Details for: ITPA

Gene ID: 3704

Symbol: ITPA

Ensembl ID: ENSG00000125877

Description: inosine triphosphatase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.72
    Marker Score: 7407
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.58
    Marker Score: 1653
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.56
    Marker Score: 2295
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.53
    Marker Score: 13194
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.49
    Marker Score: 6113
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.49
    Marker Score: 820
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.45
    Marker Score: 9258
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.43
    Marker Score: 5608
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.42
    Marker Score: 3374
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.41
    Marker Score: 953
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.39
    Marker Score: 14067
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.34
    Marker Score: 46450
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.33
    Marker Score: 14984
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.31
    Marker Score: 2769
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.31
    Marker Score: 2733
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3
    Marker Score: 869
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.3
    Marker Score: 4805
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.29
    Marker Score: 372
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.29
    Marker Score: 1361
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.28
    Marker Score: 636
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.24
    Marker Score: 1338
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.23
    Marker Score: 1962
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.23
    Marker Score: 2797
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.22
    Marker Score: 1299
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.2
    Marker Score: 30699
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.2
    Marker Score: 616
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.19
    Marker Score: 1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.18
    Marker Score: 9209
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.16
    Marker Score: 1922
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.16
    Marker Score: 1965
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.15
    Marker Score: 837
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.14
    Marker Score: 551
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.13
    Marker Score: 1212
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.13
    Marker Score: 1067
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.13
    Marker Score: 13169
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.13
    Marker Score: 1505
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.13
    Marker Score: 1819
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.12
    Marker Score: 388
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.12
    Marker Score: 708
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.11
    Marker Score: 1154
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.09
    Marker Score: 1686
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.09
    Marker Score: 256
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.08
    Marker Score: 307
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.08
    Marker Score: 4167
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.08
    Marker Score: 6889
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.08
    Marker Score: 274
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.07
    Marker Score: 1129
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.07
    Marker Score: 1201
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.07
    Marker Score: 2900
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.06
    Marker Score: 431
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.04
    Marker Score: 1056
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.04
    Marker Score: 1214
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.04
    Marker Score: 6739
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.03
    Marker Score: 972
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.03
    Marker Score: 255
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.03
    Marker Score: 2845
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.03
    Marker Score: 508
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.03
    Marker Score: 7654
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.02
    Marker Score: 1443
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 644
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.01
    Marker Score: 636
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.01
    Marker Score: 2379
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.01
    Marker Score: 241
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.01
    Marker Score: 842
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1
    Marker Score: 1951
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1
    Marker Score: 317
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1
    Marker Score: 1738
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71595
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1
    Marker Score: 679.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47819
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.99
    Marker Score: 346
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.99
    Marker Score: 1275
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.98
    Marker Score: 3493
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.98
    Marker Score: 369
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30369
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.98
    Marker Score: 872
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.97
    Marker Score: 1038
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.97
    Marker Score: 8427
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.97
    Marker Score: 311
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.96
    Marker Score: 1126
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.96
    Marker Score: 210
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.96
    Marker Score: 9474
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.96
    Marker Score: 1568.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.95
    Marker Score: 9575.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.95
    Marker Score: 12539
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.95
    Marker Score: 592
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.95
    Marker Score: 4538
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.94
    Marker Score: 1297
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.94
    Marker Score: 2143
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2380
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.93
    Marker Score: 1770
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.93
    Marker Score: 51928
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.93
    Marker Score: 488
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.92
    Marker Score: 234
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.92
    Marker Score: 2245
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.92
    Marker Score: 1638.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.92
    Marker Score: 919
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.92
    Marker Score: 721
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.91
    Marker Score: 2307

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Other Information

**Key characteristics:** * ITPA is a secreted protein that is expressed in a variety of cell types. * It is a transmembrane protein with a molecular weight of approximately 135 kDa. * ITPA is a ubiquitin-dependent protein that is regulated by a variety of factors, including growth factors and cytokines. * ITPA is a key regulator of cell growth, differentiation, and apoptosis. **Pathways and functions:** * ITPA is involved in the regulation of the cell cycle, as it is required for the synthesis of DNA nucleotides during S phase. * ITPA is also involved in the regulation of apoptosis, as it is a key regulator of cell death. * ITPA is also involved in the regulation of inflammation, as it is a key enzyme in the production of inflammatory cytokines. **Clinical significance:** * Mutations in the ITPA gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * ITPA inhibitors are being investigated as a treatment for these diseases. **Additional notes:** * ITPA is a highly conserved protein, with a similar protein found in other mammals. * ITPA is a relatively new protein, with the first known human gene encoding ITPA being identified in 1991.

Genular Protein ID: 1569053125

Symbol: ITPA_HUMAN

Name: Putative oncogene protein hlc14-06-p

UniProtKB Accession Codes:

Q9BY32 A2A2N2 A4UIM5 B2BCH7 O14878 Q5JWH4 Q9BYN1 Q9BYX0 Q9H3H8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 34 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 5 EMBL 11 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 10 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11278832

Title: Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the ITPA gene.

PubMed ID: 11278832

DOI: 10.1074/jbc.m011084200

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17090528

Title: Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.

PubMed ID: 17090528

DOI: 10.1074/jbc.m608708200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26224535

Title: Recessive ITPA mutations cause an early infantile encephalopathy.

PubMed ID: 26224535

DOI: 10.1002/ana.24496

PubMed ID: 17077483

Title: Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase.

PubMed ID: 17077483

DOI: 10.1107/s1744309106041790

PubMed ID: 17138556

Title: Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.

PubMed ID: 17138556

DOI: 10.1074/jbc.m609838200

PubMed ID: 12384777

Title: Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

PubMed ID: 12384777

DOI: 10.1007/s00439-002-0798-z

PubMed ID: 12436200

Title: DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency.

PubMed ID: 12436200

DOI: 10.1007/s100380200095

Sequence Information:

  • Length: 194
  • Mass: 21446
  • Checksum: F0EC6A523722DF05
  • Sequence:
    • MAASLVGKKI VFVTGNAKKL EEVVQILGDK FPCTLVAQKI DLPEYQGEPD EISIQKCQEA 
VRQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLAGFEDK SAYALCTFAL 
STGDPSQPVR LFRGRTSGRI VAPRGCQDFG WDPCFQPDGY EQTYAEMPKA EKNAVSHRFR 
ALLELQEYFG SLAA

Genular Protein ID: 2235929170

Symbol: Q8WWI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WWI0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GenomeRNAi 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 3 SAM 1

Sequence Information:

  • Length: 110
  • Mass: 11996
  • Checksum: 1E41DE21E529CF9D
  • Sequence:
    • MRSARLHSAP GTQASPCACS GAGPRAGSWH PEAARTLAGT PAFSLMDMSR RTQRCLRRRR 
TLSPIASGPC WSCRSTLAVW QLDFCSWRRP LRPGIWGGLA QNLPHRAGTP

Genular Protein ID: 25735896

Symbol: A0A0S2Z423_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z423

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 1 GenomeRNAi 1 HAMAP 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 153
  • Mass: 16833
  • Checksum: DDC0D289C0158A76
  • Sequence:
    • MAASLVGKKI VFVTGNAKKL EEVQGPVLVE DTCLCFNALG GLPGPYIKWF LEKLKPEGLH 
QLLAGFEDKS AYALCTFALS TGDPSQPVRL FRGRTSGRIV APRGCQDFGW DPCFQPDGYE 
QTYAEMPKAE KNAVSHRFRA LLELQEYFGS LAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.