Details for: IRF2

Gene ID: 3660

Symbol: IRF2

Ensembl ID: ENSG00000168310

Description: interferon regulatory factor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.22
    Marker Score: 2573.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.9
    Marker Score: 40568
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.67
    Marker Score: 19467
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.66
    Marker Score: 1993
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.58
    Marker Score: 1659.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.57
    Marker Score: 1736
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.52
    Marker Score: 1788
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.43
    Marker Score: 32046
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.42
    Marker Score: 2015
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.41
    Marker Score: 412
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.4
    Marker Score: 1690
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.39
    Marker Score: 486
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.38
    Marker Score: 824
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.37
    Marker Score: 1574
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.35
    Marker Score: 1744
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.34
    Marker Score: 432
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.32
    Marker Score: 1943
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.31
    Marker Score: 564
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.31
    Marker Score: 1131
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.29
    Marker Score: 3517.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.29
    Marker Score: 72249
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.29
    Marker Score: 2511.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.28
    Marker Score: 1237
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19830
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.27
    Marker Score: 9416.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.26
    Marker Score: 2233
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.25
    Marker Score: 393
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.24
    Marker Score: 2116
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.24
    Marker Score: 3089
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.24
    Marker Score: 1646
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.24
    Marker Score: 10855.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.23
    Marker Score: 2142
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.23
    Marker Score: 1364
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2863
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.21
    Marker Score: 18121.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.21
    Marker Score: 1869.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.21
    Marker Score: 289
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.2
    Marker Score: 1105
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2
    Marker Score: 594
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.2
    Marker Score: 11881
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.2
    Marker Score: 1204.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.19
    Marker Score: 414
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.19
    Marker Score: 288
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.19
    Marker Score: 4914
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.18
    Marker Score: 589
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.18
    Marker Score: 708
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.17
    Marker Score: 43075
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.16
    Marker Score: 288
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.15
    Marker Score: 574
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.15
    Marker Score: 1148
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.15
    Marker Score: 1882
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.14
    Marker Score: 831
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.14
    Marker Score: 1018
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.14
    Marker Score: 1101
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.13
    Marker Score: 1642.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.13
    Marker Score: 457
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.13
    Marker Score: 3877
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.13
    Marker Score: 325
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.12
    Marker Score: 7164
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.12
    Marker Score: 3139
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.12
    Marker Score: 256
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.12
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.11
    Marker Score: 334
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.11
    Marker Score: 584
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.1
    Marker Score: 325
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.1
    Marker Score: 9589
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.1
    Marker Score: 2162
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.1
    Marker Score: 342
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.1
    Marker Score: 41881
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.09
    Marker Score: 238
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.09
    Marker Score: 5370
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.09
    Marker Score: 2073
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.09
    Marker Score: 268
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.09
    Marker Score: 245
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.08
    Marker Score: 596
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.08
    Marker Score: 1176
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.08
    Marker Score: 815
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.07
    Marker Score: 1957
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.07
    Marker Score: 1148
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.06
    Marker Score: 730
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.06
    Marker Score: 8143
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.06
    Marker Score: 232.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.06
    Marker Score: 661
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.06
    Marker Score: 833
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.05
    Marker Score: 2399
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.05
    Marker Score: 1880
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.05
    Marker Score: 278
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.05
    Marker Score: 260
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.05
    Marker Score: 703
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.04
    Marker Score: 260
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.04
    Marker Score: 293
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.04
    Marker Score: 385
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.04
    Marker Score: 362.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.04
    Marker Score: 975
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.04
    Marker Score: 284
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63514
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.03
    Marker Score: 605
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.03
    Marker Score: 600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.03
    Marker Score: 237
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.03
    Marker Score: 2483

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Other Information

**Key characteristics:** * IRF2 is a transcription factor that is involved in the regulation of a wide range of cellular processes, including inflammation, cell growth, and differentiation. * It is a key regulator of the immune response, and its expression is increased in response to infection or injury. * IRF2 is also involved in the regulation of cell death. * It is a key factor in the development of the immune system. **Pathways and functions:** * IRF2 is a key regulator of the innate immune response. It is expressed in high levels in immune cells, including macrophages, dendritic cells, and neutrophils. * IRF2 binds to DNA sequences called IRF2-binding elements (IRF2-BREs) on the promoters of many immune genes. * When IRF2 binds to an IRE, it recruits the co-repressors IRF1 and IRF3 to the promoter, which leads to the inhibition of immune gene expression. * IRF2 also binds to DNA sequences called DNA-binding response elements (DBREs) on the promoters of many cell-cycle and differentiation genes. * This binding activates the transcription of these genes, which helps to regulate cell growth, differentiation, and apoptosis. **Clinical significance:** * Mutations in the IRF2 gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and inflammatory diseases. * The development of drugs that target IRF2 has been investigated as a potential treatment for these diseases. * However, the development of these drugs has been challenging due to the complex regulation of IRF2. **Additional information:** * IRF2 is a highly conserved protein, with a similar sequence in mice and humans. * It is a member of the IRF family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression. * IRF2 is a well-studied protein, and its role in immunity is well-established.

Genular Protein ID: 526771962

Symbol: IRF2_HUMAN

Name: Interferon regulatory factor 2

UniProtKB Accession Codes:

P14316 D6RCK5 H0Y8S3 Q6IAS7 Q96B99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 EPD 1 Ensembl 12 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2813069

Title: Sequence of a cDNA coding for human IRF-2.

PubMed ID: 2813069

DOI: 10.1093/nar/17.20.8372

PubMed ID: 8106512

Title: Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region.

PubMed ID: 8106512

DOI: 10.1016/s0021-9258(17)37685-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9540062

Title: The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes.

PubMed ID: 9540062

DOI: 10.1023/a:1006888731301

PubMed ID: 11025449

Title: Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2.

PubMed ID: 11025449

DOI: 10.1002/1097-4652(200011)185:2<269::aid-jcp12>3.0.co;2-l

PubMed ID: 11058120

Title: Cloning of an interferon regulatory factor 2 isoform with different regulatory ability.

PubMed ID: 11058120

DOI: 10.1093/nar/28.21.4219

PubMed ID: 12738767

Title: Interferon regulatory factor-2 regulates cell growth through its acetylation.

PubMed ID: 12738767

DOI: 10.1074/jbc.m213037200

PubMed ID: 12799427

Title: Identification of novel co-repressor molecules for interferon regulatory factor-2.

PubMed ID: 12799427

DOI: 10.1093/nar/gkg431

PubMed ID: 15226432

Title: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.

PubMed ID: 15226432

DOI: 10.1128/mcb.24.14.6298-6310.2004

PubMed ID: 18514056

Title: Regulation of IRF2 transcriptional activity by its sumoylation.

PubMed ID: 18514056

DOI: 10.1016/j.bbrc.2008.05.103

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 349
  • Mass: 39354
  • Checksum: 6298341652466560
  • Sequence:
    • MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMH AARHGWDVEK DAPLFRNWAI 
HTGKHQPGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIK KGNNAFRVYR MLPLSERPSK 
KGKKPKTEKE DKVKHIKQEP VESSLGLSNG VSDLSPEYAV LTSTIKNEVD STVNIIVVGQ 
SHLDSNIENQ EIVTNPPDIC QVVEVTTESD EQPVSMSELY PLQISPVSSY AESETTDSVP 
SDEESAEGRP HWRKRNIEGK QYLSNMGTRG SYLLPGMASF VTSNKPDLQV TIKEESNPVP 
YNSSWPPFQD LPLSSSMTPA SSSSRPDRET RASVIKKTSD ITQARVKSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.