Details for: IDH2

Gene ID: 3418

Symbol: IDH2

Ensembl ID: ENSG00000182054

Description: isocitrate dehydrogenase (NADP(+)) 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.59
    Marker Score: 7574.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.11
    Marker Score: 8325
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.8
    Marker Score: 2970
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.77
    Marker Score: 7656.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.72
    Marker Score: 2834
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.64
    Marker Score: 10804
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.54
    Marker Score: 4217
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.44
    Marker Score: 802
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.42
    Marker Score: 54011.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.33
    Marker Score: 2347
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3
    Marker Score: 5243
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.3
    Marker Score: 22785
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.28
    Marker Score: 4044
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.28
    Marker Score: 8941
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.22
    Marker Score: 8575
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.14
    Marker Score: 1245
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.09
    Marker Score: 18000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.05
    Marker Score: 2192
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.04
    Marker Score: 1923
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.04
    Marker Score: 5541
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.03
    Marker Score: 4247
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.02
    Marker Score: 2857
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.98
    Marker Score: 26173
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.98
    Marker Score: 4658
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.98
    Marker Score: 20020.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.96
    Marker Score: 15302
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.95
    Marker Score: 797
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.95
    Marker Score: 4911
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.91
    Marker Score: 1389.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.9
    Marker Score: 3231
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.89
    Marker Score: 928
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.84
    Marker Score: 691
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.83
    Marker Score: 870
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.83
    Marker Score: 1149
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.83
    Marker Score: 4337
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.82
    Marker Score: 63183
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.81
    Marker Score: 2566
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.81
    Marker Score: 1514
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.79
    Marker Score: 984
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.78
    Marker Score: 1884
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.77
    Marker Score: 2141
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.76
    Marker Score: 1977
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.75
    Marker Score: 2330
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.72
    Marker Score: 992
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.71
    Marker Score: 401.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.71
    Marker Score: 1772
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.69
    Marker Score: 430
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.68
    Marker Score: 464
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.68
    Marker Score: 1118
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.67
    Marker Score: 4963
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.66
    Marker Score: 534
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.64
    Marker Score: 1189
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.64
    Marker Score: 1463
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.64
    Marker Score: 685
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.64
    Marker Score: 10458
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.63
    Marker Score: 652
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.62
    Marker Score: 997
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.62
    Marker Score: 1521
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.61
    Marker Score: 564
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.59
    Marker Score: 555
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.58
    Marker Score: 985
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.57
    Marker Score: 1179
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.57
    Marker Score: 1378
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.56
    Marker Score: 13592
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.56
    Marker Score: 773
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.56
    Marker Score: 1067
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.56
    Marker Score: 18156
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.55
    Marker Score: 2276
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.54
    Marker Score: 2691.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.54
    Marker Score: 2266
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.54
    Marker Score: 1043
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.53
    Marker Score: 1303
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.52
    Marker Score: 720
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.52
    Marker Score: 1036
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.51
    Marker Score: 2879
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.5
    Marker Score: 749
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.5
    Marker Score: 799
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.5
    Marker Score: 1771
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.5
    Marker Score: 700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.5
    Marker Score: 2674
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.49
    Marker Score: 1263
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.48
    Marker Score: 498
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.48
    Marker Score: 516
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.47
    Marker Score: 31347
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.47
    Marker Score: 1487.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.46
    Marker Score: 311
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.46
    Marker Score: 605.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.45
    Marker Score: 3551.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.44
    Marker Score: 498
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165336
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.44
    Marker Score: 1015
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.44
    Marker Score: 511
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.44
    Marker Score: 772
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.44
    Marker Score: 853
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.44
    Marker Score: 10686.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.43
    Marker Score: 1080
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.41
    Marker Score: 1223
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.41
    Marker Score: 751
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.41
    Marker Score: 4839
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.4
    Marker Score: 939

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Other Information

**Key characteristics:** * IDH2 is a protein that is found in the mitochondria of eukaryotic cells. * It is a NADP(+)-dependent enzyme, which means that it requires NADP+ to function. * IDH2 is expressed in a variety of cell types, including pancreatic acinar cell, kidney loop of Henle thick ascending limb epithelial cell, kidney distal convoluted tubule epithelial cell, decidual natural killer cell, human, erythroid progenitor cell, pro-T cell, kidney collecting duct intercalated cell, fetal cardiomyocyte, regular ventricular cardiac myocyte, fraction A pre-pro B cell. * IDH2 is a highly regulated enzyme, and its activity is controlled by a number of factors, including the availability of NADP+, the levels of pyruvate and oxaloacetate, and the activity of other enzymes in the isocitrate dehydrogenase pathway. **Pathways and functions:** * The isocitrate dehydrogenase (NADP(+)) pathway is involved in a variety of cellular processes, including lipid synthesis, detoxification, and energy production. * IDH2 is responsible for the production of NADPH, a reducing agent that is involved in the following reactions: * The citric acid (tca) cycle, which is a central metabolic pathway in the mitochondria of cells. * The electron transport chain, which is responsible for generating energy for the cell. * The synthesis of lipids and proteins. **Clinical significance:** IDH2 is a promising target for the treatment of a variety of diseases, including cancer and neurodegenerative diseases. Inhibition of IDH2 has been shown to inhibit cancer cell growth and proliferation, and to protect neurons from damage. However, further research is needed to develop effective IDH2 inhibitors that can be used in humans.

Genular Protein ID: 52652461

Symbol: IDHP_HUMAN

Name: Isocitrate dehydrogenase [NADP], mitochondrial

UniProtKB Accession Codes:

P48735 B2R6L6 B4DFL2 Q96GT3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 4 CTD 1 CarbonylDB 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 12 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 11 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22416140

Title: SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.

PubMed ID: 22416140

DOI: 10.1074/jbc.m112.355206

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19228619

Title: IDH1 and IDH2 mutations in gliomas.

PubMed ID: 19228619

DOI: 10.1056/nejmoa0808710

PubMed ID: 20847235

Title: IDH2 mutations in patients with D-2-hydroxyglutaric aciduria.

PubMed ID: 20847235

DOI: 10.1126/science.1192632

PubMed ID: 25495392

Title: IDH2 mutation in gliomas including novel mutation.

PubMed ID: 25495392

DOI: 10.1111/neup.12187

PubMed ID: 26161668

Title: Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.

PubMed ID: 26161668

DOI: 10.1371/journal.pone.0131998

Sequence Information:

  • Length: 452
  • Mass: 50909
  • Checksum: 4DDC830AFC06AB52
  • Sequence:
    • MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQPRRHYA DKRIKVAKPV VEMDGDEMTR 
IIWQFIKEKL ILPHVDIQLK YFDLGLPNRD QTDDQVTIDS ALATQKYSVA VKCATITPDE 
ARVEEFKLKK MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK 
ATDFVADRAG TFKMVFTPKD GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI 
QKKWPLYMST KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS 
SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK 
GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK VCVETVESGA MTKDLAGCIH 
GLSNVKLNEH FLNTTDFLDT IKSNLDRALG RQ

Genular Protein ID: 252575406

Symbol: B4DSZ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DSZ6

Database IDs:

ARBA 19 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 DNASU 1 EMBL 2 GO 6 Gene3D 1 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 322
  • Mass: 36171
  • Checksum: DE931A052A594462
  • Sequence:
    • MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK ATDFVADRAG 
TFKMVFTPKD GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI QKKWPLYMST 
KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS SGGFVWACKN 
YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK GRPTSTNPIA 
SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK VCVETVESGA MTKDLAGCIH GLSNVKLNEH 
FLNTTDFLDT IKSNLDRALG RQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.