Details for: LCP2
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 79.35rCSI 61.14%PRS 20.79
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CSI 33.8rCSI 50.99%PRS 22.72
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CSI 16.7rCSI 12.64%PRS 30.62
-
CSI 15.05rCSI 70.45%PRS 43.44
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CSI 13.75rCSI 25.95%PRS 28.21
-
CSI 11.4rCSI 52.65%PRS 45.29
-
CSI 10.6rCSI 24.06%PRS 29.38
-
CSI 7rCSI 37.87%PRS 65.36
-
CSI 6.64rCSI 4.99%PRS 23.85
-
CSI 6.51rCSI 7.88%PRS 27.25
-
CSI 5.5rCSI 7.97%PRS 33.83
-
CSI 5.28rCSI 13.67%PRS 54.89
-
CSI 4.84rCSI 29.29%PRS 48.05
-
CSI 4.25rCSI 3.18%PRS 35.09
-
CSI 4.21rCSI 7.2%PRS 42.48
-
CSI 4.17rCSI 23.36%PRS 40
-
CSI 4.11rCSI 3.32%PRS 34.26
-
CSI 4.08rCSI 10.63%PRS 20.75
-
CSI 3.81rCSI 4.47%PRS 30.98
-
CSI 3.35rCSI 3.93%PRS 77.74
-
CSI 3.32rCSI 7.46%PRS 43.03
-
CSI 3.12rCSI 4.25%PRS 50.5
-
CSI 3.01rCSI 2.01%PRS 51.25
-
CSI 2.97rCSI 5.4%PRS 65.16
-
CSI 2.96rCSI 3.02%PRS 31.78
-
CSI 2.95rCSI 4.73%PRS 56.8
-
CSI 2.65rCSI 3.33%PRS 72.76
-
CSI 2.52rCSI 2.31%PRS 26.28
-
CSI 2.43rCSI 5.35%PRS 25.57
-
CSI 2.39rCSI 1.8%PRS 57.9
-
CSI 2.36rCSI 1.66%PRS 50.25
-
CSI 2.29rCSI 2.36%PRS 35.77
-
CSI 2.2rCSI 25.57%PRS 69.54
-
CSI 2.02rCSI 2.51%PRS 31.4
-
CSI 2.01rCSI 1.44%PRS 30.84
-
CSI 1.99rCSI 4.44%PRS 26.1
-
CSI 1.96rCSI 3.9%PRS 37.25
-
CSI 1.95rCSI 2.55%PRS 31.79
-
CSI 1.88rCSI 1.43%PRS 29.51
-
CSI 1.87rCSI 2.86%PRS 28.96
-
CSI 1.84rCSI 8.38%PRS 65.08
-
CSI 1.84rCSI 2.65%PRS 31.06
-
CSI 1.83rCSI 1.08%PRS 31.37
-
CSI 1.8rCSI 3.25%PRS 53.26
-
CSI 1.79rCSI 1.24%PRS 31.56
-
CSI 1.74rCSI 1.81%PRS 58.21
-
CSI 1.64rCSI 1.52%PRS 40.06
-
CSI 1.58rCSI 6.02%PRS 21.4
-
CSI 1.57rCSI 2%PRS 68.29
-
CSI 1.56rCSI 6.76%PRS 38.27
-
CSI 1.5rCSI 1.25%PRS 54.2
-
CSI 1.46rCSI 1.64%PRS 35.4
-
CSI 1.42rCSI 5.52%PRS 36.48
-
CSI 1.41rCSI 0.94%PRS 26.67
-
CSI 1.4rCSI 1.16%PRS 22.67
-
CSI 1.39rCSI 2.37%PRS 44.46
-
CSI 1.38rCSI 5.68%PRS 52.9
-
CSI 1.33rCSI 1.17%PRS 25.73
-
CSI 1.31rCSI 1.29%PRS 34.56
-
CSI 1.3rCSI 4.47%PRS 63.05
-
CSI 1.26rCSI 0.88%PRS 26.9
-
CSI 1.23rCSI 1.52%PRS 58.91
-
CSI 1.16rCSI 1.14%PRS 56.82
-
CSI 1.15rCSI 4.32%PRS 18.69
-
CSI 1.07rCSI 1.28%PRS 38.48
-
CSI 1.06rCSI 0.96%PRS 34.01
-
CSI 0.98rCSI 0.68%PRS 23.81
-
CSI 0.96rCSI 1.32%PRS 42.89
-
CSI 0.92rCSI 2.65%PRS 33.52
-
CSI 0.92rCSI 2.09%PRS 21.69
-
CSI 0.89rCSI 1.03%PRS 56.05
-
CSI 0.89rCSI 1.11%PRS 33.98
-
CSI 0.89rCSI 0.72%PRS 22.43
-
CSI 0.86rCSI 1.82%PRS 43.95
-
CSI 0.83rCSI 3%PRS 38.19
-
CSI 0.82rCSI 1.97%PRS 35.25
-
CSI 0.8rCSI 1.41%PRS 17.58
-
CSI 0.77rCSI 0.7%PRS 20.2
-
CSI 0.75rCSI 1.15%PRS 38.82
-
CSI 0.75rCSI 1.41%PRS 57.05
-
CSI 0.74rCSI 0.68%PRS 23.28
-
CSI 0.74rCSI 0.89%PRS 26.93
-
CSI 0.72rCSI 1.49%PRS 33.05
-
CSI 0.69rCSI 0.55%PRS 39.67
-
CSI 0.68rCSI 1.85%PRS 69.58
-
CSI 0.67rCSI 1.4%PRS 22.18
-
CSI 0.67rCSI 0.45%PRS 27.61
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CSI 0.64rCSI 0.5%PRS 32.76
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CSI 0.62rCSI 3.5%PRS 62.1
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CSI 0.61rCSI 4.01%PRS 61.52
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CSI 0.6rCSI 0.92%PRS 26.77
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CSI 0.53rCSI 5.74%PRS 65.99
-
CSI 0.51rCSI 0.88%PRS 30.13
-
CSI 0.5rCSI 2.06%PRS 38.77
-
CSI 0.44rCSI 3.55%PRS 22.04
-
CSI 0.43rCSI 2.2%PRS 42.8
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CSI 0.41rCSI 0.36%PRS 25.11
-
CSI 0.38rCSI 0.62%PRS 26.32
-
CSI 0.37rCSI 1.86%PRS 29.46
-
CSI 0.35rCSI 6.49%PRS 59.49
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CSI -0.7rCSI -0.6%PRS 39.5%
-
CSI -0.5rCSI -0.9%PRS 17.0%
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CSI 0.0rCSI 0.0%PRS 52.1%
-
CSI 0.0rCSI 0.3%PRS 53.9%
-
CSI 0.1rCSI 0.8%PRS 74.5%
-
CSI 0.1rCSI 0.2%PRS 24.4%
-
CSI 0.1rCSI 0.6%PRS 32.8%
-
CSI 0.2rCSI 4.5%PRS 86.9%
-
CSI 0.2rCSI 2.9%PRS 79.3%
-
CSI 0.2rCSI 0.3%PRS 31.1%
-
CSI 0.2rCSI 0.5%PRS 49.5%
-
CSI 0.3rCSI 1.5%PRS 32.9%
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CSI 0.3rCSI 5.3%PRS 66.0%
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CSI 0.3rCSI 0.5%PRS 49.5%
-
CSI 0.4rCSI 6.5%PRS 59.5%
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CSI 0.4rCSI 1.9%PRS 29.5%
-
CSI 0.4rCSI 0.6%PRS 26.3%
-
CSI 0.4rCSI 0.4%PRS 25.1%
-
CSI 0.4rCSI 2.2%PRS 42.8%
-
CSI 0.4rCSI 3.6%PRS 22.0%
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CSI 0.5rCSI 2.1%PRS 38.8%
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CSI 0.5rCSI 0.9%PRS 30.1%
-
CSI 0.5rCSI 5.7%PRS 66.0%
-
CSI 0.6rCSI 0.9%PRS 26.8%
-
CSI 0.6rCSI 4.0%PRS 61.5%
-
CSI 0.6rCSI 3.5%PRS 62.1%
-
CSI 0.6rCSI 0.5%PRS 32.8%
-
CSI 0.7rCSI 0.5%PRS 27.6%
-
CSI 0.7rCSI 1.4%PRS 22.2%
-
CSI 0.7rCSI 1.9%PRS 69.6%
-
CSI 0.7rCSI 0.6%PRS 39.7%
-
CSI 0.7rCSI 1.5%PRS 33.1%
-
CSI 0.7rCSI 0.9%PRS 26.9%
-
CSI 0.7rCSI 0.7%PRS 23.3%
-
CSI 0.8rCSI 1.4%PRS 57.1%
-
CSI 0.8rCSI 1.2%PRS 38.8%
-
CSI 0.8rCSI 0.7%PRS 20.2%
-
CSI 0.8rCSI 1.4%PRS 17.6%
-
CSI 0.8rCSI 2.0%PRS 35.3%
-
CSI 0.8rCSI 3.0%PRS 38.2%
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CSI 0.9rCSI 1.8%PRS 44.0%
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CSI 0.9rCSI 0.7%PRS 22.4%
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CSI 0.9rCSI 1.1%PRS 34.0%
-
CSI 0.9rCSI 1.0%PRS 56.1%
-
CSI 0.9rCSI 2.1%PRS 21.7%
-
CSI 0.9rCSI 2.7%PRS 33.5%
-
CSI 1.0rCSI 1.3%PRS 42.9%
-
CSI 1.0rCSI 0.7%PRS 23.8%
-
CSI 1.1rCSI 1.0%PRS 34.0%
-
CSI 1.1rCSI 1.3%PRS 38.5%
-
CSI 1.2rCSI 4.3%PRS 18.7%
-
CSI 1.2rCSI 1.1%PRS 56.8%
-
CSI 1.2rCSI 1.5%PRS 58.9%
-
CSI 1.3rCSI 0.9%PRS 26.9%
-
CSI 1.3rCSI 4.5%PRS 63.1%
-
CSI 1.3rCSI 1.3%PRS 34.6%
-
CSI 1.3rCSI 1.2%PRS 25.7%
-
CSI 1.4rCSI 5.7%PRS 52.9%
-
CSI 1.4rCSI 2.4%PRS 44.5%
-
CSI 1.4rCSI 1.2%PRS 22.7%
-
CSI 1.4rCSI 0.9%PRS 26.7%
-
CSI 1.4rCSI 5.5%PRS 36.5%
-
CSI 1.5rCSI 1.6%PRS 35.4%
-
CSI 1.5rCSI 1.3%PRS 54.2%
-
CSI 1.6rCSI 6.8%PRS 38.3%
-
CSI 1.6rCSI 2.0%PRS 68.3%
-
CSI 1.6rCSI 6.0%PRS 21.4%
-
CSI 1.6rCSI 1.5%PRS 40.1%
-
CSI 1.7rCSI 1.8%PRS 58.2%
-
CSI 1.8rCSI 1.2%PRS 31.6%
-
CSI 1.8rCSI 3.3%PRS 53.3%
-
CSI 1.8rCSI 1.1%PRS 31.4%
-
CSI 1.8rCSI 2.7%PRS 31.1%
-
CSI 1.8rCSI 8.4%PRS 65.1%
-
CSI 1.9rCSI 2.9%PRS 29.0%
-
CSI 1.9rCSI 1.4%PRS 29.5%
-
CSI 2.0rCSI 2.6%PRS 31.8%
-
CSI 2.0rCSI 3.9%PRS 37.3%
-
CSI 2.0rCSI 4.4%PRS 26.1%
-
CSI 2.0rCSI 1.4%PRS 30.8%
-
CSI 2.0rCSI 2.5%PRS 31.4%
-
CSI 2.2rCSI 25.6%PRS 69.5%
-
CSI 2.3rCSI 2.4%PRS 35.8%
-
CSI 2.4rCSI 1.7%PRS 50.3%
-
CSI 2.4rCSI 1.8%PRS 57.9%
-
CSI 2.4rCSI 5.4%PRS 25.6%
-
CSI 2.5rCSI 2.3%PRS 26.3%
-
CSI 2.7rCSI 3.3%PRS 72.8%
-
CSI 3.0rCSI 4.7%PRS 56.8%
-
CSI 3.0rCSI 3.0%PRS 31.8%
-
CSI 3.0rCSI 5.4%PRS 65.2%
-
CSI 3.0rCSI 2.0%PRS 51.3%
-
CSI 3.1rCSI 4.3%PRS 50.5%
-
CSI 3.3rCSI 7.5%PRS 43.0%
-
CSI 3.4rCSI 3.9%PRS 77.7%
-
CSI 3.8rCSI 4.5%PRS 31.0%
-
CSI 4.1rCSI 10.6%PRS 20.8%
-
CSI 4.1rCSI 3.3%PRS 34.3%
-
CSI 4.2rCSI 23.4%PRS 40.0%
-
CSI 4.2rCSI 7.2%PRS 42.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2071922727
Symbol: LCP2_HUMAN
Name: Lymphocyte cytosolic protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7706237
Title: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.
PubMed ID: 7706237
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8702662
Title: Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.
PubMed ID: 8702662
PubMed ID: 8673706
Title: Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.
PubMed ID: 8673706
PubMed ID: 11313406
Title: ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.
PubMed ID: 11313406
PubMed ID: 11301322
Title: PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells.
PubMed ID: 11301322
PubMed ID: 12084069
Title: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.
PubMed ID: 12084069
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 15388330
Title: Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase.
PubMed ID: 15388330
PubMed ID: 16914752
Title: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.
PubMed ID: 16914752
DOI: 10.1128/mcb.00688-06
PubMed ID: 18088087
PubMed ID: 21725281
Title: Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.
PubMed ID: 21725281
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24584089
Title: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
PubMed ID: 24584089
DOI: 10.1038/ni.2843
PubMed ID: 27335501
Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.
PubMed ID: 27335501
PubMed ID: 33231617
Title: Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.
PubMed ID: 33231617
DOI: 10.1084/jem.20201062
PubMed ID: 33436632
Title: Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis.
PubMed ID: 33436632
PubMed ID: 33159816
Title: The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.
PubMed ID: 33159816
Sequence Information:
- Length: 533
- Mass: 60188
- Checksum: C5D22F31D36200C8
- Sequence:
MALRNVPFRS EVLGWDPDSL ADYFKKLNYK DCEKAVKKYH IDGARFLNLT ENDIQKFPKL RVPILSKLSQ EINKNEERRS IFTRKPQVPR FPEETESHEE DNGGWSSFEE DDYESPNDDQ DGEDDGDYES PNEEEEAPVE DDADYEPPPS NDEEALQNSI LPAKPFPNSN SMYIDRPPSG KTPQQPPVPP QRPMAALPPP PAGRNHSPLP PPQTNHEEPS RSRNHKTAKL PAPSIDRSTK PPLDRSLAPF DREPFTLGKK PPFSDKPSIP AGRSLGEHLP KIQKPPLPPT TERHERSSPL PGKKPPVPKH GWGPDRREND EDDVHQRPLP QPALLPMSSN TFPSRSTKPS PMNPLPSSHM PGAFSESNSS FPQSASLPPY FSQGPSNRPP IRAEGRNFPL PLPNKPRPPS PAEEENSLNE EWYVSYITRP EAEAALRKIN QDGTFLVRDS SKKTTTNPYV LMVLYKDKVY NIQIRYQKES QVYLLGTGLR GKEDFLSVSD IIDYFRKMPL LLIDGKNRGS RYQCTLTHAA GYP