Details for: LCP2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 102.0925
Cell Significance Index: -15.8800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 54.6206
Cell Significance Index: -22.1900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 45.6369
Cell Significance Index: -18.8000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 44.5969
Cell Significance Index: -22.9400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 40.1745
Cell Significance Index: -10.1900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.9283
Cell Significance Index: -15.9400 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 7.9324
Cell Significance Index: 21.2500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.0427
Cell Significance Index: -18.5600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.8028
Cell Significance Index: -12.7000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.1941
Cell Significance Index: -16.5500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 4.0986
Cell Significance Index: 102.4600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.9569
Cell Significance Index: -10.6000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.8728
Cell Significance Index: 71.5800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.2613
Cell Significance Index: 95.7800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.5848
Cell Significance Index: 34.3400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0453
Cell Significance Index: 198.9300 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.0204
Cell Significance Index: 3.1100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8744
Cell Significance Index: 86.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6776
Cell Significance Index: 611.8300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4178
Cell Significance Index: 67.9600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.3338
Cell Significance Index: 5.0300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2714
Cell Significance Index: 29.5200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2142
Cell Significance Index: 5.7300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0940
Cell Significance Index: 33.7200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0651
Cell Significance Index: 4.5100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0573
Cell Significance Index: 3.7000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0447
Cell Significance Index: 27.8900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0132
Cell Significance Index: 0.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0077
Cell Significance Index: -14.5200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0103
Cell Significance Index: -7.6400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0105
Cell Significance Index: -19.3400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0108
Cell Significance Index: -0.3800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0116
Cell Significance Index: -17.8500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0148
Cell Significance Index: -8.3700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0150
Cell Significance Index: -20.4500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0170
Cell Significance Index: -0.4900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0182
Cell Significance Index: -13.7400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0222
Cell Significance Index: -4.6800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0268
Cell Significance Index: -5.3700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0275
Cell Significance Index: -5.4500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0294
Cell Significance Index: -16.0600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0314
Cell Significance Index: -22.9900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0342
Cell Significance Index: -21.7000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0352
Cell Significance Index: -15.5600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0387
Cell Significance Index: -17.5600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0445
Cell Significance Index: -12.7900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0472
Cell Significance Index: -4.8200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0536
Cell Significance Index: -2.4300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0579
Cell Significance Index: -9.8900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0730
Cell Significance Index: -1.5600 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0759
Cell Significance Index: -1.1100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0836
Cell Significance Index: -9.8600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0878
Cell Significance Index: -5.3800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0931
Cell Significance Index: -12.7800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0936
Cell Significance Index: -2.3900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0947
Cell Significance Index: -17.0800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1004
Cell Significance Index: -6.0300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1262
Cell Significance Index: -14.4100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1339
Cell Significance Index: -4.2900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1362
Cell Significance Index: -19.8000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1432
Cell Significance Index: -17.6100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1518
Cell Significance Index: -19.6100 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1528
Cell Significance Index: -2.1900 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.1536
Cell Significance Index: -1.5400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1546
Cell Significance Index: -19.8200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1556
Cell Significance Index: -16.2000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1665
Cell Significance Index: -19.0800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1757
Cell Significance Index: -7.6400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1808
Cell Significance Index: -3.7500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1828
Cell Significance Index: -14.0300 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.1852
Cell Significance Index: -1.0100 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1895
Cell Significance Index: -1.5400 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.2067
Cell Significance Index: -3.5100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2264
Cell Significance Index: -10.6400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2454
Cell Significance Index: -12.4000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2592
Cell Significance Index: -17.4300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2622
Cell Significance Index: -18.5500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2667
Cell Significance Index: -19.8800 - Cell Name: mononuclear cell (CL0000842)
Fold Change: -0.2763
Cell Significance Index: -1.1500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2789
Cell Significance Index: -17.5800 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2813
Cell Significance Index: -4.8500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3024
Cell Significance Index: -15.7100 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3086
Cell Significance Index: -3.9100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3164
Cell Significance Index: -19.4500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3170
Cell Significance Index: -14.7800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3293
Cell Significance Index: -18.4800 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3360
Cell Significance Index: -2.7400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3495
Cell Significance Index: -18.3500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.3567
Cell Significance Index: -5.1300 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.3838
Cell Significance Index: -5.1000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3918
Cell Significance Index: -17.3300 - Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: -0.4076
Cell Significance Index: -2.9300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4159
Cell Significance Index: -8.9900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4193
Cell Significance Index: -21.8400 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.4204
Cell Significance Index: -8.2200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4358
Cell Significance Index: -12.1800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4454
Cell Significance Index: -16.3500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4470
Cell Significance Index: -15.6600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4571
Cell Significance Index: -17.3100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4827
Cell Significance Index: -12.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2071922727
Symbol: LCP2_HUMAN
Name: Lymphocyte cytosolic protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7706237
Title: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.
PubMed ID: 7706237
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8702662
Title: Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.
PubMed ID: 8702662
PubMed ID: 8673706
Title: Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.
PubMed ID: 8673706
PubMed ID: 11313406
Title: ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.
PubMed ID: 11313406
PubMed ID: 11301322
Title: PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells.
PubMed ID: 11301322
PubMed ID: 12084069
Title: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.
PubMed ID: 12084069
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 15388330
Title: Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase.
PubMed ID: 15388330
PubMed ID: 16914752
Title: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.
PubMed ID: 16914752
DOI: 10.1128/mcb.00688-06
PubMed ID: 18088087
PubMed ID: 21725281
Title: Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.
PubMed ID: 21725281
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24584089
Title: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
PubMed ID: 24584089
DOI: 10.1038/ni.2843
PubMed ID: 27335501
Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.
PubMed ID: 27335501
PubMed ID: 33231617
Title: Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.
PubMed ID: 33231617
DOI: 10.1084/jem.20201062
PubMed ID: 33436632
Title: Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis.
PubMed ID: 33436632
PubMed ID: 33159816
Title: The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.
PubMed ID: 33159816
Sequence Information:
- Length: 533
- Mass: 60188
- Checksum: C5D22F31D36200C8
- Sequence:
MALRNVPFRS EVLGWDPDSL ADYFKKLNYK DCEKAVKKYH IDGARFLNLT ENDIQKFPKL RVPILSKLSQ EINKNEERRS IFTRKPQVPR FPEETESHEE DNGGWSSFEE DDYESPNDDQ DGEDDGDYES PNEEEEAPVE DDADYEPPPS NDEEALQNSI LPAKPFPNSN SMYIDRPPSG KTPQQPPVPP QRPMAALPPP PAGRNHSPLP PPQTNHEEPS RSRNHKTAKL PAPSIDRSTK PPLDRSLAPF DREPFTLGKK PPFSDKPSIP AGRSLGEHLP KIQKPPLPPT TERHERSSPL PGKKPPVPKH GWGPDRREND EDDVHQRPLP QPALLPMSSN TFPSRSTKPS PMNPLPSSHM PGAFSESNSS FPQSASLPPY FSQGPSNRPP IRAEGRNFPL PLPNKPRPPS PAEEENSLNE EWYVSYITRP EAEAALRKIN QDGTFLVRDS SKKTTTNPYV LMVLYKDKVY NIQIRYQKES QVYLLGTGLR GKEDFLSVSD IIDYFRKMPL LLIDGKNRGS RYQCTLTHAA GYP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.