Details for: KRT10

Gene ID: 3858

Symbol: KRT10

Ensembl ID: ENSG00000186395

Description: keratin 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 435.9504
    Cell Significance Index: -67.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 273.2182
    Cell Significance Index: -69.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 190.7039
    Cell Significance Index: -78.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 164.6987
    Cell Significance Index: -66.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 161.8435
    Cell Significance Index: -76.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 146.4855
    Cell Significance Index: -75.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 114.5864
    Cell Significance Index: -76.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 70.8777
    Cell Significance Index: -67.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.2269
    Cell Significance Index: -75.4900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 27.8601
    Cell Significance Index: 62.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.7622
    Cell Significance Index: -63.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.0048
    Cell Significance Index: -78.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.2532
    Cell Significance Index: -43.5400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 5.3144
    Cell Significance Index: 15.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.2400
    Cell Significance Index: 244.3200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.2078
    Cell Significance Index: 32.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0102
    Cell Significance Index: 136.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.6309
    Cell Significance Index: 1605.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.4847
    Cell Significance Index: 72.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.0704
    Cell Significance Index: 217.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9552
    Cell Significance Index: 220.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8667
    Cell Significance Index: 393.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.8212
    Cell Significance Index: 25.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7971
    Cell Significance Index: 343.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7888
    Cell Significance Index: 144.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6841
    Cell Significance Index: 126.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6641
    Cell Significance Index: 480.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.6275
    Cell Significance Index: 60.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4089
    Cell Significance Index: 1315.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6699
    Cell Significance Index: 43.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6142
    Cell Significance Index: 104.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5707
    Cell Significance Index: 45.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4726
    Cell Significance Index: 173.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2737
    Cell Significance Index: 14.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2696
    Cell Significance Index: 162.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2615
    Cell Significance Index: 16.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1661
    Cell Significance Index: 221.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1149
    Cell Significance Index: 12.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0959
    Cell Significance Index: 141.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8473
    Cell Significance Index: 24.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7032
    Cell Significance Index: 120.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6740
    Cell Significance Index: 35.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6313
    Cell Significance Index: 18.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4955
    Cell Significance Index: 17.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4063
    Cell Significance Index: 10.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3612
    Cell Significance Index: 71.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3377
    Cell Significance Index: 5.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2282
    Cell Significance Index: 45.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1922
    Cell Significance Index: 31.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1887
    Cell Significance Index: 11.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1780
    Cell Significance Index: 134.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1251
    Cell Significance Index: 7.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1148
    Cell Significance Index: 84.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1013
    Cell Significance Index: 1.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -2.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0043
    Cell Significance Index: -0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0166
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0304
    Cell Significance Index: -57.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0317
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0398
    Cell Significance Index: -24.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0462
    Cell Significance Index: -85.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0541
    Cell Significance Index: -83.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0585
    Cell Significance Index: -5.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0627
    Cell Significance Index: -85.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0733
    Cell Significance Index: -7.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0820
    Cell Significance Index: -29.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0861
    Cell Significance Index: -48.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0920
    Cell Significance Index: -58.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0988
    Cell Significance Index: -68.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1020
    Cell Significance Index: -21.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1460
    Cell Significance Index: -66.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1484
    Cell Significance Index: -17.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1784
    Cell Significance Index: -9.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2045
    Cell Significance Index: -58.8300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2560
    Cell Significance Index: -2.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2674
    Cell Significance Index: -5.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3269
    Cell Significance Index: -4.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3291
    Cell Significance Index: -38.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4121
    Cell Significance Index: -13.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4419
    Cell Significance Index: -11.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4792
    Cell Significance Index: -69.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4996
    Cell Significance Index: -57.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5131
    Cell Significance Index: -40.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5213
    Cell Significance Index: -23.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5546
    Cell Significance Index: -34.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6481
    Cell Significance Index: -16.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6569
    Cell Significance Index: -45.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7647
    Cell Significance Index: -79.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8999
    Cell Significance Index: -69.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9167
    Cell Significance Index: -61.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1036
    Cell Significance Index: -29.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1218
    Cell Significance Index: -62.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2152
    Cell Significance Index: -22.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2452
    Cell Significance Index: -76.3400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.3358
    Cell Significance Index: -27.8600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.4632
    Cell Significance Index: -9.1600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4775
    Cell Significance Index: -25.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5224
    Cell Significance Index: -44.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.6377
    Cell Significance Index: -28.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6601
    Cell Significance Index: -73.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Keratin 10 is a member of the keratin family, which consists of diverse proteins that provide structural support and mechanical stability to epithelial cells. KRT10 is a type I keratin, characterized by its unique ability to form heterodimers with keratin 5 (KRT5) and its role in the formation of the cornified envelope, a complex structure composed of keratin filaments, lipids, and other proteins. KRT10 is expressed in various epithelial tissues, including the skin, mucosa, and salivary glands, and is significantly upregulated during keratinocyte differentiation. **Pathways and Functions:** The expression and function of KRT10 are intricately linked to the keratinization process, which involves the transformation of basal keratinocytes into suprabasal keratinocytes. During this process, KRT10 forms heterodimers with KRT5 and other keratins, which are then incorporated into the cornified envelope. The cornified envelope provides mechanical strength and resistance to environmental stresses, allowing epithelial cells to withstand the rigors of the external environment. KRT10 also plays a role in the regulation of epidermal development, including the positive regulation of epidermis development and the formation of the extracellular matrix. **Clinical Significance:** Dysregulation of KRT10 expression has been implicated in various epithelial disorders, including epidermolysis bullosa simplex (EBS), a genetic disorder characterized by blistering skin lesions. Mutations in the KRT10 gene have been identified as a cause of EBS, highlighting the critical role of KRT10 in maintaining the integrity of the epidermis. Additionally, KRT10 has been studied in the context of cancer, where its dysregulation has been linked to the development and progression of various epithelial cancers, including squamous cell carcinoma. In conclusion, Keratin 10 (KRT10) plays a vital role in the structural integrity and function of epithelial cells, particularly during keratinocyte differentiation and the formation of the cornified envelope. Its dysregulation has been implicated in various epithelial disorders, including epidermolysis bullosa simplex and epithelial cancers. Further research into the mechanisms of KRT10 expression and function is necessary to fully understand its role in maintaining epithelial homeostasis and to identify potential therapeutic targets for the treatment of epithelial disorders. **Signaling Pathways:** KRT10 is involved in various signaling pathways, including: * Positive regulation of epidermis development * Formation of the extracellular matrix * Protein binding and heterodimerization * Protein heterotetramerization * Peptide cross-linking **Cell Types:** KRT10 is expressed in the following cell types: * Epithelial cells * Secretory cells * IgG-negative class switched memory B cells * Epithelial cells of the urethra * Acinar cells of salivary glands * Mesodermal cells * Basal cells of epithelium of trachea * Progenitor cells of mammary luminal epithelium * Basal cells of prostate epithelium * Fibroblasts of mammary gland **Proteins:** KRT10 interacts with the following proteins: * Keratin 5 (KRT5) * Keratin 14 (KRT14) * Keratin 17 (KRT17) * Keratin 19 (KRT19) * Loricrin * Filaggrin * Keratin-associated proteins (KAPs)

Genular Protein ID: 938679933

Symbol: K1C10_HUMAN

Name: Keratin, type I cytoskeletal 10

UniProtKB Accession Codes:

P13645 Q14664 Q8N175

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 3 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2459124

Title: The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences.

PubMed ID: 2459124

DOI: 10.1016/s0021-9258(19)37628-8

PubMed ID: 2464696

Title: Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10.

PubMed ID: 2464696

DOI: 10.1016/0022-2836(88)90045-9

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2448602

Title: Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression.

PubMed ID: 2448602

DOI: 10.1007/bf00444680

PubMed ID: 7507150

Title: Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing.

PubMed ID: 7507150

DOI: 10.1111/1523-1747.ep12371723

PubMed ID: 1378806

Title: Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats.

PubMed ID: 1378806

DOI: 10.1016/0378-1119(92)90521-p

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 1381287

Title: The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes.

PubMed ID: 1381287

DOI: 10.1016/0092-8674(92)90314-3

PubMed ID: 12427098

Title: Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization.

PubMed ID: 12427098

DOI: 10.1046/j.1462-5822.2002.00231.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15385531

Title: Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10.

PubMed ID: 15385531

DOI: 10.1074/jbc.m408713200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19474805

Title: Recessive epidermolytic hyperkeratosis caused by a previously unreported termination codon mutation in the keratin 10 gene.

PubMed ID: 19474805

DOI: 10.1038/jid.2009.131

PubMed ID: 19627498

Title: The Streptococcus pneumoniae adhesin PsrP binds to keratin 10 on lung cells.

PubMed ID: 19627498

DOI: 10.1111/j.1365-2958.2009.06796.x

PubMed ID: 20302579

Title: Lethal autosomal recessive epidermolytic ichthyosis due to a novel donor splice-site mutation in KRT10.

PubMed ID: 20302579

DOI: 10.1111/j.1365-2133.2010.09665.x

PubMed ID: 20798280

Title: Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10.

PubMed ID: 20798280

DOI: 10.1126/science.1192280

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 24430336

Title: The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.

PubMed ID: 24430336

DOI: 10.1098/rsob.130090

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32179842

Title: Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes.

PubMed ID: 32179842

DOI: 10.1038/s41598-020-61640-9

PubMed ID: 22719251

Title: Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB.

PubMed ID: 22719251

DOI: 10.1371/journal.ppat.1002751

PubMed ID: 27595935

Title: The X-Ray Crystal Structure of the Keratin1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease.

PubMed ID: 27595935

DOI: 10.1016/j.jid.2016.08.018

PubMed ID: 1371013

Title: Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops.

PubMed ID: 1371013

DOI: 10.1073/pnas.89.3.910

PubMed ID: 1380725

Title: Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis.

PubMed ID: 1380725

DOI: 10.1126/science.257.5073.1128

PubMed ID: 7509230

Title: A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis.

PubMed ID: 7509230

DOI: 10.1093/hmg/2.12.2147

PubMed ID: 7508181

Title: Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis.

PubMed ID: 7508181

PubMed ID: 7512983

Title: Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity.

PubMed ID: 7512983

DOI: 10.1172/jci117132

PubMed ID: 7507152

Title: Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE).

PubMed ID: 7507152

DOI: 10.1111/1523-1747.ep12371726

PubMed ID: 7526210

Title: Genetic and clinical mosaicism in a type of epidermal nevus.

PubMed ID: 7526210

DOI: 10.1056/nejm199411243312103

PubMed ID: 9036939

Title: A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma.

PubMed ID: 9036939

DOI: 10.1111/1523-1747.ep12286491

PubMed ID: 9856845

Title: A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma.

PubMed ID: 9856845

DOI: 10.1046/j.1523-1747.1998.00451.x

PubMed ID: 10201536

Title: A novel substitution in keratin 10 in epidermolytic hyperkeratosis.

PubMed ID: 10201536

DOI: 10.1046/j.1523-1747.1999.00557.x

PubMed ID: 16505000

Title: A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis.

PubMed ID: 16505000

DOI: 10.1093/hmg/ddl028

PubMed ID: 18219278

Title: Mild recessive bullous congenital ichthyosiform erythroderma due to a previously unidentified homozygous keratin 10 nonsense mutation.

PubMed ID: 18219278

DOI: 10.1038/sj.jid.5701257

PubMed ID: 21271994

Title: Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis.

PubMed ID: 21271994

DOI: 10.1111/j.1365-2133.2010.10096.x

PubMed ID: 27212473

Title: Ichthyosis hystrix Lambert type and Curth-Macklin type are a single entity with affected (KRT1 mutation) or unaffected (KRT10 mutation) palms and soles?

PubMed ID: 27212473

DOI: 10.1684/ejd.2016.2808

Sequence Information:

  • Length: 584
  • Mass: 58827
  • Checksum: 4941ECD2AE46D417
  • Sequence:
    • MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG GFSGGSFSRG 
SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG IFGGGSFGGG SFGGGSFGGG 
GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM QNLNDRLASY LDKVRALEES NYELEGKIKE 
WYEKHGNSHQ GEPRDYSKYY KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN 
EVALRQSVEA DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG 
DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE IDNNIEQISS 
YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY CVQLSQIQAQ ISALEEQLQQ 
IRAETECQNT EYQQLLDIKI RLENEIQTYR SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG 
GSSGGGHGGG HGGSSGGGYG GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG 
GYGGGSSGGG SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.