Details for: SMAD1
Gene ID: 4086
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SMAD1
Ensembl ID: ENSG00000170365
Description: SMAD family member 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 30.25rCSI 35.07%PRS 84.73
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CSI 26.55rCSI 22.16%PRS 84.69
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CSI 23.95rCSI 42.45%PRS 59.76
-
CSI 23.7rCSI 48.94%PRS 83.85
-
CSI 22.06rCSI 31.2%PRS 85.39
-
CSI 21.45rCSI 25.99%PRS 69.75
-
CSI 19.87rCSI 27.08%PRS 59.11
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CSI 18.2rCSI 28.95%PRS 83.97
-
CSI 17.42rCSI 28.44%PRS 59.36
-
CSI 16.66rCSI 13.8%PRS 90.76
-
CSI 13.91rCSI 12.23%PRS 80.18
-
CSI 12.31rCSI 26.57%PRS 88.59
-
CSI 9.92rCSI 48.9%PRS 93.23
-
CSI 8.79rCSI 20.49%PRS 95.16
-
CSI 8.19rCSI 17%PRS 87.18
-
CSI 7.01rCSI 6.74%PRS 96.19
-
CSI 6.9rCSI 13.68%PRS 91.05
-
CSI 6.68rCSI 8.02%PRS 87.78
-
CSI 6.33rCSI 25.56%PRS 89.67
-
CSI 6.11rCSI 8.49%PRS 87.54
-
CSI 5.75rCSI 6%PRS 87.98
-
CSI 5.53rCSI 5.8%PRS 86.56
-
CSI 5.39rCSI 12.09%PRS 75.62
-
CSI 5.21rCSI 10.46%PRS 82.38
-
CSI 5.19rCSI 11.88%PRS 89.93
-
CSI 5.18rCSI 8.27%PRS 81.38
-
CSI 4.97rCSI 8.6%PRS 83.2
-
CSI 4.95rCSI 3.68%PRS 95.31
-
CSI 4.81rCSI 6.54%PRS 93.86
-
CSI 4.78rCSI 5.13%PRS 90.58
-
CSI 4.72rCSI 9.58%PRS 70.75
-
CSI 4.69rCSI 26.89%PRS 88.76
-
CSI 4.68rCSI 3.7%PRS 81.32
-
CSI 4.56rCSI 5.85%PRS 85.61
-
CSI 4.44rCSI 6.3%PRS 86.5
-
CSI 4.37rCSI 8.18%PRS 79.93
-
CSI 4.17rCSI 5.18%PRS 72.89
-
CSI 4.08rCSI 29.82%PRS 93.84
-
CSI 4rCSI 3.85%PRS 87.77
-
CSI 4rCSI 21.86%PRS 85.74
-
CSI 3.81rCSI 18.26%PRS 89.62
-
CSI 3.8rCSI 3.79%PRS 83.4
-
CSI 3.77rCSI 4.35%PRS 81.83
-
CSI 3.76rCSI 5.12%PRS 82.34
-
CSI 3.72rCSI 2.79%PRS 96.33
-
CSI 3.72rCSI 3.46%PRS 90.11
-
CSI 3.68rCSI 22.99%PRS 82.49
-
CSI 3.61rCSI 5.16%PRS 89.32
-
CSI 3.57rCSI 4.77%PRS 92.62
-
CSI 3.53rCSI 8.57%PRS 72.79
-
CSI 3.5rCSI 3.44%PRS 90.78
-
CSI 3.47rCSI 12.99%PRS 83.9
-
CSI 3.37rCSI 4.95%PRS 83.49
-
CSI 3.18rCSI 3.87%PRS 92.95
-
CSI 3.16rCSI 5.53%PRS 85.05
-
CSI 3.15rCSI 3.91%PRS 88.87
-
CSI 3.14rCSI 9.83%PRS 78.33
-
CSI 3.07rCSI 3.67%PRS 75.17
-
CSI 3.01rCSI 5.39%PRS 87.91
-
CSI 3.01rCSI 4.92%PRS 81.32
-
CSI 2.98rCSI 4.37%PRS 92.53
-
CSI 2.98rCSI 4.79%PRS 76.21
-
CSI 2.97rCSI 7.52%PRS 82.17
-
CSI 2.96rCSI 3.81%PRS 76.23
-
CSI 2.95rCSI 5.36%PRS 82.27
-
CSI 2.94rCSI 9.86%PRS 75.17
-
CSI 2.86rCSI 7.45%PRS 90.32
-
CSI 2.85rCSI 4.55%PRS 91.63
-
CSI 2.82rCSI 7.06%PRS 96.22
-
CSI 2.76rCSI 3.67%PRS 92.14
-
CSI 2.73rCSI 2.86%PRS 91.08
-
CSI 2.69rCSI 3.43%PRS 92.82
-
CSI 2.68rCSI 3.85%PRS 80.95
-
CSI 2.62rCSI 6.77%PRS 85.78
-
CSI 2.58rCSI 6.38%PRS 89.48
-
CSI 2.58rCSI 2.48%PRS 84.61
-
CSI 2.55rCSI 9.65%PRS 75.33
-
CSI 2.55rCSI 7.97%PRS 76.46
-
CSI 2.43rCSI 5.94%PRS 82.09
-
CSI 2.39rCSI 2.48%PRS 90.87
-
CSI 2.34rCSI 2.71%PRS 83.25
-
CSI 2.28rCSI 4.03%PRS 74.57
-
CSI 2.23rCSI 3.41%PRS 88.41
-
CSI 2.21rCSI 2%PRS 87.91
-
CSI 2.16rCSI 6.06%PRS 84.95
-
CSI 2.08rCSI 49.75%PRS 72.79
-
CSI 2.07rCSI 4.94%PRS 89.03
-
CSI 2.04rCSI 49.28%PRS 73.09
-
CSI 2.04rCSI 4.87%PRS 78.01
-
CSI 2.02rCSI 11.89%PRS 75.58
-
CSI 2.01rCSI 5.25%PRS 85.4
-
CSI 1.93rCSI 4.26%PRS 77.84
-
CSI 1.92rCSI 2.2%PRS 93.99
-
CSI 1.91rCSI 5.26%PRS 86
-
CSI 1.85rCSI 4.82%PRS 88.48
-
CSI 1.85rCSI 6.57%PRS 90.52
-
CSI 1.81rCSI 6.5%PRS 73.02
-
CSI 1.73rCSI 1.81%PRS 86.67
-
CSI 1.62rCSI 2.72%PRS 75.08
-
CSI 1.42rCSI 4.68%PRS 77.01
-
CSI 0.3rCSI 2.6%PRS 80.4%
-
CSI 0.7rCSI 4.7%PRS 92.6%
-
CSI 0.7rCSI 5.4%PRS 79.9%
-
CSI 0.9rCSI 20.3%PRS 92.9%
-
CSI 0.9rCSI 7.5%PRS 85.6%
-
CSI 1.0rCSI 2.9%PRS 80.2%
-
CSI 1.2rCSI 3.3%PRS 90.2%
-
CSI 1.3rCSI 5.8%PRS 89.5%
-
CSI 1.3rCSI 12.3%PRS 87.2%
-
CSI 1.4rCSI 3.8%PRS 83.0%
-
CSI 1.4rCSI 4.7%PRS 77.0%
-
CSI 1.6rCSI 2.7%PRS 75.1%
-
CSI 1.7rCSI 1.8%PRS 86.7%
-
CSI 1.8rCSI 6.5%PRS 73.0%
-
CSI 1.9rCSI 6.6%PRS 90.5%
-
CSI 1.9rCSI 4.8%PRS 88.5%
-
CSI 1.9rCSI 5.3%PRS 86.0%
-
CSI 1.9rCSI 2.2%PRS 94.0%
-
CSI 1.9rCSI 4.3%PRS 77.8%
-
CSI 2.0rCSI 5.3%PRS 85.4%
-
CSI 2.0rCSI 11.9%PRS 75.6%
-
CSI 2.0rCSI 4.9%PRS 78.0%
-
CSI 2.0rCSI 49.3%PRS 73.1%
-
CSI 2.1rCSI 4.9%PRS 89.0%
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CSI 2.1rCSI 49.8%PRS 72.8%
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CSI 2.2rCSI 6.1%PRS 85.0%
-
CSI 2.2rCSI 2.0%PRS 87.9%
-
CSI 2.2rCSI 3.4%PRS 88.4%
-
CSI 2.3rCSI 4.0%PRS 74.6%
-
CSI 2.3rCSI 2.7%PRS 83.3%
-
CSI 2.4rCSI 2.5%PRS 90.9%
-
CSI 2.4rCSI 5.9%PRS 82.1%
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CSI 2.6rCSI 8.0%PRS 76.5%
-
CSI 2.6rCSI 9.7%PRS 75.3%
-
CSI 2.6rCSI 2.5%PRS 84.6%
-
CSI 2.6rCSI 6.4%PRS 89.5%
-
CSI 2.6rCSI 6.8%PRS 85.8%
-
CSI 2.7rCSI 3.9%PRS 81.0%
-
CSI 2.7rCSI 3.4%PRS 92.8%
-
CSI 2.7rCSI 2.9%PRS 91.1%
-
CSI 2.8rCSI 3.7%PRS 92.1%
-
CSI 2.8rCSI 7.1%PRS 96.2%
-
CSI 2.9rCSI 4.6%PRS 91.6%
-
CSI 2.9rCSI 7.5%PRS 90.3%
-
CSI 2.9rCSI 9.9%PRS 75.2%
-
CSI 3.0rCSI 5.4%PRS 82.3%
-
CSI 3.0rCSI 3.8%PRS 76.2%
-
CSI 3.0rCSI 7.5%PRS 82.2%
-
CSI 3.0rCSI 4.8%PRS 76.2%
-
CSI 3.0rCSI 4.4%PRS 92.5%
-
CSI 3.0rCSI 4.9%PRS 81.3%
-
CSI 3.0rCSI 5.4%PRS 87.9%
-
CSI 3.1rCSI 3.7%PRS 75.2%
-
CSI 3.1rCSI 9.8%PRS 78.3%
-
CSI 3.2rCSI 3.9%PRS 88.9%
-
CSI 3.2rCSI 5.5%PRS 85.1%
-
CSI 3.2rCSI 3.9%PRS 93.0%
-
CSI 3.4rCSI 5.0%PRS 83.5%
-
CSI 3.5rCSI 13.0%PRS 83.9%
-
CSI 3.5rCSI 3.4%PRS 90.8%
-
CSI 3.5rCSI 8.6%PRS 72.8%
-
CSI 3.6rCSI 4.8%PRS 92.6%
-
CSI 3.6rCSI 5.2%PRS 89.3%
-
CSI 3.7rCSI 23.0%PRS 82.5%
-
CSI 3.7rCSI 3.5%PRS 90.1%
-
CSI 3.7rCSI 2.8%PRS 96.3%
-
CSI 3.8rCSI 5.1%PRS 82.3%
-
CSI 3.8rCSI 4.4%PRS 81.8%
-
CSI 3.8rCSI 3.8%PRS 83.4%
-
CSI 3.8rCSI 18.3%PRS 89.6%
-
CSI 4.0rCSI 21.9%PRS 85.7%
-
CSI 4.0rCSI 3.9%PRS 87.8%
-
CSI 4.1rCSI 29.8%PRS 93.8%
-
CSI 4.2rCSI 5.2%PRS 72.9%
-
CSI 4.4rCSI 8.2%PRS 79.9%
-
CSI 4.4rCSI 6.3%PRS 86.5%
-
CSI 4.6rCSI 5.9%PRS 85.6%
-
CSI 4.7rCSI 3.7%PRS 81.3%
-
CSI 4.7rCSI 26.9%PRS 88.8%
-
CSI 4.7rCSI 9.6%PRS 70.8%
-
CSI 4.8rCSI 5.1%PRS 90.6%
-
CSI 4.8rCSI 6.5%PRS 93.9%
-
CSI 5.0rCSI 3.7%PRS 95.3%
-
CSI 5.0rCSI 8.6%PRS 83.2%
-
CSI 5.2rCSI 8.3%PRS 81.4%
-
CSI 5.2rCSI 11.9%PRS 89.9%
-
CSI 5.2rCSI 10.5%PRS 82.4%
-
CSI 5.4rCSI 12.1%PRS 75.6%
-
CSI 5.5rCSI 5.8%PRS 86.6%
-
CSI 5.8rCSI 6.0%PRS 88.0%
-
CSI 6.1rCSI 8.5%PRS 87.5%
-
CSI 6.3rCSI 25.6%PRS 89.7%
-
CSI 6.7rCSI 8.0%PRS 87.8%
-
CSI 6.9rCSI 13.7%PRS 91.1%
-
CSI 7.0rCSI 6.7%PRS 96.2%
-
CSI 8.2rCSI 17.0%PRS 87.2%
-
CSI 8.8rCSI 20.5%PRS 95.2%
-
CSI 9.9rCSI 48.9%PRS 93.2%
-
CSI 12.3rCSI 26.6%PRS 88.6%
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CSI 13.9rCSI 12.2%PRS 80.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1178477828
Symbol: SMAD1_HUMAN
Name: Mothers against decapentaplegic homolog 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8673135
PubMed ID: 8637600
Title: A human Mad protein acting as a BMP-regulated transcriptional activator.
PubMed ID: 8637600
DOI: 10.1038/381620a0
PubMed ID: 8653785
Title: MADR1, a MAD-related protein that functions in BMP2 signaling pathways.
PubMed ID: 8653785
PubMed ID: 8663601
Title: Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.
PubMed ID: 8663601
PubMed ID: 8774881
Title: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
PubMed ID: 8774881
DOI: 10.1038/383168a0
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9335504
Title: Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.
PubMed ID: 9335504
DOI: 10.1038/39348
PubMed ID: 9136927
Title: The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
PubMed ID: 9136927
DOI: 10.1101/gad.11.8.984
PubMed ID: 9759503
PubMed ID: 10647776
Title: Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.
PubMed ID: 10647776
PubMed ID: 10660046
Title: OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
PubMed ID: 10660046
PubMed ID: 10708948
PubMed ID: 10708949
PubMed ID: 12097147
Title: A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
PubMed ID: 12097147
PubMed ID: 14630787
Title: Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells.
PubMed ID: 14630787
PubMed ID: 15647271
Title: The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.
PubMed ID: 15647271
PubMed ID: 17292623
Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
PubMed ID: 17292623
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21690388
Title: Smad inhibition by the Ste20 kinase Misshapen.
PubMed ID: 21690388
PubMed ID: 21947082
Title: USP15 is a deubiquitylating enzyme for receptor-activated SMADs.
PubMed ID: 21947082
DOI: 10.1038/ncb2346
PubMed ID: 22781750
Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
PubMed ID: 22781750
PubMed ID: 21898662
Title: Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension.
PubMed ID: 21898662
DOI: 10.1002/humu.21605
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23150675
Title: Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.
PubMed ID: 23150675
PubMed ID: 24554596
Title: Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.
PubMed ID: 24554596
DOI: 10.1098/rsob.130210
PubMed ID: 25755279
Title: Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein signaling and mesenchymal stem cell differentiation.
PubMed ID: 25755279
DOI: 10.1128/mcb.00121-15
PubMed ID: 33667543
Title: Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling.
PubMed ID: 33667543
PubMed ID: 11779505
Title: Structural basis of Smad1 activation by receptor kinase phosphorylation.
PubMed ID: 11779505
PubMed ID: 21685363
Title: A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
PubMed ID: 21685363
DOI: 10.1101/gad.2060811
PubMed ID: 21454478
Title: Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP).
PubMed ID: 21454478
Sequence Information:
- Length: 465
- Mass: 52260
- Checksum: 2DD34B7F434DBC7E
- Sequence:
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE LEKALSCPGQ PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH HELKPLECCE FPFGSKQKEV CINPYHYKRV ESPVLPPVLV PRHSEYNPQH SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN SHPFPHSPNS SYPNSPGSSS STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMTQDGSQ PMDTNMMAPP LPSEINRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF ETVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPHNP ISSVS