Details for: MDH2

Gene ID: 4191

Symbol: MDH2

Ensembl ID: ENSG00000146701

Description: malate dehydrogenase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 380.0181
    Cell Significance Index: -59.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.0092
    Cell Significance Index: -47.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 171.5024
    Cell Significance Index: -70.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 156.0096
    Cell Significance Index: -63.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.4938
    Cell Significance Index: -72.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 140.3034
    Cell Significance Index: -72.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 109.1022
    Cell Significance Index: -73.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.3375
    Cell Significance Index: -64.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.9290
    Cell Significance Index: -67.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.0180
    Cell Significance Index: -71.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.0670
    Cell Significance Index: -45.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.7613
    Cell Significance Index: -48.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.8063
    Cell Significance Index: 41.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7558
    Cell Significance Index: 128.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.6157
    Cell Significance Index: 54.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5462
    Cell Significance Index: 74.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1248
    Cell Significance Index: 274.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1011
    Cell Significance Index: 98.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0904
    Cell Significance Index: 147.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.0597
    Cell Significance Index: 54.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0528
    Cell Significance Index: 16.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0239
    Cell Significance Index: 277.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9585
    Cell Significance Index: 126.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9117
    Cell Significance Index: 1044.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8692
    Cell Significance Index: 220.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8684
    Cell Significance Index: 336.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8070
    Cell Significance Index: 16.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7644
    Cell Significance Index: 131.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7607
    Cell Significance Index: 778.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6437
    Cell Significance Index: 202.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5591
    Cell Significance Index: 36.0200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5305
    Cell Significance Index: 19.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4538
    Cell Significance Index: 75.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4151
    Cell Significance Index: 97.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1053
    Cell Significance Index: 109.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9933
    Cell Significance Index: 21.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9519
    Cell Significance Index: 49.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8681
    Cell Significance Index: 23.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8414
    Cell Significance Index: 29.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8408
    Cell Significance Index: 107.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7507
    Cell Significance Index: 128.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6611
    Cell Significance Index: 7.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5642
    Cell Significance Index: 107.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5637
    Cell Significance Index: 111.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5549
    Cell Significance Index: 90.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4771
    Cell Significance Index: 95.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1983
    Cell Significance Index: 8.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1728
    Cell Significance Index: 10.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1508
    Cell Significance Index: 4.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1276
    Cell Significance Index: 45.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1116
    Cell Significance Index: 81.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1072
    Cell Significance Index: 81.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0314
    Cell Significance Index: 0.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0277
    Cell Significance Index: 0.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0143
    Cell Significance Index: 0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0109
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0236
    Cell Significance Index: -44.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0369
    Cell Significance Index: -23.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0450
    Cell Significance Index: -83.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0544
    Cell Significance Index: -83.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0633
    Cell Significance Index: -2.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0650
    Cell Significance Index: -88.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0696
    Cell Significance Index: -39.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0706
    Cell Significance Index: -48.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0762
    Cell Significance Index: -8.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0845
    Cell Significance Index: -53.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0862
    Cell Significance Index: -2.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0916
    Cell Significance Index: -4.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1222
    Cell Significance Index: -55.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1336
    Cell Significance Index: -28.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1622
    Cell Significance Index: -2.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2539
    Cell Significance Index: -73.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2884
    Cell Significance Index: -8.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2950
    Cell Significance Index: -22.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2963
    Cell Significance Index: -7.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3742
    Cell Significance Index: -10.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3775
    Cell Significance Index: -4.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4041
    Cell Significance Index: -24.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4154
    Cell Significance Index: -60.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4345
    Cell Significance Index: -49.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4393
    Cell Significance Index: -51.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4496
    Cell Significance Index: -35.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5758
    Cell Significance Index: -35.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6028
    Cell Significance Index: -6.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6780
    Cell Significance Index: -70.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7705
    Cell Significance Index: -51.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8033
    Cell Significance Index: -23.6600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8599
    Cell Significance Index: -15.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8823
    Cell Significance Index: -49.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9396
    Cell Significance Index: -12.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.1084
    Cell Significance Index: -9.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.1758
    Cell Significance Index: -28.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2045
    Cell Significance Index: -73.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2640
    Cell Significance Index: -55.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2717
    Cell Significance Index: -31.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.2788
    Cell Significance Index: -7.8700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.4890
    Cell Significance Index: -20.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4927
    Cell Significance Index: -38.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5026
    Cell Significance Index: -56.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MDH2 is a mitochondrial enzyme that catalyzes the oxidative decarboxylation of malate to oxaloacetate, generating NADH in the process. This enzyme is highly conserved across species, with high sequence identity among different organisms. MDH2 is composed of two subunits, A and B, which interact to form a heterodimeric enzyme. The enzyme's activity is regulated by various factors, including NAD+ and malate concentrations, and is influenced by post-translational modifications, such as phosphorylation and ubiquitination. **Pathways and Functions:** MDH2 is integral to several metabolic pathways, including: 1. **Aerobic Respiration:** MDH2 is a key enzyme in the electron transport chain, where it generates NADH, which is then used to produce ATP during oxidative phosphorylation. 2. **Citric Acid Cycle (TCA Cycle):** MDH2 participates in the TCA cycle by converting malate to oxaloacetate, producing NADH and generating energy for the cell. 3. **Glucose Metabolism:** MDH2 is involved in glycolysis, gluconeogenesis, and glycogenolysis, regulating glucose metabolism and energy production. 4. **Mitochondrial Protein Degradation:** MDH2 is also implicated in the regulation of mitochondrial protein degradation, influencing cellular energy homeostasis. **Clinical Significance:** MDH2 has significant implications in various diseases, including: 1. **Mitochondrial Disorders:** Mutations in the MDH2 gene have been linked to mitochondrial disorders, such as Leigh syndrome and mitochondrial myopathies. 2. **Cancer:** MDH2 is overexpressed in various cancers, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 3. **Infectious Diseases:** MDH2 is involved in the regulation of immune responses, and alterations in its expression have been observed in infectious diseases, such as tuberculosis and HIV. **Significantly Expressed Cells:** MDH2 is highly expressed in various cell types, including: 1. **Skeletal Muscle Satellite Cells:** MDH2 plays a crucial role in muscle regeneration and energy metabolism. 2. **Myeloid Dendritic Cells:** MDH2 is involved in the regulation of immune responses and antigen presentation. 3. **Erythroid Progenitor Cells:** MDH2 is essential for the production of red blood cells and energy metabolism. In conclusion, MDH2 is a critical enzyme that plays a vital role in various metabolic pathways, including aerobic respiration, citric acid cycle, and glucose metabolism. Its dysregulation has significant implications in various diseases, including mitochondrial disorders, cancer, and infectious diseases. Further research is needed to fully understand the mechanisms underlying MDH2's functions and to explore its therapeutic potential. **References:** * [Insert relevant references] **Recommendations:** * Further research is needed to elucidate the mechanisms underlying MDH2's functions and regulation. * Investigation of MDH2's role in various diseases, including mitochondrial disorders, cancer, and infectious diseases, is warranted. * Development of therapeutic strategies targeting MDH2 may provide new avenues for treatment of these diseases.

Genular Protein ID: 217293042

Symbol: MDHM_HUMAN

Name: Malate dehydrogenase, mitochondrial

UniProtKB Accession Codes:

P40926 A8K414 B2RE78 B4DE44 E9PDB2 O43682

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 5 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 3 RefSeq 3 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20167786

Title: Regulation of cellular metabolism by protein lysine acetylation.

PubMed ID: 20167786

DOI: 10.1126/science.1179689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27989324

Title: Mutations in MDH2, encoding a Krebs cycle enzyme, cause early-onset severe encephalopathy.

PubMed ID: 27989324

DOI: 10.1016/j.ajhg.2016.11.014

Sequence Information:

  • Length: 338
  • Mass: 35503
  • Checksum: AAB9F5E5B2FBC8CA
  • Sequence:
    • MLSALARPAS AALRRSFSTS AQNNAKVAVL GASGGIGQPL SLLLKNSPLV SRLTLYDIAH 
TPGVAADLSH IETKAAVKGY LGPEQLPDCL KGCDVVVIPA GVPRKPGMTR DDLFNTNATI 
VATLTAACAQ HCPEAMICVI ANPVNSTIPI TAEVFKKHGV YNPNKIFGVT TLDIVRANTF 
VAELKGLDPA RVNVPVIGGH AGKTIIPLIS QCTPKVDFPQ DQLTALTGRI QEAGTEVVKA 
KAGAGSATLS MAYAGARFVF SLVDAMNGKE GVVECSFVKS QETECTYFST PLLLGKKGIE 
KNLGIGKVSS FEEKMISDAI PELKASIKKG EDFVKTLK

Genular Protein ID: 995844631

Symbol: B3KTM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KTM1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 2 InterPro 6 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 4 RefSeq 3 Rhea 1 RuleBase 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 231
  • Mass: 24657
  • Checksum: 4F67FC3D120A7066
  • Sequence:
    • MTRDDLFNTN ATIVATLTAA CAQHCPEAMI CVIANPVNST IPITAEVFKK HGVYNPNKIF 
GVTTLDIVRA NTFVAELKGL DPARVNVPVI GGHAGKTIIP LISQCTPKVD FPQDQLTALT 
GRFQEAGTEV VKAKAGAGSA TLSMAYAGAR FVFSLVDAMN GKEGVVECSF VKSQETECTY 
FSTPLLLGKK GIERNLGIGK VSSFEEKMIS DAIPELKASI KKGEDFVKTL K

Genular Protein ID: 514997742

Symbol: G3XAL0_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3XAL0

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 RuleBase 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 231
  • Mass: 24595
  • Checksum: F90A418BCE2CFD3E
  • Sequence:
    • MTRDDLFNTN ATIVATLTAA CAQHCPEAMI CVIANPVNST IPITAEVFKK HGVYNPNKIF 
GVTTLDIVRA NTFVAELKGL DPARVNVPVI GGHAGKTIIP LISQCTPKVD FPQDQLTALT 
GRIQEAGTEV VKAKAGAGSA TLSMAYAGAR FVFSLVDAMN GKEGVVECSF VKSQETECTY 
FSTPLLLGKK GIEKNLGIGK VSSFEEKMIS DAIPELKASI KKGEDFVKTL K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.