Details for: FOXN2

Gene ID: 3344

Symbol: FOXN2

Ensembl ID: ENSG00000170802

Description: forkhead box N2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 201.9991
    Cell Significance Index: -31.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.1363
    Cell Significance Index: -31.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 78.5294
    Cell Significance Index: -32.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.6941
    Cell Significance Index: -28.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.2320
    Cell Significance Index: -33.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.4061
    Cell Significance Index: -29.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.7487
    Cell Significance Index: -32.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9939
    Cell Significance Index: -32.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9241
    Cell Significance Index: -27.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4566
    Cell Significance Index: -33.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9046
    Cell Significance Index: -17.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0237
    Cell Significance Index: 113.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8511
    Cell Significance Index: 96.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.8097
    Cell Significance Index: 31.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6414
    Cell Significance Index: 325.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1187
    Cell Significance Index: 181.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0429
    Cell Significance Index: 121.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8347
    Cell Significance Index: 167.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6716
    Cell Significance Index: 73.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4843
    Cell Significance Index: 47.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3674
    Cell Significance Index: 131.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2995
    Cell Significance Index: 20.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2330
    Cell Significance Index: 161.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2046
    Cell Significance Index: 13.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1839
    Cell Significance Index: 3.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1822
    Cell Significance Index: 5.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1393
    Cell Significance Index: 8.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1370
    Cell Significance Index: 24.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1217
    Cell Significance Index: 2.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1152
    Cell Significance Index: 14.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1047
    Cell Significance Index: 142.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1029
    Cell Significance Index: 2.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0982
    Cell Significance Index: 0.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0799
    Cell Significance Index: 3.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0790
    Cell Significance Index: 9.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0683
    Cell Significance Index: 37.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0570
    Cell Significance Index: 25.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0515
    Cell Significance Index: 23.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0293
    Cell Significance Index: 1.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0265
    Cell Significance Index: 0.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0173
    Cell Significance Index: 3.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0088
    Cell Significance Index: 13.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0025
    Cell Significance Index: -0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0029
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0057
    Cell Significance Index: -0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0194
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0203
    Cell Significance Index: -12.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0269
    Cell Significance Index: -1.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0307
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0316
    Cell Significance Index: -5.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0355
    Cell Significance Index: -26.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0394
    Cell Significance Index: -28.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0411
    Cell Significance Index: -31.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0494
    Cell Significance Index: -27.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0548
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0604
    Cell Significance Index: -37.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0673
    Cell Significance Index: -2.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0759
    Cell Significance Index: -7.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0835
    Cell Significance Index: -4.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1015
    Cell Significance Index: -29.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1117
    Cell Significance Index: -5.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1181
    Cell Significance Index: -1.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1307
    Cell Significance Index: -6.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1479
    Cell Significance Index: -3.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1716
    Cell Significance Index: -8.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1719
    Cell Significance Index: -36.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1910
    Cell Significance Index: -24.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1999
    Cell Significance Index: -25.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2028
    Cell Significance Index: -5.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2050
    Cell Significance Index: -6.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2131
    Cell Significance Index: -15.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2304
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2326
    Cell Significance Index: -26.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2564
    Cell Significance Index: -6.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3030
    Cell Significance Index: -31.5500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3470
    Cell Significance Index: -4.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3769
    Cell Significance Index: -23.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3785
    Cell Significance Index: -28.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3966
    Cell Significance Index: -31.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4049
    Cell Significance Index: -25.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4651
    Cell Significance Index: -12.4400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4729
    Cell Significance Index: -5.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5127
    Cell Significance Index: -16.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5814
    Cell Significance Index: -16.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6011
    Cell Significance Index: -15.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6176
    Cell Significance Index: -9.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6889
    Cell Significance Index: -23.9400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6981
    Cell Significance Index: -10.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7205
    Cell Significance Index: -23.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7299
    Cell Significance Index: -25.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7336
    Cell Significance Index: -21.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7563
    Cell Significance Index: -16.5600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7640
    Cell Significance Index: -13.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7674
    Cell Significance Index: -24.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7714
    Cell Significance Index: -18.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7810
    Cell Significance Index: -16.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8118
    Cell Significance Index: -29.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The FOXN2 gene is a member of the forkhead box (FOX) family of transcription factors, which play a pivotal role in regulating gene expression. FOXN2 is a 300-amino acid protein that belongs to the class II of FOX proteins. It is highly conserved across species, with a high degree of sequence identity among vertebrates. FOXN2 is primarily expressed in cells of the nervous system, muscle cells, and certain types of immune cells. **Pathways and Functions** FOXN2 is involved in several key pathways, including: 1. **Chromatin remodeling**: FOXN2 regulates chromatin structure and accessibility by interacting with chromatin-modifying enzymes, such as histone acetyltransferases and histone deacetylases. 2. **Transcriptional regulation**: FOXN2 binds to specific DNA sequences, known as cis-regulatory elements, to activate or repress the expression of target genes. 3. **Cell differentiation**: FOXN2 is essential for the differentiation of neural cells, muscle cells, and immune cells, such as T cells and natural killer cells. 4. **Apoptosis**: FOXN2 can induce apoptosis in certain cell types, such as neurons and muscle cells, by regulating the expression of pro-apoptotic genes. **Clinical Significance** Dysregulation of FOXN2 has been implicated in various diseases, including: 1. **Muscular dystrophy**: Mutations in the FOXN2 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Neurological disorders**: FOXN2 has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: FOXN2 has been found to be overexpressed in certain types of cancer, including prostate cancer and breast cancer. 4. **Immune system disorders**: FOXN2 plays a crucial role in the development and function of immune cells, such as T cells and natural killer cells, and dysregulation of FOXN2 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, FOXN2 is a multifunctional transcription factor that plays a critical role in various cellular processes, including cell differentiation, survival, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of FOXN2 in maintaining tissue homeostasis and overall health.

Genular Protein ID: 1654936308

Symbol: FOXN2_HUMAN

Name: Forkhead box protein N2

UniProtKB Accession Codes:

P32314 Q15769 Q6P4Q2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 10 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1639393

Title: Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF.

PubMed ID: 1639393

DOI: 10.1016/0888-7543(92)90138-i

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 431
  • Mass: 47161
  • Checksum: 5F71D3C0E4BA1797
  • Sequence:
    • MGPVIGMTPD KRAETPGAEK IAGLSQIYKM GSLPEAVDAA RPKATLVDSE SADDELTNLN 
WLHESTNLLT NFSLGSEGLP IVSPLYDIEG DDVPSFGPAC YQNPEKKSAT SKPPYSFSLL 
IYMAIEHSPN KCLPVKEIYS WILDHFPYFA TAPTGWKNSV RHNLSLNKCF QKVERSHGKV 
NGKGSLWCVD PEYKPNLIQA LKKQPFSSAS SQNGSLSPHY LSSVIKQNQV RNLKESDIDA 
AAAMMLLNTS IEQGILECEK PLPLKTALQK KRSYGNAFHH PSAVRLQESD SLATSIDPKE 
DHNYSASSMA AQRCASRSSV SSLSSVDEVY EFIPKNSHVG SDGSEGFHSE EDTDVDYEDD 
PLGDSGYASQ PCAKISEKGQ SGKKMRKQTC QEIDEELKEA AGSLLHLAGI RTCLGSLIST 
AKTQNQKQRK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.