Gene IL12RB1 - ENSG00000096996 | NCBI Gene ID: 3594

Details for: IL12RB1

Gene ID: 3594

Symbol: IL12RB1

Ensembl ID: ENSG00000096996

Description: interleukin 12 receptor subunit beta 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Interleukin-23 signaling
(R-HSA-9020933)
Signaling by interleukins
(R-HSA-449147)
Cellular response to type ii interferon
(GO:0071346)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine binding
(GO:0019955)
Cytokine receptor activity
(GO:0004896)
External side of plasma membrane
(GO:0009897)
Interleukin-12 receptor activity
(GO:0016517)
Interleukin-12 receptor binding
(GO:0005143)
Interleukin-12 receptor complex
(GO:0042022)
Interleukin-12-mediated signaling pathway
(GO:0035722)
Interleukin-23 binding
(GO:0042019)
Interleukin-23 receptor activity
(GO:0042020)
Interleukin-23 receptor complex
(GO:0072536)
Interleukin-23-mediated signaling pathway
(GO:0038155)
Plasma membrane
(GO:0005886)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of defense response to virus by host
(GO:0002230)
Positive regulation of memory t cell differentiation
(GO:0043382)
Positive regulation of t-helper 1 type immune response
(GO:0002827)
Positive regulation of t-helper 17 cell lineage commitment
(GO:2000330)
Positive regulation of t-helper 17 type immune response
(GO:2000318)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of type ii interferon production
(GO:0032729)
Receptor complex
(GO:0043235)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.67
Marker Score: 5061
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.58
Marker Score: 1145
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.24
Marker Score: 554
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.23
Marker Score: 833
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.17
Marker Score: 7486
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4778
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.14
Marker Score: 471
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.13
Marker Score: 2302.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.12
Marker Score: 675
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71785.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48009.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.97
Marker Score: 313
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 493
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.95
Marker Score: 301
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.93
Marker Score: 14483
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5251
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2728
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.91
Marker Score: 2645
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9
Marker Score: 359.5
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 315
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5270
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.84
Marker Score: 384
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.83
Marker Score: 2629
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.81
Marker Score: 1680
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.8
Marker Score: 382
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.76
Marker Score: 1241
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 580
Cell Name: mature T cell (CL0002419)
Fold Change: 0.75
Marker Score: 7404
Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 678
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 382
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7
Marker Score: 446
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.67
Marker Score: 1305
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.63
Marker Score: 562.5
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.62
Marker Score: 544.5
Cell Name: blood cell (CL0000081)
Fold Change: 0.61
Marker Score: 7103
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.6
Marker Score: 352
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.59
Marker Score: 1756
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.57
Marker Score: 317
Cell Name: Unknown (CL0000548)
Fold Change: 0.57
Marker Score: 418.5
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.57
Marker Score: 790
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.57
Marker Score: 327
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.56
Marker Score: 826
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: plasmablast (CL0000980)
Fold Change: 0.54
Marker Score: 717
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.53
Marker Score: 169
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.53
Marker Score: 516
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.53
Marker Score: 28196
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.53
Marker Score: 235
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.53
Marker Score: 1481
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.53
Marker Score: 2263
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.51
Marker Score: 429
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.51
Marker Score: 1310
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.5
Marker Score: 166
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.48
Marker Score: 352
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.47
Marker Score: 1293
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.47
Marker Score: 1097
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.45
Marker Score: 439
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.45
Marker Score: 484.5
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.44
Marker Score: 117
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.43
Marker Score: 481
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.43
Marker Score: 1057
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.42
Marker Score: 10797
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.41
Marker Score: 297
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.41
Marker Score: 175
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.4
Marker Score: 292
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.4
Marker Score: 967
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.4
Marker Score: 370
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.39
Marker Score: 767
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.39
Marker Score: 242
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.39
Marker Score: 201
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.39
Marker Score: 332
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.39
Marker Score: 665
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.39
Marker Score: 417
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.39
Marker Score: 500
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.38
Marker Score: 139
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.38
Marker Score: 673
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.38
Marker Score: 308
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.37
Marker Score: 374
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.37
Marker Score: 99
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.37
Marker Score: 244
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.37
Marker Score: 589
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.37
Marker Score: 399
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.36
Marker Score: 314
Cell Name: centrocyte (CL0009111)
Fold Change: 0.35
Marker Score: 83
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.35
Marker Score: 88
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.34
Marker Score: 343.5
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.34
Marker Score: 170
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.33
Marker Score: 76
Cell Name: centroblast (CL0009112)
Fold Change: 0.33
Marker Score: 163.5
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.33
Marker Score: 251
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.33
Marker Score: 18388
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.33
Marker Score: 66
Cell Name: B cell (CL0000236)
Fold Change: 0.32
Marker Score: 307
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.32
Marker Score: 1317
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.32
Marker Score: 724
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.32
Marker Score: 70

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**Key characteristics:** * IL12RB1 is a type I cytokine receptor. * It is a member of the interleukin-12 receptor family. * It is expressed in high levels in mucosal and epithelial tissues. * It is involved in the regulation of immune responses to viruses. **Pathways and functions:** * IL12RB1 is a key component of the cytokine-mediated signaling pathway, which is responsible for regulating immune responses to cytokines. * It binds to IL12, a cytokine that is produced by various cell types in response to infection or injury. * When IL12 binds to IL12RB1, it activates the pathway, which leads to the activation of downstream signaling molecules and the production of cytokines and chemokines that promote inflammation and tissue repair. **Clinical significance:** * Mutations in the IL12RB1 gene have been linked to a number of inflammatory diseases, including asthma, inflammatory bowel disease, and rheumatoid arthritis. * Targeting IL12RB1 signaling has been shown to be a promising strategy for treating these diseases. **Other important points:** * IL12RB1 is a highly conserved protein, with similar sequences found in mammals, birds, and fish. * It is a key regulator of immune responses to viruses, and its expression is increased in response to viral infection. * It is also involved in the regulation of cell growth, differentiation, and migration.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-12 receptor subunit beta-1

Genular Protein ID: 3667425472

Symbol: I12R1_HUMAN

Name: Interleukin-12 receptor subunit beta-1

UniProtKB Accession Codes:

P42701 A8K308 B2RPF1 B7ZKK3 Q8N6Q7

Database IDs:

Citations:

PubMed ID: 7911493

Title: Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

PubMed ID: 7911493

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8943050

Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

PubMed ID: 8943050

DOI: 10.1073/pnas.93.24.14002

PubMed ID: 12023369

Title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.

PubMed ID: 12023369

DOI: 10.4049/jimmunol.168.11.5699

PubMed ID: 11424023

Title: Interleukin-12 receptor beta-1 deficiency in a patient with abdominal tuberculosis.

PubMed ID: 11424023

DOI: 10.1086/321999

Sequence Information:

Length: 662
Mass: 73109
Checksum: 541ADA60F62DA1EF
Sequence:

MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY 
ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR 
NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP 
WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ 
VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT 
LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA 
RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA 
SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE 
YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE 
VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ 
WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCKA 
KM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL12RB1

Associated with

Cells (max top 100)

Other Information

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. PubMed ID: 7911493

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. PubMed ID: 8943050

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. PubMed ID: 12023369

Interleukin-12 receptor beta-1 deficiency in a patient with abdominal tuberculosis. PubMed ID: 11424023