Details for: IDH2

Gene ID: 3418

Symbol: IDH2

Ensembl ID: ENSG00000182054

Description: isocitrate dehydrogenase (NADP(+)) 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.6928
    Cell Significance Index: -54.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.2583
    Cell Significance Index: -31.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.2440
    Cell Significance Index: -48.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 115.4361
    Cell Significance Index: -54.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.7500
    Cell Significance Index: -55.4300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.1269
    Cell Significance Index: -12.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 81.1300
    Cell Significance Index: -54.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.0088
    Cell Significance Index: -49.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.7028
    Cell Significance Index: -44.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.2380
    Cell Significance Index: -40.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7723
    Cell Significance Index: -50.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1648
    Cell Significance Index: -27.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3518
    Cell Significance Index: -16.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0791
    Cell Significance Index: 358.8300
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 2.9664
    Cell Significance Index: 2.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5924
    Cell Significance Index: 120.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.5364
    Cell Significance Index: 53.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4208
    Cell Significance Index: 180.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2261
    Cell Significance Index: 59.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2132
    Cell Significance Index: 24.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9609
    Cell Significance Index: 126.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.7552
    Cell Significance Index: 42.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7197
    Cell Significance Index: 222.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5465
    Cell Significance Index: 53.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3706
    Cell Significance Index: 161.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3699
    Cell Significance Index: 748.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1930
    Cell Significance Index: 56.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1859
    Cell Significance Index: 34.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1850
    Cell Significance Index: 192.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0016
    Cell Significance Index: 76.8600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9920
    Cell Significance Index: 7.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9433
    Cell Significance Index: 49.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9348
    Cell Significance Index: 185.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8602
    Cell Significance Index: 24.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8524
    Cell Significance Index: 44.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8237
    Cell Significance Index: 23.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7992
    Cell Significance Index: 47.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6273
    Cell Significance Index: 62.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5375
    Cell Significance Index: 4.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4991
    Cell Significance Index: 100.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4872
    Cell Significance Index: 87.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4711
    Cell Significance Index: 57.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4644
    Cell Significance Index: 205.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4349
    Cell Significance Index: 13.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.3760
    Cell Significance Index: 29.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3602
    Cell Significance Index: 264.1300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3541
    Cell Significance Index: 2.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3536
    Cell Significance Index: 5.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3259
    Cell Significance Index: 44.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2911
    Cell Significance Index: 49.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2879
    Cell Significance Index: 54.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2195
    Cell Significance Index: 12.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2070
    Cell Significance Index: 74.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1691
    Cell Significance Index: 11.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1192
    Cell Significance Index: 82.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0941
    Cell Significance Index: 84.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0817
    Cell Significance Index: 10.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0729
    Cell Significance Index: 2.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0167
    Cell Significance Index: 31.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -3.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0084
    Cell Significance Index: -0.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0137
    Cell Significance Index: -0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0161
    Cell Significance Index: -24.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0175
    Cell Significance Index: -13.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0292
    Cell Significance Index: -53.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0315
    Cell Significance Index: -3.2200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0460
    Cell Significance Index: -0.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0566
    Cell Significance Index: -35.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0600
    Cell Significance Index: -3.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0666
    Cell Significance Index: -49.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0922
    Cell Significance Index: -51.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0943
    Cell Significance Index: -58.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1228
    Cell Significance Index: -5.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1330
    Cell Significance Index: -3.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1582
    Cell Significance Index: -3.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1607
    Cell Significance Index: -46.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1889
    Cell Significance Index: -1.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2286
    Cell Significance Index: -6.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2332
    Cell Significance Index: -5.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2518
    Cell Significance Index: -36.6000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2672
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2801
    Cell Significance Index: -58.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3067
    Cell Significance Index: -35.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3240
    Cell Significance Index: -7.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3646
    Cell Significance Index: -9.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3831
    Cell Significance Index: -5.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3924
    Cell Significance Index: -40.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4400
    Cell Significance Index: -11.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5293
    Cell Significance Index: -35.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5312
    Cell Significance Index: -27.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5592
    Cell Significance Index: -9.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5684
    Cell Significance Index: -25.1400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.5798
    Cell Significance Index: -2.2200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5859
    Cell Significance Index: -12.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6018
    Cell Significance Index: -41.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6189
    Cell Significance Index: -9.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6658
    Cell Significance Index: -19.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7458
    Cell Significance Index: -28.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7630
    Cell Significance Index: -46.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: IDH2 is primarily localized in the mitochondrial matrix, where it plays a crucial role in the regulation of energy metabolism. 2. **NADP+ dependence**: IDH2 requires NADP+ as a cofactor to catalyze the conversion of isocitrate to α-ketoglutarate. 3. **Isoenzymes**: IDH2 exists as a heterodimer, composed of two subunits, which allows for the regulation of enzyme activity. 4. **Tissue-specific expression**: IDH2 is highly expressed in various tissues, including the pancreas, kidney, and heart, where it plays a crucial role in energy metabolism. **Pathways and Functions:** 1. **Citric acid cycle (TCA cycle)**: IDH2 is a key enzyme in the TCA cycle, which is essential for energy production, biosynthesis, and redox balance. 2. **Carbohydrate metabolism**: IDH2 is involved in the metabolism of carbohydrates, particularly in the regulation of glycolysis and gluconeogenesis. 3. **Mitochondrial biogenesis**: IDH2 is required for the regulation of mitochondrial biogenesis and maintenance. 4. **Redox balance**: IDH2 helps maintain redox balance by regulating the levels of NAD+ and NADP+. **Clinical Significance:** 1. **Cancer**: Mutations in IDH2 have been identified in various types of cancer, including acute myeloid leukemia (AML), glioblastoma, and colorectal cancer. IDH2 mutations lead to the production of an oncometabolite, 2-hydroxyglutarate, which disrupts cellular metabolism and promotes tumorigenesis. 2. **Mitochondrial disorders**: IDH2 mutations have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MERRF syndrome, which are characterized by a range of symptoms, including muscle weakness, neuropathy, and cardiac dysfunction. 3. **Cardiovascular disease**: IDH2 has been implicated in the regulation of cardiac energy metabolism, and mutations in IDH2 have been associated with an increased risk of cardiovascular disease. In conclusion, IDH2 is a critical enzyme in cellular metabolism, playing a pivotal role in the regulation of energy production, biosynthesis, and redox balance. Its dysregulation has been implicated in various diseases, including cancer, mitochondrial disorders, and cardiovascular disease. Further research is necessary to fully understand the complex role of IDH2 in human health and disease.

Genular Protein ID: 52652461

Symbol: IDHP_HUMAN

Name: Isocitrate dehydrogenase [NADP], mitochondrial

UniProtKB Accession Codes:

P48735 B2R6L6 B4DFL2 Q96GT3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 4 CTD 1 CarbonylDB 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 12 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 Rhea 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22416140

Title: SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.

PubMed ID: 22416140

DOI: 10.1074/jbc.m112.355206

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19228619

Title: IDH1 and IDH2 mutations in gliomas.

PubMed ID: 19228619

DOI: 10.1056/nejmoa0808710

PubMed ID: 20847235

Title: IDH2 mutations in patients with D-2-hydroxyglutaric aciduria.

PubMed ID: 20847235

DOI: 10.1126/science.1192632

PubMed ID: 25495392

Title: IDH2 mutation in gliomas including novel mutation.

PubMed ID: 25495392

DOI: 10.1111/neup.12187

PubMed ID: 26161668

Title: Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.

PubMed ID: 26161668

DOI: 10.1371/journal.pone.0131998

Sequence Information:

  • Length: 452
  • Mass: 50909
  • Checksum: 4DDC830AFC06AB52
  • Sequence:
    • MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQPRRHYA DKRIKVAKPV VEMDGDEMTR 
IIWQFIKEKL ILPHVDIQLK YFDLGLPNRD QTDDQVTIDS ALATQKYSVA VKCATITPDE 
ARVEEFKLKK MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK 
ATDFVADRAG TFKMVFTPKD GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI 
QKKWPLYMST KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS 
SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK 
GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK VCVETVESGA MTKDLAGCIH 
GLSNVKLNEH FLNTTDFLDT IKSNLDRALG RQ

Genular Protein ID: 252575406

Symbol: B4DSZ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DSZ6

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 322
  • Mass: 36171
  • Checksum: DE931A052A594462
  • Sequence:
    • MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK ATDFVADRAG 
TFKMVFTPKD GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI QKKWPLYMST 
KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS SGGFVWACKN 
YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK GRPTSTNPIA 
SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK VCVETVESGA MTKDLAGCIH GLSNVKLNEH 
FLNTTDFLDT IKSNLDRALG RQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.