Details for: SMAD1

Gene ID: 4086

Symbol: SMAD1

Ensembl ID: ENSG00000170365

Description: SMAD family member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 313.9923
    Cell Significance Index: -48.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.0987
    Cell Significance Index: -47.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.2738
    Cell Significance Index: -49.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 94.4476
    Cell Significance Index: -38.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.2097
    Cell Significance Index: -44.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.1993
    Cell Significance Index: -38.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.1799
    Cell Significance Index: -49.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0487
    Cell Significance Index: -48.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.6278
    Cell Significance Index: -49.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.6117
    Cell Significance Index: 18.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5291
    Cell Significance Index: 79.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4734
    Cell Significance Index: 295.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9855
    Cell Significance Index: 37.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9646
    Cell Significance Index: 42.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8987
    Cell Significance Index: 97.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7765
    Cell Significance Index: 21.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6219
    Cell Significance Index: 223.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5787
    Cell Significance Index: 94.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5712
    Cell Significance Index: 32.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5352
    Cell Significance Index: 236.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5260
    Cell Significance Index: 363.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5181
    Cell Significance Index: 3.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4918
    Cell Significance Index: 22.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3870
    Cell Significance Index: 26.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3859
    Cell Significance Index: 8.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3537
    Cell Significance Index: 70.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3372
    Cell Significance Index: 25.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3278
    Cell Significance Index: 9.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3088
    Cell Significance Index: 55.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2952
    Cell Significance Index: 29.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2814
    Cell Significance Index: 7.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2727
    Cell Significance Index: 33.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1571
    Cell Significance Index: 85.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1027
    Cell Significance Index: 4.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0886
    Cell Significance Index: 16.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0771
    Cell Significance Index: 145.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0653
    Cell Significance Index: 11.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0550
    Cell Significance Index: 49.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0250
    Cell Significance Index: 0.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0222
    Cell Significance Index: 0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0127
    Cell Significance Index: 8.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0131
    Cell Significance Index: -0.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0163
    Cell Significance Index: -0.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0204
    Cell Significance Index: -2.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0213
    Cell Significance Index: -9.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0238
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0317
    Cell Significance Index: -19.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0337
    Cell Significance Index: -62.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0355
    Cell Significance Index: -54.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0423
    Cell Significance Index: -31.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0431
    Cell Significance Index: -58.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0514
    Cell Significance Index: -7.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0608
    Cell Significance Index: -8.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0666
    Cell Significance Index: -50.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0667
    Cell Significance Index: -37.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0751
    Cell Significance Index: -4.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1409
    Cell Significance Index: -40.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1827
    Cell Significance Index: -38.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1994
    Cell Significance Index: -23.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2045
    Cell Significance Index: -23.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2447
    Cell Significance Index: -25.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2594
    Cell Significance Index: -33.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3191
    Cell Significance Index: -20.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3248
    Cell Significance Index: -8.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3400
    Cell Significance Index: -5.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3417
    Cell Significance Index: -17.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3445
    Cell Significance Index: -4.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3519
    Cell Significance Index: -12.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3756
    Cell Significance Index: -44.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3769
    Cell Significance Index: -7.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3790
    Cell Significance Index: -6.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4097
    Cell Significance Index: -42.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4110
    Cell Significance Index: -46.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4441
    Cell Significance Index: -33.1000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4933
    Cell Significance Index: -7.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5038
    Cell Significance Index: -23.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5088
    Cell Significance Index: -40.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5470
    Cell Significance Index: -17.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6127
    Cell Significance Index: -21.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6572
    Cell Significance Index: -9.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6705
    Cell Significance Index: -43.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6977
    Cell Significance Index: -36.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7648
    Cell Significance Index: -15.8700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.7923
    Cell Significance Index: -5.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7955
    Cell Significance Index: -48.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8631
    Cell Significance Index: -24.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8635
    Cell Significance Index: -18.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9355
    Cell Significance Index: -20.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0879
    Cell Significance Index: -28.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1036
    Cell Significance Index: -32.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1100
    Cell Significance Index: -26.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.2284
    Cell Significance Index: -32.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2362
    Cell Significance Index: -39.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2447
    Cell Significance Index: -35.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -1.2479
    Cell Significance Index: -20.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.2730
    Cell Significance Index: -64.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2758
    Cell Significance Index: -41.7700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.2761
    Cell Significance Index: -22.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3009
    Cell Significance Index: -25.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SMAD1 exhibits several key characteristics that distinguish it from other SMAD family members: 1. **Receptor binding**: SMAD1 binds to the TGF-β and BMP signaling pathways, mediating the transmission of signals from these receptors to the nucleus. 2. **Transcriptional regulation**: SMAD1 regulates gene expression by interacting with transcription factors, such as Runx2, to modulate the expression of target genes involved in development and differentiation. 3. **Cellular localization**: SMAD1 is primarily localized to the nucleus, where it interacts with chromatin and regulates transcription. 4. **Protein-protein interactions**: SMAD1 interacts with other SMAD proteins, as well as with Runx2 and other transcription factors, to modulate signaling pathways. **Pathways and Functions** SMAD1 is involved in various signaling pathways, including: 1. **TGF-β signaling pathway**: SMAD1 mediates TGF-β signaling by interacting with TGF-β receptors and modulating the expression of target genes involved in cell growth, differentiation, and apoptosis. 2. **BMP signaling pathway**: SMAD1 is also involved in BMP signaling, which is essential for bone development, cartilage formation, and cardiac conduction system development. 3. **Runx2 regulation**: SMAD1 interacts with Runx2 to regulate the expression of target genes involved in bone development, osteoblast differentiation, and osteogenesis. SMAD1 plays a critical role in various cellular processes, including: 1. **Cell differentiation**: SMAD1 regulates the expression of genes involved in cell differentiation, including osteoblast differentiation, cartilage formation, and cardiac conduction system development. 2. **Developmental biology**: SMAD1 is essential for regulating developmental processes, including embryonic pattern specification, germ cell development, and organogenesis. 3. **Gene expression**: SMAD1 regulates gene expression by interacting with transcription factors and modulating the expression of target genes involved in development, differentiation, and cell growth. **Clinical Significance** Dysregulation of SMAD1 has been implicated in various diseases, including: 1. **Bone disorders**: SMAD1 mutations have been linked to bone disorders, such as osteoporosis, bone cancer, and bone metastases. 2. **Cancer**: SMAD1 is involved in the regulation of cell growth and differentiation, and its dysregulation has been implicated in the development of various cancers, including osteosarcoma and breast cancer. 3. **Cardiovascular disease**: SMAD1 is involved in cardiac conduction system development, and its dysregulation has been implicated in the development of cardiovascular disease. In summary, SMAD1 is a critical gene involved in various cellular processes, including development, differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of SMAD1 in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 1178477828

Symbol: SMAD1_HUMAN

Name: Mothers against decapentaplegic homolog 1

UniProtKB Accession Codes:

Q15797 A8KAJ0 D3DNZ9 Q16636 Q9UFT8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 57 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 8 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8673135

Title: Mad-related genes in the human.

PubMed ID: 8673135

DOI: 10.1038/ng0796-347

PubMed ID: 8637600

Title: A human Mad protein acting as a BMP-regulated transcriptional activator.

PubMed ID: 8637600

DOI: 10.1038/381620a0

PubMed ID: 8653785

Title: MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

PubMed ID: 8653785

DOI: 10.1016/s0092-8674(00)81250-7

PubMed ID: 8663601

Title: Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.

PubMed ID: 8663601

DOI: 10.1074/jbc.271.30.17617

PubMed ID: 8774881

Title: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

PubMed ID: 8774881

DOI: 10.1038/383168a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9335504

Title: Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.

PubMed ID: 9335504

DOI: 10.1038/39348

PubMed ID: 9136927

Title: The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

PubMed ID: 9136927

DOI: 10.1101/gad.11.8.984

PubMed ID: 9759503

Title: TGF-beta signal transduction.

PubMed ID: 9759503

DOI: 10.1146/annurev.biochem.67.1.753

PubMed ID: 10647776

Title: Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

PubMed ID: 10647776

DOI: 10.1016/s1359-6101(99)00012-x

PubMed ID: 10660046

Title: OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.

PubMed ID: 10660046

DOI: 10.1016/s0092-8674(00)81561-5

PubMed ID: 10708948

Title: The Smad pathway.

PubMed ID: 10708948

DOI: 10.1016/s1359-6101(99)00024-6

PubMed ID: 10708949

Title: TGF-beta signaling by Smad proteins.

PubMed ID: 10708949

DOI: 10.1016/s1359-6101(99)00025-8

PubMed ID: 12097147

Title: A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).

PubMed ID: 12097147

DOI: 10.1186/1471-2121-3-15

PubMed ID: 14630787

Title: Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.

PubMed ID: 14630787

DOI: 10.1182/blood-2003-07-2388

PubMed ID: 15647271

Title: The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.

PubMed ID: 15647271

DOI: 10.1074/jbc.m411234200

PubMed ID: 17292623

Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.

PubMed ID: 17292623

DOI: 10.1016/j.mcn.2007.01.002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21690388

Title: Smad inhibition by the Ste20 kinase Misshapen.

PubMed ID: 21690388

DOI: 10.1073/pnas.1104128108

PubMed ID: 21947082

Title: USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

PubMed ID: 21947082

DOI: 10.1038/ncb2346

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 21898662

Title: Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension.

PubMed ID: 21898662

DOI: 10.1002/humu.21605

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23150675

Title: Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.

PubMed ID: 23150675

DOI: 10.1074/jbc.m112.413856

PubMed ID: 24554596

Title: Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.

PubMed ID: 24554596

DOI: 10.1098/rsob.130210

PubMed ID: 25755279

Title: Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein signaling and mesenchymal stem cell differentiation.

PubMed ID: 25755279

DOI: 10.1128/mcb.00121-15

PubMed ID: 33667543

Title: Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling.

PubMed ID: 33667543

DOI: 10.1016/j.jbc.2021.100496

PubMed ID: 11779505

Title: Structural basis of Smad1 activation by receptor kinase phosphorylation.

PubMed ID: 11779505

DOI: 10.1016/s1097-2765(01)00417-8

PubMed ID: 21685363

Title: A Smad action turnover switch operated by WW domain readers of a phosphoserine code.

PubMed ID: 21685363

DOI: 10.1101/gad.2060811

PubMed ID: 21454478

Title: Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP).

PubMed ID: 21454478

DOI: 10.1074/jbc.m110.201814

Sequence Information:

  • Length: 465
  • Mass: 52260
  • Checksum: 2DD34B7F434DBC7E
  • Sequence:
    • MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LEKALSCPGQ 
PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKPLECCE FPFGSKQKEV 
CINPYHYKRV ESPVLPPVLV PRHSEYNPQH SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN 
SHPFPHSPNS SYPNSPGSSS STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMTQDGSQ 
PMDTNMMAPP LPSEINRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC 
NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF ETVYELTKMC TIRMSFVKGW 
GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPHNP ISSVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.