Details for: LIG3

Gene ID: 3980

Symbol: LIG3

Ensembl ID: ENSG00000005156

Description: DNA ligase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.6284
    Cell Significance Index: -16.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.9768
    Cell Significance Index: -15.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.4479
    Cell Significance Index: -17.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.5748
    Cell Significance Index: -13.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.2866
    Cell Significance Index: -13.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8204
    Cell Significance Index: -17.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2975
    Cell Significance Index: -16.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3639
    Cell Significance Index: -17.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2758
    Cell Significance Index: 433.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1367
    Cell Significance Index: 1026.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9854
    Cell Significance Index: 59.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9239
    Cell Significance Index: 100.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8553
    Cell Significance Index: 11.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7777
    Cell Significance Index: 126.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5380
    Cell Significance Index: 27.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5279
    Cell Significance Index: 15.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4872
    Cell Significance Index: 33.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4670
    Cell Significance Index: 12.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4265
    Cell Significance Index: 9.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4168
    Cell Significance Index: 23.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3576
    Cell Significance Index: 70.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3486
    Cell Significance Index: 69.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3428
    Cell Significance Index: 9.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3105
    Cell Significance Index: 38.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3096
    Cell Significance Index: 55.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2615
    Cell Significance Index: 11.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2459
    Cell Significance Index: 5.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2416
    Cell Significance Index: 86.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2407
    Cell Significance Index: 166.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2332
    Cell Significance Index: 14.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1875
    Cell Significance Index: 8.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1787
    Cell Significance Index: 6.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1781
    Cell Significance Index: 17.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1733
    Cell Significance Index: 12.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1694
    Cell Significance Index: 23.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1655
    Cell Significance Index: 90.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1636
    Cell Significance Index: 72.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1236
    Cell Significance Index: 7.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1130
    Cell Significance Index: 8.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1127
    Cell Significance Index: 7.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1109
    Cell Significance Index: 3.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0930
    Cell Significance Index: 2.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0619
    Cell Significance Index: 1.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0592
    Cell Significance Index: 1.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0559
    Cell Significance Index: 4.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0479
    Cell Significance Index: 1.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0255
    Cell Significance Index: 3.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0208
    Cell Significance Index: 39.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0130
    Cell Significance Index: 23.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0115
    Cell Significance Index: 0.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0113
    Cell Significance Index: 17.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0057
    Cell Significance Index: 3.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0022
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0069
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0099
    Cell Significance Index: -4.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0161
    Cell Significance Index: -12.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0194
    Cell Significance Index: -14.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0263
    Cell Significance Index: -1.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0295
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0313
    Cell Significance Index: -19.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0330
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0424
    Cell Significance Index: -7.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0447
    Cell Significance Index: -12.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0564
    Cell Significance Index: -6.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0610
    Cell Significance Index: -6.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0620
    Cell Significance Index: -4.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0633
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0880
    Cell Significance Index: -18.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0969
    Cell Significance Index: -1.6600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1004
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1024
    Cell Significance Index: -11.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1213
    Cell Significance Index: -3.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1309
    Cell Significance Index: -2.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1373
    Cell Significance Index: -14.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1431
    Cell Significance Index: -3.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1457
    Cell Significance Index: -3.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1470
    Cell Significance Index: -7.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1576
    Cell Significance Index: -8.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1647
    Cell Significance Index: -10.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1661
    Cell Significance Index: -1.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1704
    Cell Significance Index: -13.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2093
    Cell Significance Index: -5.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2206
    Cell Significance Index: -4.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2411
    Cell Significance Index: -2.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2790
    Cell Significance Index: -6.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3432
    Cell Significance Index: -9.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3538
    Cell Significance Index: -10.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3701
    Cell Significance Index: -10.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3708
    Cell Significance Index: -13.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3774
    Cell Significance Index: -11.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3836
    Cell Significance Index: -4.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3876
    Cell Significance Index: -11.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3882
    Cell Significance Index: -12.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4047
    Cell Significance Index: -20.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4058
    Cell Significance Index: -4.6100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.4063
    Cell Significance Index: -4.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LIG3 is a member of the DNA ligase family, which is responsible for sealing DNA breaks by forming phosphodiester bonds between the 3'-hydroxyl group of one nucleotide and the 5'-phosphate group of another. LIG3 is specifically involved in the resolution of apical (abasic) sites and the single-nucleotide replacement pathway, which is a mechanism for repairing DNA damage caused by oxidative stress. The enzyme is also involved in base excision repair (BER) and nucleotide excision repair (NER), which are pathways for repairing DNA damage caused by environmental mutagens. **Pathways and Functions:** LIG3 is involved in several key DNA repair pathways, including: 1. **Apex1-independent resolution of ap sites via the single nucleotide replacement pathway:** This pathway involves the direct ligation of DNA strands to repair apical sites, which are caused by oxidative stress. 2. **Atp binding:** LIG3 binds to ATP, which is necessary for the enzyme's catalytic activity. 3. **Base-excision repair:** LIG3 is involved in the repair of DNA damage caused by environmental mutagens, such as aldehydes and purine bases. 4. **Gap-filling:** LIG3 is involved in the repair of DNA gaps caused by DNA polymerase errors. 5. **Double-strand break repair:** LIG3 is involved in the repair of DNA double-strand breaks through the NHEJ pathway. 6. **Homology directed repair:** LIG3 is involved in the repair of DNA double-strand breaks through homology-directed repair (HDR), which is a more precise mechanism for repairing DNA damage. **Clinical Significance:** Dysregulation of LIG3 has been implicated in various diseases, including: 1. **Cancer:** Mutations in the LIG3 gene have been associated with an increased risk of cancer, including breast, ovarian, and colon cancer. 2. **Neurodegenerative disorders:** Dysregulation of LIG3 has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Genetic instability:** LIG3 is involved in maintaining genome stability, and dysregulation of the enzyme can lead to genetic instability, which is a hallmark of cancer. 4. **Mitochondrial DNA replication:** LIG3 is involved in the maintenance of mitochondrial DNA, and dysregulation of the enzyme can lead to mitochondrial dysfunction. In conclusion, LIG3 is a crucial enzyme involved in DNA repair and maintenance. Dysregulation of the enzyme has been implicated in various diseases, including cancer and neurodegenerative disorders. Further research is needed to understand the mechanisms by which LIG3 regulates DNA repair and to develop new therapeutic strategies for treating diseases associated with LIG3 dysfunction.

Genular Protein ID: 1418192741

Symbol: DNLI3_HUMAN

Name: DNA ligase 3

UniProtKB Accession Codes:

P49916 E5KLB5 E5KLB6 Q16714 Q6NVK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 88 EMDB 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7760816

Title: Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination.

PubMed ID: 7760816

DOI: 10.1128/mcb.15.6.3206

PubMed ID: 7565692

Title: Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination.

PubMed ID: 7565692

DOI: 10.1128/mcb.15.10.5412

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10207110

Title: The human DNA ligase III gene encodes nuclear and mitochondrial proteins.

PubMed ID: 10207110

DOI: 10.1128/mcb.19.5.3869

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19336415

Title: Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

PubMed ID: 19336415

DOI: 10.1093/nar/gkp201

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24674627

Title: Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.

PubMed ID: 24674627

DOI: 10.1016/j.dnarep.2014.01.015

PubMed ID: 11281714

Title: Expression, purification, and biophysical characterization of the BRCT domain of human DNA ligase IIIalpha.

PubMed ID: 11281714

DOI: 10.1006/prep.2001.1391

PubMed ID: 15288782

Title: Solution structure and DNA binding of the zinc-finger domain from DNA ligase IIIalpha.

PubMed ID: 15288782

DOI: 10.1016/j.jmb.2004.06.035

PubMed ID: 20518483

Title: Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.

PubMed ID: 20518483

DOI: 10.1021/bi100503w

PubMed ID: 21652643

Title: The structural basis for partitioning of the XRCC1/DNA ligase III-? BRCT-mediated dimer complexes.

PubMed ID: 21652643

DOI: 10.1093/nar/gkr419

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 33855352

Title: Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.

PubMed ID: 33855352

DOI: 10.1093/brain/awab056

PubMed ID: 34165507

Title: Myopathic mitochondrial DNA depletion syndrome associated with biallelic variants in LIG3.

PubMed ID: 34165507

DOI: 10.1093/brain/awab238

Sequence Information:

  • Length: 1009
  • Mass: 112907
  • Checksum: 0E4057E33C3F19A6
  • Sequence:
    • MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF LRRKPVLSFQ 
GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR GTAGCKKCKE KIVKGVCRIG 
KVVPNPFSES GGDMKEWYHI KCMFEKLERA RATTKKIEDL TELEGWEELE DNEKEQITQH 
IADLSSKAAG TPKKKAVVQA KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP 
SSPTPKRSLS SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH 
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV SETIRVFFEQ 
SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI ASRCTANDLK CIIRLIKHDL 
KMNSGAKHVL DALDPNAYEA FKASRNLQDV VERVLHNAQE VEKEPGQRRA LSVQASLMTP 
VQPMLAEACK SVEYAMKKCP NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH 
FKDYIPQAFP GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF 
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI QEGLEGLVLK 
DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG QGSKGGMMSI FLMGCYDPGS 
QKWCTVTKCA GGHDDATLAR LQNELDMVKI SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA 
VWEITGAEFS KSEAHTADGI SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV 
VAGDEGSSTT GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS 
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP DFSRLRRYFV 
AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI RKRRLVAPC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.