Details for: LGALS3
Gene ID: 3958
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: LGALS3
Ensembl ID: ENSG00000131981
Description: galectin 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 90.16rCSI 94.45%PRS 9.85
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CSI 89.25rCSI 81.94%PRS 12.11
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CSI 88.71rCSI 76.48%PRS 17.24
-
CSI 85.83rCSI 76.19%PRS 10.59
-
CSI 84.44rCSI 88.11%PRS 10.86
-
CSI 80.64rCSI 86.42%PRS 9.72
-
CSI 78.4rCSI 81.94%PRS 11.17
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CSI 77.41rCSI 60.01%PRS 10.1
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CSI 75.89rCSI 80.64%PRS 18.84
-
CSI 75.61rCSI 75.46%PRS 9.08
-
CSI 74.23rCSI 70.15%PRS 11.05
-
CSI 72.41rCSI 63.67%PRS 7.67
-
CSI 72.35rCSI 60.65%PRS 12.67
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CSI 70.72rCSI 100%PRS 11.2
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CSI 69.21rCSI 86.09%PRS 11.2
-
CSI 68.82rCSI 79.82%PRS 15.69
-
CSI 67.83rCSI 79.67%PRS 12.55
-
CSI 66.83rCSI 81.35%PRS 13.34
-
CSI 65.8rCSI 63.45%PRS 7.08
-
CSI 64.03rCSI 52.02%PRS 11.21
-
CSI 61.75rCSI 47.57%PRS 9.58
-
CSI 60.85rCSI 70.36%PRS 7.76
-
CSI 56.63rCSI 58.66%PRS 12.45
-
CSI 54.47rCSI 67.38%PRS 9.29
-
CSI 54.3rCSI 77.83%PRS 14.53
-
CSI 53.25rCSI 39.44%PRS 9.5
-
CSI 53.06rCSI 66.7%PRS 16.2
-
CSI 51.86rCSI 83.62%PRS 16.94
-
CSI 49.39rCSI 63.34%PRS 12.21
-
CSI 48.96rCSI 74.77%PRS 10.6
-
CSI 46.62rCSI 74.04%PRS 13.73
-
CSI 45.91rCSI 67.25%PRS 12.38
-
CSI 44.7rCSI 35.8%PRS 19.17
-
CSI 44.54rCSI 73.37%PRS 12.38
-
CSI 43.75rCSI 42.12%PRS 10.93
-
CSI 43.73rCSI 66.88%PRS 17.2
-
CSI 42.33rCSI 100%PRS 13.48
-
CSI 42.08rCSI 39.16%PRS 10.65
-
CSI 42.08rCSI 68.17%PRS 10.84
-
CSI 40.79rCSI 89.04%PRS 21.43
-
CSI 40.78rCSI 58.78%PRS 17.05
-
CSI 39.11rCSI 60.1%PRS 15.13
-
CSI 38.53rCSI 59.54%PRS 9.92
-
CSI 38.51rCSI 56.42%PRS 51.18
-
CSI 38.46rCSI 69.87%PRS 16.18
-
CSI 38.01rCSI 60.03%PRS 10.59
-
CSI 37.06rCSI 57.48%PRS 16.31
-
CSI 35.08rCSI 29.08%PRS 10
-
CSI 34.72rCSI 50.91%PRS 13.9
-
CSI 34.37rCSI 73.17%PRS 17.09
-
CSI 34.06rCSI 47.17%PRS 15.26
-
CSI 34.02rCSI 37.26%PRS 12.21
-
CSI 33.09rCSI 53.05%PRS 33.08
-
CSI 33.05rCSI 78.57%PRS 15.93
-
CSI 32.33rCSI 77.59%PRS 19.57
-
CSI 32.09rCSI 70.28%PRS 14.2
-
CSI 31.98rCSI 47.42%PRS 68.3
-
CSI 31.85rCSI 50.86%PRS 11.54
-
CSI 31.7rCSI 72.27%PRS 11.09
-
CSI 30.72rCSI 37.1%PRS 12.43
-
CSI 29.07rCSI 38.87%PRS 11.57
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CSI 29rCSI 38.77%PRS 14.09
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CSI 28.89rCSI 69.46%PRS 16.03
-
CSI 28.82rCSI 37.76%PRS 14.8
-
CSI 28.48rCSI 81.46%PRS 19.09
-
CSI 27.83rCSI 41.99%PRS 10.42
-
CSI 27.82rCSI 62.45%PRS 22.39
-
CSI 27.62rCSI 18.61%PRS 12.69
-
CSI 27.5rCSI 65.68%PRS 16.69
-
CSI 26.96rCSI 74.08%PRS 17.55
-
CSI 26.03rCSI 21.73%PRS 31.52
-
CSI 25.62rCSI 69.07%PRS 13.63
-
CSI 25.5rCSI 48.21%PRS 23.01
-
CSI 24.79rCSI 17.24%PRS 12.37
-
CSI 24.68rCSI 55.12%PRS 12
-
CSI 23.95rCSI 42.71%PRS 18.03
-
CSI 23.92rCSI 62.97%PRS 20.79
-
CSI 23.66rCSI 36.15%PRS 12.17
-
CSI 22.32rCSI 40.6%PRS 42.58
-
CSI 21.97rCSI 63.61%PRS 11.97
-
CSI 21.74rCSI 33.2%PRS 18.5
-
CSI 21.72rCSI 49.57%PRS 9.4
-
CSI 21.7rCSI 45.02%PRS 10.55
-
CSI 20.51rCSI 15.41%PRS 10.95
-
CSI 20.4rCSI 31.16%PRS 13.35
-
CSI 20.33rCSI 57.18%PRS 15.2
-
CSI 20.15rCSI 14.47%PRS 14.37
-
CSI 19.99rCSI 67.57%PRS 17.93
-
CSI 19.79rCSI 25.31%PRS 43.21
-
CSI 19.55rCSI 56.57%PRS 23.6
-
CSI 19.37rCSI 29.75%PRS 12.35
-
CSI 19.24rCSI 38.14%PRS 32.4
-
CSI 18.85rCSI 23.48%PRS 15.08
-
CSI 18.01rCSI 71.98%PRS 23.39
-
CSI 18.01rCSI 63.18%PRS 19.16
-
CSI 17.95rCSI 72.41%PRS 9.78
-
CSI 17.15rCSI 15.85%PRS 19.27
-
CSI 17.08rCSI 38.76%PRS 14.7
-
CSI 16.92rCSI 20.85%PRS 34.05
-
CSI 16.74rCSI 30.26%PRS 28.82
-
CSI -4.5rCSI -7.8%PRS 8.0%
-
CSI -4.2rCSI -9.5%PRS 6.5%
-
CSI -4.0rCSI -25.0%PRS 8.4%
-
CSI -2.5rCSI -8.0%PRS 7.6%
-
CSI -1.1rCSI -19.2%PRS 42.4%
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CSI -0.7rCSI -1.0%PRS 9.5%
-
CSI -0.7rCSI -1.2%PRS 7.7%
-
CSI -0.1rCSI -0.2%PRS 11.3%
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CSI 0.5rCSI 2.7%PRS 33.6%
-
CSI 0.5rCSI 3.0%PRS 15.5%
-
CSI 0.9rCSI 2.9%PRS 13.5%
-
CSI 1.0rCSI 5.6%PRS 16.4%
-
CSI 1.1rCSI 2.8%PRS 17.6%
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CSI 1.1rCSI 7.0%PRS 34.0%
-
CSI 1.1rCSI 3.0%PRS 12.7%
-
CSI 1.2rCSI 1.6%PRS 11.0%
-
CSI 1.2rCSI 6.8%PRS 26.5%
-
CSI 1.5rCSI 7.1%PRS 28.6%
-
CSI 1.5rCSI 29.7%PRS 34.5%
-
CSI 1.6rCSI 6.5%PRS 23.8%
-
CSI 1.7rCSI 37.2%PRS 48.3%
-
CSI 1.7rCSI 2.8%PRS 21.4%
-
CSI 1.7rCSI 44.0%PRS 49.9%
-
CSI 1.8rCSI 8.9%PRS 13.8%
-
CSI 1.8rCSI 8.2%PRS 40.0%
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CSI 2.0rCSI 48.3%PRS 36.8%
-
CSI 2.0rCSI 38.7%PRS 59.1%
-
CSI 2.2rCSI 19.0%PRS 54.8%
-
CSI 2.3rCSI 10.2%PRS 10.4%
-
CSI 2.3rCSI 12.7%PRS 20.0%
-
CSI 2.5rCSI 15.4%PRS 34.3%
-
CSI 2.6rCSI 41.2%PRS 53.8%
-
CSI 2.7rCSI 42.8%PRS 76.9%
-
CSI 2.7rCSI 26.8%PRS 61.9%
-
CSI 2.7rCSI 68.9%PRS 34.7%
-
CSI 2.8rCSI 65.5%PRS 18.6%
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CSI 2.9rCSI 66.1%PRS 63.5%
-
CSI 2.9rCSI 5.9%PRS 4.4%
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CSI 3.0rCSI 19.5%PRS 59.4%
-
CSI 3.0rCSI 16.7%PRS 33.8%
-
CSI 3.1rCSI 32.3%PRS 15.4%
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CSI 3.1rCSI 4.4%PRS 8.4%
-
CSI 3.1rCSI 25.3%PRS 11.0%
-
CSI 3.3rCSI 25.3%PRS 41.4%
-
CSI 3.4rCSI 12.3%PRS 18.1%
-
CSI 3.4rCSI 59.5%PRS 42.0%
-
CSI 3.4rCSI 9.0%PRS 10.1%
-
CSI 3.5rCSI 30.6%PRS 20.2%
-
CSI 3.7rCSI 4.4%PRS 18.3%
-
CSI 3.8rCSI 9.7%PRS 8.1%
-
CSI 3.8rCSI 21.8%PRS 41.9%
-
CSI 3.9rCSI 42.1%PRS 19.3%
-
CSI 3.9rCSI 18.3%PRS 23.4%
-
CSI 4.0rCSI 10.4%PRS 29.8%
-
CSI 4.0rCSI 13.9%PRS 41.1%
-
CSI 4.2rCSI 10.3%PRS 10.7%
-
CSI 4.2rCSI 63.2%PRS 33.7%
-
CSI 4.2rCSI 11.0%PRS 29.4%
-
CSI 4.3rCSI 8.2%PRS 17.0%
-
CSI 4.4rCSI 7.1%PRS 9.1%
-
CSI 4.7rCSI 16.1%PRS 42.1%
-
CSI 4.7rCSI 8.6%PRS 29.1%
-
CSI 4.8rCSI 12.1%PRS 10.8%
-
CSI 4.8rCSI 47.1%PRS 32.0%
-
CSI 4.9rCSI 8.3%PRS 21.4%
-
CSI 4.9rCSI 3.7%PRS 17.8%
-
CSI 5.0rCSI 3.9%PRS 7.3%
-
CSI 5.0rCSI 13.0%PRS 9.9%
-
CSI 5.1rCSI 78.3%PRS 26.3%
-
CSI 5.1rCSI 7.2%PRS 11.9%
-
CSI 5.4rCSI 48.4%PRS 68.3%
-
CSI 5.5rCSI 32.1%PRS 45.2%
-
CSI 5.5rCSI 9.7%PRS 14.0%
-
CSI 5.6rCSI 49.7%PRS 44.9%
-
CSI 5.7rCSI 9.7%PRS 14.2%
-
CSI 5.8rCSI 6.9%PRS 10.5%
-
CSI 5.8rCSI 13.9%PRS 56.2%
-
CSI 5.8rCSI 63.3%PRS 20.5%
-
CSI 5.9rCSI 26.3%PRS 31.7%
-
CSI 5.9rCSI 11.3%PRS 25.1%
-
CSI 6.0rCSI 6.1%PRS 19.8%
-
CSI 6.1rCSI 42.1%PRS 20.8%
-
CSI 6.2rCSI 11.6%PRS 13.1%
-
CSI 6.3rCSI 50.1%PRS 43.4%
-
CSI 6.4rCSI 12.3%PRS 23.8%
-
CSI 6.4rCSI 16.7%PRS 14.5%
-
CSI 6.5rCSI 8.3%PRS 11.1%
-
CSI 6.5rCSI 8.3%PRS 12.3%
-
CSI 6.6rCSI 19.0%PRS 15.3%
-
CSI 6.7rCSI 13.0%PRS 10.8%
-
CSI 6.7rCSI 9.5%PRS 9.9%
-
CSI 6.7rCSI 36.8%PRS 19.6%
-
CSI 6.8rCSI 38.3%PRS 23.7%
-
CSI 6.9rCSI 48.4%PRS 32.8%
-
CSI 7.0rCSI 77.9%PRS 35.4%
-
CSI 7.1rCSI 9.8%PRS 12.0%
-
CSI 7.2rCSI 10.6%PRS 12.1%
-
CSI 7.3rCSI 38.3%PRS 20.3%
-
CSI 7.3rCSI 27.9%PRS 11.0%
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CSI 7.5rCSI 73.9%PRS 38.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 123982098
Symbol: LEG3_HUMAN
Name: Galectin-3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2261464
Title: Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.
PubMed ID: 2261464
DOI: 10.1021/bi00487a015
PubMed ID: 2402511
Title: Molecular cloning of a human macrophage lectin specific for galactose.
PubMed ID: 2402511
PubMed ID: 2022338
Title: Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.
PubMed ID: 2022338
PubMed ID: 2009535
Title: Molecular cloning and chromosomal mapping of a human galactoside-binding protein.
PubMed ID: 2009535
PubMed ID: 7682704
Title: Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.
PubMed ID: 7682704
PubMed ID: 9439577
Title: The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter.
PubMed ID: 9439577
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8253806
Title: L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.
PubMed ID: 8253806
PubMed ID: 9501082
Title: Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.
PubMed ID: 9501082
PubMed ID: 15181153
Title: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.
PubMed ID: 15181153
PubMed ID: 19594635
Title: The regulation of inflammation by galectin-3.
PubMed ID: 19594635
PubMed ID: 19497882
Title: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.
PubMed ID: 19497882
PubMed ID: 19616076
Title: Dynamics of galectin-3 in the nucleus and cytoplasm.
PubMed ID: 19616076
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24945728
Title: Modulation of CD6 function through interaction with galectin-1 and -3.
PubMed ID: 24945728
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27693506
Title: TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.
PubMed ID: 27693506
PubMed ID: 32272059
Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.
PubMed ID: 32272059
PubMed ID: 9582341
Title: X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.
PubMed ID: 9582341
Sequence Information:
- Length: 250
- Mass: 26152
- Checksum: C49DDF6D67AE0C88
- Sequence:
MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI DLTSASYTMI