Details for: LRCH4

Gene ID: 4034

Symbol: LRCH4

Ensembl ID: ENSG00000077454

Description: leucine rich repeats and calponin homology domain containing 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.6343
    Cell Significance Index: -13.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.4451
    Cell Significance Index: -10.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.4886
    Cell Significance Index: -15.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.8851
    Cell Significance Index: -17.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.6144
    Cell Significance Index: -14.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3790
    Cell Significance Index: -13.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8241
    Cell Significance Index: -15.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6583
    Cell Significance Index: -9.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5496
    Cell Significance Index: -5.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5168
    Cell Significance Index: 104.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2699
    Cell Significance Index: 1146.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9600
    Cell Significance Index: 20.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9203
    Cell Significance Index: 59.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7821
    Cell Significance Index: 127.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7647
    Cell Significance Index: 83.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7118
    Cell Significance Index: 19.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5941
    Cell Significance Index: 10.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5665
    Cell Significance Index: 34.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4892
    Cell Significance Index: 4.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3511
    Cell Significance Index: 63.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3257
    Cell Significance Index: 65.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3197
    Cell Significance Index: 39.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2579
    Cell Significance Index: 7.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2498
    Cell Significance Index: 6.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2467
    Cell Significance Index: 6.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2399
    Cell Significance Index: 45.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2383
    Cell Significance Index: 130.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2236
    Cell Significance Index: 26.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1950
    Cell Significance Index: 8.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1823
    Cell Significance Index: 3.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1791
    Cell Significance Index: 24.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1693
    Cell Significance Index: 7.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1636
    Cell Significance Index: 21.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1636
    Cell Significance Index: 58.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1402
    Cell Significance Index: 61.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1314
    Cell Significance Index: 6.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1283
    Cell Significance Index: 25.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1264
    Cell Significance Index: 3.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1263
    Cell Significance Index: 3.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1063
    Cell Significance Index: 7.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0974
    Cell Significance Index: 67.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0795
    Cell Significance Index: 7.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0773
    Cell Significance Index: 9.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0605
    Cell Significance Index: 1.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0555
    Cell Significance Index: 1.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0465
    Cell Significance Index: 1.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0451
    Cell Significance Index: 0.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0094
    Cell Significance Index: 0.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0016
    Cell Significance Index: 0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0005
    Cell Significance Index: 0.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0064
    Cell Significance Index: -0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0070
    Cell Significance Index: -0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0086
    Cell Significance Index: -13.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0113
    Cell Significance Index: -15.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0146
    Cell Significance Index: -10.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0173
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0256
    Cell Significance Index: -16.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0272
    Cell Significance Index: -17.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0347
    Cell Significance Index: -0.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0351
    Cell Significance Index: -0.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0354
    Cell Significance Index: -16.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0447
    Cell Significance Index: -7.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0472
    Cell Significance Index: -13.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0538
    Cell Significance Index: -6.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0624
    Cell Significance Index: -2.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0724
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0751
    Cell Significance Index: -8.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0794
    Cell Significance Index: -16.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0820
    Cell Significance Index: -2.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0863
    Cell Significance Index: -6.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1067
    Cell Significance Index: -15.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1108
    Cell Significance Index: -7.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1363
    Cell Significance Index: -3.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1368
    Cell Significance Index: -4.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1371
    Cell Significance Index: -5.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1441
    Cell Significance Index: -15.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1618
    Cell Significance Index: -8.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1790
    Cell Significance Index: -9.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1815
    Cell Significance Index: -11.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1827
    Cell Significance Index: -10.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2001
    Cell Significance Index: -15.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2068
    Cell Significance Index: -4.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2073
    Cell Significance Index: -4.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2093
    Cell Significance Index: -9.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2307
    Cell Significance Index: -14.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2492
    Cell Significance Index: -7.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2543
    Cell Significance Index: -9.6300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2573
    Cell Significance Index: -2.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2592
    Cell Significance Index: -9.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2669
    Cell Significance Index: -7.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2907
    Cell Significance Index: -3.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2962
    Cell Significance Index: -3.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3099
    Cell Significance Index: -4.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3237
    Cell Significance Index: -11.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3387
    Cell Significance Index: -4.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3406
    Cell Significance Index: -11.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** LRCH4 is expressed in a wide range of cell types, including cardiac endothelial cells, pancreatic A cells, and immune cells such as mononuclear cells and myeloid leukocytes. 2. **Protein-binding capabilities:** LRCH4 contains leucine-rich repeats and calponin homology domains, which enable it to interact with various proteins and modulate their activity. 3. **Membrane association:** LRCH4 has been implicated in regulating membrane dynamics, particularly in the context of membrane raft assembly and plasma membrane organization. **Pathways and Functions:** 1. **Membrane raft assembly:** LRCH4 has been shown to regulate the formation and maintenance of membrane rafts, which are critical for signaling and trafficking processes. 2. **Nervous system development:** LRCH4 expression is observed in the developing nervous system, particularly in cerebral cortex GABAergic interneurons and forebrain radial glial cells, suggesting a role in neuronal development and function. 3. **Positive regulation of toll-like receptor signaling pathway:** LRCH4 has been implicated in the regulation of toll-like receptor (TLR) signaling, which is crucial for immune responses and inflammation. 4. **Protein binding:** LRCH4's protein-binding capabilities enable it to interact with various proteins, including those involved in membrane dynamics, immune responses, and neuronal function. **Clinical Significance:** 1. **Immune regulation:** LRCH4's role in regulating immune responses, particularly in the context of TLR signaling, has significant implications for understanding immune-related disorders, such as autoimmune diseases and cancer. 2. **Neuronal function:** The involvement of LRCH4 in neuronal development and function raises questions about its potential involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Membrane dynamics:** LRCH4's regulation of membrane dynamics has significant implications for understanding various cellular processes, including signaling, trafficking, and cell migration. In conclusion, LRCH4 is a gene with a complex and multifaceted role in regulating membrane dynamics, immune responses, and neuronal function. Further research is necessary to fully elucidate its mechanisms of action and clinical significance, but the available evidence suggests that LRCH4 is a gene of great importance for understanding human health and disease.

Genular Protein ID: 3986297404

Symbol: LRCH4_HUMAN

Name: Leucine-rich repeat neuronal protein 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9799793

Title: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PubMed ID: 9799793

DOI: 10.1101/gr.8.10.1060

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 683
  • Mass: 73450
  • Checksum: AF297AA30E4DA353
  • Sequence:
  • MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS NRRLKHFPRG 
    AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH NCLRCLNPAL GNLTALTYLN 
    LSRNQLSLLP PYICQLPLRV LIVSNNKLGA LPPDIGTLGS LRQLDVSSNE LQSLPSELCG 
    LSSLRDLNVR RNQLSTLPEE LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ 
    SPPAQVCLKG KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS 
    GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD PVQIDFIDSH 
    VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE ERRRPDTLQL WQERERRQQQ 
    QSGAWGAPRK DSLLKPGLRA VVGGAAAVST QAMHNGSPKS SASQAGAAAG QGAPAPAPAS 
    QEPLPIAGPA TAPAPRPLGS IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL 
    MTQLRQVLES RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA 
    RKNVESFLEA CRKMGVPEAD LCSPSDLLQG TARGLRTALE AVKRVGGKAL PPLWPPSGLG 
    GFVVFYVVLM LLLYVTYTRL LGS

Genular Protein ID: 2691127581

Symbol: H7C5D9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 652
  • Mass: 70220
  • Checksum: A68645E50094008C
  • Sequence:
  • MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS NRRLKHFPRG 
    AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH NCLRCLNPAL GNLTALTYLN 
    LSRNQLSLLP PYICQLPLRV LIVSNNKLGA LPPDIGTLGS LRQLDVSSNE LQSLPSELCG 
    LSSLRDLNVR RNQLSTLPEE LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ 
    SPPAQVCLKG KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS 
    GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD PVQIDFIDSH 
    VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE ERRRPDTLQL WQERERRQQQ 
    QSGAWGAPRK DSLLKPGLRA VVGGAAAVST QAMHNGSPKS SASQAGAAAG QGAPAPAPAS 
    QEPLPIAGPA TAPAPRPLGS IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL 
    MTQLRQVLES RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA 
    RKNVESFLEA CRKMGVPEES LCQPHHILEE EGAPGRGLPY IAAVVHALLD RP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.