Details for: LIG3

Gene ID: 3980

Symbol: LIG3

Ensembl ID: ENSG00000005156

Description: DNA ligase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.7
    Marker Score: 6574
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.37
    Marker Score: 2394
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71759
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14464
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4990
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2621
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.73
    Marker Score: 778
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 546
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 285
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.7
    Marker Score: 6074
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2847.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.67
    Marker Score: 1526
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 608
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.65
    Marker Score: 524
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.64
    Marker Score: 803.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.63
    Marker Score: 5448
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.62
    Marker Score: 566
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.6
    Marker Score: 2513
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.6
    Marker Score: 926
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.6
    Marker Score: 348
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.59
    Marker Score: 5622
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.59
    Marker Score: 870.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.59
    Marker Score: 1391
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.59
    Marker Score: 2267
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.57
    Marker Score: 390
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.57
    Marker Score: 5404
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.57
    Marker Score: 35243.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.57
    Marker Score: 275
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 181
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.55
    Marker Score: 2041.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.54
    Marker Score: 20625
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 324
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.54
    Marker Score: 1317
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.53
    Marker Score: 556
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.53
    Marker Score: 566
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.52
    Marker Score: 350
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.52
    Marker Score: 752
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3106
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1051
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.51
    Marker Score: 550
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.51
    Marker Score: 326
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.49
    Marker Score: 488
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.48
    Marker Score: 1134
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.48
    Marker Score: 17771
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.48
    Marker Score: 1002
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 317
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.48
    Marker Score: 264
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.48
    Marker Score: 218
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.48
    Marker Score: 633.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.47
    Marker Score: 805
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.47
    Marker Score: 2304.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.46
    Marker Score: 162
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.46
    Marker Score: 1814
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.46
    Marker Score: 1254.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.46
    Marker Score: 3525
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.46
    Marker Score: 256
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 142
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.45
    Marker Score: 798
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.44
    Marker Score: 833
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.43
    Marker Score: 295
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.43
    Marker Score: 230
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.43
    Marker Score: 6458
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.43
    Marker Score: 444
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.42
    Marker Score: 397
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.42
    Marker Score: 8366
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.42
    Marker Score: 2710
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.42
    Marker Score: 118
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.41
    Marker Score: 1716.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.41
    Marker Score: 431
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4
    Marker Score: 269
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4
    Marker Score: 443
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4
    Marker Score: 834
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.39
    Marker Score: 231
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.39
    Marker Score: 1628
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.39
    Marker Score: 162
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.39
    Marker Score: 193
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 376
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.39
    Marker Score: 3919
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.39
    Marker Score: 168
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.39
    Marker Score: 136
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.39
    Marker Score: 192
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.39
    Marker Score: 263
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 183
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.38
    Marker Score: 156
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.38
    Marker Score: 513.5

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Other Information

## Summary LIG3 is a key enzyme in DNA repair pathways, playing a crucial role in the resolution of abasic sites (ap sites) in DNA. It is involved in various cellular processes, including neural development, stem cell function, and genomic integrity. ## Key characteristics * LIG3 is a DNA ligase enzyme that plays a critical role in the repair of DNA damage caused by a variety of agents, including oxidative stress, alkylation, and deamination. * It is a key enzyme in the single-nucleotide replacement pathway of DNA repair. * It is also involved in the homologous directed repair pathway, where a new nucleotide is inserted into an ap site to restore the integrity of the DNA molecule. * It is expressed in a wide range of cell types, including neural progenitor cells, germ cells, and stem cells. ## Pathways and functions * **Single-nucleotide replacement pathway:** LIG3 is responsible for the resolution of abasic sites through the single-nucleotide replacement pathway. This pathway involves the insertion of a new nucleotide into an ap site, restoring the integrity of the DNA molecule. * **Homology directed repair pathway:** In the homology directed repair pathway, LIG3 is involved in the repair of DNA damage by using a template strand to repair the damage. * **Global genome nucleotide excision repair (gg-ner):** LIG3 is one of the key enzymes in the global genome nucleotide excision repair (gg-ner) pathway, which is responsible for repairing DNA damage in genomic DNA. * **Hdr through mmej (alt-nhej):** LIG3 is also involved in the Hdr through mmej (alt-nhej) pathway, which is responsible for repairing DNA damage in mitochondrial DNA. * **Protein binding:** LIG3 can bind to various proteins, including DNA repair proteins, transcription factors, and RNA molecules. ## Clinical significance * Mutations in LIG3 have been linked to various human diseases, including neurodegenerative disorders, cancer, and developmental abnormalities. * Inhibition of LIG3 has been shown to be effective in repairing DNA damage and preventing the development of cancer. * Therefore, LIG3 is a promising target for the treatment of human diseases that are caused by DNA damage.

Genular Protein ID: 1418192741

Symbol: DNLI3_HUMAN

Name: DNA ligase 3

UniProtKB Accession Codes:

P49916 E5KLB5 E5KLB6 Q16714 Q6NVK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 88 EMDB 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 8 PIR 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7760816

Title: Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination.

PubMed ID: 7760816

DOI: 10.1128/mcb.15.6.3206

PubMed ID: 7565692

Title: Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination.

PubMed ID: 7565692

DOI: 10.1128/mcb.15.10.5412

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10207110

Title: The human DNA ligase III gene encodes nuclear and mitochondrial proteins.

PubMed ID: 10207110

DOI: 10.1128/mcb.19.5.3869

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19336415

Title: Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

PubMed ID: 19336415

DOI: 10.1093/nar/gkp201

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24674627

Title: Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.

PubMed ID: 24674627

DOI: 10.1016/j.dnarep.2014.01.015

PubMed ID: 11281714

Title: Expression, purification, and biophysical characterization of the BRCT domain of human DNA ligase IIIalpha.

PubMed ID: 11281714

DOI: 10.1006/prep.2001.1391

PubMed ID: 15288782

Title: Solution structure and DNA binding of the zinc-finger domain from DNA ligase IIIalpha.

PubMed ID: 15288782

DOI: 10.1016/j.jmb.2004.06.035

PubMed ID: 20518483

Title: Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.

PubMed ID: 20518483

DOI: 10.1021/bi100503w

PubMed ID: 21652643

Title: The structural basis for partitioning of the XRCC1/DNA ligase III-? BRCT-mediated dimer complexes.

PubMed ID: 21652643

DOI: 10.1093/nar/gkr419

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 33855352

Title: Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.

PubMed ID: 33855352

DOI: 10.1093/brain/awab056

PubMed ID: 34165507

Title: Myopathic mitochondrial DNA depletion syndrome associated with biallelic variants in LIG3.

PubMed ID: 34165507

DOI: 10.1093/brain/awab238

Sequence Information:

  • Length: 1009
  • Mass: 112907
  • Checksum: 0E4057E33C3F19A6
  • Sequence:
    • MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF LRRKPVLSFQ 
GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR GTAGCKKCKE KIVKGVCRIG 
KVVPNPFSES GGDMKEWYHI KCMFEKLERA RATTKKIEDL TELEGWEELE DNEKEQITQH 
IADLSSKAAG TPKKKAVVQA KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP 
SSPTPKRSLS SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH 
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV SETIRVFFEQ 
SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI ASRCTANDLK CIIRLIKHDL 
KMNSGAKHVL DALDPNAYEA FKASRNLQDV VERVLHNAQE VEKEPGQRRA LSVQASLMTP 
VQPMLAEACK SVEYAMKKCP NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH 
FKDYIPQAFP GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF 
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI QEGLEGLVLK 
DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG QGSKGGMMSI FLMGCYDPGS 
QKWCTVTKCA GGHDDATLAR LQNELDMVKI SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA 
VWEITGAEFS KSEAHTADGI SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV 
VAGDEGSSTT GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS 
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP DFSRLRRYFV 
AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI RKRRLVAPC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.