Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: secretory cell (CL0000151)
Fold Change: 2.86
Marker Score: 5212 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.85
Marker Score: 2810.5 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.84
Marker Score: 2237 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.77
Marker Score: 6317 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.75
Marker Score: 36307 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.74
Marker Score: 20414.5 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.71
Marker Score: 93921 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.65
Marker Score: 10208 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.62
Marker Score: 6397 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.56
Marker Score: 87099 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.55
Marker Score: 19887 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.48
Marker Score: 1495.5 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.48
Marker Score: 2213 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.47
Marker Score: 873.5 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.45
Marker Score: 10565.5 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.45
Marker Score: 15918 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.42
Marker Score: 818 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.4
Marker Score: 26998 - Cell Name: mature T cell (CL0002419)
Fold Change: 2.39
Marker Score: 23717.5 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.38
Marker Score: 820 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.36
Marker Score: 20335 - Cell Name: epithelial cell (CL0000066)
Fold Change: 2.35
Marker Score: 3745 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.35
Marker Score: 12353 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.34
Marker Score: 1170 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.33
Marker Score: 6525 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.25
Marker Score: 3314.5 - Cell Name: PP cell (CL0000696)
Fold Change: 2.25
Marker Score: 506 - Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.24
Marker Score: 894 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.23
Marker Score: 2386 - Cell Name: malignant cell (CL0001064)
Fold Change: 2.23
Marker Score: 30003 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.23
Marker Score: 793 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.22
Marker Score: 2337 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.2
Marker Score: 14362 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.2
Marker Score: 3024.5 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.17
Marker Score: 2033 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.16
Marker Score: 5786 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.16
Marker Score: 3575 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.14
Marker Score: 2013 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.12
Marker Score: 7849 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.12
Marker Score: 1091 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.11
Marker Score: 21264 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.11
Marker Score: 2750 - Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.11
Marker Score: 1796 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.1
Marker Score: 3369.5 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.09
Marker Score: 18144 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.08
Marker Score: 987 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.07
Marker Score: 4144 - Cell Name: basal cell (CL0000646)
Fold Change: 2.07
Marker Score: 2675 - Cell Name: supporting cell (CL0000630)
Fold Change: 2.07
Marker Score: 3890 - Cell Name: Unknown (CL0002371)
Fold Change: 2.07
Marker Score: 2199 - Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 2.07
Marker Score: 755 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.06
Marker Score: 4677 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.06
Marker Score: 962 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.05
Marker Score: 1728 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.05
Marker Score: 5371 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.04
Marker Score: 8767 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.03
Marker Score: 4962 - Cell Name: reticular cell (CL0000432)
Fold Change: 2.03
Marker Score: 741 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.03
Marker Score: 2059.5 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 2.03
Marker Score: 1281 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.02
Marker Score: 999 - Cell Name: club cell (CL0000158)
Fold Change: 2.02
Marker Score: 2360 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.02
Marker Score: 5582.5 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.01
Marker Score: 5459 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.01
Marker Score: 579 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2
Marker Score: 478.5 - Cell Name: Unknown (CL0000548)
Fold Change: 2
Marker Score: 1458 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.99
Marker Score: 4694 - Cell Name: memory B cell (CL0000787)
Fold Change: 1.99
Marker Score: 1508 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.99
Marker Score: 20158 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.99
Marker Score: 12675 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.99
Marker Score: 3518.5 - Cell Name: peptic cell (CL0000155)
Fold Change: 1.98
Marker Score: 831 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.98
Marker Score: 1739 - Cell Name: neural crest cell (CL0011012)
Fold Change: 1.98
Marker Score: 2111 - Cell Name: naive B cell (CL0000788)
Fold Change: 1.97
Marker Score: 1762 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.97
Marker Score: 633 - Cell Name: keratinocyte (CL0000312)
Fold Change: 1.96
Marker Score: 1634 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.95
Marker Score: 617 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.92
Marker Score: 2065.5 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.91
Marker Score: 461 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.91
Marker Score: 1621 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.9
Marker Score: 589 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.89
Marker Score: 7753.5 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.89
Marker Score: 1108.5 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 1.89
Marker Score: 2101.5 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.89
Marker Score: 99950 - Cell Name: IgG plasma cell (CL0000985)
Fold Change: 1.89
Marker Score: 825 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.89
Marker Score: 3095 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.89
Marker Score: 424 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.88
Marker Score: 5943 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.88
Marker Score: 2112 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.88
Marker Score: 1769 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.88
Marker Score: 1681 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.87
Marker Score: 1330 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.87
Marker Score: 461 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.87
Marker Score: 805 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.86
Marker Score: 5504 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.85
Marker Score: 2728 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.84
Marker Score: 1080
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Other Information
Genular Protein ID: 938679933
Symbol: K1C10_HUMAN
Name: Keratin, type I cytoskeletal 10
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2459124
Title: The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences.
PubMed ID: 2459124
PubMed ID: 2464696
Title: Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10.
PubMed ID: 2464696
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2448602
Title: Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression.
PubMed ID: 2448602
DOI: 10.1007/bf00444680
PubMed ID: 7507150
Title: Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing.
PubMed ID: 7507150
PubMed ID: 1378806
Title: Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats.
PubMed ID: 1378806
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 1381287
Title: The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes.
PubMed ID: 1381287
PubMed ID: 12427098
Title: Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization.
PubMed ID: 12427098
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15385531
Title: Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10.
PubMed ID: 15385531
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19627498
Title: The Streptococcus pneumoniae adhesin PsrP binds to keratin 10 on lung cells.
PubMed ID: 19627498
PubMed ID: 20798280
Title: Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10.
PubMed ID: 20798280
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24940650
Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.
PubMed ID: 24940650
DOI: 10.1038/jid.2014.255
PubMed ID: 24430336
Title: The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.
PubMed ID: 24430336
DOI: 10.1098/rsob.130090
Title:
DOI: 10.1098/rsob.140172
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 32179842
Title: Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes.
PubMed ID: 32179842
PubMed ID: 22719251
Title: Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB.
PubMed ID: 22719251
PubMed ID: 27595935
Title: The X-Ray Crystal Structure of the Keratin1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease.
PubMed ID: 27595935
PubMed ID: 1371013
Title: Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops.
PubMed ID: 1371013
PubMed ID: 1380725
Title: Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis.
PubMed ID: 1380725
PubMed ID: 7509230
Title: A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis.
PubMed ID: 7509230
PubMed ID: 7508181
Title: Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis.
PubMed ID: 7508181
PubMed ID: 7512983
Title: Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity.
PubMed ID: 7512983
DOI: 10.1172/jci117132
PubMed ID: 7507152
Title: Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE).
PubMed ID: 7507152
PubMed ID: 7526210
Title: Genetic and clinical mosaicism in a type of epidermal nevus.
PubMed ID: 7526210
PubMed ID: 9036939
Title: A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma.
PubMed ID: 9036939
PubMed ID: 9856845
Title: A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma.
PubMed ID: 9856845
PubMed ID: 10201536
Title: A novel substitution in keratin 10 in epidermolytic hyperkeratosis.
PubMed ID: 10201536
PubMed ID: 16505000
Title: A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis.
PubMed ID: 16505000
DOI: 10.1093/hmg/ddl028
PubMed ID: 21271994
Title: Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis.
PubMed ID: 21271994
PubMed ID: 27212473
Title: Ichthyosis hystrix Lambert type and Curth-Macklin type are a single entity with affected (KRT1 mutation) or unaffected (KRT10 mutation) palms and soles?
PubMed ID: 27212473
Sequence Information:
- Length: 584
- Mass: 58827
- Checksum: 4941ECD2AE46D417
- Sequence:
MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG GFSGGSFSRG SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG IFGGGSFGGG SFGGGSFGGG GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM QNLNDRLASY LDKVRALEES NYELEGKIKE WYEKHGNSHQ GEPRDYSKYY KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN EVALRQSVEA DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE IDNNIEQISS YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY CVQLSQIQAQ ISALEEQLQQ IRAETECQNT EYQQLLDIKI RLENEIQTYR SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG GSSGGGHGGG HGGSSGGGYG GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG GYGGGSSGGG SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.