Gene FOXN2 - ENSG00000170802 | NCBI Gene ID: 3344

Details for: FOXN2

Gene ID: 3344

Symbol: FOXN2

Ensembl ID: ENSG00000170802

Description: forkhead box N2

Associated with

Chromatin
(GO:0000785)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Intracellular membrane-bounded organelle
(GO:0043231)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle cell differentiation
(GO:0035914)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.03
Marker Score: 4848
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.71
Marker Score: 1001
Cell Name: germ cell (CL0000586)
Fold Change: 1.6
Marker Score: 2795
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.59
Marker Score: 13923
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.47
Marker Score: 1819
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.43
Marker Score: 30604
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.27
Marker Score: 6639
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.25
Marker Score: 2742
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.24
Marker Score: 401
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.19
Marker Score: 2419
Cell Name: blood cell (CL0000081)
Fold Change: 1.18
Marker Score: 13763
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.16
Marker Score: 698
Cell Name: fat cell (CL0000136)
Fold Change: 1.16
Marker Score: 647
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.15
Marker Score: 17983
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 1.13
Marker Score: 403.5
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.08
Marker Score: 523
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.07
Marker Score: 1328.5
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.05
Marker Score: 2605
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 1.04
Marker Score: 1032.5
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.03
Marker Score: 1098.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71668
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47892
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.99
Marker Score: 945.5
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.99
Marker Score: 362
Cell Name: contractile cell (CL0000183)
Fold Change: 0.98
Marker Score: 532
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30386
Cell Name: Unknown (CL0000548)
Fold Change: 0.98
Marker Score: 713
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.97
Marker Score: 660
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.96
Marker Score: 301
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.96
Marker Score: 976
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.96
Marker Score: 53581.5
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.95
Marker Score: 333
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.95
Marker Score: 473
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2394
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.93
Marker Score: 1796
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 479
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.92
Marker Score: 9522.5
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 435
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.92
Marker Score: 548
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.91
Marker Score: 18076
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2700
Cell Name: astrocyte (CL0000127)
Fold Change: 0.9
Marker Score: 778
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.89
Marker Score: 1029
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.89
Marker Score: 1739
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.89
Marker Score: 1445
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.89
Marker Score: 321
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.88
Marker Score: 2157
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5294
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.87
Marker Score: 22327
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.87
Marker Score: 5592
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.86
Marker Score: 1044
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.86
Marker Score: 989
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.86
Marker Score: 273
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.86
Marker Score: 1808
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.85
Marker Score: 1999
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.85
Marker Score: 32182
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.84
Marker Score: 608
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.84
Marker Score: 4786
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.84
Marker Score: 657
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.83
Marker Score: 7152
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.83
Marker Score: 574
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.83
Marker Score: 4983
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.82
Marker Score: 392
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.82
Marker Score: 3163
Cell Name: neuron (CL0000540)
Fold Change: 0.81
Marker Score: 3318
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.81
Marker Score: 765
Cell Name: melanocyte (CL0000148)
Fold Change: 0.81
Marker Score: 329
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.81
Marker Score: 743
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 322
Cell Name: erythroblast (CL0000765)
Fold Change: 0.8
Marker Score: 499.5
Cell Name: podocyte (CL0000653)
Fold Change: 0.8
Marker Score: 294
Cell Name: plasmablast (CL0000980)
Fold Change: 0.79
Marker Score: 1052
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.79
Marker Score: 1137
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 603
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.79
Marker Score: 1213.5
Cell Name: myelocyte (CL0002193)
Fold Change: 0.78
Marker Score: 338
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.78
Marker Score: 1150
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.78
Marker Score: 1528
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.78
Marker Score: 777
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.77
Marker Score: 634.5
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.77
Marker Score: 3325
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.77
Marker Score: 574.5
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.77
Marker Score: 3174
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.76
Marker Score: 242
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.76
Marker Score: 2948
Cell Name: neural cell (CL0002319)
Fold Change: 0.76
Marker Score: 367
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.76
Marker Score: 1104
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.76
Marker Score: 631
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.75
Marker Score: 909
Cell Name: granulocyte (CL0000094)
Fold Change: 0.75
Marker Score: 337
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.75
Marker Score: 4027
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.75
Marker Score: 323
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.75
Marker Score: 167
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.75
Marker Score: 3201
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.74
Marker Score: 718
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3106.5
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.74
Marker Score: 505
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.73
Marker Score: 159
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.73
Marker Score: 641

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**Key characteristics:** * FOXN2 is a basic transcription factor that is expressed in a variety of cell types. * It is a key regulator of the development of the central nervous system. * It is involved in a variety of cellular processes, including cell differentiation, proliferation, and survival. * FOXN2 is a target for a number of human diseases, including autism, schizophrenia, and cancer. **Pathways and functions:** * FOXN2 is a key regulator of the development of the central nervous system. It is expressed in oligodendrocytes, which are a type of nerve cell that is responsible for the development of the brain and spinal cord. FOXN2 is also expressed in a variety of other cell types, including neurons, astrocytes, and oligodendrocyte precursor cells. * FOXN2 is involved in a variety of cellular processes, including cell differentiation, proliferation, and survival. * It is a key regulator of the development of the immune system. * FOXN2 is a target for a number of human diseases, including autism, schizophrenia, and cancer. **Clinical significance:** FOXN2 is a promising target for the treatment of a variety of human diseases. By understanding the role of FOXN2 in development and disease, researchers can develop new treatments that could improve the lives of millions of people with these conditions. **Additional information:** * FOXN2 is a member of the forkhead box (FOXO) family of transcription factors. * It is a highly conserved protein that is found in mammals and birds. * FOXN2 is a well-studied protein that has been extensively characterized in both vertebrates and invertebrates.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Forkhead box protein N2

Genular Protein ID: 1654936308

Symbol: FOXN2_HUMAN

Name: Forkhead box protein N2

UniProtKB Accession Codes:

P32314 Q15769 Q6P4Q2

Database IDs:

Citations:

PubMed ID: 1639393

Title: Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF.

PubMed ID: 1639393

DOI: 10.1016/0888-7543(92)90138-i

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 431
Mass: 47161
Checksum: 5F71D3C0E4BA1797
Sequence:

MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN 
WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL 
IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV 
NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA 
AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE 
DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD 
PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST 
AKTQNQKQRK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.