Details for: SMAD5
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 18.77rCSI 33.59%PRS 23.98
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CSI 12.2rCSI 17.51%PRS 20.23
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CSI 7.27rCSI 35.82%PRS 34.52
-
CSI 6.07rCSI 9.78%PRS 37.35
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CSI 5.94rCSI 13.12%PRS 18.52
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CSI 5.43rCSI 8.31%PRS 40.62
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CSI 5.35rCSI 7.9%PRS 39.57
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CSI 5.32rCSI 6.25%PRS 29.46
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CSI 5.29rCSI 31.14%PRS 16.46
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CSI 5.27rCSI 5.07%PRS 26.71
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CSI 5.25rCSI 4.57%PRS 32.39
-
CSI 4.57rCSI 12.07%PRS 30.72
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CSI 4.09rCSI 9.83%PRS 39.97
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CSI 3.96rCSI 24.72%PRS 20.57
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CSI 3.82rCSI 8.55%PRS 16.27
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CSI 3.67rCSI 13.22%PRS 14.82
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CSI 3.53rCSI 9.13%PRS 23.84
-
CSI 3.5rCSI 4.49%PRS 24.63
-
CSI 3.27rCSI 7.23%PRS 23.81
-
CSI 3.17rCSI 4.31%PRS 37.55
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CSI 3.16rCSI 3.24%PRS 44.7
-
CSI 3.15rCSI 2.45%PRS 37.7
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CSI 3.15rCSI 4.68%PRS 29.51
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CSI 3.12rCSI 3.35%PRS 23.79
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CSI 3.04rCSI 2.87%PRS 27
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CSI 2.9rCSI 7.37%PRS 25.2
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CSI 2.85rCSI 4.19%PRS 23.77
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CSI 2.84rCSI 7.96%PRS 39.28
-
CSI 2.62rCSI 4.18%PRS 21.99
-
CSI 2.61rCSI 3.28%PRS 33.28
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CSI 2.61rCSI 6.25%PRS 43.26
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CSI 2.59rCSI 3.3%PRS 29.59
-
CSI 2.59rCSI 12.06%PRS 51.18
-
CSI 2.57rCSI 1.79%PRS 27.39
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CSI 2.43rCSI 9.91%PRS 36.13
-
CSI 2.34rCSI 1.94%PRS 24.55
-
CSI 2.28rCSI 6.67%PRS 62.21
-
CSI 2.25rCSI 3.3%PRS 33.56
-
CSI 2.22rCSI 6.59%PRS 35.12
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CSI 2.22rCSI 1.97%PRS 26.06
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CSI 2.2rCSI 4.14%PRS 47.15
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CSI 2.17rCSI 1.63%PRS 27.62
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CSI 2.16rCSI 10.33%PRS 22.23
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CSI 2.15rCSI 5.01%PRS 54.17
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CSI 2.14rCSI 1.44%PRS 32.03
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CSI 2.13rCSI 4.99%PRS 35.75
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CSI 2.1rCSI 4.81%PRS 25.23
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CSI 2.1rCSI 1.84%PRS 29.61
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CSI 2.07rCSI 5.38%PRS 25.75
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CSI 2.06rCSI 2.81%PRS 29.06
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CSI 2.06rCSI 2.02%PRS 27.65
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CSI 2.05rCSI 2.45%PRS 15.47
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CSI 2rCSI 3.23%PRS 25.75
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CSI 1.99rCSI 5.2%PRS 37.25
-
CSI 1.98rCSI 2.46%PRS 14.7
-
CSI 1.95rCSI 3.48%PRS 40.78
-
CSI 1.95rCSI 1.61%PRS 26.18
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CSI 1.94rCSI 9.28%PRS 30.57
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CSI 1.92rCSI 1.92%PRS 22.11
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CSI 1.92rCSI 2.3%PRS 24.98
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CSI 1.91rCSI 1.99%PRS 26.47
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CSI 1.9rCSI 1.99%PRS 27.4
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CSI 1.88rCSI 1.39%PRS 22.12
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CSI 1.87rCSI 2.65%PRS 23.94
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CSI 1.84rCSI 3.65%PRS 55.68
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CSI 1.83rCSI 4.37%PRS 28.72
-
CSI 1.81rCSI 6.86%PRS 16.29
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CSI 1.78rCSI 1.83%PRS 40.38
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CSI 1.77rCSI 1.38%PRS 25.1
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CSI 1.76rCSI 2.45%PRS 26
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CSI 1.76rCSI 2.88%PRS 19.98
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CSI 1.75rCSI 4%PRS 26.16
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CSI 1.75rCSI 2.34%PRS 32.75
-
CSI 1.73rCSI 1.29%PRS 41.92
-
CSI 1.73rCSI 3.29%PRS 39.97
-
CSI 1.72rCSI 4.09%PRS 31.29
-
CSI 1.69rCSI 1.63%PRS 19.11
-
CSI 1.68rCSI 1.56%PRS 25.79
-
CSI 1.68rCSI 1.45%PRS 37.25
-
CSI 1.67rCSI 2.6%PRS 36.95
-
CSI 1.66rCSI 1.92%PRS 22.33
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CSI 1.63rCSI 3.48%PRS 39.76
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CSI 1.62rCSI 7.04%PRS 42.02
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CSI 1.61rCSI 8.07%PRS 33.93
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CSI 1.6rCSI 1.39%PRS 28.92
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CSI 1.59rCSI 1.89%PRS 43.47
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CSI 1.58rCSI 5.92%PRS 21.71
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CSI 1.58rCSI 3.27%PRS 25.53
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CSI 1.57rCSI 1.27%PRS 26.92
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CSI 1.56rCSI 2.31%PRS 29.33
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CSI 1.55rCSI 2.68%PRS 19.8
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CSI 1.54rCSI 2.79%PRS 38.91
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CSI 1.53rCSI 1.35%PRS 18.9
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CSI 1.53rCSI 1.21%PRS 17.78
-
CSI 1.52rCSI 2.22%PRS 27.38
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CSI 1.52rCSI 1.66%PRS 28.83
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CSI 1.51rCSI 1.6%PRS 41.79
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CSI 1.5rCSI 2.37%PRS 26.01
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CSI 1.5rCSI 2.04%PRS 22.38
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CSI 1.48rCSI 3.37%PRS 22.11
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CSI 0.1rCSI 3.5%PRS 51.2%
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CSI 0.2rCSI 3.9%PRS 14.5%
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CSI 0.2rCSI 2.0%PRS 43.5%
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CSI 0.2rCSI 0.3%PRS 19.8%
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CSI 0.2rCSI 5.1%PRS 15.4%
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CSI 0.3rCSI 2.1%PRS 46.8%
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CSI 0.3rCSI 3.5%PRS 46.6%
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CSI 0.3rCSI 2.0%PRS 37.1%
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CSI 0.4rCSI 1.1%PRS 17.9%
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CSI 0.4rCSI 0.7%PRS 26.7%
-
CSI 0.4rCSI 2.7%PRS 45.2%
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CSI 0.4rCSI 1.5%PRS 32.5%
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CSI 0.4rCSI 1.8%PRS 56.0%
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CSI 0.4rCSI 1.2%PRS 16.5%
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CSI 0.4rCSI 1.4%PRS 40.1%
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CSI 0.4rCSI 2.2%PRS 42.5%
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CSI 0.5rCSI 1.2%PRS 15.4%
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CSI 0.5rCSI 1.5%PRS 28.8%
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CSI 0.5rCSI 1.4%PRS 24.2%
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CSI 0.5rCSI 0.9%PRS 15.7%
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CSI 0.6rCSI 2.4%PRS 45.2%
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CSI 0.6rCSI 1.5%PRS 21.5%
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CSI 0.6rCSI 2.9%PRS 27.6%
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CSI 0.6rCSI 2.5%PRS 54.9%
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CSI 0.6rCSI 14.0%PRS 46.5%
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CSI 0.6rCSI 1.8%PRS 20.2%
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CSI 0.6rCSI 1.0%PRS 33.1%
-
CSI 0.6rCSI 1.5%PRS 18.1%
-
CSI 0.6rCSI 4.7%PRS 58.7%
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CSI 0.7rCSI 1.0%PRS 23.7%
-
CSI 0.7rCSI 1.7%PRS 37.4%
-
CSI 0.7rCSI 1.9%PRS 33.3%
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CSI 0.7rCSI 0.8%PRS 36.5%
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CSI 0.8rCSI 1.7%PRS 38.2%
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CSI 0.8rCSI 0.6%PRS 24.3%
-
CSI 0.8rCSI 2.5%PRS 22.0%
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CSI 0.8rCSI 1.9%PRS 36.8%
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CSI 0.8rCSI 1.1%PRS 28.3%
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CSI 0.8rCSI 1.5%PRS 50.6%
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CSI 0.8rCSI 2.6%PRS 34.8%
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CSI 0.8rCSI 2.4%PRS 43.1%
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CSI 0.8rCSI 1.0%PRS 43.2%
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CSI 0.8rCSI 1.6%PRS 26.6%
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CSI 0.9rCSI 1.5%PRS 15.4%
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CSI 0.9rCSI 1.5%PRS 32.9%
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CSI 0.9rCSI 2.5%PRS 31.6%
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CSI 1.0rCSI 1.2%PRS 16.3%
-
CSI 1.0rCSI 7.1%PRS 16.4%
-
CSI 1.0rCSI 3.8%PRS 46.3%
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CSI 1.0rCSI 5.9%PRS 42.5%
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CSI 1.0rCSI 0.8%PRS 26.0%
-
CSI 1.0rCSI 1.0%PRS 30.4%
-
CSI 1.0rCSI 1.6%PRS 21.7%
-
CSI 1.0rCSI 2.2%PRS 34.1%
-
CSI 1.0rCSI 1.6%PRS 17.1%
-
CSI 1.0rCSI 2.6%PRS 19.7%
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CSI 1.0rCSI 1.6%PRS 29.4%
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CSI 1.1rCSI 4.2%PRS 41.7%
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CSI 1.1rCSI 1.3%PRS 19.1%
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CSI 1.1rCSI 4.9%PRS 25.1%
-
CSI 1.1rCSI 2.6%PRS 46.6%
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CSI 1.1rCSI 1.4%PRS 29.7%
-
CSI 1.1rCSI 1.6%PRS 39.4%
-
CSI 1.1rCSI 6.0%PRS 52.9%
-
CSI 1.1rCSI 3.1%PRS 40.9%
-
CSI 1.1rCSI 1.7%PRS 24.2%
-
CSI 1.1rCSI 3.6%PRS 26.6%
-
CSI 1.1rCSI 1.0%PRS 30.3%
-
CSI 1.2rCSI 1.1%PRS 26.9%
-
CSI 1.2rCSI 2.8%PRS 24.0%
-
CSI 1.2rCSI 2.1%PRS 21.4%
-
CSI 1.2rCSI 3.8%PRS 30.3%
-
CSI 1.2rCSI 1.8%PRS 26.0%
-
CSI 1.2rCSI 1.6%PRS 25.2%
-
CSI 1.2rCSI 2.2%PRS 32.8%
-
CSI 1.2rCSI 2.9%PRS 37.3%
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CSI 1.2rCSI 2.2%PRS 22.0%
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CSI 1.2rCSI 4.8%PRS 41.9%
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CSI 1.2rCSI 2.5%PRS 19.2%
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CSI 1.2rCSI 1.8%PRS 28.7%
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CSI 1.2rCSI 5.0%PRS 24.1%
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CSI 1.2rCSI 1.3%PRS 24.1%
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CSI 1.3rCSI 1.6%PRS 27.6%
-
CSI 1.3rCSI 1.6%PRS 24.9%
-
CSI 1.3rCSI 3.6%PRS 28.2%
-
CSI 1.3rCSI 3.7%PRS 30.0%
-
CSI 1.3rCSI 3.0%PRS 20.9%
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CSI 1.3rCSI 3.4%PRS 24.4%
-
CSI 1.3rCSI 3.3%PRS 31.6%
-
CSI 1.3rCSI 1.8%PRS 28.0%
-
CSI 1.3rCSI 1.8%PRS 28.5%
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CSI 1.3rCSI 1.2%PRS 33.8%
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CSI 1.3rCSI 5.2%PRS 34.5%
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CSI 1.4rCSI 1.2%PRS 23.5%
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CSI 1.4rCSI 2.5%PRS 18.9%
-
CSI 1.4rCSI 2.0%PRS 28.6%
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CSI 1.4rCSI 1.7%PRS 22.7%
-
CSI 1.4rCSI 2.5%PRS 20.1%
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CSI 1.5rCSI 2.3%PRS 28.3%
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CSI 1.5rCSI 1.5%PRS 26.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3828878677
Symbol: SMAD5_HUMAN
Name: Mothers against decapentaplegic homolog 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8673135
PubMed ID: 9288787
Title: Localization of SMAD5 and its evaluation as a candidate myeloid tumor suppressor.
PubMed ID: 9288787
PubMed ID: 9264367
Title: Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60.
PubMed ID: 9264367
PubMed ID: 9484787
Title: hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors.
PubMed ID: 9484787
PubMed ID: 9442019
Title: Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12.
PubMed ID: 9442019
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9759503
PubMed ID: 10647776
Title: Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.
PubMed ID: 10647776
PubMed ID: 10708948
PubMed ID: 10708949
PubMed ID: 12370310
Title: Identification of mZnf8, a mouse Kruppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
PubMed ID: 12370310
PubMed ID: 12064918
Title: Inhibition of Smad5 in human hematopoietic progenitors blocks erythroid differentiation induced by BMP4.
PubMed ID: 12064918
PubMed ID: 12849988
Title: Mitochondrial localization of Smad5 in a human chondrogenic cell line.
PubMed ID: 12849988
PubMed ID: 15107829
Title: Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.
PubMed ID: 15107829
PubMed ID: 15647271
Title: The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.
PubMed ID: 15647271
PubMed ID: 16516194
Title: Hgs physically interacts with Smad5 and attenuates BMP signaling.
PubMed ID: 16516194
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 25755279
Title: Nuclear export of Smads by RanBP3L regulates bone morphogenetic protein signaling and mesenchymal stem cell differentiation.
PubMed ID: 25755279
DOI: 10.1128/mcb.00121-15
PubMed ID: 28675158
Title: Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis.
PubMed ID: 28675158
DOI: 10.1038/cr.2017.85
PubMed ID: 33510867
Title: Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes.
PubMed ID: 33510867
Sequence Information:
- Length: 465
- Mass: 52258
- Checksum: 4A1FD7EC7BD06728
- Sequence:
MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME ELEKALSSPG QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS HHELKPLDIC EFPFGSKQKE VCINPYHYKR VESPVLPPVL VPRHNEFNPQ HSLLVQFRNL SHNEPHMPQN ATFPDSFHQP NNTPFPLSPN SPYPPSPASS TYPNSPASSG PGSPFQLPAD TPPPAYMPPD DQMGQDNSQP MDTSNNMIPQ IMPSISSRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT DPSNNKSRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC NFHHGFHPTT VCKIPSSCSL KIFNNQEFAQ LLAQSVNHGF EAVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPLNP ISSVS