Details for: LMO2

Gene ID: 4005

Symbol: LMO2

Ensembl ID: ENSG00000135363

Description: LIM domain only 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.88
    Marker Score: 3908
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.63
    Marker Score: 23107.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.23
    Marker Score: 1087
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2
    Marker Score: 22264
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.07
    Marker Score: 518
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.02
    Marker Score: 874
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.81
    Marker Score: 2191
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.76
    Marker Score: 1196
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.72
    Marker Score: 3442
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.65
    Marker Score: 985
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.59
    Marker Score: 339
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.55
    Marker Score: 603
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.52
    Marker Score: 1431
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.5
    Marker Score: 3058
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.43
    Marker Score: 4037
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.43
    Marker Score: 339
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.34
    Marker Score: 321
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.3
    Marker Score: 1174.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.27
    Marker Score: 70744
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.25
    Marker Score: 290
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.24
    Marker Score: 3691
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.24
    Marker Score: 744
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.23
    Marker Score: 1102
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.18
    Marker Score: 804
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.16
    Marker Score: 842
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4773
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.12
    Marker Score: 764
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.09
    Marker Score: 1838.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.08
    Marker Score: 807.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16484
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.05
    Marker Score: 1526
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.04
    Marker Score: 326
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1
    Marker Score: 2453
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48004
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.99
    Marker Score: 1130
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.97
    Marker Score: 478.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.96
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.94
    Marker Score: 597
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.94
    Marker Score: 572
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.93
    Marker Score: 258.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.92
    Marker Score: 2291.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5220
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.9
    Marker Score: 773
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.87
    Marker Score: 479
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5269
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.86
    Marker Score: 1252
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.86
    Marker Score: 537
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.86
    Marker Score: 923.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.84
    Marker Score: 183
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.83
    Marker Score: 1039
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.83
    Marker Score: 826
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.82
    Marker Score: 358
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 804
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.81
    Marker Score: 7059
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 613.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.78
    Marker Score: 843
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.78
    Marker Score: 411
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.77
    Marker Score: 378
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1245
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.75
    Marker Score: 1767
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.75
    Marker Score: 198
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.74
    Marker Score: 255
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.74
    Marker Score: 1435
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 234
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.72
    Marker Score: 726
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.71
    Marker Score: 517
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.71
    Marker Score: 179
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.7
    Marker Score: 436
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.69
    Marker Score: 240
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.68
    Marker Score: 348
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.67
    Marker Score: 1692
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.66
    Marker Score: 676
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.65
    Marker Score: 2249
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.65
    Marker Score: 209
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.65
    Marker Score: 1038
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.64
    Marker Score: 233
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.64
    Marker Score: 3917.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.63
    Marker Score: 1515
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.63
    Marker Score: 166
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.62
    Marker Score: 257
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.61
    Marker Score: 634
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.6
    Marker Score: 206
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.59
    Marker Score: 246
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.59
    Marker Score: 2447
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.58
    Marker Score: 135
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.57
    Marker Score: 156
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 264

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Other Information

**Key characteristics:** - LMO2 is a protein of the LIM domain only 2 (LMO2) family of transcription factors. - It is a key regulator of gene expression, particularly in myeloid cells. - It is involved in the regulation of cell differentiation, proliferation, and survival. - It is a key regulator of the development and function of myeloid cells. **Pathways and functions:** - LMO2 is a key regulator of Bhlh transcription factor binding. - It is involved in the regulation of the expression of genes involved in myeloid cell differentiation, including Runx1. - It is also involved in the regulation of the expression of genes involved in the development and function of endothelial cells. **Clinical significance:** - Mutations in the LMO2 gene have been linked to several human diseases, including leukemia and lymphoma. - LMO2 is a potential target for cancer therapy. - By targeting LMO2, it may be possible to inhibit the growth and proliferation of cancer cells. **Additional information:** - LMO2 is a highly conserved protein, with similar genes found in other mammals. - It is a multi-functional protein that can interact with a variety of transcription factors. - It is a key regulator of inflammation and immune responses.

Genular Protein ID: 2182667479

Symbol: RBTN2_HUMAN

Name: Rhombotin-2

UniProtKB Accession Codes:

P25791 Q9HD58

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1923511

Title: TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).

PubMed ID: 1923511

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9129143

Title: T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2.

PubMed ID: 9129143

DOI: 10.1038/sj.onc.1200988

PubMed ID: 16314316

Title: Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex.

PubMed ID: 16314316

DOI: 10.1093/nar/gki964

Sequence Information:

  • Length: 158
  • Mass: 18358
  • Checksum: 1B4FF02505528C93
  • Sequence:
    • MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC 
GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF 
KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.