Details for: LCP2

Gene ID: 3937

Symbol: LCP2

Ensembl ID: ENSG00000043462

Description: lymphocyte cytosolic protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.61
    Marker Score: 5089
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.53
    Marker Score: 3580
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.5
    Marker Score: 7903.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.37
    Marker Score: 23472
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.28
    Marker Score: 127442
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.28
    Marker Score: 2200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.26
    Marker Score: 9694
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.26
    Marker Score: 119258.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.18
    Marker Score: 25395
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.18
    Marker Score: 6030
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.16
    Marker Score: 6052
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.15
    Marker Score: 4221
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.02
    Marker Score: 4935
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.01
    Marker Score: 12851
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.91
    Marker Score: 3414.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.9
    Marker Score: 2171
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.86
    Marker Score: 1651
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.82
    Marker Score: 1600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.82
    Marker Score: 1819
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.82
    Marker Score: 1425.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.75
    Marker Score: 1947
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.73
    Marker Score: 2551
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.72
    Marker Score: 4158
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.64
    Marker Score: 1203
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.57
    Marker Score: 2172
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1132
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.55
    Marker Score: 1123
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.52
    Marker Score: 622
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.51
    Marker Score: 1675
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.51
    Marker Score: 2585
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.47
    Marker Score: 904
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.47
    Marker Score: 323
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167571
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.45
    Marker Score: 439
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.44
    Marker Score: 622
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.41
    Marker Score: 451
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.38
    Marker Score: 428
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.36
    Marker Score: 784
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.35
    Marker Score: 489
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.35
    Marker Score: 673
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.34
    Marker Score: 341
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.34
    Marker Score: 3480
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.33
    Marker Score: 1103
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.31
    Marker Score: 33509
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.29
    Marker Score: 935
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.26
    Marker Score: 526
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.22
    Marker Score: 924
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.2
    Marker Score: 878
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.2
    Marker Score: 1224
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.2
    Marker Score: 1020
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.17
    Marker Score: 2907
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.16
    Marker Score: 2109
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.16
    Marker Score: 7034
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.13
    Marker Score: 4643
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4741
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.13
    Marker Score: 363
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.12
    Marker Score: 917.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.11
    Marker Score: 389
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1
    Marker Score: 580
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.1
    Marker Score: 1221
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.09
    Marker Score: 4543
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.09
    Marker Score: 602
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.07
    Marker Score: 641
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.06
    Marker Score: 526
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.06
    Marker Score: 369
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.05
    Marker Score: 765
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.05
    Marker Score: 984
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.02
    Marker Score: 231
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71716
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47942
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.98
    Marker Score: 2873
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 407
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 664
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.98
    Marker Score: 574
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.95
    Marker Score: 614
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.93
    Marker Score: 721
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.91
    Marker Score: 764
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 417
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5161
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.85
    Marker Score: 292
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.82
    Marker Score: 369
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.82
    Marker Score: 390
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.82
    Marker Score: 489
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.82
    Marker Score: 269
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.82
    Marker Score: 549.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.81
    Marker Score: 12172
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1521
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.8
    Marker Score: 334
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.79
    Marker Score: 545

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * LCP2 is a protein that is involved in the regulation of the adaptive immune system. * It is a member of the immunoglobulin superfamily and is expressed in a variety of cell types. * LCP2 is a key regulator of inflammation and is involved in the regulation of immune responses to pathogens. * It is a key regulator of the generation of second messenger molecules, including IL-12 and IL-18. * LCP2 is also involved in the regulation of the activation of T cells and the generation of effector molecules. **Pathways and functions** * LCP2 is involved in the regulation of the adaptive immune system through the generation of second messenger molecules. * It is involved in the activation of T cells and the generation of effector molecules. * It is also involved in the regulation of inflammation. * LCP2 is a key regulator of the development and function of dendritic cells. **Clinical significance** * Mutations in the LCP2 gene have been linked to a number of human diseases, including inflammatory bowel disease, rheumatoid arthritis, and asthma. * LCP2 is a potential target for the treatment of inflammatory diseases. **Additional information** * The LCP2 gene is located on chromosome 14q23.1. * It is a relatively large gene, with a size of approximately 1.5 million base pairs. * It contains 13 exons and 12 introns. * LCP2 is a highly conserved protein, with a similar gene found in mice and rats.

Genular Protein ID: 2071922727

Symbol: LCP2_HUMAN

Name: Lymphocyte cytosolic protein 2

UniProtKB Accession Codes:

Q13094 A8KA25 Q53XV4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7706237

Title: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.

PubMed ID: 7706237

DOI: 10.1074/jbc.270.13.7029

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11301322

Title: PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells.

PubMed ID: 11301322

DOI: 10.1074/jbc.m011683200

PubMed ID: 12084069

Title: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.

PubMed ID: 12084069

DOI: 10.1046/j.1432-1033.2002.03008.x

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15388330

Title: Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase.

PubMed ID: 15388330

DOI: 10.1016/j.febslet.2004.07.090

PubMed ID: 16914752

Title: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.

PubMed ID: 16914752

DOI: 10.1128/mcb.00688-06

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21725281

Title: Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

PubMed ID: 21725281

DOI: 10.1038/emboj.2011.213

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24584089

Title: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.

PubMed ID: 24584089

DOI: 10.1038/ni.2843

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 33231617

Title: Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.

PubMed ID: 33231617

DOI: 10.1084/jem.20201062

Sequence Information:

  • Length: 533
  • Mass: 60188
  • Checksum: C5D22F31D36200C8
  • Sequence:
    • MALRNVPFRS EVLGWDPDSL ADYFKKLNYK DCEKAVKKYH IDGARFLNLT ENDIQKFPKL 
RVPILSKLSQ EINKNEERRS IFTRKPQVPR FPEETESHEE DNGGWSSFEE DDYESPNDDQ 
DGEDDGDYES PNEEEEAPVE DDADYEPPPS NDEEALQNSI LPAKPFPNSN SMYIDRPPSG 
KTPQQPPVPP QRPMAALPPP PAGRNHSPLP PPQTNHEEPS RSRNHKTAKL PAPSIDRSTK 
PPLDRSLAPF DREPFTLGKK PPFSDKPSIP AGRSLGEHLP KIQKPPLPPT TERHERSSPL 
PGKKPPVPKH GWGPDRREND EDDVHQRPLP QPALLPMSSN TFPSRSTKPS PMNPLPSSHM 
PGAFSESNSS FPQSASLPPY FSQGPSNRPP IRAEGRNFPL PLPNKPRPPS PAEEENSLNE 
EWYVSYITRP EAEAALRKIN QDGTFLVRDS SKKTTTNPYV LMVLYKDKVY NIQIRYQKES 
QVYLLGTGLR GKEDFLSVSD IIDYFRKMPL LLIDGKNRGS RYQCTLTHAA GYP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.