL0000060)
Fold Change: 1.37
Cell Significance Index: 1
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.32
Cell Significance Index: 2
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.29
Cell Significance Index: 1
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.27
Cell Significance Index: 1
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.22
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.21
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.17
Cell Significance Index: 1
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.15
Cell Significance Index: 2
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.14
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: lactocyte (CL0002325)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: activated type II NK T cell (CL0000931)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: theca cell (CL0000503)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.96
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Molecular Chaperone Function**: HSPA8 acts as a molecular chaperone, facilitating the correct folding and unfolding of proteins, and promoting their stability and degradation. 2. **Heat Shock Protein Family**: HSPA8 belongs to the Hsp70 family, which is characterized by their ability to bind and release heat-shocked proteins, and their involvement in protein folding and degradation. 3. **Wide Expression Pattern**: HSPA8 is expressed in various cell types, including immune cells, thyroid follicular cells, and fibroblasts, indicating its importance in maintaining cellular homeostasis. 4. **Antiviral Mechanism**: HSPA8 has been implicated in the antiviral response, particularly in the context of viral infections such as respiratory syncytial virus (RSV). **Pathways and Functions** 1. **Autophagy**: HSPA8 is involved in the regulation of autophagy, a process by which cells degrade and recycle damaged or dysfunctional proteins and organelles. 2. **Chaperone-Mediated Autophagy**: HSPA8 plays a critical role in the regulation of chaperone-mediated autophagy, a process by which proteins are degraded by autophagosomes. 3. **Protein Folding and Degradation**: HSPA8 facilitates the correct folding and unfolding of proteins, and promotes their stability and degradation. 4. **Immune Response**: HSPA8 is involved in the regulation of immune responses, particularly in the context of viral infections and immune cell function. 5. **Stress Response**: HSPA8 is activated in response to stress, such as heat shock, and plays a critical role in maintaining protein homeostasis during this process. **Clinical Significance** 1. **Cancer**: HSPA8 has been implicated in cancer, particularly in the context of tumor progression and metastasis. 2. **Autoimmune Diseases**: HSPA8 has been implicated in autoimmune diseases, such as multiple sclerosis, where it is thought to play a role in the regulation of immune responses. 3. **Neurological Disorders**: HSPA8 has been implicated in neurological disorders, such as Alzheimer's disease, where it is thought to play a role in the regulation of protein homeostasis. 4. **Viral Infections**: HSPA8 has been implicated in the regulation of antiviral responses, particularly in the context of viral infections such as RSV. In conclusion, HSPA8 is a critical gene involved in maintaining protein homeostasis, and plays a significant role in the regulation of autophagy, immune responses, and stress responses. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully understand the functions and clinical significance of HSPA8.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.