Details for: IRF2

Gene ID: 3660

Symbol: IRF2

Ensembl ID: ENSG00000168310

Description: interferon regulatory factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 243.4019
    Cell Significance Index: -37.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.6158
    Cell Significance Index: -38.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.3868
    Cell Significance Index: -44.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.0199
    Cell Significance Index: -37.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.7979
    Cell Significance Index: -42.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 65.8399
    Cell Significance Index: -44.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.2412
    Cell Significance Index: -38.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.8293
    Cell Significance Index: -41.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1832
    Cell Significance Index: -37.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9528
    Cell Significance Index: -32.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9958
    Cell Significance Index: -43.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4911
    Cell Significance Index: 162.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3495
    Cell Significance Index: 103.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3229
    Cell Significance Index: 238.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0981
    Cell Significance Index: 135.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0309
    Cell Significance Index: 53.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9511
    Cell Significance Index: 154.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8417
    Cell Significance Index: 168.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7061
    Cell Significance Index: 13.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6481
    Cell Significance Index: 16.6600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6281
    Cell Significance Index: 10.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5937
    Cell Significance Index: 81.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5861
    Cell Significance Index: 14.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5779
    Cell Significance Index: 114.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5587
    Cell Significance Index: 305.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5240
    Cell Significance Index: 4.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4864
    Cell Significance Index: 57.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4689
    Cell Significance Index: 22.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4611
    Cell Significance Index: 12.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4523
    Cell Significance Index: 312.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4285
    Cell Significance Index: 22.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3877
    Cell Significance Index: 26.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3754
    Cell Significance Index: 165.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3631
    Cell Significance Index: 35.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3447
    Cell Significance Index: 16.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3398
    Cell Significance Index: 9.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3152
    Cell Significance Index: 113.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3085
    Cell Significance Index: 9.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3079
    Cell Significance Index: 6.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3055
    Cell Significance Index: 8.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2671
    Cell Significance Index: 17.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2462
    Cell Significance Index: 11.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2177
    Cell Significance Index: 41.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1731
    Cell Significance Index: 156.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1483
    Cell Significance Index: 94.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1431
    Cell Significance Index: 7.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1172
    Cell Significance Index: 15.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0552
    Cell Significance Index: 103.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0484
    Cell Significance Index: 2.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0392
    Cell Significance Index: 72.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0299
    Cell Significance Index: 45.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0033
    Cell Significance Index: 1.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0185
    Cell Significance Index: -2.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0194
    Cell Significance Index: -26.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0290
    Cell Significance Index: -21.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0350
    Cell Significance Index: -26.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0369
    Cell Significance Index: -5.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0491
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0555
    Cell Significance Index: -41.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0585
    Cell Significance Index: -5.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0814
    Cell Significance Index: -50.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0818
    Cell Significance Index: -46.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0945
    Cell Significance Index: -6.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1270
    Cell Significance Index: -3.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1314
    Cell Significance Index: -37.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1479
    Cell Significance Index: -25.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1655
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1692
    Cell Significance Index: -19.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1856
    Cell Significance Index: -8.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1952
    Cell Significance Index: -6.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2029
    Cell Significance Index: -12.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2171
    Cell Significance Index: -14.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2369
    Cell Significance Index: -49.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2442
    Cell Significance Index: -7.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2763
    Cell Significance Index: -3.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2877
    Cell Significance Index: -7.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2879
    Cell Significance Index: -32.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2972
    Cell Significance Index: -8.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3317
    Cell Significance Index: -12.5600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3365
    Cell Significance Index: -4.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3372
    Cell Significance Index: -25.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3381
    Cell Significance Index: -2.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3558
    Cell Significance Index: -37.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4070
    Cell Significance Index: -25.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4249
    Cell Significance Index: -9.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4412
    Cell Significance Index: -6.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4662
    Cell Significance Index: -36.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4816
    Cell Significance Index: -7.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4823
    Cell Significance Index: -8.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5321
    Cell Significance Index: -8.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5365
    Cell Significance Index: -28.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6143
    Cell Significance Index: -13.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7006
    Cell Significance Index: -18.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7070
    Cell Significance Index: -43.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7392
    Cell Significance Index: -12.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7492
    Cell Significance Index: -17.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7761
    Cell Significance Index: -26.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7911
    Cell Significance Index: -15.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8616
    Cell Significance Index: -22.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8834
    Cell Significance Index: -26.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IRF2 is a DNA-binding transcription factor that belongs to the interferon regulatory factor family. It is characterized by its ability to bind to specific DNA sequences, regulating the transcription of target genes. IRF2 is predominantly expressed in hematopoietic cells, including T cells, B cells, and dendritic cells, as well as in non-hematopoietic cells such as astrocytes and pulmonary interstitial fibroblasts. The protein is highly conserved across species, with a high degree of sequence similarity to other IRF family members. **Pathways and Functions:** IRF2 plays a pivotal role in regulating various cellular processes, including: 1. **Interferon signaling:** IRF2 is a key component of the interferon regulatory factor complex, which is essential for the transcriptional regulation of interferon-stimulated genes (ISGs). 2. **Immune system development:** IRF2 is involved in the development and differentiation of immune cells, including T cells and B cells. 3. **Apoptosis:** IRF2 can modulate the expression of pro-apoptotic and anti-apoptotic genes, influencing the regulation of cell death. 4. **Cell proliferation:** IRF2 can regulate cell cycle progression and cell proliferation, particularly in the context of immune cell development. **Clinical Significance:** IRF2 dysregulation has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Alterations in IRF2 expression have been linked to autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** IRF2 has been shown to play a role in cancer development and progression, particularly in the context of immune cell infiltration. 3. **Viral infections:** IRF2 is essential for the regulation of ISGs, which are critical for the defense against viral infections. In conclusion, IRF2 plays a crucial role in regulating immune responses and modulating various cellular processes. Further research is needed to fully elucidate the mechanisms by which IRF2 regulates immune function and to explore its potential as a therapeutic target for immune-related disorders. **Significantly expressed cells:** - Pulmonary interstitial fibroblast - Astrocyte of the cerebral cortex - Blood cell - Small pre-B-II cell - Conjunctival epithelial cell - Corneal epithelial cell - Late pro-B cell - Regular ventricular cardiac myocyte - CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell - Non-pigmented ciliary epithelial cell **Proteins:** - IRF2_HUMAN (Interferon regulatory factor 2)

Genular Protein ID: 526771962

Symbol: IRF2_HUMAN

Name: Interferon regulatory factor 2

UniProtKB Accession Codes:

P14316 D6RCK5 H0Y8S3 Q6IAS7 Q96B99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 Ensembl 12 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2813069

Title: Sequence of a cDNA coding for human IRF-2.

PubMed ID: 2813069

DOI: 10.1093/nar/17.20.8372

PubMed ID: 8106512

Title: Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region.

PubMed ID: 8106512

DOI: 10.1016/s0021-9258(17)37685-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9540062

Title: The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes.

PubMed ID: 9540062

DOI: 10.1023/a:1006888731301

PubMed ID: 11025449

Title: Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2.

PubMed ID: 11025449

DOI: 10.1002/1097-4652(200011)185:2<269::aid-jcp12>3.0.co;2-l

PubMed ID: 11058120

Title: Cloning of an interferon regulatory factor 2 isoform with different regulatory ability.

PubMed ID: 11058120

DOI: 10.1093/nar/28.21.4219

PubMed ID: 12738767

Title: Interferon regulatory factor-2 regulates cell growth through its acetylation.

PubMed ID: 12738767

DOI: 10.1074/jbc.m213037200

PubMed ID: 12799427

Title: Identification of novel co-repressor molecules for interferon regulatory factor-2.

PubMed ID: 12799427

DOI: 10.1093/nar/gkg431

PubMed ID: 15226432

Title: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.

PubMed ID: 15226432

DOI: 10.1128/mcb.24.14.6298-6310.2004

PubMed ID: 18514056

Title: Regulation of IRF2 transcriptional activity by its sumoylation.

PubMed ID: 18514056

DOI: 10.1016/j.bbrc.2008.05.103

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 349
  • Mass: 39354
  • Checksum: 6298341652466560
  • Sequence:
    • MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMH AARHGWDVEK DAPLFRNWAI 
HTGKHQPGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIK KGNNAFRVYR MLPLSERPSK 
KGKKPKTEKE DKVKHIKQEP VESSLGLSNG VSDLSPEYAV LTSTIKNEVD STVNIIVVGQ 
SHLDSNIENQ EIVTNPPDIC QVVEVTTESD EQPVSMSELY PLQISPVSSY AESETTDSVP 
SDEESAEGRP HWRKRNIEGK QYLSNMGTRG SYLLPGMASF VTSNKPDLQV TIKEESNPVP 
YNSSWPPFQD LPLSSSMTPA SSSSRPDRET RASVIKKTSD ITQARVKSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.