Gene LGALS3 - ENSG00000131981 | NCBI Gene ID: 3958

Details for: LGALS3

Gene ID: 3958

Symbol: LGALS3

Ensembl ID: ENSG00000131981

Description: galectin 3

Associated with

Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of myeloid cells
(R-HSA-8939246)
Runx2 regulates genes involved in differentiation of myeloid cells
(R-HSA-8941333)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Carbohydrate binding
(GO:0030246)
Cell surface
(GO:0009986)
Chemoattractant activity
(GO:0042056)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Disaccharide binding
(GO:0048030)
Eosinophil chemotaxis
(GO:0048245)
Epithelial cell differentiation
(GO:0030855)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule membrane
(GO:0101003)
Ige binding
(GO:0019863)
Immunological synapse
(GO:0001772)
Innate immune response
(GO:0045087)
Laminin binding
(GO:0043236)
Macrophage chemotaxis
(GO:0048246)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Molecular condensate scaffold activity
(GO:0140693)
Monocyte chemotaxis
(GO:0002548)
Mononuclear cell migration
(GO:0071674)
Mrna processing
(GO:0006397)
Negative regulation of endocytosis
(GO:0045806)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of immunological synapse formation
(GO:2000521)
Negative regulation of protein tyrosine phosphatase activity
(GO:1903614)
Negative regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
(GO:2001189)
Negative regulation of t cell receptor signaling pathway
(GO:0050860)
Neutrophil chemotaxis
(GO:0030593)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive chemotaxis
(GO:0050918)
Positive regulation of calcium ion import
(GO:0090280)
Positive regulation of dendritic cell differentiation
(GO:2001200)
Positive regulation of mononuclear cell migration
(GO:0071677)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Protein phosphatase inhibitor activity
(GO:0004864)
Regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902041)
Regulation of t cell apoptotic process
(GO:0070232)
Regulation of t cell proliferation
(GO:0042129)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Secretory granule membrane
(GO:0030667)
Spliceosomal complex
(GO:0005681)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: secretory cell (CL0000151)
Fold Change: 4.3
Marker Score: 7854
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.22
Marker Score: 143411.5
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.16
Marker Score: 2217
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.96
Marker Score: 12422
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.83
Marker Score: 4619
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.79
Marker Score: 211684.5
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.72
Marker Score: 3174
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 3.69
Marker Score: 2512
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.62
Marker Score: 31426
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.52
Marker Score: 18515
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.51
Marker Score: 3360
Cell Name: enterocyte (CL0000584)
Fold Change: 3.49
Marker Score: 16738
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.41
Marker Score: 25381
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.4
Marker Score: 5645
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.36
Marker Score: 5352
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.33
Marker Score: 26040.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.31
Marker Score: 3537
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.26
Marker Score: 7965
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.25
Marker Score: 2560
Cell Name: basophil (CL0000767)
Fold Change: 3.24
Marker Score: 1539
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.22
Marker Score: 6275.5
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.22
Marker Score: 20539
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.13
Marker Score: 3581
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.09
Marker Score: 20126.5
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.07
Marker Score: 1280
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.07
Marker Score: 8034
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.03
Marker Score: 105004
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 3.03
Marker Score: 2023
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 3
Marker Score: 76931.5
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3
Marker Score: 4127
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3
Marker Score: 33734
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.97
Marker Score: 11469.5
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.97
Marker Score: 3123
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.92
Marker Score: 1668
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.91
Marker Score: 25084
Cell Name: decidual cell (CL2000002)
Fold Change: 2.91
Marker Score: 12548
Cell Name: basal cell (CL0000646)
Fold Change: 2.84
Marker Score: 3662
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.83
Marker Score: 4785
Cell Name: club cell (CL0000158)
Fold Change: 2.8
Marker Score: 3269
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.76
Marker Score: 6254
Cell Name: ciliated cell (CL0000064)
Fold Change: 2.73
Marker Score: 9395
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.7
Marker Score: 1388
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.69
Marker Score: 4141
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.68
Marker Score: 4309
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.67
Marker Score: 4723
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.66
Marker Score: 1109
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.65
Marker Score: 1308
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.64
Marker Score: 4336
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.64
Marker Score: 1133.5
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.63
Marker Score: 833
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.62
Marker Score: 4973.5
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.56
Marker Score: 909
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.55
Marker Score: 1189
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.54
Marker Score: 15456.5
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.53
Marker Score: 6373
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.52
Marker Score: 12379
Cell Name: stem cell (CL0000034)
Fold Change: 2.51
Marker Score: 5954
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.49
Marker Score: 15927.5
Cell Name: blood cell (CL0000081)
Fold Change: 2.49
Marker Score: 28947
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.49
Marker Score: 3665
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.48
Marker Score: 2214.5
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.47
Marker Score: 838
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.47
Marker Score: 6730
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.45
Marker Score: 592
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 2.44
Marker Score: 704.5
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.43
Marker Score: 1094
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.42
Marker Score: 10069
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.39
Marker Score: 691
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.38
Marker Score: 765
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.35
Marker Score: 5359
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.35
Marker Score: 584
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.34
Marker Score: 4682.5
Cell Name: reticular cell (CL0000432)
Fold Change: 2.34
Marker Score: 854.5
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.33
Marker Score: 5615
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.33
Marker Score: 584
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.32
Marker Score: 6014
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.28
Marker Score: 2521.5
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 2.28
Marker Score: 1400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.28
Marker Score: 8955
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 2.28
Marker Score: 1437.5
Cell Name: keratocyte (CL0002363)
Fold Change: 2.26
Marker Score: 521
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.23
Marker Score: 1057
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.22
Marker Score: 836
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 2.22
Marker Score: 995
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.21
Marker Score: 2241
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.17
Marker Score: 538
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.16
Marker Score: 1353.5
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.14
Marker Score: 5320.5
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.12
Marker Score: 2613
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.11
Marker Score: 1240
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.08
Marker Score: 2084.5
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.07
Marker Score: 2871
Cell Name: fibroblast (CL0000057)
Fold Change: 2.06
Marker Score: 1993
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.04
Marker Score: 586.5
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 2.04
Marker Score: 433
Cell Name: lactocyte (CL0002325)
Fold Change: 2.03
Marker Score: 32584
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.03
Marker Score: 1743
Cell Name: stromal cell (CL0000499)
Fold Change: 2.02
Marker Score: 2370.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.02
Marker Score: 2011
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.01
Marker Score: 2847

Hover over a box to see details here...

**Key characteristics:** - It is a secreted protein that is expressed in high levels in the plasma of patients with cancer. - It is a multi-functional protein that can interact with a variety of proteins, including collagen, fibronectin, and integrins. - It is involved in a variety of cellular processes, including cell adhesion, migration, and signaling. **Pathways and functions:** - Galectin-3 is a key regulator of cell adhesion and migration. It is expressed in high levels on the surface of endothelial cells, which are responsible for maintaining the integrity of blood vessels. When galectin-3 binds to collagen, it promotes the adhesion of endothelial cells to each other and the migration of endothelial cells into tissues. - It is also involved in cell signaling. When galectin-3 binds to its ligand, decorin, it activates the advanced glycosylation endproduct receptor signaling pathway. This pathway is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. - Galectin-3 is also involved in the regulation of inflammation. It is expressed in high levels in inflammatory tissues, where it helps to recruit immune cells to the site of inflammation. **Clinical significance:** - Galectin-3 is a promising target for cancer immunotherapy. Antibodies against galectin-3 have been shown to be effective in inhibiting tumor growth in preclinical models of cancer. - The development of galectin-3 inhibitors is an active area of research, as it could potentially be used to treat a variety of cancers.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Galectin-3

Genular Protein ID: 123982098

Symbol: LEG3_HUMAN

Name: Galectin-3

UniProtKB Accession Codes:

P17931 B2RC38 Q16005 Q6IBA7 Q96J47

Database IDs:

Citations:

PubMed ID: 2261464

Title: Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.

PubMed ID: 2261464

DOI: 10.1021/bi00487a015

PubMed ID: 2402511

Title: Molecular cloning of a human macrophage lectin specific for galactose.

PubMed ID: 2402511

DOI: 10.1073/pnas.87.18.7324

PubMed ID: 2022338

Title: Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.

PubMed ID: 2022338

DOI: 10.1016/0378-1119(91)90139-3

PubMed ID: 2009535

Title: Molecular cloning and chromosomal mapping of a human galactoside-binding protein.

PubMed ID: 2009535

PubMed ID: 7682704

Title: Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.

PubMed ID: 7682704

DOI: 10.1073/pnas.90.8.3466

PubMed ID: 9439577

Title: The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter.

PubMed ID: 9439577

DOI: 10.1006/abbi.1997.0447

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8253806

Title: L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.

PubMed ID: 8253806

DOI: 10.1016/s0021-9258(19)74371-3

PubMed ID: 9501082

Title: Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

PubMed ID: 9501082

DOI: 10.1093/emboj/17.6.1606

PubMed ID: 15181153

Title: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.

PubMed ID: 15181153

DOI: 10.1091/mbc.e04-03-0236

PubMed ID: 19594635

Title: The regulation of inflammation by galectin-3.

PubMed ID: 19594635

DOI: 10.1111/j.1600-065x.2009.00794.x

PubMed ID: 19497882

Title: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.

PubMed ID: 19497882

DOI: 10.1073/pnas.0903568106

PubMed ID: 19616076

Title: Dynamics of galectin-3 in the nucleus and cytoplasm.

PubMed ID: 19616076

DOI: 10.1016/j.bbagen.2009.07.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24945728

Title: Modulation of CD6 function through interaction with galectin-1 and -3.

PubMed ID: 24945728

DOI: 10.1016/j.febslet.2014.05.064

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27693506

Title: TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

PubMed ID: 27693506

DOI: 10.1016/j.devcel.2016.08.003

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 9582341

Title: X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.

PubMed ID: 9582341

DOI: 10.1074/jbc.273.21.13047

Sequence Information:

Length: 250
Mass: 26152
Checksum: C49DDF6D67AE0C88
Sequence:

MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP 
GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL 
PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN 
WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI 
DLTSASYTMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LGALS3

Associated with

Cells (max top 100)

Other Information

Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms. PubMed ID: 2261464

Molecular cloning of a human macrophage lectin specific for galactose. PubMed ID: 2402511

Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen. PubMed ID: 2022338

Molecular cloning and chromosomal mapping of a human galactoside-binding protein. PubMed ID: 2009535

Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. PubMed ID: 7682704

The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter. PubMed ID: 9439577

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I. PubMed ID: 8253806

Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. PubMed ID: 9501082

NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. PubMed ID: 15181153

The regulation of inflammation by galectin-3. PubMed ID: 19594635

A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. PubMed ID: 19497882

Dynamics of galectin-3 in the nucleus and cytoplasm. PubMed ID: 19616076

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Modulation of CD6 function through interaction with galectin-1 and -3. PubMed ID: 24945728

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. PubMed ID: 27693506

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059

X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution. PubMed ID: 9582341