Details for: KRT10

Gene ID: 3858

Symbol: KRT10

Ensembl ID: ENSG00000186395

Description: keratin 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.86
    Marker Score: 5212
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.85
    Marker Score: 2810.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.84
    Marker Score: 2237
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.77
    Marker Score: 6317
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.75
    Marker Score: 36307
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.74
    Marker Score: 20414.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.71
    Marker Score: 93921
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.65
    Marker Score: 10208
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.62
    Marker Score: 6397
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.56
    Marker Score: 87099
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.55
    Marker Score: 19887
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.48
    Marker Score: 1495.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.48
    Marker Score: 2213
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.47
    Marker Score: 873.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.45
    Marker Score: 10565.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.45
    Marker Score: 15918
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.42
    Marker Score: 818
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4
    Marker Score: 26998
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.39
    Marker Score: 23717.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.38
    Marker Score: 820
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.36
    Marker Score: 20335
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.35
    Marker Score: 3745
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.35
    Marker Score: 12353
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.34
    Marker Score: 1170
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.33
    Marker Score: 6525
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.25
    Marker Score: 3314.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.25
    Marker Score: 506
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.24
    Marker Score: 894
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.23
    Marker Score: 2386
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.23
    Marker Score: 30003
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.23
    Marker Score: 793
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.22
    Marker Score: 2337
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.2
    Marker Score: 14362
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.2
    Marker Score: 3024.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.17
    Marker Score: 2033
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.16
    Marker Score: 5786
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.16
    Marker Score: 3575
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.14
    Marker Score: 2013
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.12
    Marker Score: 7849
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.12
    Marker Score: 1091
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.11
    Marker Score: 21264
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.11
    Marker Score: 2750
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.11
    Marker Score: 1796
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.1
    Marker Score: 3369.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.09
    Marker Score: 18144
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.08
    Marker Score: 987
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.07
    Marker Score: 4144
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.07
    Marker Score: 2675
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.07
    Marker Score: 3890
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.07
    Marker Score: 2199
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.07
    Marker Score: 755
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.06
    Marker Score: 4677
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.06
    Marker Score: 962
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.05
    Marker Score: 1728
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.05
    Marker Score: 5371
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.04
    Marker Score: 8767
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.03
    Marker Score: 4962
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.03
    Marker Score: 741
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.03
    Marker Score: 2059.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.03
    Marker Score: 1281
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.02
    Marker Score: 999
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.02
    Marker Score: 2360
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.02
    Marker Score: 5582.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.01
    Marker Score: 5459
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.01
    Marker Score: 579
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2
    Marker Score: 478.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2
    Marker Score: 1458
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.99
    Marker Score: 4694
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.99
    Marker Score: 1508
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.99
    Marker Score: 20158
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.99
    Marker Score: 12675
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.99
    Marker Score: 3518.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.98
    Marker Score: 831
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.98
    Marker Score: 1739
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.98
    Marker Score: 2111
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.97
    Marker Score: 1762
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.97
    Marker Score: 633
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.96
    Marker Score: 1634
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.95
    Marker Score: 617
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.92
    Marker Score: 2065.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.91
    Marker Score: 461
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.91
    Marker Score: 1621
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.9
    Marker Score: 589
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.89
    Marker Score: 7753.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.89
    Marker Score: 1108.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.89
    Marker Score: 2101.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.89
    Marker Score: 99950
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.89
    Marker Score: 825
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.89
    Marker Score: 3095
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.89
    Marker Score: 424
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.88
    Marker Score: 5943
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.88
    Marker Score: 2112
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.88
    Marker Score: 1769
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.88
    Marker Score: 1681
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.87
    Marker Score: 1330
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.87
    Marker Score: 461
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.87
    Marker Score: 805
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.86
    Marker Score: 5504
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.85
    Marker Score: 2728
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.84
    Marker Score: 1080

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Other Information

**Key characteristics:** * KRT10 is a transmembrane protein that is expressed in all layers of the skin. * It is a member of the keratin family of proteins, which are important for the structural integrity of skin. * KRT10 is a key protein in the formation of the cornified envelope. * It is also involved in the regulation of epidermal differentiation and growth. **Pathways and functions:** * KRT10 is involved in the formation of the cornified envelope by interacting with other keratin proteins. * It is also involved in the regulation of epidermal differentiation and growth. * It is a key protein in the maintenance of skin integrity and barrier function. **Clinical significance:** Mutations in the KRT10 gene have been linked to a number of skin disorders, including psoriasis and eczema. These disorders are characterized by inflammation and hyperkeratosis (excessive skin growth). KRT10 mutations can also lead to the formation of benign and malignant skin tumors. **Additional information:** * The KRT10 gene is located on chromosome 17p13.1. * It is a highly conserved gene, with a similar gene found in mice and rats. * KRT10 is a well-characterized protein that has been extensively studied.

Genular Protein ID: 938679933

Symbol: K1C10_HUMAN

Name: Keratin, type I cytoskeletal 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2459124

Title: The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences.

PubMed ID: 2459124

DOI: 10.1016/s0021-9258(19)37628-8

PubMed ID: 2464696

Title: Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10.

PubMed ID: 2464696

DOI: 10.1016/0022-2836(88)90045-9

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2448602

Title: Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression.

PubMed ID: 2448602

DOI: 10.1007/bf00444680

PubMed ID: 7507150

Title: Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing.

PubMed ID: 7507150

DOI: 10.1111/1523-1747.ep12371723

PubMed ID: 1378806

Title: Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats.

PubMed ID: 1378806

DOI: 10.1016/0378-1119(92)90521-p

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 1381287

Title: The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes.

PubMed ID: 1381287

DOI: 10.1016/0092-8674(92)90314-3

PubMed ID: 12427098

Title: Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization.

PubMed ID: 12427098

DOI: 10.1046/j.1462-5822.2002.00231.x

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15385531

Title: Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10.

PubMed ID: 15385531

DOI: 10.1074/jbc.m408713200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19627498

Title: The Streptococcus pneumoniae adhesin PsrP binds to keratin 10 on lung cells.

PubMed ID: 19627498

DOI: 10.1111/j.1365-2958.2009.06796.x

PubMed ID: 20798280

Title: Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10.

PubMed ID: 20798280

DOI: 10.1126/science.1192280

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 24430336

Title: The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.

PubMed ID: 24430336

DOI: 10.1098/rsob.130090

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32179842

Title: Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes.

PubMed ID: 32179842

DOI: 10.1038/s41598-020-61640-9

PubMed ID: 22719251

Title: Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB.

PubMed ID: 22719251

DOI: 10.1371/journal.ppat.1002751

PubMed ID: 27595935

Title: The X-Ray Crystal Structure of the Keratin1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease.

PubMed ID: 27595935

DOI: 10.1016/j.jid.2016.08.018

PubMed ID: 1371013

Title: Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops.

PubMed ID: 1371013

DOI: 10.1073/pnas.89.3.910

PubMed ID: 1380725

Title: Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis.

PubMed ID: 1380725

DOI: 10.1126/science.257.5073.1128

PubMed ID: 7509230

Title: A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis.

PubMed ID: 7509230

DOI: 10.1093/hmg/2.12.2147

PubMed ID: 7508181

Title: Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis.

PubMed ID: 7508181

PubMed ID: 7512983

Title: Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity.

PubMed ID: 7512983

DOI: 10.1172/jci117132

PubMed ID: 7507152

Title: Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE).

PubMed ID: 7507152

DOI: 10.1111/1523-1747.ep12371726

PubMed ID: 7526210

Title: Genetic and clinical mosaicism in a type of epidermal nevus.

PubMed ID: 7526210

DOI: 10.1056/nejm199411243312103

PubMed ID: 9036939

Title: A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma.

PubMed ID: 9036939

DOI: 10.1111/1523-1747.ep12286491

PubMed ID: 9856845

Title: A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma.

PubMed ID: 9856845

DOI: 10.1046/j.1523-1747.1998.00451.x

PubMed ID: 10201536

Title: A novel substitution in keratin 10 in epidermolytic hyperkeratosis.

PubMed ID: 10201536

DOI: 10.1046/j.1523-1747.1999.00557.x

PubMed ID: 16505000

Title: A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis.

PubMed ID: 16505000

DOI: 10.1093/hmg/ddl028

PubMed ID: 21271994

Title: Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis.

PubMed ID: 21271994

DOI: 10.1111/j.1365-2133.2010.10096.x

PubMed ID: 27212473

Title: Ichthyosis hystrix Lambert type and Curth-Macklin type are a single entity with affected (KRT1 mutation) or unaffected (KRT10 mutation) palms and soles?

PubMed ID: 27212473

DOI: 10.1684/ejd.2016.2808

Sequence Information:

  • Length: 584
  • Mass: 58827
  • Checksum: 4941ECD2AE46D417
  • Sequence:
  • MSVRYSSSKH YSSSRSGGGG GGGGCGGGGG VSSLRISSSK GSLGGGFSSG GFSGGSFSRG 
    SSGGGCFGGS SGGYGGLGGF GGGSFRGSYG SSSFGGSYGG IFGGGSFGGG SFGGGSFGGG 
    GFGGGGFGGG FGGGFGGDGG LLSGNEKVTM QNLNDRLASY LDKVRALEES NYELEGKIKE 
    WYEKHGNSHQ GEPRDYSKYY KTIDDLKNQI LNLTTDNANI LLQIDNARLA ADDFRLKYEN 
    EVALRQSVEA DINGLRRVLD ELTLTKADLE MQIESLTEEL AYLKKNHEEE MKDLRNVSTG 
    DVNVEMNAAP GVDLTQLLNN MRSQYEQLAE QNRKDAEAWF NEKSKELTTE IDNNIEQISS 
    YKSEITELRR NVQALEIELQ SQLALKQSLE ASLAETEGRY CVQLSQIQAQ ISALEEQLQQ 
    IRAETECQNT EYQQLLDIKI RLENEIQTYR SLLEGEGSSG GGGRGGGSFG GGYGGGSSGG 
    GSSGGGHGGG HGGSSGGGYG GGSSGGGSSG GGYGGGSSSG GHGGSSSGGY GGGSSGGGGG 
    GYGGGSSGGG SSSGGGYGGG SSSGGHKSSS SGSVGESSSK GPRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.