Details for: ITPA
Gene ID: 3704
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ITPA
Ensembl ID: ENSG00000125877
Description: inosine triphosphatase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 11.78rCSI 14.57%PRS 35.42
-
CSI 8.72rCSI 16.46%PRS 48.7
-
CSI 8.51rCSI 6.92%PRS 40.31
-
CSI 7.3rCSI 20.84%PRS 54.14
-
CSI 6.12rCSI 11.91%PRS 41.07
-
CSI 4.91rCSI 28.16%PRS 50.33
-
CSI 4.37rCSI 9.69%PRS 36.66
-
CSI 4.31rCSI 10.38%PRS 56.46
-
CSI 4.18rCSI 4.03%PRS 39.92
-
CSI 3.72rCSI 9.82%PRS 46.24
-
CSI 3.64rCSI 10.43%PRS 55.86
-
CSI 3.64rCSI 3.51%PRS 30.88
-
CSI 3.4rCSI 5.12%PRS 40.86
-
CSI 3.32rCSI 2.52%PRS 49.78
-
CSI 3.11rCSI 2.34%PRS 42.26
-
CSI 3.08rCSI 6.9%PRS 26.1
-
CSI 3.06rCSI 2.31%PRS 50.81
-
CSI 2.99rCSI 4.09%PRS 43.82
-
CSI 2.87rCSI 4.44%PRS 37.43
-
CSI 2.84rCSI 7.21%PRS 36.31
-
CSI 2.8rCSI 2.09%PRS 53.44
-
CSI 2.63rCSI 4.04%PRS 42.92
-
CSI 2.56rCSI 3.1%PRS 46.28
-
CSI 2.54rCSI 4.57%PRS 33.53
-
CSI 2.5rCSI 2.87%PRS 62.12
-
CSI 2.49rCSI 3.44%PRS 45.09
-
CSI 2.44rCSI 3.11%PRS 44.29
-
CSI 2.44rCSI 1.64%PRS 48.64
-
CSI 2.43rCSI 4.87%PRS 30.39
-
CSI 2.37rCSI 1.99%PRS 56.04
-
CSI 2.33rCSI 1.62%PRS 47.08
-
CSI 2.32rCSI 3.31%PRS 42.07
-
CSI 2.29rCSI 1.6%PRS 51.55
-
CSI 2.27rCSI 7.35%PRS 42.8
-
CSI 2.26rCSI 3.32%PRS 39.76
-
CSI 2.26rCSI 2.07%PRS 46.12
-
CSI 2.23rCSI 3.61%PRS 38.24
-
CSI 2.18rCSI 7.9%PRS 58.07
-
CSI 2.17rCSI 2.13%PRS 53.97
-
CSI 2.12rCSI 2.01%PRS 40.48
-
CSI 2.1rCSI 1.9%PRS 36.2
-
CSI 2.1rCSI 4.68%PRS 45.33
-
CSI 2.08rCSI 3.07%PRS 56.24
-
CSI 2.07rCSI 3.65%PRS 24.62
-
CSI 2.06rCSI 3.52%PRS 65.29
-
CSI 2.06rCSI 1.37%PRS 43.38
-
CSI 2.05rCSI 1.21%PRS 53.07
-
CSI 2.03rCSI 5.98%PRS 43.59
-
CSI 2.02rCSI 3.21%PRS 33.37
-
CSI 2.01rCSI 1.58%PRS 45.23
-
CSI 1.94rCSI 1.7%PRS 48.68
-
CSI 1.94rCSI 2.01%PRS 44.8
-
CSI 1.92rCSI 15.64%PRS 35.01
-
CSI 1.92rCSI 2.31%PRS 37.63
-
CSI 1.91rCSI 4.99%PRS 38.5
-
CSI 1.9rCSI 3.45%PRS 55.1
-
CSI 1.9rCSI 3.19%PRS 25.55
-
CSI 1.87rCSI 9.38%PRS 49.61
-
CSI 1.86rCSI 1.94%PRS 39.93
-
CSI 1.86rCSI 1.44%PRS 39.43
-
CSI 1.82rCSI 4.16%PRS 38.88
-
CSI 1.81rCSI 1.85%PRS 57.87
-
CSI 1.8rCSI 1.56%PRS 47.66
-
CSI 1.79rCSI 6.69%PRS 33.54
-
CSI 1.78rCSI 1.32%PRS 51.84
-
CSI 1.78rCSI 1.41%PRS 28.39
-
CSI 1.74rCSI 2.46%PRS 36.82
-
CSI 1.74rCSI 1.53%PRS 44.11
-
CSI 1.73rCSI 1.82%PRS 41.71
-
CSI 1.73rCSI 2.84%PRS 31.22
-
CSI 1.72rCSI 3.01%PRS 32.49
-
CSI 1.68rCSI 1.73%PRS 56.48
-
CSI 1.66rCSI 1.16%PRS 41.04
-
CSI 1.65rCSI 2.63%PRS 42.6
-
CSI 1.57rCSI 1.4%PRS 38.56
-
CSI 1.57rCSI 1.64%PRS 39.28
-
CSI 1.56rCSI 1.37%PRS 29.7
-
CSI 1.56rCSI 17.03%PRS 56.39
-
CSI 1.54rCSI 1.92%PRS 41.89
-
CSI 1.53rCSI 1.77%PRS 34.45
-
CSI 1.52rCSI 2.5%PRS 44.45
-
CSI 1.51rCSI 2.08%PRS 59.74
-
CSI 1.51rCSI 1.3%PRS 48.73
-
CSI 1.51rCSI 2%PRS 43.59
-
CSI 1.51rCSI 1.87%PRS 24.21
-
CSI 1.5rCSI 1.96%PRS 52.07
-
CSI 1.5rCSI 2.38%PRS 49.1
-
CSI 1.48rCSI 2.18%PRS 49.88
-
CSI 1.46rCSI 1.21%PRS 40.12
-
CSI 1.44rCSI 3.44%PRS 42.02
-
CSI 1.42rCSI 1.52%PRS 37.25
-
CSI 1.42rCSI 2.17%PRS 39.84
-
CSI 1.41rCSI 1.48%PRS 36.89
-
CSI 1.41rCSI 2.48%PRS 38.19
-
CSI 1.4rCSI 1.49%PRS 54.85
-
CSI 1.39rCSI 1.75%PRS 48.36
-
CSI 1.38rCSI 2.23%PRS 31.2
-
CSI 1.38rCSI 1.77%PRS 43.86
-
CSI 1.38rCSI 1.91%PRS 39.1
-
CSI 1.36rCSI 1.75%PRS 26.42
-
CSI 0.2rCSI 5.3%PRS 64.5%
-
CSI 0.2rCSI 4.3%PRS 62.3%
-
CSI 0.3rCSI 0.8%PRS 31.1%
-
CSI 0.3rCSI 0.8%PRS 38.3%
-
CSI 0.4rCSI 1.2%PRS 24.5%
-
CSI 0.4rCSI 1.9%PRS 54.5%
-
CSI 0.4rCSI 2.1%PRS 50.4%
-
CSI 0.5rCSI 2.1%PRS 62.4%
-
CSI 0.5rCSI 2.1%PRS 56.2%
-
CSI 0.5rCSI 2.8%PRS 50.5%
-
CSI 0.5rCSI 2.2%PRS 38.0%
-
CSI 0.6rCSI 1.7%PRS 41.9%
-
CSI 0.6rCSI 1.4%PRS 24.8%
-
CSI 0.6rCSI 1.9%PRS 47.6%
-
CSI 0.6rCSI 3.1%PRS 63.4%
-
CSI 0.6rCSI 2.7%PRS 59.2%
-
CSI 0.6rCSI 0.9%PRS 55.4%
-
CSI 0.6rCSI 2.9%PRS 63.2%
-
CSI 0.6rCSI 1.7%PRS 48.1%
-
CSI 0.6rCSI 0.8%PRS 37.2%
-
CSI 0.7rCSI 5.7%PRS 57.2%
-
CSI 0.7rCSI 1.3%PRS 25.2%
-
CSI 0.8rCSI 1.8%PRS 49.9%
-
CSI 0.8rCSI 1.1%PRS 43.9%
-
CSI 0.8rCSI 5.9%PRS 59.8%
-
CSI 0.8rCSI 1.1%PRS 33.8%
-
CSI 0.8rCSI 2.6%PRS 26.6%
-
CSI 0.8rCSI 1.5%PRS 37.8%
-
CSI 0.9rCSI 1.1%PRS 25.5%
-
CSI 0.9rCSI 1.0%PRS 30.4%
-
CSI 0.9rCSI 6.0%PRS 62.1%
-
CSI 0.9rCSI 2.3%PRS 37.5%
-
CSI 0.9rCSI 1.5%PRS 34.0%
-
CSI 1.0rCSI 2.0%PRS 54.3%
-
CSI 1.0rCSI 3.4%PRS 55.2%
-
CSI 1.0rCSI 1.8%PRS 55.2%
-
CSI 1.0rCSI 1.6%PRS 40.3%
-
CSI 1.0rCSI 2.9%PRS 54.1%
-
CSI 1.0rCSI 1.5%PRS 42.1%
-
CSI 1.1rCSI 1.4%PRS 42.0%
-
CSI 1.1rCSI 2.0%PRS 59.5%
-
CSI 1.1rCSI 2.0%PRS 62.4%
-
CSI 1.1rCSI 1.6%PRS 49.3%
-
CSI 1.1rCSI 1.9%PRS 48.4%
-
CSI 1.1rCSI 2.6%PRS 51.8%
-
CSI 1.1rCSI 1.4%PRS 46.5%
-
CSI 1.2rCSI 1.4%PRS 43.1%
-
CSI 1.2rCSI 1.0%PRS 43.1%
-
CSI 1.2rCSI 1.0%PRS 44.4%
-
CSI 1.2rCSI 4.2%PRS 76.4%
-
CSI 1.2rCSI 3.5%PRS 57.4%
-
CSI 1.2rCSI 1.8%PRS 53.0%
-
CSI 1.2rCSI 1.0%PRS 39.8%
-
CSI 1.2rCSI 1.9%PRS 56.8%
-
CSI 1.2rCSI 4.2%PRS 49.9%
-
CSI 1.2rCSI 1.6%PRS 52.5%
-
CSI 1.2rCSI 1.2%PRS 34.1%
-
CSI 1.3rCSI 1.9%PRS 45.7%
-
CSI 1.3rCSI 1.6%PRS 37.5%
-
CSI 1.3rCSI 1.0%PRS 37.9%
-
CSI 1.3rCSI 1.2%PRS 40.4%
-
CSI 1.3rCSI 3.5%PRS 62.4%
-
CSI 1.3rCSI 1.1%PRS 37.9%
-
CSI 1.4rCSI 1.8%PRS 26.4%
-
CSI 1.4rCSI 1.9%PRS 39.1%
-
CSI 1.4rCSI 1.8%PRS 43.9%
-
CSI 1.4rCSI 2.2%PRS 31.2%
-
CSI 1.4rCSI 1.8%PRS 48.4%
-
CSI 1.4rCSI 1.5%PRS 54.9%
-
CSI 1.4rCSI 2.5%PRS 38.2%
-
CSI 1.4rCSI 1.5%PRS 36.9%
-
CSI 1.4rCSI 2.2%PRS 39.8%
-
CSI 1.4rCSI 1.5%PRS 37.3%
-
CSI 1.4rCSI 3.4%PRS 42.0%
-
CSI 1.5rCSI 1.2%PRS 40.1%
-
CSI 1.5rCSI 2.2%PRS 49.9%
-
CSI 1.5rCSI 2.4%PRS 49.1%
-
CSI 1.5rCSI 2.0%PRS 52.1%
-
CSI 1.5rCSI 1.9%PRS 24.2%
-
CSI 1.5rCSI 2.0%PRS 43.6%
-
CSI 1.5rCSI 1.3%PRS 48.7%
-
CSI 1.5rCSI 2.1%PRS 59.7%
-
CSI 1.5rCSI 2.5%PRS 44.5%
-
CSI 1.5rCSI 1.8%PRS 34.5%
-
CSI 1.5rCSI 1.9%PRS 41.9%
-
CSI 1.6rCSI 17.0%PRS 56.4%
-
CSI 1.6rCSI 1.4%PRS 29.7%
-
CSI 1.6rCSI 1.6%PRS 39.3%
-
CSI 1.6rCSI 1.4%PRS 38.6%
-
CSI 1.7rCSI 2.6%PRS 42.6%
-
CSI 1.7rCSI 1.2%PRS 41.0%
-
CSI 1.7rCSI 1.7%PRS 56.5%
-
CSI 1.7rCSI 3.0%PRS 32.5%
-
CSI 1.7rCSI 2.8%PRS 31.2%
-
CSI 1.7rCSI 1.8%PRS 41.7%
-
CSI 1.7rCSI 1.5%PRS 44.1%
-
CSI 1.7rCSI 2.5%PRS 36.8%
-
CSI 1.8rCSI 1.4%PRS 28.4%
-
CSI 1.8rCSI 1.3%PRS 51.8%
-
CSI 1.8rCSI 6.7%PRS 33.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1569053125
Symbol: ITPA_HUMAN
Name: Putative oncogene protein hlc14-06-p
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11278832
Title: Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the ITPA gene.
PubMed ID: 11278832
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17090528
Title: Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.
PubMed ID: 17090528
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 26224535
Title: Recessive ITPA mutations cause an early infantile encephalopathy.
PubMed ID: 26224535
DOI: 10.1002/ana.24496
PubMed ID: 17077483
Title: Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase.
PubMed ID: 17077483
PubMed ID: 17138556
Title: Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.
PubMed ID: 17138556
PubMed ID: 12384777
Title: Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.
PubMed ID: 12384777
PubMed ID: 12436200
Title: DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency.
PubMed ID: 12436200
Sequence Information:
- Length: 194
- Mass: 21446
- Checksum: F0EC6A523722DF05
- Sequence:
MAASLVGKKI VFVTGNAKKL EEVVQILGDK FPCTLVAQKI DLPEYQGEPD EISIQKCQEA VRQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLAGFEDK SAYALCTFAL STGDPSQPVR LFRGRTSGRI VAPRGCQDFG WDPCFQPDGY EQTYAEMPKA EKNAVSHRFR ALLELQEYFG SLAA
Genular Protein ID: 2235929170
Symbol: Q8WWI0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 110
- Mass: 11996
- Checksum: 1E41DE21E529CF9D
- Sequence:
MRSARLHSAP GTQASPCACS GAGPRAGSWH PEAARTLAGT PAFSLMDMSR RTQRCLRRRR TLSPIASGPC WSCRSTLAVW QLDFCSWRRP LRPGIWGGLA QNLPHRAGTP
Genular Protein ID: 25735896
Symbol: A0A0S2Z423_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 153
- Mass: 16833
- Checksum: DDC0D289C0158A76
- Sequence:
MAASLVGKKI VFVTGNAKKL EEVQGPVLVE DTCLCFNALG GLPGPYIKWF LEKLKPEGLH QLLAGFEDKS AYALCTFALS TGDPSQPVRL FRGRTSGRIV APRGCQDFGW DPCFQPDGYE QTYAEMPKAE KNAVSHRFRA LLELQEYFGS LAA