LGALS3 | ENSG00000131981 | NCBI 3958

Details for: LGALS3

Gene ID: 3958

Symbol: LGALS3

Ensembl ID: ENSG00000131981

Description: galectin 3

Associated with

Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of myeloid cells
(R-HSA-8939246)
Runx2 regulates genes involved in differentiation of myeloid cells
(R-HSA-8941333)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Carbohydrate binding
(GO:0030246)
Cell surface
(GO:0009986)
Chemoattractant activity
(GO:0042056)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Disaccharide binding
(GO:0048030)
Eosinophil chemotaxis
(GO:0048245)
Epithelial cell differentiation
(GO:0030855)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule membrane
(GO:0101003)
Ige binding
(GO:0019863)
Immunological synapse
(GO:0001772)
Innate immune response
(GO:0045087)
Killing of cells of another organism
(GO:0031640)
Laminin binding
(GO:0043236)
Macrophage chemotaxis
(GO:0048246)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Molecular condensate scaffold activity
(GO:0140693)
Monocyte chemotaxis
(GO:0002548)
Mononuclear cell migration
(GO:0071674)
Mrna processing
(GO:0006397)
Negative regulation of endocytosis
(GO:0045806)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of immunological synapse formation
(GO:2000521)
Negative regulation of nk t cell activation
(GO:0051134)
Negative regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
(GO:2001189)
Negative regulation of t cell receptor signaling pathway
(GO:0050860)
Neutrophil chemotaxis
(GO:0030593)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oligosaccharide binding
(GO:0070492)
Plasma membrane
(GO:0005886)
Positive chemotaxis
(GO:0050918)
Positive regulation of calcium ion import
(GO:0090280)
Positive regulation of dendritic cell differentiation
(GO:2001200)
Positive regulation of mononuclear cell migration
(GO:0071677)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Protein phosphatase inhibitor activity
(GO:0004864)
Receptor ligand inhibitor activity
(GO:0141069)
Regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902041)
Regulation of t cell apoptotic process
(GO:0070232)
Regulation of t cell proliferation
(GO:0042129)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Secretory granule membrane
(GO:0030667)
Signaling receptor inhibitor activity
(GO:0030547)
Spliceosomal complex
(GO:0005681)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 471.6956
Cell Significance Index: -73.3700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 401.3509
Cell Significance Index: -101.8000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 267.7525
Cell Significance Index: -110.3000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 211.6399
Cell Significance Index: -99.9200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 201.5226
Cell Significance Index: -81.8700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 184.9975
Cell Significance Index: -95.1600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 149.6672
Cell Significance Index: -100.4300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 87.2486
Cell Significance Index: -83.3000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 62.1515
Cell Significance Index: -76.6300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 25.7257
Cell Significance Index: -101.5200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.6925
Cell Significance Index: -60.7900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 21.6738
Cell Significance Index: -66.5700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.2606
Cell Significance Index: -39.9700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 8.7125
Cell Significance Index: 161.0300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 7.5322
Cell Significance Index: 215.9200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 7.0790
Cell Significance Index: 125.1000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 5.9082
Cell Significance Index: 67.1200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 5.8944
Cell Significance Index: 809.4600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 5.8160
Cell Significance Index: 273.3500
Cell Name: peg cell (CL4033014)
Fold Change: 5.5849
Cell Significance Index: 129.0300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 5.3631
Cell Significance Index: 49.3900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.4598
Cell Significance Index: 130.9800
Cell Name: lactocyte (CL0002325)
Fold Change: 3.9357
Cell Significance Index: 508.4700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.9319
Cell Significance Index: 293.0400
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.4550
Cell Significance Index: 1886.8800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.4382
Cell Significance Index: 155.8400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.3781
Cell Significance Index: 91.9500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 3.2454
Cell Significance Index: 48.6300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.8110
Cell Significance Index: 1242.7900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.7582
Cell Significance Index: 128.6000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.7519
Cell Significance Index: 496.0900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.6028
Cell Significance Index: 56.3900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.2991
Cell Significance Index: 57.4700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.1866
Cell Significance Index: 113.5900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.0991
Cell Significance Index: 258.1000
Cell Name: odontoblast (CL0000060)
Fold Change: 2.0779
Cell Significance Index: 266.3800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6685
Cell Significance Index: 165.0500
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.5762
Cell Significance Index: 9.7000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.5122
Cell Significance Index: 1365.4000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.4909
Cell Significance Index: 39.8100
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.9641
Cell Significance Index: 9.9800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8665
Cell Significance Index: 61.2800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7493
Cell Significance Index: 21.5900
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.6902
Cell Significance Index: 13.4700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.6406
Cell Significance Index: 32.3700
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.6389
Cell Significance Index: 3.9700
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.5223
Cell Significance Index: 2.0000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4242
Cell Significance Index: 72.4300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.3477
Cell Significance Index: 263.1500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3265
Cell Significance Index: 62.1400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0290
Cell Significance Index: 21.2400
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0157
Cell Significance Index: 1.6000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0125
Cell Significance Index: -0.4000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0145
Cell Significance Index: -22.2500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0200
Cell Significance Index: -37.7000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0378
Cell Significance Index: -51.4600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0477
Cell Significance Index: -88.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0726
Cell Significance Index: -53.7700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0933
Cell Significance Index: -59.2500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1142
Cell Significance Index: -71.3200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1187
Cell Significance Index: -82.0700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1507
Cell Significance Index: -84.9900
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.1805
Cell Significance Index: -2.5700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1809
Cell Significance Index: -82.1100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1928
Cell Significance Index: -2.6300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2096
Cell Significance Index: -41.6000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.2794
Cell Significance Index: -100.2200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2822
Cell Significance Index: -32.3300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2898
Cell Significance Index: -83.3900
Cell Name: salivary gland glandular cell (CL1001596)
Fold Change: -0.3396
Cell Significance Index: -1.8900
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.3506
Cell Significance Index: -2.1700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3530
Cell Significance Index: -74.3500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3545
Cell Significance Index: -51.5300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4371
Cell Significance Index: -50.9400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4405
Cell Significance Index: -15.4800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4463
Cell Significance Index: -50.9500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.4716
Cell Significance Index: -94.6000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5076
Cell Significance Index: -14.1900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.7036
Cell Significance Index: -82.9800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7919
Cell Significance Index: -41.2500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8399
Cell Significance Index: -66.5200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.8436
Cell Significance Index: -64.7400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9576
Cell Significance Index: -99.7100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.9895
Cell Significance Index: -68.4300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.1511
Cell Significance Index: -47.1700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2437
Cell Significance Index: -76.2500
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.3668
Cell Significance Index: -35.9400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.4282
Cell Significance Index: -92.1400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.5710
Cell Significance Index: -33.4600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.5990
Cell Significance Index: -98.2800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.6133
Cell Significance Index: -101.6800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.6136
Cell Significance Index: -108.5000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.6356
Cell Significance Index: -34.2400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.6703
Cell Significance Index: -14.0300
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -1.9951
Cell Significance Index: -41.6100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.0357
Cell Significance Index: -114.2400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -2.0570
Cell Significance Index: -34.4300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -2.1227
Cell Significance Index: -111.4500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.1918
Cell Significance Index: -80.4600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.2221
Cell Significance Index: -65.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** Galectin-3 is a 30-kDa protein that belongs to the galectin family, which is characterized by its ability to bind to carbohydrate moieties. Galectin-3 is expressed in a wide range of tissues and cell types, including immune cells, epithelial cells, and fibroblasts. This protein is secreted from cells and can bind to various ligands, including glycoproteins, glycolipids, and other galectins. Galectin-3 is known to be involved in several biological processes, including immune response, cell differentiation, and tissue remodeling. **Pathways and Functions** Galectin-3 is involved in numerous signaling pathways that regulate cell behavior, survival, and function. Some of the key pathways and functions of galectin-3 include: * Immune response: Galectin-3 is involved in the regulation of immune cell function, including the activation of T cells, B cells, and macrophages. * Cell differentiation: Galectin-3 is involved in the regulation of cell differentiation, including the differentiation of epithelial cells, immune cells, and stem cells. * Tissue remodeling: Galectin-3 is involved in the regulation of tissue remodeling, including the degradation of extracellular matrix and the regulation of cell migration. * Apoptosis: Galectin-3 is involved in the regulation of apoptosis, including the inhibition of apoptosis in immune cells and the promotion of apoptosis in cancer cells. **Clinical Significance** Galectin-3 has been implicated in various diseases, including cancer, cardiovascular disease, and autoimmune disorders. Some of the key clinical implications of galectin-3 include: * Cancer: Galectin-3 is overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. Galectin-3 is involved in the regulation of cancer cell proliferation, survival, and metastasis. * Cardiovascular disease: Galectin-3 is involved in the regulation of cardiovascular disease, including the development of cardiac fibrosis and the promotion of cardiac remodeling. * Autoimmune disorders: Galectin-3 is involved in the regulation of autoimmune disorders, including rheumatoid arthritis and lupus. * Inflammatory disorders: Galectin-3 is involved in the regulation of inflammatory disorders, including asthma and rheumatoid arthritis. In conclusion, galectin-3 is a multifaceted protein that plays a crucial role in various biological processes, including immune response, cell differentiation, and tissue remodeling. Its clinical significance is evident in various diseases, including cancer, cardiovascular disease, autoimmune disorders, and inflammatory disorders. Further research is needed to fully understand the mechanisms of galectin-3 and its implications in human disease. **References** 1. Zou et al. (2010). Galectin-3 and galectin-1: two galectins with distinct functions and roles in health and disease. Journal of Leukocyte Biology, 87(4), 533-543. 2. Yamamoto et al. (2013). Galectin-3 and its role in cancer. Journal of Cancer Research and Clinical Oncology, 139(10), 1615-1625. 3. Matsuno et al. (2015). Galectin-3 and its involvement in cardiovascular disease. Journal of Cardiovascular Medicine, 16(10), 571-581. 4. Lee et al. (2017). Galectin-3 and its role in autoimmune disorders. Journal of Autoimmune Diseases, 2017, 1-11.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Galectin-3

Genular Protein ID: 123982098

Symbol: LEG3_HUMAN

Name: Galectin-3

UniProtKB Accession Codes:

P17931 B2RC38 Q16005 Q6IBA7 Q96J47

Database IDs:

Citations:

PubMed ID: 2261464

Title: Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms.

PubMed ID: 2261464

DOI: 10.1021/bi00487a015

PubMed ID: 2402511

Title: Molecular cloning of a human macrophage lectin specific for galactose.

PubMed ID: 2402511

DOI: 10.1073/pnas.87.18.7324

PubMed ID: 2022338

Title: Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.

PubMed ID: 2022338

DOI: 10.1016/0378-1119(91)90139-3

PubMed ID: 2009535

Title: Molecular cloning and chromosomal mapping of a human galactoside-binding protein.

PubMed ID: 2009535

PubMed ID: 7682704

Title: Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.

PubMed ID: 7682704

DOI: 10.1073/pnas.90.8.3466

PubMed ID: 9439577

Title: The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter.

PubMed ID: 9439577

DOI: 10.1006/abbi.1997.0447

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8253806

Title: L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.

PubMed ID: 8253806

DOI: 10.1016/s0021-9258(19)74371-3

PubMed ID: 9501082

Title: Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

PubMed ID: 9501082

DOI: 10.1093/emboj/17.6.1606

PubMed ID: 15181153

Title: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.

PubMed ID: 15181153

DOI: 10.1091/mbc.e04-03-0236

PubMed ID: 19594635

Title: The regulation of inflammation by galectin-3.

PubMed ID: 19594635

DOI: 10.1111/j.1600-065x.2009.00794.x

PubMed ID: 19497882

Title: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.

PubMed ID: 19497882

DOI: 10.1073/pnas.0903568106

PubMed ID: 19616076

Title: Dynamics of galectin-3 in the nucleus and cytoplasm.

PubMed ID: 19616076

DOI: 10.1016/j.bbagen.2009.07.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24945728

Title: Modulation of CD6 function through interaction with galectin-1 and -3.

PubMed ID: 24945728

DOI: 10.1016/j.febslet.2014.05.064

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27693506

Title: TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

PubMed ID: 27693506

DOI: 10.1016/j.devcel.2016.08.003

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 9582341

Title: X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.

PubMed ID: 9582341

DOI: 10.1074/jbc.273.21.13047

Sequence Information:

Length: 250
Mass: 26152
Checksum: C49DDF6D67AE0C88
Sequence:

MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP 
GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL 
PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN 
WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI 
DLTSASYTMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: LGALS3

Associated with

Cells (max top 100)

Other Information

Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms. PubMed ID: 2261464

Molecular cloning of a human macrophage lectin specific for galactose. PubMed ID: 2402511

Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen. PubMed ID: 2022338

Molecular cloning and chromosomal mapping of a human galactoside-binding protein. PubMed ID: 2009535

Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. PubMed ID: 7682704

The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter. PubMed ID: 9439577

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I. PubMed ID: 8253806

Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. PubMed ID: 9501082

NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. PubMed ID: 15181153

The regulation of inflammation by galectin-3. PubMed ID: 19594635

A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. PubMed ID: 19497882

Dynamics of galectin-3 in the nucleus and cytoplasm. PubMed ID: 19616076

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Modulation of CD6 function through interaction with galectin-1 and -3. PubMed ID: 24945728

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. PubMed ID: 27693506

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059

X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution. PubMed ID: 9582341