Details for: LCP2

Gene ID: 3937

Symbol: LCP2

Ensembl ID: ENSG00000043462

Description: lymphocyte cytosolic protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.0925
    Cell Significance Index: -15.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.6206
    Cell Significance Index: -22.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.6369
    Cell Significance Index: -18.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.5969
    Cell Significance Index: -22.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.1745
    Cell Significance Index: -10.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.9283
    Cell Significance Index: -15.9400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.9324
    Cell Significance Index: 21.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0427
    Cell Significance Index: -18.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8028
    Cell Significance Index: -12.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1941
    Cell Significance Index: -16.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.0986
    Cell Significance Index: 102.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.9569
    Cell Significance Index: -10.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.8728
    Cell Significance Index: 71.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.2613
    Cell Significance Index: 95.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5848
    Cell Significance Index: 34.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0453
    Cell Significance Index: 198.9300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.0204
    Cell Significance Index: 3.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8744
    Cell Significance Index: 86.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6776
    Cell Significance Index: 611.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4178
    Cell Significance Index: 67.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3338
    Cell Significance Index: 5.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2714
    Cell Significance Index: 29.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2142
    Cell Significance Index: 5.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0940
    Cell Significance Index: 33.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0651
    Cell Significance Index: 4.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0573
    Cell Significance Index: 3.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0447
    Cell Significance Index: 27.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0132
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0077
    Cell Significance Index: -14.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0116
    Cell Significance Index: -17.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0148
    Cell Significance Index: -8.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0150
    Cell Significance Index: -20.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0170
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0222
    Cell Significance Index: -4.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0268
    Cell Significance Index: -5.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0275
    Cell Significance Index: -5.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0294
    Cell Significance Index: -16.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0314
    Cell Significance Index: -22.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0342
    Cell Significance Index: -21.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0352
    Cell Significance Index: -15.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0387
    Cell Significance Index: -17.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0445
    Cell Significance Index: -12.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0472
    Cell Significance Index: -4.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0536
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0579
    Cell Significance Index: -9.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0730
    Cell Significance Index: -1.5600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0759
    Cell Significance Index: -1.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0836
    Cell Significance Index: -9.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0878
    Cell Significance Index: -5.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0931
    Cell Significance Index: -12.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0936
    Cell Significance Index: -2.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0947
    Cell Significance Index: -17.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1004
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1262
    Cell Significance Index: -14.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1339
    Cell Significance Index: -4.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1362
    Cell Significance Index: -19.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1432
    Cell Significance Index: -17.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1518
    Cell Significance Index: -19.6100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1528
    Cell Significance Index: -2.1900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1536
    Cell Significance Index: -1.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1546
    Cell Significance Index: -19.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1556
    Cell Significance Index: -16.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1665
    Cell Significance Index: -19.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1757
    Cell Significance Index: -7.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1808
    Cell Significance Index: -3.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1828
    Cell Significance Index: -14.0300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1852
    Cell Significance Index: -1.0100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1895
    Cell Significance Index: -1.5400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2067
    Cell Significance Index: -3.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2264
    Cell Significance Index: -10.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2454
    Cell Significance Index: -12.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2592
    Cell Significance Index: -17.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2622
    Cell Significance Index: -18.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2667
    Cell Significance Index: -19.8800
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.2763
    Cell Significance Index: -1.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2789
    Cell Significance Index: -17.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2813
    Cell Significance Index: -4.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3024
    Cell Significance Index: -15.7100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3086
    Cell Significance Index: -3.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3164
    Cell Significance Index: -19.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3170
    Cell Significance Index: -14.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3293
    Cell Significance Index: -18.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3360
    Cell Significance Index: -2.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3495
    Cell Significance Index: -18.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3567
    Cell Significance Index: -5.1300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3838
    Cell Significance Index: -5.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3918
    Cell Significance Index: -17.3300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.4076
    Cell Significance Index: -2.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4159
    Cell Significance Index: -8.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4193
    Cell Significance Index: -21.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4204
    Cell Significance Index: -8.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4358
    Cell Significance Index: -12.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4454
    Cell Significance Index: -16.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4470
    Cell Significance Index: -15.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4571
    Cell Significance Index: -17.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4827
    Cell Significance Index: -12.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LCP2 is a cytosolic protein, meaning it resides within the cell cytoplasm, and is characterized by its ability to interact with multiple signaling molecules and receptors. Its unique structure allows it to modulate various signaling pathways, including those involved in cell-cell junctions, cytosol, and intracellular signal transduction. LCP2 has been shown to interact with several key signaling molecules, such as DAP12 and FcεRI, which are essential for the regulation of immune responses. **Pathways and Functions:** LCP2 is involved in multiple signaling pathways, including: 1. **Adaptive Immune System:** LCP2 plays a crucial role in T cell receptor signaling, which is essential for the activation and proliferation of T cells. 2. **Innate Immune System:** LCP2 is involved in the regulation of innate immune responses, including the activation of mast cells and the generation of second messenger molecules. 3. **Cell-Cell Junctions:** LCP2 interacts with DAP12, a receptor that regulates cell-cell junctions and the formation of the immunological synapse. 4. **Cytosol:** LCP2 modulates the activity of various cytosolic proteins, including those involved in protein kinase activity and protein binding. 5. **DAP12 Signaling:** LCP2 interacts with DAP12, a receptor that regulates the activation of immune cells, including mast cells and natural killer cells. **Clinical Significance:** LCP2's involvement in various immune cell signaling pathways has significant implications for the diagnosis and treatment of immune-related disorders. For example: 1. **Autoimmune Diseases:** Dysregulation of LCP2 signaling pathways may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** Aberrant LCP2 expression has been linked to the progression of various cancers, including leukemia and lymphoma. 3. **Allergic Diseases:** LCP2's role in mast cell activation and the generation of second messenger molecules makes it a potential target for the treatment of allergic diseases, such as asthma and anaphylaxis. In conclusion, LCP2 is a complex protein that plays a critical role in various immune cell signaling pathways. Further research is needed to fully understand the mechanisms by which LCP2 regulates immune responses and to explore its potential as a therapeutic target for immune-related disorders.

Genular Protein ID: 2071922727

Symbol: LCP2_HUMAN

Name: Lymphocyte cytosolic protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7706237

Title: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.

PubMed ID: 7706237

DOI: 10.1074/jbc.270.13.7029

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8702662

Title: Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.

PubMed ID: 8702662

DOI: 10.1074/jbc.271.33.19641

PubMed ID: 8673706

Title: Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.

PubMed ID: 8673706

DOI: 10.1016/s1074-7613(00)80485-9

PubMed ID: 11313406

Title: ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.

PubMed ID: 11313406

DOI: 10.4049/jimmunol.166.9.5654

PubMed ID: 11301322

Title: PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells.

PubMed ID: 11301322

DOI: 10.1074/jbc.m011683200

PubMed ID: 12084069

Title: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.

PubMed ID: 12084069

DOI: 10.1046/j.1432-1033.2002.03008.x

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15388330

Title: Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase.

PubMed ID: 15388330

DOI: 10.1016/j.febslet.2004.07.090

PubMed ID: 16914752

Title: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.

PubMed ID: 16914752

DOI: 10.1128/mcb.00688-06

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21725281

Title: Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

PubMed ID: 21725281

DOI: 10.1038/emboj.2011.213

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24584089

Title: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.

PubMed ID: 24584089

DOI: 10.1038/ni.2843

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 33231617

Title: Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.

PubMed ID: 33231617

DOI: 10.1084/jem.20201062

PubMed ID: 33436632

Title: Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis.

PubMed ID: 33436632

DOI: 10.1038/s41467-020-20577-3

PubMed ID: 33159816

Title: The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.

PubMed ID: 33159816

DOI: 10.1002/1873-3468.13993

Sequence Information:

  • Length: 533
  • Mass: 60188
  • Checksum: C5D22F31D36200C8
  • Sequence:
  • MALRNVPFRS EVLGWDPDSL ADYFKKLNYK DCEKAVKKYH IDGARFLNLT ENDIQKFPKL 
    RVPILSKLSQ EINKNEERRS IFTRKPQVPR FPEETESHEE DNGGWSSFEE DDYESPNDDQ 
    DGEDDGDYES PNEEEEAPVE DDADYEPPPS NDEEALQNSI LPAKPFPNSN SMYIDRPPSG 
    KTPQQPPVPP QRPMAALPPP PAGRNHSPLP PPQTNHEEPS RSRNHKTAKL PAPSIDRSTK 
    PPLDRSLAPF DREPFTLGKK PPFSDKPSIP AGRSLGEHLP KIQKPPLPPT TERHERSSPL 
    PGKKPPVPKH GWGPDRREND EDDVHQRPLP QPALLPMSSN TFPSRSTKPS PMNPLPSSHM 
    PGAFSESNSS FPQSASLPPY FSQGPSNRPP IRAEGRNFPL PLPNKPRPPS PAEEENSLNE 
    EWYVSYITRP EAEAALRKIN QDGTFLVRDS SKKTTTNPYV LMVLYKDKVY NIQIRYQKES 
    QVYLLGTGLR GKEDFLSVSD IIDYFRKMPL LLIDGKNRGS RYQCTLTHAA GYP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.