Details for: KIR2DS4

Gene ID: 3809

Symbol: KIR2DS4

Ensembl ID: ENSG00000221957

Description: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 (gene/pseudogene)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.3261
    Cell Significance Index: 3.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.5700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0043
    Cell Significance Index: -0.6300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0153
    Cell Significance Index: -0.2600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0169
    Cell Significance Index: -0.1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0253
    Cell Significance Index: -0.2800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0261
    Cell Significance Index: -0.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0262
    Cell Significance Index: -0.9600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0263
    Cell Significance Index: -0.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0377
    Cell Significance Index: -0.9600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0394
    Cell Significance Index: -0.6800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0512
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0517
    Cell Significance Index: -0.4900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0527
    Cell Significance Index: -0.3300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0552
    Cell Significance Index: -0.7200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0582
    Cell Significance Index: -0.6700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0602
    Cell Significance Index: -0.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0604
    Cell Significance Index: -0.7200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0605
    Cell Significance Index: -0.7300
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.0610
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0616
    Cell Significance Index: -0.6500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0623
    Cell Significance Index: -0.7800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0642
    Cell Significance Index: -0.8400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0652
    Cell Significance Index: -0.7900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0656
    Cell Significance Index: -0.8200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0673
    Cell Significance Index: -0.7700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0679
    Cell Significance Index: -0.7600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0698
    Cell Significance Index: -0.7800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0700
    Cell Significance Index: -0.7500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0703
    Cell Significance Index: -0.6600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0707
    Cell Significance Index: -0.9300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0715
    Cell Significance Index: -0.9500
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.0719
    Cell Significance Index: -0.6700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0734
    Cell Significance Index: -0.7400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0735
    Cell Significance Index: -0.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0770
    Cell Significance Index: -0.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0772
    Cell Significance Index: -0.9700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0773
    Cell Significance Index: -0.7900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0795
    Cell Significance Index: -0.8800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0795
    Cell Significance Index: -0.9400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0797
    Cell Significance Index: -1.0400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0798
    Cell Significance Index: -0.8800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0808
    Cell Significance Index: -0.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0810
    Cell Significance Index: -0.8800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0823
    Cell Significance Index: -0.8400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0833
    Cell Significance Index: -0.7700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0841
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0850
    Cell Significance Index: -0.8000
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0850
    Cell Significance Index: -0.9000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0861
    Cell Significance Index: -1.0000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0870
    Cell Significance Index: -0.9300
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0891
    Cell Significance Index: -0.9100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0898
    Cell Significance Index: -0.9300
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.0902
    Cell Significance Index: -0.7200
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.0905
    Cell Significance Index: -0.8400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0912
    Cell Significance Index: -0.9000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0916
    Cell Significance Index: -0.7000
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0933
    Cell Significance Index: -0.9200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0945
    Cell Significance Index: -0.8800
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0948
    Cell Significance Index: -0.7100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0953
    Cell Significance Index: -0.8400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0957
    Cell Significance Index: -0.7900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1003
    Cell Significance Index: -0.8300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1023
    Cell Significance Index: -0.9400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1031
    Cell Significance Index: -0.8000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1047
    Cell Significance Index: -0.9200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1196
    Cell Significance Index: -0.7100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1226
    Cell Significance Index: -0.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KIR2DS4 exhibits several distinct features that set it apart from other members of the CD158 family. Its unique Ig-like domains enable it to recognize and bind to major histocompatibility complex (MHC) class Ib proteins, a crucial step in modulating the activity of immune cells. The short cytoplasmic tail of KIR2DS4 is also noteworthy, as it facilitates its interaction with signaling molecules and other receptors, thereby influencing the downstream signaling events that govern immune cell function. **Pathways and Functions:** KIR2DS4's primary function is to regulate the activity of NK cells and other immune cells through its interaction with MHC class Ib proteins. This interaction leads to the activation or inhibition of NK cell function, depending on the specific ligand and the cellular context. KIR2DS4 also plays a role in modulating the activity of T cells, particularly CD8+ T cells, which are crucial for eliminating infected cells and tumor cells. Additionally, KIR2DS4 has been implicated in the regulation of professional antigen-presenting cells, such as dendritic cells and macrophages, which are essential for initiating and regulating immune responses. **Clinical Significance:** Dysregulation of KIR2DS4 expression has been associated with various diseases, including infectious diseases, autoimmune disorders, and cancer. For instance, alterations in KIR2DS4 expression have been linked to an increased risk of developing certain types of cancer, such as leukemia and lymphoma. Furthermore, KIR2DS4 has been shown to play a critical role in the regulation of immune responses to viral infections, highlighting its importance in vaccine development and immunotherapy. In conclusion, KIR2DS4 is a vital component of the immune system, playing a critical role in regulating the activity of immune cells and influencing the outcome of various diseases. Further research into the mechanisms of KIR2DS4 function and its role in disease pathogenesis will provide valuable insights into the development of novel therapeutic strategies for the treatment of immune-related disorders. **Recommendations for Future Research:** 1. Investigate the mechanisms by which KIR2DS4 regulates NK cell function and T cell activity. 2. Explore the role of KIR2DS4 in the regulation of immune responses to viral infections and cancer. 3. Develop novel therapeutic strategies targeting KIR2DS4 expression or function to treat immune-related disorders. By elucidating the function of KIR2DS4, researchers can gain a deeper understanding of the complex interactions between immune cells and develop innovative approaches to modulating immune responses and treating disease.

Genular Protein ID: 229608910

Symbol: KI2S4_HUMAN

Name: CD158 antigen-like family member I

UniProtKB Accession Codes:

P43632 Q6H2G7

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 15 EvolutionaryTrace 1 GO 3 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 SUPFAM 1 SignaLink 1 UCSC 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7749980

Title: Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

PubMed ID: 7749980

DOI: 10.1016/1074-7613(95)90025-x

PubMed ID: 8662091

Title: Alternatively spliced forms of human killer inhibitory receptors.

PubMed ID: 8662091

DOI: 10.1007/bf02602590

PubMed ID: 8765026

Title: A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation.

PubMed ID: 8765026

DOI: 10.1002/eji.1830260823

PubMed ID: 14607943

Title: Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.

PubMed ID: 14607943

DOI: 10.4049/jimmunol.171.10.5396

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24018270

Title: HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.

PubMed ID: 24018270

DOI: 10.4049/jimmunol.1300081

PubMed ID: 19858347

Title: KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.

PubMed ID: 19858347

DOI: 10.1084/jem.20091010

Sequence Information:

  • Length: 304
  • Mass: 33583
  • Checksum: CEFDAFF3FD679A3F
  • Sequence:
    • MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL 
HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM 
VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAVRSINGT 
FQADFPLGPA THGGTYRCFG SFRDAPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN 
PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE 
VSYA

Genular Protein ID: 2248219778

Symbol: Q86VI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86VI6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 12391228

Title: Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets.

PubMed ID: 12391228

Sequence Information:

  • Length: 222
  • Mass: 24167
  • Checksum: 1A23219EE2C6CFA4
  • Sequence:
    • MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL 
HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM 
VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SIYPGRGRPM NVGSLQCAAS TEHSRPTFLW 
ALPPTEGPTD ASALSVTLPT SGQTRVIHCL FPSQVTPDTY MF

Genular Protein ID: 681161733

Symbol: Q8NHJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NHJ0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 12445308

Title: A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey.

PubMed ID: 12445308

DOI: 10.1034/j.1399-0039.2002.600307.x

Sequence Information:

  • Length: 232
  • Mass: 25188
  • Checksum: 056F2D6F4F53F234
  • Sequence:
    • MACVGFFLLQ GAWPQEGVHR KPSFLALPGH LVKSEETVIL QCWSDVMFEH FLLHREGKFN 
NTLHLIGEHH DGVSKANFSI GPMMPVLAGT YRCYGSVPHS PYQLSAPSDP LDMVIIGLYE 
KPSLSAQPGP TVQAGENVTL SCSSIYPGKG RPMNVGSLQC AASTEHSRPT FLWALPPTEG 
PTDASALSVT LPTSGQTRVI HCLFPSQETL QIVGLHPLNQ APKPVTPDTY MF

Genular Protein ID: 1121160076

Symbol: A0A0C4ZN30_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4ZN30

Database IDs:

ARBA 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 Gene3D 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 239
  • Mass: 25976
  • Checksum: 494BB353BE57003E
  • Sequence:
    • MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL 
HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM 
VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SIYPGKGRPM NVGSLQCAAS TEHSRPTFLW 
ALPPTEGPTD ASALSVTLPT SGQTRVIHCL FPSQETLQIV GLHPLNQAPK PVTPDTYMF

Genular Protein ID: 55280537

Symbol: A0A1W2PR63_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1W2PR63

Database IDs:

ARBA 1 AlphaFoldDB 1 BioMuta 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 Gene3D 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 222
  • Mass: 24139
  • Checksum: 1A2336B9D2D1E894
  • Sequence:
    • MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL 
HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM 
VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SIYPGKGRPM NVGSLQCAAS TEHSRPTFLW 
ALPPTEGPTD ASALSVTLPT SGQTRVIHCL FPSQVTPDTY MF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.