Details for: LMO2

Gene ID: 4005

Symbol: LMO2

Ensembl ID: ENSG00000135363

Description: LIM domain only 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.3397
    Cell Significance Index: -9.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 50.6375
    Cell Significance Index: -20.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.5439
    Cell Significance Index: -17.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.8534
    Cell Significance Index: -20.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.3215
    Cell Significance Index: -9.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.6438
    Cell Significance Index: -17.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8204
    Cell Significance Index: -17.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7300
    Cell Significance Index: -18.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.2330
    Cell Significance Index: 220.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3485
    Cell Significance Index: 216.0300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.8093
    Cell Significance Index: 10.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.6610
    Cell Significance Index: 30.2300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.3490
    Cell Significance Index: 16.8700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.3269
    Cell Significance Index: 36.0000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.2088
    Cell Significance Index: 14.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.8326
    Cell Significance Index: 32.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.8307
    Cell Significance Index: 48.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1461
    Cell Significance Index: 135.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9238
    Cell Significance Index: 175.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8641
    Cell Significance Index: 15.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5835
    Cell Significance Index: 57.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5156
    Cell Significance Index: 465.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4555
    Cell Significance Index: 74.0800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.3874
    Cell Significance Index: 2.5700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.3596
    Cell Significance Index: 2.5900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.3561
    Cell Significance Index: 2.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2205
    Cell Significance Index: 23.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2190
    Cell Significance Index: 43.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2124
    Cell Significance Index: 14.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2065
    Cell Significance Index: 112.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1970
    Cell Significance Index: 27.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1402
    Cell Significance Index: 17.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1399
    Cell Significance Index: 61.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1300
    Cell Significance Index: 23.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0925
    Cell Significance Index: 57.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0682
    Cell Significance Index: 0.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0537
    Cell Significance Index: 3.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0533
    Cell Significance Index: 1.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0440
    Cell Significance Index: 2.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0055
    Cell Significance Index: 0.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0011
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0059
    Cell Significance Index: -4.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0110
    Cell Significance Index: -3.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -6.9900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0135
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0140
    Cell Significance Index: -25.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0163
    Cell Significance Index: -25.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0180
    Cell Significance Index: -0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0189
    Cell Significance Index: -25.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0212
    Cell Significance Index: -0.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0235
    Cell Significance Index: -1.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0246
    Cell Significance Index: -18.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0265
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0269
    Cell Significance Index: -20.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0294
    Cell Significance Index: -18.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0377
    Cell Significance Index: -7.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0424
    Cell Significance Index: -8.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0454
    Cell Significance Index: -20.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0502
    Cell Significance Index: -14.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0503
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0535
    Cell Significance Index: -9.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0620
    Cell Significance Index: -7.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0743
    Cell Significance Index: -1.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1058
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1121
    Cell Significance Index: -12.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1321
    Cell Significance Index: -15.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1324
    Cell Significance Index: -13.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1333
    Cell Significance Index: -15.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1361
    Cell Significance Index: -17.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1436
    Cell Significance Index: -3.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1506
    Cell Significance Index: -7.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1511
    Cell Significance Index: -4.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1675
    Cell Significance Index: -4.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1716
    Cell Significance Index: -8.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1733
    Cell Significance Index: -18.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2125
    Cell Significance Index: -15.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2287
    Cell Significance Index: -8.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2308
    Cell Significance Index: -10.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2356
    Cell Significance Index: -18.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2391
    Cell Significance Index: -4.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2449
    Cell Significance Index: -6.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2475
    Cell Significance Index: -18.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2542
    Cell Significance Index: -10.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2649
    Cell Significance Index: -19.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2722
    Cell Significance Index: -14.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2811
    Cell Significance Index: -7.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2874
    Cell Significance Index: -13.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3269
    Cell Significance Index: -9.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3347
    Cell Significance Index: -20.5200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.3486
    Cell Significance Index: -2.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3634
    Cell Significance Index: -20.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4149
    Cell Significance Index: -26.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4656
    Cell Significance Index: -16.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4858
    Cell Significance Index: -16.8800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4992
    Cell Significance Index: -6.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5110
    Cell Significance Index: -18.7600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.5134
    Cell Significance Index: -4.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **LIM domain:** The LIM domain of LMO2 is a critical feature that enables it to interact with various transcription factors and co-regulators, facilitating its role as a transcriptional regulator. 2. **Hematopoietic specificity:** LMO2 is specifically expressed in hematopoietic cells, including early promyelocytes, hematopoietic multipotent progenitors, and pro-B cells, underscoring its importance in hematopoiesis. 3. **Transcriptional regulation:** LMO2 acts as a transcriptional co-regulator, interacting with transcription factors and co-regulators to regulate gene expression. 4. **Runx1 interaction:** LMO2 has been shown to interact with Runx1, a key transcription factor in hematopoiesis, highlighting its role in regulating transcriptional programs. **Pathways and Functions:** 1. **Bhlh transcription factor binding:** LMO2 interacts with Bhlh transcription factors, regulating their transcriptional activity. 2. **Dna-binding transcription factor binding:** LMO2 binds to DNA-binding transcription factors, modulating their ability to regulate gene expression. 3. **Gene expression (transcription):** LMO2 regulates gene expression by interacting with transcription factors and co-regulators, influencing the transcriptional program of hematopoietic cells. 4. **Metal ion binding:** The LIM domain of LMO2 can bind metal ions, which may influence its interactions with transcription factors and co-regulators. 5. **Transcriptional regulation by RNA polymerase II:** LMO2 regulates transcription by interacting with RNA polymerase II-specific DNA-binding transcription factors, influencing the transcriptional program of hematopoietic cells. **Clinical Significance:** 1. **Hematopoietic disorders:** Dysregulation of LMO2 expression has been implicated in various hematopoietic disorders, including leukemia and lymphoma. 2. **Hematopoietic stem cell transplantation:** LMO2 may play a role in the regulation of hematopoietic stem cell transplantation, influencing the success of this therapeutic approach. 3. **Cancer research:** LMO2's role in regulating transcriptional programs makes it an attractive target for cancer research, particularly in the context of hematopoietic malignancies. 4. **Gene therapy:** LMO2's involvement in the regulation of hematopoietic cell development and differentiation highlights its potential as a target for gene therapy approaches aimed at correcting hematopoietic disorders. In conclusion, LMO2 is a critical transcriptional regulator that plays a pivotal role in the development and differentiation of hematopoietic cells. Its unique LIM domain and interactions with transcription factors and co-regulators highlight its importance in regulating transcriptional programs. Further research is needed to fully elucidate the clinical significance of LMO2 in hematopoietic disorders and to explore its potential as a therapeutic target.

Genular Protein ID: 2182667479

Symbol: RBTN2_HUMAN

Name: Rhombotin-2

UniProtKB Accession Codes:

P25791 Q9HD58

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1923511

Title: TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).

PubMed ID: 1923511

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9129143

Title: T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2.

PubMed ID: 9129143

DOI: 10.1038/sj.onc.1200988

PubMed ID: 16314316

Title: Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex.

PubMed ID: 16314316

DOI: 10.1093/nar/gki964

Sequence Information:

  • Length: 158
  • Mass: 18358
  • Checksum: 1B4FF02505528C93
  • Sequence:
    • MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC 
GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF 
KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.