Details for: IL12RB1

Gene ID: 3594

Symbol: IL12RB1

Ensembl ID: ENSG00000096996

Description: interleukin 12 receptor subunit beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.5950
    Cell Significance Index: -5.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.9780
    Cell Significance Index: -4.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.0335
    Cell Significance Index: -6.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 13.9584
    Cell Significance Index: -7.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.1080
    Cell Significance Index: -5.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8839
    Cell Significance Index: 40.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.6246
    Cell Significance Index: -4.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6020
    Cell Significance Index: 47.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3845
    Cell Significance Index: -3.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.6421
    Cell Significance Index: -1.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5794
    Cell Significance Index: 110.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4370
    Cell Significance Index: 51.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3827
    Cell Significance Index: 8.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3566
    Cell Significance Index: 35.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2656
    Cell Significance Index: 239.8400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2483
    Cell Significance Index: 2.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2429
    Cell Significance Index: 14.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2293
    Cell Significance Index: 24.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1916
    Cell Significance Index: 31.1600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1523
    Cell Significance Index: 1.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1421
    Cell Significance Index: 9.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1307
    Cell Significance Index: 2.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1084
    Cell Significance Index: 2.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0955
    Cell Significance Index: 6.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0897
    Cell Significance Index: 1.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0749
    Cell Significance Index: 1.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0691
    Cell Significance Index: 1.9900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0516
    Cell Significance Index: 0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0399
    Cell Significance Index: 8.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0346
    Cell Significance Index: 0.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0259
    Cell Significance Index: 0.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0207
    Cell Significance Index: 14.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0034
    Cell Significance Index: 0.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0016
    Cell Significance Index: -0.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0087
    Cell Significance Index: -4.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0092
    Cell Significance Index: -6.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0096
    Cell Significance Index: -5.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0112
    Cell Significance Index: -0.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0137
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0156
    Cell Significance Index: -4.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0196
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0232
    Cell Significance Index: -0.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0246
    Cell Significance Index: -1.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0251
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0264
    Cell Significance Index: -5.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0298
    Cell Significance Index: -4.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0301
    Cell Significance Index: -0.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0304
    Cell Significance Index: -3.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0317
    Cell Significance Index: -0.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0357
    Cell Significance Index: -4.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0462
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0463
    Cell Significance Index: -5.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0464
    Cell Significance Index: -5.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0469
    Cell Significance Index: -6.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0478
    Cell Significance Index: -4.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0479
    Cell Significance Index: -3.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0529
    Cell Significance Index: -2.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0551
    Cell Significance Index: -2.4000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0555
    Cell Significance Index: -0.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0592
    Cell Significance Index: -2.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0601
    Cell Significance Index: -0.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0613
    Cell Significance Index: -4.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0615
    Cell Significance Index: -1.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0622
    Cell Significance Index: -4.7700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0655
    Cell Significance Index: -1.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0752
    Cell Significance Index: -2.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0755
    Cell Significance Index: -1.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0797
    Cell Significance Index: -2.5200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0824
    Cell Significance Index: -1.2100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0825
    Cell Significance Index: -0.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0876
    Cell Significance Index: -6.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0908
    Cell Significance Index: -5.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0975
    Cell Significance Index: -5.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1014
    Cell Significance Index: -3.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1038
    Cell Significance Index: -3.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1043
    Cell Significance Index: -3.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1055
    Cell Significance Index: -4.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1063
    Cell Significance Index: -5.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1063
    Cell Significance Index: -2.9700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1084
    Cell Significance Index: -0.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1096
    Cell Significance Index: -2.1400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1192
    Cell Significance Index: -2.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1319
    Cell Significance Index: -6.8700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1354
    Cell Significance Index: -1.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1398
    Cell Significance Index: -7.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1474
    Cell Significance Index: -5.4100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1492
    Cell Significance Index: -1.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1545
    Cell Significance Index: -1.2600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1550
    Cell Significance Index: -1.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1590
    Cell Significance Index: -6.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL12RB1 is a transmembrane protein, with a molecular weight of approximately 30 kDa, and is expressed on various cell types, including cardiac endothelial cells, epithelial cells, and immune cells such as CD4-positive T cells and natural killer cells. The protein exhibits a high degree of homology with other IL-12 receptor subunits, suggesting a conserved functional role across species. IL12RB1 is also known to interact with other cytokine receptors, including IL-23R, to modulate immune responses. **Pathways and Functions:** IL12RB1 is a key player in the IL-12 signaling pathway, which regulates the activation and differentiation of T helper 1 (Th1) and Th17 cells. Upon binding to IL-12, IL12RB1 recruits and activates the associated Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins, leading to the transcriptional activation of target genes involved in immune responses. IL12RB1 also interacts with other cytokines, such as IL-23, to modulate immune homeostasis and promote the development of Th17 cells. Furthermore, IL12RB1 is involved in the regulation of T cell-mediated cytotoxicity, defense against viral infections, and the production of type II interferons. **Clinical Significance:** Dysregulation of IL12RB1 has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Additionally, alterations in IL12RB1 expression have been associated with cancer, where it can promote tumor growth and immune evasion. Furthermore, IL12RB1 has been identified as a potential therapeutic target for the treatment of inflammatory and autoimmune diseases. For instance, monoclonal antibodies targeting IL12RB1 have shown promise in preclinical studies for the treatment of autoimmune diseases. In conclusion, IL12RB1 plays a critical role in regulating immune responses, and its dysregulation has been implicated in various immune-related disorders. Further research into the molecular mechanisms underlying IL12RB1 function and its clinical significance is necessary to fully appreciate its importance in immune homeostasis and disease pathogenesis.

Genular Protein ID: 3667425472

Symbol: I12R1_HUMAN

Name: Interleukin-12 receptor subunit beta-1

UniProtKB Accession Codes:

P42701 A8K308 B2RPF1 B7ZKK3 Q8N6Q7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 EMDB 2 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7911493

Title: Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.

PubMed ID: 7911493

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8943050

Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

PubMed ID: 8943050

DOI: 10.1073/pnas.93.24.14002

PubMed ID: 12023369

Title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.

PubMed ID: 12023369

DOI: 10.4049/jimmunol.168.11.5699

PubMed ID: 11424023

Title: Interleukin-12 receptor beta-1 deficiency in a patient with abdominal tuberculosis.

PubMed ID: 11424023

DOI: 10.1086/321999

Sequence Information:

  • Length: 662
  • Mass: 73109
  • Checksum: 541ADA60F62DA1EF
  • Sequence:
    • MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY 
ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR 
NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP 
WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ 
VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT 
LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA 
RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA 
SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE 
YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE 
VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ 
WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCKA 
KM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.