Details for: LRCH4

Gene ID: 4034

Symbol: LRCH4

Ensembl ID: ENSG00000077454

Description: leucine rich repeats and calponin homology domain containing 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.19
    Marker Score: 2260.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.16
    Marker Score: 1132
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.15
    Marker Score: 4688
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.08
    Marker Score: 347
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.07
    Marker Score: 1289
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.03
    Marker Score: 1805
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.01
    Marker Score: 10224
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1
    Marker Score: 55778
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71710
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47935
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.99
    Marker Score: 5899
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15369
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.98
    Marker Score: 306
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.97
    Marker Score: 659
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.95
    Marker Score: 3730
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.94
    Marker Score: 934.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2706
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.89
    Marker Score: 901
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.89
    Marker Score: 2207
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.88
    Marker Score: 530
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.88
    Marker Score: 589
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5237
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4848
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.81
    Marker Score: 1908
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.79
    Marker Score: 272
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.78
    Marker Score: 782.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.78
    Marker Score: 2146
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.77
    Marker Score: 7625
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.76
    Marker Score: 1481
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.73
    Marker Score: 1331
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.73
    Marker Score: 834
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.72
    Marker Score: 1119
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.72
    Marker Score: 1864
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.71
    Marker Score: 777
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4285
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2957.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7
    Marker Score: 7230
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.68
    Marker Score: 401
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.68
    Marker Score: 1859.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.68
    Marker Score: 1918
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.68
    Marker Score: 433
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.67
    Marker Score: 329
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.67
    Marker Score: 1957
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.67
    Marker Score: 232
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 606
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.66
    Marker Score: 402
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.66
    Marker Score: 405
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.66
    Marker Score: 200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.65
    Marker Score: 1367
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.65
    Marker Score: 390
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.65
    Marker Score: 605
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.64
    Marker Score: 369
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.64
    Marker Score: 266
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.64
    Marker Score: 314
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.63
    Marker Score: 761
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.63
    Marker Score: 311
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.63
    Marker Score: 446
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 541
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 410
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.61
    Marker Score: 623
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 391
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.61
    Marker Score: 413
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 291
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.61
    Marker Score: 460
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.6
    Marker Score: 1053
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.6
    Marker Score: 31873
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.6
    Marker Score: 208
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.6
    Marker Score: 592.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.6
    Marker Score: 396
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.59
    Marker Score: 154
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.59
    Marker Score: 431
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.59
    Marker Score: 255.5
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.59
    Marker Score: 205
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.59
    Marker Score: 287
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.59
    Marker Score: 239
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.58
    Marker Score: 134
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.58
    Marker Score: 837.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.58
    Marker Score: 562
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.58
    Marker Score: 206
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.58
    Marker Score: 4988.5
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.58
    Marker Score: 208
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.58
    Marker Score: 235
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.58
    Marker Score: 263
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.57
    Marker Score: 35188
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.57
    Marker Score: 145.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.57
    Marker Score: 3706
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.57
    Marker Score: 670
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.57
    Marker Score: 2430
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.56
    Marker Score: 1009
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.56
    Marker Score: 473

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Other Information

**Key characteristics:** * The LRCH4 gene is located on chromosome 16p13.1. * It is a large gene, with a length of approximately 11.6 kb. * The protein encoded by LRCH4 is a transmembrane protein with a molecular weight of approximately 150 kDa. * The protein is expressed in a variety of cell types, including cardiac endothelial cells, pancreatic A cells, pro-T cells, mononuclear cells, myeloid leukocytes, germ cells, early pro-B cells, CD14-positive, CD16-negative classical monocyte, cerebral cortex GABAergic interneuron, and forebrain radial glial cells. **Pathways and functions:** * The LRCH4 protein is involved in the assembly of membrane rafts. Membrane rafts are formed by the self-association of LRCH4 proteins, which are expressed in a highly concentrated manner in these structures. * The protein is also involved in the regulation of the Toll-like receptor signaling pathway. The LRCH4 protein is a ligand for Toll-like receptor 4 (TLR4), which is a key receptor for the innate immune system. When LRCH4 binds to TLR4, it recruits TLR4 to the plasma membrane, where it can interact with other TLRs and initiate the inflammatory response. * The LRCH4 protein is also involved in the development of the nervous system. Studies have shown that mutations in the LRCH4 gene can lead to a number of neurodevelopmental disorders, including autism and schizophrenia. **Clinical significance:** The LRCH4 gene is a promising target for the treatment of neurodevelopmental disorders. Mutations in the LRCH4 gene have been linked to a number of neurological diseases, including autism, schizophrenia, and epilepsy. Inhibition of LRCH4 has been shown to be effective in correcting these diseases in animal models.

Genular Protein ID: 3986297404

Symbol: LRCH4_HUMAN

Name: Leucine-rich repeat neuronal protein 4

UniProtKB Accession Codes:

O75427 A4D2D5 Q8WV85 Q96ID0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799793

Title: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PubMed ID: 9799793

DOI: 10.1101/gr.8.10.1060

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 683
  • Mass: 73450
  • Checksum: AF297AA30E4DA353
  • Sequence:
    • MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS NRRLKHFPRG 
AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH NCLRCLNPAL GNLTALTYLN 
LSRNQLSLLP PYICQLPLRV LIVSNNKLGA LPPDIGTLGS LRQLDVSSNE LQSLPSELCG 
LSSLRDLNVR RNQLSTLPEE LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ 
SPPAQVCLKG KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS 
GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD PVQIDFIDSH 
VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE ERRRPDTLQL WQERERRQQQ 
QSGAWGAPRK DSLLKPGLRA VVGGAAAVST QAMHNGSPKS SASQAGAAAG QGAPAPAPAS 
QEPLPIAGPA TAPAPRPLGS IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL 
MTQLRQVLES RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA 
RKNVESFLEA CRKMGVPEAD LCSPSDLLQG TARGLRTALE AVKRVGGKAL PPLWPPSGLG 
GFVVFYVVLM LLLYVTYTRL LGS

Genular Protein ID: 2691127581

Symbol: H7C5D9_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7C5D9

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 3 EPD 2 Ensembl 2 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 652
  • Mass: 70220
  • Checksum: A68645E50094008C
  • Sequence:
    • MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS NRRLKHFPRG 
AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH NCLRCLNPAL GNLTALTYLN 
LSRNQLSLLP PYICQLPLRV LIVSNNKLGA LPPDIGTLGS LRQLDVSSNE LQSLPSELCG 
LSSLRDLNVR RNQLSTLPEE LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ 
SPPAQVCLKG KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS 
GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD PVQIDFIDSH 
VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE ERRRPDTLQL WQERERRQQQ 
QSGAWGAPRK DSLLKPGLRA VVGGAAAVST QAMHNGSPKS SASQAGAAAG QGAPAPAPAS 
QEPLPIAGPA TAPAPRPLGS IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL 
MTQLRQVLES RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA 
RKNVESFLEA CRKMGVPEES LCQPHHILEE EGAPGRGLPY IAAVVHALLD RP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.