Details for: KIR2DS4

Gene ID: 3809

Symbol: KIR2DS4

Ensembl ID: ENSG00000221957

Description: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 206
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 34.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 12.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 8.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 17

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Other Information

**Key characteristics:** * KIR2DS4 is a member of the killer cell immunoglobulin like receptor (KIR) family of cell surface receptors. * It is expressed on activated T cells, NK cells, and epithelial cells. * It is a type I membrane protein with two Ig domains and a short cytoplasmic tail. **Pathways and functions:** * KIR2DS4 is a receptor for the CD158 antigen, which is expressed on activated T cells. * When KIR2DS4 binds to CD158, it triggers a signaling cascade that leads to the activation of the immune response. * KIR2DS4 is involved in the regulation of T cell responses and the development of autoimmune diseases. **Clinical significance:** * KIR2DS4 is a potential therapeutic target for autoimmune diseases that are characterized by excessive T cell activity, such as rheumatoid arthritis, lupus, and multiple sclerosis. * Blocking KIR2DS4 signaling has been shown to be effective in inhibiting T cell activation and reducing inflammation. * KIR2DS4 is a promising target for the development of novel therapeutic strategies for autoimmune diseases.

Genular Protein ID: 229608910

Symbol: KI2S4_HUMAN

Name: CD158 antigen-like family member I

UniProtKB Accession Codes:

P43632 Q6H2G7

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 15 EvolutionaryTrace 1 GO 2 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 1 SMR 1 SUPFAM 1 SignaLink 1 UCSC 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7749980

Title: Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

PubMed ID: 7749980

DOI: 10.1016/1074-7613(95)90025-x

PubMed ID: 8662091

Title: Alternatively spliced forms of human killer inhibitory receptors.

PubMed ID: 8662091

DOI: 10.1007/bf02602590

PubMed ID: 8765026

Title: A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation.

PubMed ID: 8765026

DOI: 10.1002/eji.1830260823

PubMed ID: 14607943

Title: Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.

PubMed ID: 14607943

DOI: 10.4049/jimmunol.171.10.5396

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24018270

Title: HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.

PubMed ID: 24018270

DOI: 10.4049/jimmunol.1300081

PubMed ID: 19858347

Title: KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.

PubMed ID: 19858347

DOI: 10.1084/jem.20091010

Sequence Information:

  • Length: 304
  • Mass: 33583
  • Checksum: CEFDAFF3FD679A3F
  • Sequence:
    • MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL 
HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM 
VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAVRSINGT 
FQADFPLGPA THGGTYRCFG SFRDAPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN 
PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE 
VSYA

Genular Protein ID: 1121160076

Symbol: A0A0C4ZN30_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4ZN30

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 7 Ensembl 2 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 239
  • Mass: 25976
  • Checksum: 494BB353BE57003E
  • Sequence:
    • MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL 
HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM 
VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SIYPGKGRPM NVGSLQCAAS TEHSRPTFLW 
ALPPTEGPTD ASALSVTLPT SGQTRVIHCL FPSQETLQIV GLHPLNQAPK PVTPDTYMF

Genular Protein ID: 2248219778

Symbol: Q86VI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86VI6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 12391228

Title: Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets.

PubMed ID: 12391228

Sequence Information:

  • Length: 222
  • Mass: 24167
  • Checksum: 1A23219EE2C6CFA4
  • Sequence:
    • MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL 
HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM 
VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SIYPGRGRPM NVGSLQCAAS TEHSRPTFLW 
ALPPTEGPTD ASALSVTLPT SGQTRVIHCL FPSQVTPDTY MF

Genular Protein ID: 55280537

Symbol: A0A1W2PR63_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1W2PR63

Database IDs:

ARBA 1 AlphaFoldDB 1 BioMuta 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 Gene3D 1 GenomeRNAi 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 222
  • Mass: 24139
  • Checksum: 1A2336B9D2D1E894
  • Sequence:
    • MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL 
HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM 
VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SIYPGKGRPM NVGSLQCAAS TEHSRPTFLW 
ALPPTEGPTD ASALSVTLPT SGQTRVIHCL FPSQVTPDTY MF

Genular Protein ID: 681161733

Symbol: Q8NHJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NHJ0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 4 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 12445308

Title: A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey.

PubMed ID: 12445308

DOI: 10.1034/j.1399-0039.2002.600307.x

Sequence Information:

  • Length: 232
  • Mass: 25188
  • Checksum: 056F2D6F4F53F234
  • Sequence:
    • MACVGFFLLQ GAWPQEGVHR KPSFLALPGH LVKSEETVIL QCWSDVMFEH FLLHREGKFN 
NTLHLIGEHH DGVSKANFSI GPMMPVLAGT YRCYGSVPHS PYQLSAPSDP LDMVIIGLYE 
KPSLSAQPGP TVQAGENVTL SCSSIYPGKG RPMNVGSLQC AASTEHSRPT FLWALPPTEG 
PTDASALSVT LPTSGQTRVI HCLFPSQETL QIVGLHPLNQ APKPVTPDTY MF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.